Motif ID: REST.p3

Z-value: 1.213


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor



Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_66244314 2.179 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr5_-_151284515 1.946 NM_000171
NM_001146040
GLRA1

glycine receptor, alpha 1

chr1_+_33124658 1.546 NM_002143
HPCA
hippocalcin
chr9_-_73251639 1.478 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr5_+_71050745 1.401 NM_004291
CARTPT
CART prepropeptide
chr20_+_61798512 1.041 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_-_149955870 0.979 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr20_+_61798446 0.881 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr11_-_123030091 0.864 SCN3B
sodium channel, voltage-gated, type III, beta
chr17_-_3248453 0.829 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr9_-_138236775 0.825 NM_178138
LHX3
LIM homeobox 3
chr17_+_70178911 0.800 RAB37
RAB37, member RAS oncogene family
chr19_+_45728270 0.779 SPTBN4
spectrin, beta, non-erythrocytic 4
chr17_-_24357014 0.763 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chr17_+_70178850 0.747 NM_175738
RAB37
RAB37, member RAS oncogene family
chr19_+_45728207 0.737 NM_025213
SPTBN4
spectrin, beta, non-erythrocytic 4
chr19_-_45416043 0.731 TTC9B
tetratricopeptide repeat domain 9B
chr1_-_173979292 0.730 NM_003285
TNR
tenascin R (restrictin, janusin)
chr15_+_73074882 0.725 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr20_+_5839973 0.627 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr4_+_158361185 0.609 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr6_+_158877455 0.599 NM_020823
TMEM181
transmembrane protein 181
chr18_-_5187240 0.586 NM_001145194
LOC642597
hypothetical protein LOC642597
chr6_+_43711566 0.571 MAD2L1BP
MAD2L1 binding protein
chr5_+_33972247 0.558 NM_016568
RXFP3
relaxin/insulin-like family peptide receptor 3
chr14_-_104142125 0.555 NM_207379
TMEM179
transmembrane protein 179
chr1_+_208178160 0.530 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr6_+_43711532 0.522 NM_014628
MAD2L1BP
MAD2L1 binding protein
chr6_+_158877640 0.522 TMEM181
transmembrane protein 181
chr19_-_45416112 0.519 NM_152479
TTC9B
tetratricopeptide repeat domain 9B
chr6_+_25760352 0.512 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr19_+_38867273 0.510 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr1_+_208178198 0.503 SYT14
synaptotagmin XIV
chr20_+_44091219 0.494 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr12_-_3472245 0.493 LOC100129223
hypothetical LOC100129223
chr19_-_44427446 0.490 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr7_+_8439762 0.485 NXPH1
neurexophilin 1
chr14_+_92459197 0.484 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr9_+_116131889 0.470 NM_000608
ORM2
orosomucoid 2
chr1_-_207892420 0.462 NM_000228
LAMB3
laminin, beta 3
chr3_-_188870799 0.456 NM_001048
SST
somatostatin
chr7_+_8440109 0.454 NM_152745
NXPH1
neurexophilin 1
chr19_+_4720144 0.453 C19orf30
chromosome 19 open reading frame 30
chr16_+_24174975 0.450 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr12_-_29827952 0.446 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr1_-_239587090 0.425 NM_002924
RGS7
regulator of G-protein signaling 7
chr9_+_139153409 0.413 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr2_+_114916368 0.404 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr6_+_35881048 0.387 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr19_-_60383280 0.379 NM_003180
SYT5
synaptotagmin V
chr12_+_112280753 0.377 NM_001159727
NM_173542
PLBD2

phospholipase B domain containing 2

chr3_+_62280435 0.368 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr16_+_4948318 0.367 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr7_+_154943466 0.366 NM_001427
EN2
engrailed homeobox 2
chr12_+_112280757 0.364 PLBD2
phospholipase B domain containing 2
chr8_-_145723209 0.359 NM_001024678
LRRC24
leucine rich repeat containing 24
chr14_+_92459244 0.358 CHGA
chromogranin A (parathyroid secretory protein 1)
chr7_+_8440541 0.355 NXPH1
neurexophilin 1
chr12_-_97812633 0.353 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr5_-_135729062 0.347 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr9_-_103397023 0.344 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr2_+_131230252 0.333 NM_001105194
NM_001105195
FAM123C

