Motif ID: HSF1,2.p2

Z-value: 1.357


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2



Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_21203136 1.684 NM_001001912
OR4E2
olfactory receptor, family 4, subfamily E, member 2
chr14_-_21108714 1.542 NM_001005465
OR10G3
olfactory receptor, family 10, subfamily G, member 3
chr20_+_18742369 1.258 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr13_+_48582389 1.244 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr6_-_32839244 1.121 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr4_+_123380569 1.115 KIAA1109
KIAA1109
chr4_+_76700281 1.060 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr4_-_84625241 1.042 NM_139076
FAM175A
family with sequence similarity 175, member A
chr11_+_27019084 1.000 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chrX_+_134711153 0.991 NM_001017435
CT45A3
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A2
chr1_+_227506751 0.972 NM_006542
SPHAR
S-phase response (cyclin related)
chr17_-_53849888 0.962 RNF43
ring finger protein 43
chr9_+_130485926 0.925 SET
SET nuclear oncogene
chr17_-_53849929 0.904 NM_017763
RNF43
ring finger protein 43
chr7_-_14847479 0.881 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chrX_+_134693879 0.858 NM_001017436
NM_152582
CT45A3
CT45A4
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A2
chr14_-_64479198 0.846 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr7_-_33047042 0.842 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr1_-_167822334 0.808 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr14_-_24173205 0.806 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr13_-_40735619 0.793 NM_004294
MTRF1
mitochondrial translational release factor 1
chr1_-_167822248 0.776 F5
coagulation factor V (proaccelerin, labile factor)
chr4_+_47403107 0.762


chrX_-_134781564 0.762 NM_001007551
NM_001172288
CT45A5

cancer/testis antigen family 45, member A5

chr7_+_129913271 0.744 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr14_+_104218487 0.714


chr7_-_36730525 0.706 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr6_+_29472310 0.705 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr14_-_23754977 0.702 NM_138476
MDP1
magnesium-dependent phosphatase 1
chrX_-_134764397 0.702 NM_001017436
CT45A3
CT45A4
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A2
chr16_-_46823682 0.692 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chrX_-_134798808 0.677 NM_001017438
CT45A3
CT45A4
CT45A5
CT45A6
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A5
cancer/testis antigen family 45, member A6
cancer/testis antigen family 45, member A1
chr6_+_151688327 0.673 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr13_+_75232797 0.670 NM_015842
LMO7
LIM domain 7
chr9_+_110664366 0.663 NM_006687
ACTL7A
actin-like 7A
chr2_+_11591692 0.652 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr1_+_119851348 0.647 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr2_+_172530120 0.634 HAT1
histone acetyltransferase 1
chr11_+_62893836 0.633 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr3_+_123817151 0.625 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr12_-_121767272 0.624 NM_006018
GPR109B
G protein-coupled receptor 109B
chr20_+_35406497 0.621 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr2_+_241213334 0.621 NM_005301
GPR35
G protein-coupled receptor 35
chr16_-_73292188 0.620 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr8_+_86563382 0.620 NM_000067
CA2
carbonic anhydrase II
chr14_+_71468902 0.614 RGS6
regulator of G-protein signaling 6
chr17_-_59327602 0.612 NM_001317
NM_022640
NM_022641
CSH1


CSH2
chorionic somatomammotropin hormone 1 (placental lactogen)


chorionic somatomammotropin hormone 2
chr6_+_32713160 0.605 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_+_228386800 0.603 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr5_-_135729062 0.600 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr3_+_1109619 0.600 NM_014461
CNTN6
contactin 6
chr21_-_42659671 0.597 NM_003225
TFF1
trefoil factor 1
chr16_-_88358946 0.593 FANCA
Fanconi anemia, complementation group A
chr17_+_69941430 0.592 NM_018653
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr1_-_158190585 0.584 NM_001146172
NM_001146173
NM_033438
SLAMF9


SLAM family member 9


chr20_+_19818209 0.583 NM_018993
RIN2
Ras and Rab interactor 2
chr2_-_231498184 0.582 NM_005683
GPR55
G protein-coupled receptor 55
chr15_+_73278285 0.580 C15orf39
chromosome 15 open reading frame 39
chr13_+_45174446 0.578 NM_152719
SPERT
spermatid associated
chrX_-_15593074 0.576 NM_020665
TMEM27
transmembrane protein 27
chr3_-_57301749 0.565 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr2_-_152538694 0.559 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr20_+_41576459 0.554 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr4_-_101658094 0.553 NM_001159694
NM_016242
EMCN

endomucin

chr12_-_12994584 0.549 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr11_+_22171150 0.546 NM_001142649
NM_213599
ANO5

