Motif ID: ZIC1..3.p2

Z-value: 1.534


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)



Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_73756668 2.235 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr3_+_64645819 1.418 LOC100507098
hypothetical LOC100507098
chr9_+_108665168 1.300 NM_021224
 ZNF462
zinc finger protein 462
chr7_-_106088565 1.239 NM_175884
 FLJ36031
hypothetical protein FLJ36031
chr10_-_90702490 1.196 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_174803768 1.101 NM_000794
 DRD1
dopamine receptor D1
chr21_-_27139563 1.095 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr16_-_31390926 1.078


chr7_+_129918408 1.072 NM_177525
 MEST
mesoderm specific transcript homolog (mouse)
chr14_+_64077171 1.048 HSPA2
heat shock 70kDa protein 2
chr3_+_155321826 1.023 NM_015595
 ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr12_-_3732614 0.993 NM_001144958
NM_001144959
NM_032680
 EFCAB4B


EF-hand calcium binding domain 4B


chr21_+_41461962 0.976 BACE2
beta-site APP-cleaving enzyme 2
chr16_+_65790514 0.951 NM_024712
 ELMO3
engulfment and cell motility 3
chr11_+_131285747 0.939 NM_001144058
NM_001144059
NM_016522
 NTM


neurotrimin


chr21_-_27139143 0.937 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_+_130846263 0.928 PTPN18
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
chr12_-_3732478 0.898 EFCAB4B
EF-hand calcium binding domain 4B
chr14_+_64076916 0.894 NM_021979
 HSPA2
heat shock 70kDa protein 2
chr11_+_44074322 0.887 NM_000401
 EXT2
exostosin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 116 entries
enrichment   p-value GO term description
3.42 2.77e-02 GO:0001952 regulation of cell-matrix adhesion
2.94 8.75e-03 GO:0010810 regulation of cell-substrate adhesion
2.85 2.62e-02 GO:0042058 regulation of epidermal growth factor receptor signaling pathway
2.39 5.90e-04 GO:0034329 cell junction assembly
2.27 1.36e-03 GO:0034330 cell junction organization
2.23 8.26e-04 GO:0009952 anterior/posterior pattern formation
2.03 2.04e-02 GO:0030155 regulation of cell adhesion
2.00 2.88e-03 GO:0048514 blood vessel morphogenesis
1.99 1.46e-02 GO:0048732 gland development
1.95 1.03e-03 GO:0030334 regulation of cell migration
1.94 3.23e-04 GO:0001944 vasculature development
1.92 1.26e-03 GO:0001568 blood vessel development
1.92 1.61e-03 GO:2000145 regulation of cell motility
1.91 8.02e-03 GO:0003002 regionalization
1.90 1.90e-05 GO:0009792 embryo development ending in birth or egg hatching
1.90 2.43e-05 GO:0043009 chordate embryonic development
1.90 8.53e-04 GO:0051270 regulation of cellular component movement
1.87 2.91e-02 GO:0002009 morphogenesis of an epithelium
1.85 1.59e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.85 3.65e-03 GO:0040012 regulation of locomotion

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
6.21 7.14e-03 GO:0043256 laminin complex
4.49 1.95e-02 GO:0005605 basal lamina
3.39 1.18e-03 GO:0030667 secretory granule membrane
2.34 3.86e-03 GO:0005925 focal adhesion
2.23 1.09e-02 GO:0005924 cell-substrate adherens junction
2.14 9.50e-04 GO:0005912 adherens junction
2.14 2.36e-02 GO:0030055 cell-substrate junction
1.98 5.73e-03 GO:0070161 anchoring junction
1.47 1.39e-02 GO:0030054 cell junction
1.29 1.76e-04 GO:0044459 plasma membrane part
1.11 6.44e-04 GO:0005737 cytoplasm
1.08 5.78e-06 GO:0005622 intracellular
1.08 5.62e-05 GO:0044424 intracellular part
1.08 1.43e-02 GO:0043229 intracellular organelle
1.08 1.74e-02 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.61 5.18e-03 GO:0019904 protein domain specific binding
1.52 1.10e-03 GO:0043565 sequence-specific DNA binding
1.42 1.13e-03 GO:0030528 transcription regulator activity
1.41 2.06e-03 GO:0001071 nucleic acid binding transcription factor activity
1.41 2.06e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.16 2.49e-07 GO:0005515 protein binding
1.08 6.33e-06 GO:0005488 binding