family with sequence similarity 123C

chr15_+_92575767 0.330 MCTP2
multiple C2 domains, transmembrane 2
chr11_-_125278296 0.317 NM_031307
PUS3
pseudouridylate synthase 3
chr2_+_207215386 0.307 NM_001102659
LOC200726
hCG1657980
chrX_-_48943582 0.298 NM_003179
SYP
synaptophysin
chr11_-_74818858 0.287 KLHL35
kelch-like 35 (Drosophila)
chr1_-_33108876 0.280 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr2_+_46377952 0.273 NM_001430
EPAS1
endothelial PAS domain protein 1
chr2_-_51112743 0.272 NRXN1
neurexin 1
chr14_+_20226762 0.270 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_-_48675321 0.259 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr16_+_67902751 0.255 NM_013245
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr10_-_102780840 0.254 PDZD7
PDZ domain containing 7
chr17_+_39741306 0.249 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr20_+_44091265 0.238 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr3_-_133236447 0.234 NM_130808
CPNE4
copine IV
chr17_+_77925441 0.216 NM_018949
UTS2R
urotensin 2 receptor
chr12_+_117903682 0.215 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr10_+_60607232 0.207 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr20_-_61755145 0.203 NM_015894
STMN3
stathmin-like 3
chr12_-_29828958 0.202 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr16_+_2450081 0.202 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr11_+_64565118 0.200 SAC3D1
SAC3 domain containing 1
chr10_+_99599984 0.193 NM_001010917
GOLGA7B
golgin A7 family, member B
chr19_-_50618982 0.188 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr8_-_145530639 0.183 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr1_-_239587007 0.181 RGS7
regulator of G-protein signaling 7
chr12_+_111714096 0.179 RPH3A
rabphilin 3A homolog (mouse)
chr5_+_175231170 0.178


chr10_-_102780867 0.176 NM_001195263
NM_024895
PDZD7

PDZ domain containing 7

chr15_-_81175542 0.169 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr20_+_35445350 0.163 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr5_+_175231210 0.157 CPLX2
complexin 2
chr18_-_39111243 0.153 NM_020783
SYT4
synaptotagmin IV
chr11_+_45863774 0.151 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr5_+_175231098 0.146 NM_001008220
CPLX2
complexin 2
chr14_-_93829347 0.138 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr9_+_137593420 0.136 NM_001018049
NM_002571
PAEP

progestagen-associated endometrial protein

chr1_-_239749634 0.134 FH
fumarate hydratase
chr19_-_50619015 0.133 NM_001166049
NM_001983
ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr11_-_72170533 0.131 STARD10
StAR-related lipid transfer (START) domain containing 10
chr20_-_13713509 0.130 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr11_-_74819165 0.130 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr11_-_1725924 0.123 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr22_+_18388656 0.123 C22orf25
chromosome 22 open reading frame 25
chr7_-_100595552 0.118 NM_003378
VGF
VGF nerve growth factor inducible
chr8_-_91164100 0.116 NM_004929
CALB1
calbindin 1, 28kDa
chr22_+_18388633 0.113 C22orf25
chromosome 22 open reading frame 25
chr19_-_50618921 0.111 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr22_+_18388602 0.108 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr11_-_74818685 0.104 KLHL35
kelch-like 35 (Drosophila)
chr10_+_102780974 0.102 NM_030971
SFXN3
sideroflexin 3
chr19_-_50618599 0.100 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr15_-_70399301 0.094 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr10_+_69990050 0.092 NM_030625
TET1
tet oncogene 1
chr1_-_239749683 0.089 NM_000143
FH
fumarate hydratase
chr17_-_3283884 0.089 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr19_-_50618659 0.087 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr6_+_138767007 0.086 NM_014320
HEBP2
heme binding protein 2
chr11_-_27698800 0.085 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr11_-_1725662 0.083 LOC402778
CD225 family protein FLJ76511
chr11_+_22316242 0.080 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr5_+_175231144 0.079 CPLX2
complexin 2
chr8_+_69027143 0.070 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr8_+_69027277 0.070 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr16_+_2959342 0.067 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr18_-_53404783 0.065 NM_000140
NM_001012515
FECH