anoctamin 5

chr12_+_111980044 0.537 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chr8_+_82807218 0.536 NM_152284
CHMP4C
chromatin modifying protein 4C
chr9_+_135491305 0.534 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr20_-_43693320 0.529 NM_147198
WFDC9
WAP four-disulfide core domain 9
chr13_+_48720047 0.524 NM_001193478
NM_030911
CDADC1

cytidine and dCMP deaminase domain containing 1

chr17_+_7199178 0.514 NM_198154
TMEM95
transmembrane protein 95
chr5_-_41107161 0.509 NM_173489
HEATR7B2
HEAT repeat family member 7B2
chr18_-_26996742 0.507 NM_004948
NM_024421
DSC1

desmocollin 1

chr4_-_6434473 0.504 NM_181876
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr6_-_123999640 0.500 NM_006073
TRDN
triadin
chr20_+_29598848 0.500 HM13
histocompatibility (minor) 13
chr4_-_22126437 0.498 NM_145290
GPR125
G protein-coupled receptor 125
chr2_+_198073358 0.497 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr20_+_17622319 0.493 NM_001159495
BANF2
barrier to autointegration factor 2
chrX_-_31436335 0.492 NM_004014
DMD
dystrophin
chr19_-_9186512 0.487 NM_001005191
OR7D4
olfactory receptor, family 7, subfamily D, member 4
chr8_-_82769761 0.484 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr14_-_105948734 0.477 LOC100126583
IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr6_+_32230172 0.476 PPT2
palmitoyl-protein thioesterase 2
chr2_+_233093416 0.475 NM_001195129
LOC646960
trypsin serine protease-like
chr16_+_29739256 0.470 MVP
major vault protein
chr10_+_115501202 0.468 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr1_+_48460943 0.462 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr2_-_113259441 0.462 NM_000575
IL1A
interleukin 1, alpha
chr11_+_5431213 0.462 NM_001004754
OR51I2
olfactory receptor, family 51, subfamily I, member 2
chr1_-_102234959 0.460 OLFM3
olfactomedin 3
chr16_+_29739215 0.457 NM_005115
NM_017458
MVP

major vault protein

chr10_-_56230953 0.457 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr1_-_148174722 0.455 NM_181873
MTMR11
myotubularin related protein 11
chr6_+_167624792 0.449 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr1_-_155788775 0.445 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr1_-_166965034 0.445 NM_001937
DPT
dermatopontin
chr17_+_38306339 0.443 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr22_+_44059491 0.442 NM_001167574
NM_006953
UPK3A

uroplakin 3A

chr3_+_46514488 0.441 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr5_-_95044415 0.438 NM_031952
SPATA9
spermatogenesis associated 9
chr20_+_16676997 0.437 NM_020157
OTOR
otoraplin
chr11_-_16953135 0.436 RPL36A
ribosomal protein L36a
chr19_-_54258935 0.436 NM_006179
NTF4
neurotrophin 4
chr18_+_27425727 0.434 NM_000371
TTR
transthyretin
chrX_+_134674850 0.433 NM_001017417
CT45A3
CT45A4
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A1
chr6_+_41118214 0.432 NM_001010873
NM_001159726
TSPO2

translocator protein 2

chr2_+_201756048 0.429 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr2_-_224611568 0.427 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_+_47774247 0.422 NM_153838
GPR115
G protein-coupled receptor 115
chr1_+_144188375 0.421 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr19_+_3659358 0.421 TJP3
tight junction protein 3 (zona occludens 3)
chr6_+_28342766 0.417 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chr2_-_58321947 0.416 NM_001114636
NM_018062
FANCL

Fanconi anemia, complementation group L

chr1_-_240679380 0.415 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr15_+_74416129 0.415 ISL2
ISL LIM homeobox 2
chr12_-_121224676 0.414 NM_001014336
IL31
interleukin 31
chr15_-_79403494 0.414 NM_181900
STARD5
StAR-related lipid transfer (START) domain containing 5
chr10_+_135190855 0.413 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr2_+_211166323 0.413 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr19_+_46574277 0.412 NM_001098821
NM_001098822
NM_001098823
NM_001098824
TMEM91



transmembrane protein 91



chr11_-_104411065 0.410 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr21_-_36836767 0.407 NM_001146078
CLDN14
claudin 14
chr19_-_14490235 0.405 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr18_+_29573152 0.404 ASXL3
additional sex combs like 3 (Drosophila)
chr2_-_85435074 0.402 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr8_-_81246215 0.399 NM_001025253
NM_005079
TPD52

