Motif ID: NR1H4.p2

Z-value: 1.692


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4



Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_3097070 2.316 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr6_+_31731647 2.095 NM_019101
APOM
apolipoprotein M
chr6_+_31731667 2.091 APOM
apolipoprotein M
chr3_-_50315983 1.964 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr1_-_27113018 1.714 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr3_+_52803823 1.693 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr14_-_22825148 1.583 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr12_-_7172641 1.533 NM_031491
RBP5
retinol binding protein 5, cellular
chr19_+_15644885 1.515 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_-_150070849 1.515 NM_005060
RORC
RAR-related orphan receptor C
chr2_-_73723001 1.477 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr19_+_59107802 1.404 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr22_+_23329113 1.378 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr6_-_33655811 1.273 BAK1
BCL2-antagonist/killer 1
chr17_+_18796202 1.240 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr9_-_135074364 1.208 NM_014581
OBP2B
OBP2A
odorant binding protein 2B
odorant binding protein 2A
chr6_-_33655995 1.195 NM_001188
BAK1
BCL2-antagonist/killer 1
chr3_-_127719283 1.185 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr7_+_26298136 1.158 SNX10
sorting nexin 10
chr14_-_22825072 1.099 HOMEZ
homeobox and leucine zipper encoding
chr19_-_15451203 1.082 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr19_-_40995564 1.065 PRODH2
proline dehydrogenase (oxidase) 2
chr21_+_41663853 1.063 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr7_+_99052489 1.023 NM_145115
ZNF498
zinc finger protein 498
chr4_-_69852090 1.021 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr20_+_61839931 1.011 LIME1
Lck interacting transmembrane adaptor 1
chr2_-_96167900 1.001 NM_001002036
ASTL
astacin-like metallo-endopeptidase (M12 family)
chr20_+_61967094 0.991 TPD52L2
tumor protein D52-like 2
chr20_+_61967078 0.967 TPD52L2
tumor protein D52-like 2
chr1_+_152560179 0.960 NM_080429
AQP10
aquaporin 10
chr11_-_64459910 0.932 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr7_+_134567270 0.925 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr17_-_71352182 0.923 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr20_+_61967122 0.900 TPD52L2
tumor protein D52-like 2
chr17_-_24062998 0.859 NM_152465
PROCA1
protein interacting with cyclin A1
chr20_+_35964962 0.859 VSTM2L
V-set and transmembrane domain containing 2 like
chr14_-_106064887 0.858 LOC100126583
IGHV3-48
IGHA1
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 3-48
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr17_+_2627099 0.854 RAP1GAP2
RAP1 GTPase activating protein 2
chr5_+_140559366 0.851 NM_018931
PCDHB11
protocadherin beta 11
chr9_+_137577805 0.846 NM_014582
OBP2A
odorant binding protein 2A
chr12_+_51728999 0.842 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr7_+_128099581 0.841 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr14_-_23107106 0.826 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr17_-_30414789 0.817 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr1_+_64983312 0.807 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr16_+_24765052 0.779 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr20_+_35964912 0.764 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr12_+_51729239 0.763 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr17_-_33753218 0.753 NM_001004334
GPR179
G protein-coupled receptor 179
chr20_-_22512893 0.750 FOXA2
forkhead box A2
chr2_+_108271526 0.749 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr2_-_178645718 0.748 NM_016953
PDE11A
phosphodiesterase 11A
chr16_+_25135783 0.735 NM_001169
AQP8
aquaporin 8
chr17_-_71352090 0.733 UNC13D
unc-13 homolog D (C. elegans)
chr12_-_56422120 0.731 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr2_-_21079145 0.730 APOB
apolipoprotein B (including Ag(x) antigen)
chr5_+_140568451 0.707 NM_018932
PCDHB12
protocadherin beta 12
chr14_+_21015198 0.695 TOX4
TOX high mobility group box family member 4
chr14_+_21015211 0.679 TOX4
TOX high mobility group box family member 4
chr20_-_33750457 0.674 NM_001198989
NM_021100
NFS1

