Motif ID: HNF1A.p2

Z-value: 4.014


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A



Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_40995564 10.367 PRODH2
proline dehydrogenase (oxidase) 2
chr19_-_40995606 8.443 PRODH2
proline dehydrogenase (oxidase) 2
chr16_-_86527608 6.610 NM_001739
 CA5A
carbonic anhydrase VA, mitochondrial
chr7_-_44547382 5.595 NM_001101648
NM_013389
 NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr6_-_52060327 5.520 NM_138694
NM_170724
 PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr2_-_88208650 4.713 NM_001443
 FABP1
fatty acid binding protein 1, liver
chr6_-_24491498 4.696 NM_001195610
 DCDC2
doublecortin domain containing 2
chr4_-_69852090 4.559 NM_024743
 UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr17_+_71065478 4.547 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr21_-_46399900 4.545 NM_006657
NM_206965
 FTCD

formiminotransferase cyclodeaminase

chr6_+_31731667 4.455 APOM
apolipoprotein M
chr3_-_162572441 4.441 NM_001040100
 C3orf57
chromosome 3 open reading frame 57
chr17_+_71154240 4.376 NM_001162997
 LOC100130933
hypothetical protein LOC100130933
chr6_+_31731647 4.312 NM_019101
 APOM
apolipoprotein M
chr4_-_69116839 4.144 NM_001077
 UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr14_+_38772870 4.073 NM_054024
 MIA2
melanoma inhibitory activity 2
chr4_-_977163 4.006 NM_022042
NM_134425
NM_213613
 SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr1_+_48460943 3.958 NM_001011547
NM_001135181
 SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr20_+_42417752 3.780 NM_001030003
NM_001030004
NM_175914
 HNF4A


hepatocyte nuclear factor 4, alpha


chr2_+_27573206 3.684 NM_001486
 GCKR
glucokinase (hexokinase 4) regulator

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
51.13 9.32e-03 GO:0034392 negative regulation of smooth muscle cell apoptosis
28.41 4.11e-04 GO:0009812 flavonoid metabolic process
23.24 1.46e-03 GO:0009698 phenylpropanoid metabolic process
20.45 3.45e-02 GO:0019934 cGMP-mediated signaling
15.98 1.27e-02 GO:0015721 bile acid and bile salt transport
13.46 3.23e-02 GO:0034381 plasma lipoprotein particle clearance
10.96 1.75e-02 GO:0030195 negative regulation of blood coagulation
10.58 2.17e-02 GO:0050819 negative regulation of coagulation
9.30 4.74e-02 GO:0001523 retinoid metabolic process
9.30 4.74e-02 GO:0016101 diterpenoid metabolic process
8.95 1.37e-02 GO:0030301 cholesterol transport
8.73 1.63e-02 GO:0006721 terpenoid metabolic process
8.73 1.63e-02 GO:0015918 sterol transport
8.38 3.31e-04 GO:0010951 negative regulation of endopeptidase activity
8.08 1.72e-10 GO:0006805 xenobiotic metabolic process
8.08 1.72e-10 GO:0071466 cellular response to xenobiotic stimulus
8.02 2.00e-10 GO:0009410 response to xenobiotic stimulus
7.46 4.74e-02 GO:0061041 regulation of wound healing
6.82 2.59e-02 GO:0033500 carbohydrate homeostasis
6.82 2.59e-02 GO:0042593 glucose homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
6.89 1.25e-02 GO:0031983 vesicle lumen
6.82 4.44e-02 GO:0005903 brush border
6.17 2.54e-02 GO:0031091 platelet alpha granule
5.48 1.02e-06 GO:0016324 apical plasma membrane
4.85 1.21e-06 GO:0045177 apical part of cell
3.90 1.84e-04 GO:0005792 microsome
3.77 2.98e-04 GO:0042598 vesicular fraction
2.60 8.76e-06 GO:0005624 membrane fraction
2.52 2.04e-05 GO:0005626 insoluble fraction
2.31 5.08e-03 GO:0005789 endoplasmic reticulum membrane
2.26 3.18e-05 GO:0000267 cell fraction
2.26 7.72e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
2.13 1.66e-02 GO:0044432 endoplasmic reticulum part
2.11 1.49e-02 GO:0005615 extracellular space
1.89 2.26e-02 GO:0005783 endoplasmic reticulum
1.67 5.32e-03 GO:0005576 extracellular region
1.60 1.55e-02 GO:0044459 plasma membrane part
1.37 4.94e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
21.91 1.73e-11 GO:0015020 glucuronosyltransferase activity
18.59 1.27e-02 GO:0001972 retinoic acid binding
13.64 4.92e-02 GO:0008514 organic anion transmembrane transporter activity
7.94 5.08e-04 GO:0033293 monocarboxylic acid binding
7.87 3.00e-02 GO:0005504 fatty acid binding
5.81 2.46e-03 GO:0004867 serine-type endopeptidase inhibitor activity
5.64 1.56e-04 GO:0008194 UDP-glycosyltransferase activity
4.18 9.56e-03 GO:0004866 endopeptidase inhibitor activity
4.07 1.25e-02 GO:0031406 carboxylic acid binding
4.01 1.42e-02 GO:0061135 endopeptidase regulator activity
3.96 1.61e-02 GO:0030414 peptidase inhibitor activity
3.84 1.08e-02 GO:0016758 transferase activity, transferring hexosyl groups
3.73 1.41e-04 GO:0004857 enzyme inhibitor activity
2.98 4.30e-03 GO:0022804 active transmembrane transporter activity
1.95 4.74e-02 GO:0030234 enzyme regulator activity