ferrochelatase

chr2_-_51113040 0.065 NM_001135659
NM_004801
NRXN1

neurexin 1

chr16_+_2959362 0.058 PAQR4
progestin and adipoQ receptor family member IV
chr12_+_111713931 0.056 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr3_+_52787478 0.054 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr8_+_6553278 0.051 NM_018361
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr1_+_1836125 0.051 NM_138705
CALML6
calmodulin-like 6
chr17_+_1120607 0.050 NM_001164405
BHLHA9
basic helix-loop-helix family, member a9
chr15_-_70399181 0.048 CELF6
CUGBP, Elav-like family member 6
chr8_+_69026895 0.043 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr2_-_96174502 0.041 DUSP2
dual specificity phosphatase 2
chr8_-_94046891 0.039 NM_001191036
C8orf83
chromosome 8 open reading frame 83
chr15_+_65904994 0.033 NM_001031807
SKOR1
SKI family transcriptional corepressor 1
chr6_+_43257883 0.030 NM_015089
CUL9
cullin 9
chr6_+_138767151 0.027 HEBP2
heme binding protein 2
chr19_-_3922032 0.024 DAPK3
death-associated protein kinase 3
chr14_-_73962557 0.023 NM_001105579
TMEM90A
transmembrane protein 90A
chr11_-_6633427 0.023 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr6_+_43257903 0.023 CUL9
cullin 9
chr8_+_57520915 0.022


chr8_+_80685859 0.020 STMN2
stathmin-like 2
chr19_+_15058790 0.013 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr5_+_141283550 0.013 NM_001142603
NM_014773
KIAA0141

KIAA0141

chr1_-_151390050 0.009 NM_001014291
SPRR2G
small proline-rich protein 2G
chr8_+_6553322 0.008 AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr15_-_29950070 0.008 OTUD7A
OTU domain containing 7A
chr17_-_62793129 0.003 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr5_+_141283647 0.002 KIAA0141
KIAA0141

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.04 2.11e-03 GO:0007268 synaptic transmission
4.49 6.81e-03 GO:0019226 transmission of nerve impulse
4.49 6.81e-03 GO:0035637 multicellular organismal signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
22.26 2.93e-05 GO:0030672 synaptic vesicle membrane
7.10 4.61e-05 GO:0030659 cytoplasmic vesicle membrane
6.86 6.47e-05 GO:0012506 vesicle membrane
13.76 8.23e-05 GO:0030665 clathrin coated vesicle membrane
13.60 8.92e-05 GO:0008021 synaptic vesicle
6.41 1.27e-04 GO:0044456 synapse part
5.89 2.86e-04 GO:0044433 cytoplasmic vesicle part
5.19 3.69e-04 GO:0045202 synapse
8.36 5.75e-04 GO:0030136 clathrin-coated vesicle
10.17 6.32e-04 GO:0030662 coated vesicle membrane
3.66 1.47e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
3.59 1.84e-03 GO:0031988 membrane-bounded vesicle
4.79 2.04e-03 GO:0043005 neuron projection
6.82 2.53e-03 GO:0030135 coated vesicle
3.44 3.00e-03 GO:0031410 cytoplasmic vesicle
3.33 4.35e-03 GO:0031982 vesicle
6.84 8.23e-03 GO:0043025 neuronal cell body
6.65 9.86e-03 GO:0044297 cell body
8.44 3.51e-02 GO:0019717 synaptosome

Nothing significant found in function category.