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

chr16_-_23559978 0.661 NM_024675
PALB2
partner and localizer of BRCA2
chr20_+_61967033 0.659 NM_003288
NM_199359
NM_199360
NM_199361
NM_199362
NM_199363
TPD52L2





tumor protein D52-like 2





chr22_+_19651446 0.650 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr22_+_43451600 0.646 PRR5
proline rich 5 (renal)
chr5_-_35266305 0.645 PRLR
prolactin receptor
chr2_+_27225362 0.633 NM_175769
TCF23
transcription factor 23
chr17_+_61729193 0.628 PRKCA
protein kinase C, alpha
chr1_+_559618 0.628


chr1_+_45046740 0.625 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr14_-_21014871 0.612 NM_032846
RAB2B
RAB2B, member RAS oncogene family
chr16_+_65552600 0.612 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr14_+_21015168 0.606 NM_014828
TOX4
TOX high mobility group box family member 4
chr20_+_5055393 0.598 NM_003818
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr8_+_21938299 0.588 NM_182795
NPM2
nucleophosmin/nucleoplasmin 2
chr1_+_32489426 0.579 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr14_-_105589467 0.576 LOC100126583
IGHA1
IGHG1
IGHG2
IGHM
hypothetical LOC100126583
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr17_-_71352017 0.559 UNC13D
unc-13 homolog D (C. elegans)
chr16_+_56259657 0.558 NM_170776
GPR97
G protein-coupled receptor 97
chr17_+_40581704 0.558 HEXIM1
hexamethylene bis-acetamide inducible 1
chr20_-_29464301 0.557 NM_001171832
DEFB121
defensin, beta 121
chr1_+_32512298 0.554 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr12_-_120781002 0.550 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr14_-_34001164 0.541 NM_138288
C14orf147
chromosome 14 open reading frame 147
chr1_+_15941503 0.540 NM_001013641
TMEM82
transmembrane protein 82
chr20_-_3592045 0.540 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chr17_+_61729306 0.532 NM_002737
PRKCA
protein kinase C, alpha
chr3_-_28365510 0.528 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr2_+_62786290 0.527 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr17_+_45858606 0.527 ACSF2
acyl-CoA synthetase family member 2
chr17_-_58871906 0.523 NM_001017917
CYB561
cytochrome b-561
chr3_-_28365284 0.521 AZI2
5-azacytidine induced 2
chr14_+_22581215 0.520 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr14_+_23095028 0.520 NM_001126339
NM_024328
THTPA

thiamine triphosphatase

chr16_+_23560187 0.519 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr15_+_87540238 0.517 ABHD2
abhydrolase domain containing 2
chr14_-_23095240 0.516


chr9_-_34366831 0.512 NM_020702
KIAA1161
KIAA1161
chr11_+_64114857 0.508 NM_144585
NM_153378
SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12

chr8_+_145692916 0.506 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr20_+_5055653 0.506 CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr14_-_24173205 0.502 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr17_-_9880598 0.497 GAS7
growth arrest-specific 7
chr17_+_39778016 0.491 NM_002087
GRN
granulin
chr5_-_176671897 0.491 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr1_+_148496792 0.485 NM_012113
CA14
carbonic anhydrase XIV
chr14_-_106184988 0.484 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_-_66258072 0.480 NM_032140
C16orf48
chromosome 16 open reading frame 48
chr17_+_40581617 0.478 HEXIM1
hexamethylene bis-acetamide inducible 1
chr2_+_176724358 0.476 NM_014621
HOXD4
homeobox D4
chr19_-_51109875 0.475 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr2_-_25047988 0.474 DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr17_+_77910411 0.471 NM_207459
TEX19
testis expressed 19
chr16_+_28782682 0.467 NM_001145812
NM_015503
SH2B1

SH2B adaptor protein 1

chr18_-_26935883 0.464 NM_004949
NM_024422
DSC2

desmocollin 2

chr10_+_685887 0.450 C10orf108
chromosome 10 open reading frame 108
chr2_-_118488133 0.448 CCDC93
coiled-coil domain containing 93
chr7_-_94863558 0.444 NM_000940
PON3
paraoxonase 3
chr17_-_77647505 0.442 FASN
fatty acid synthase
chr14_-_23968570 0.441 NM_001039771
CBLN3
cerebellin 3 precursor
chr2_-_118488041 0.440 CCDC93
coiled-coil domain containing 93
chr17_+_18221803 0.439 NM_001145127
EVPLL
envoplakin-like
chr12_+_50592379 0.437 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr17_-_9880729 0.431 NM_201432
GAS7
growth arrest-specific 7
chr17_-_70770036 0.426 NM_001172703
NM_001172704
GGA3