tumor protein D52

chr19_+_2240996 0.398


chr7_-_86686754 0.396 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr17_+_21249040 0.396 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr3_-_42427026 0.394 NM_144634
LYZL4
lysozyme-like 4
chr9_+_130485754 0.392 NM_001122821
SET
SET nuclear oncogene
chr2_-_166638376 0.391 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr2_+_234292162 0.390 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr8_-_124289107 0.390


chr11_+_7463175 0.389 NM_198474
OLFML1
olfactomedin-like 1
chrX_+_17665483 0.387 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr3_+_191588354 0.386 NM_006580
CLDN16
claudin 16
chr20_+_31334601 0.386 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr2_-_37727472 0.384 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_+_11600287 0.382 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr1_+_150749943 0.382 NM_178438
LCE5A
late cornified envelope 5A
chr15_+_22652790 0.380 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_+_143858428 0.380 NM_001172312
PLS1
plastin 1
chr10_-_62002672 0.380 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_+_18221803 0.379 NM_001145127
EVPLL
envoplakin-like
chr3_+_102926126 0.378 NM_024548
CEP97
centrosomal protein 97kDa
chr4_+_9094611 0.377 NM_001040071
LOC650293
seven transmembrane helix receptor
chr2_+_85435351 0.376 NM_001135021
NM_001135022
NM_001135023
NM_032213
ELMOD3



ELMO/CED-12 domain containing 3



chr12_+_79362256 0.376 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr5_+_147423727 0.375 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr2_+_214984705 0.375 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr15_-_46890475 0.374 NM_001194998
NM_014985
CEP152

centrosomal protein 152kDa

chr16_-_20610078 0.374 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr19_-_14490160 0.373 NM_006145
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr14_-_44046202 0.370 NM_032135
FSCB
fibrous sheath CABYR binding protein
chr1_-_159459999 0.370 NM_001643
APOA2
apolipoprotein A-II
chrX_-_107112244 0.370 NM_031273
TEX13B
testis expressed 13B
chr20_-_55368284 0.369 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr10_+_93548261 0.369 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr20_-_33706532 0.368 RBM12
RNA binding motif protein 12
chr12_-_55134692 0.363 NM_012064
MIP
major intrinsic protein of lens fiber
chr11_+_6854431 0.361 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr14_-_54438913 0.361 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr6_+_44234525 0.361 NM_007058
CAPN11
calpain 11
chr1_-_173979292 0.360 NM_003285
TNR
tenascin R (restrictin, janusin)
chr20_+_31219543 0.360 NM_080574
C20orf70
chromosome 20 open reading frame 70
chr11_-_117589283 0.358 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr14_+_23610582 0.358 NM_006032
CPNE6
copine VI (neuronal)
chr12_+_103677388 0.357 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_+_27120836 0.356 NUDC
nuclear distribution gene C homolog (A. nidulans)
chr5_-_135259403 0.353 NM_000590
IL9
interleukin 9
chr11_+_65027721 0.352


chr19_+_56049982 0.351 NM_001030047
NM_001030048
NM_001030050
NM_001648
KLK3



kallikrein-related peptidase 3



chr16_+_54247042 0.351 NM_001172501
SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr6_-_32742265 0.351 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr9_+_37412645 0.351 NM_012203
GRHPR
glyoxylate reductase/hydroxypyruvate reductase
chr15_+_39739933 0.350 MGA
MAX gene associated
chr19_-_14490227 0.350 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr9_-_115877104 0.350 AMBP
alpha-1-microglobulin/bikunin precursor
chr20_-_17487480 0.349 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr15_+_39739864 0.347 NM_001080541
NM_001164273
MGA

MAX gene associated

chr6_-_130585650 0.347 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr8_-_17787342 0.345 FGL1
fibrinogen-like 1
chr20_+_9406460 0.343 PLCB4
phospholipase C, beta 4
chr5_-_22248630 0.343 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr19_-_59368625 0.342 NM_001145303
NM_144686
TMC4

transmembrane channel-like 4

chr14_-_105845570 0.340 IGHA1
immunoglobulin heavy constant alpha 1
chr11_-_121492010 0.339 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr6_-_122807439 0.338 SERINC1
serine incorporator 1
chr9_+_91115924 0.337 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr17_-_36996611 0.335 NM_000526
KRT14
keratin 14
chr17_-_36890877 0.333 NM_002280
KRT35
keratin 35
chr8_-_68821131 0.332 NM_020361
CPA6
carboxypeptidase A6
chr20_+_2309553 0.332 NM_198994
TGM6
transglutaminase 6
chr10_+_102212787 0.330 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr6_-_128263868 0.330 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr14_-_69616616 0.328 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr3_-_152144712 0.328 NM_052995
CLRN1
clarin 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.22 3.32e-02 GO:0008091 spectrin

Nothing significant found in function category.