golgi-associated, gamma adaptin ear containing, ARF binding protein 3

chr7_+_45899080 0.421 IGFBP1
insulin-like growth factor binding protein 1
chr14_+_69415880 0.420 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr17_+_45858517 0.418 NM_025149
ACSF2
acyl-CoA synthetase family member 2
chr17_-_51164443 0.411 NM_001099640
TMEM100
transmembrane protein 100
chr20_-_43577677 0.410 NM_006652
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr16_+_1979959 0.409 NM_004209
SYNGR3
synaptogyrin 3
chr14_-_104330982 0.407 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr19_-_56567602 0.406 NM_005601
NKG7
natural killer cell group 7 sequence
chr17_+_71486895 0.405 NM_001113324
C17orf106
C17orf106-CDK3
chromosome 17 open reading frame 106
C17orf106-CDK3 read-through transcript
chr19_+_59077241 0.405 NM_002739
PRKCG
protein kinase C, gamma
chr2_+_157822355 0.404 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr17_+_75319476 0.402 NM_178543
ENPP7
ectonucleotide pyrophosphatase/phosphodiesterase 7
chr6_+_167456230 0.401 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr2_+_211129567 0.400 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr16_+_66131247 0.400 FAM65A
family with sequence similarity 65, member A
chr20_-_54534387 0.399 NM_080615
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr7_+_142346724 0.397 NM_178829
C7orf34
chromosome 7 open reading frame 34
chr17_-_71487038 0.396 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr2_+_241213334 0.392 NM_005301
GPR35
G protein-coupled receptor 35
chr16_+_29892714 0.387 NM_004783
NM_016151
TAOK2

TAO kinase 2

chr10_-_21854616 0.383 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr16_-_1369613 0.381 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr17_+_70244553 0.377 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr8_+_144173674 0.373 LY6E
lymphocyte antigen 6 complex, locus E
chr8_-_57521702 0.373 NM_001135690
PENK
proenkephalin
chr22_+_23309717 0.371 NM_013430
GGT1
gamma-glutamyltransferase 1
chr13_-_99422163 0.371 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr20_+_1041905 0.370 NM_178578
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chrX_+_7147471 0.368 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr5_+_145297490 0.367 SH3RF2
SH3 domain containing ring finger 2
chr2_+_176724583 0.365


chr3_-_188935363 0.364 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr15_-_76700174 0.361 CHRNA3
cholinergic receptor, nicotinic, alpha 3
chr17_+_70769600 0.360 MRPS7
mitochondrial ribosomal protein S7
chr11_+_60391590 0.360 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr1_-_2129031 0.352 NM_001146310
C1orf86
chromosome 1 open reading frame 86
chr12_+_56299959 0.351 NM_133489
SLC26A10
solute carrier family 26, member 10
chr17_-_43283529 0.351 SP6
Sp6 transcription factor
chr7_-_44547382 0.351 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr16_-_65775326 0.348 NM_001040715
KIAA0895L
KIAA0895-like
chr17_+_71487080 0.347 C17orf106
chromosome 17 open reading frame 106
chr9_+_126094388 0.346 NM_001166169
NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr19_-_8473473 0.346 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chr3_-_49701085 0.346 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr6_+_112775224 0.344 NM_001013734
RFPL4B
ret finger protein-like 4B
chr16_+_22011362 0.342 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr3_+_134947940 0.341 TF
transferrin
chr11_+_59001421 0.339 NM_001004705
OR4D10
olfactory receptor, family 4, subfamily D, member 10
chr14_+_23968979 0.336 NM_015299
KHNYN
KH and NYN domain containing
chr2_-_241270982 0.335 NM_001102467
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr20_-_61907299 0.335 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr8_-_27157157 0.334 STMN4
stathmin-like 4
chr1_+_44229818 0.333 NM_152499
CCDC24
coiled-coil domain containing 24
chr13_-_40735619 0.333 NM_004294
MTRF1
mitochondrial translational release factor 1
chr17_+_7474177 0.331 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr5_+_109052945 0.331 MAN2A1
mannosidase, alpha, class 2A, member 1
chr14_-_23623657 0.331 NM_006177
NRL
neural retina leucine zipper
chr17_-_6557375 0.331 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr15_+_63124760 0.329 NM_178859
OSTBETA
organic solute transporter beta
chr2_+_179053461 0.328 PLEKHA3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr5_+_23543480 0.328 NM_020227
PRDM9
PR domain containing 9
chr17_+_70769340 0.325 NM_015971
MRPS7
mitochondrial ribosomal protein S7
chr6_-_149847809 0.324 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr14_-_105542441 0.323 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr17_+_38412267 0.323 NM_005533
IFI35
interferon-induced protein 35
chr1_-_158306570 0.323 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr1_-_46436637 0.321 POMGNT1
protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase
chr6_+_43846155 0.321 VEGFA
vascular endothelial growth factor A
chr6_+_30082331 0.320 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr17_+_71154240 0.320 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr11_+_64705837 0.319 CAPN1
calpain 1, (mu/I) large subunit
chr20_+_36643251 0.317 NM_001018082
ADIG
adipogenin
chr2_+_201756048 0.317 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr2_+_201755865 0.317 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr12_-_6355165 0.316 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_-_218329684 0.316 BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.68 2.82e-02 GO:0032970 regulation of actin filament-based process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.24 1.32e-03 GO:0003823 antigen binding
4.14 4.11e-03 GO:0051087 chaperone binding