Motif ID: EWSR1-FLI1.p2

Z-value: 0.595


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1



Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_67697622 1.168 NM_138612
 HAS3
hyaluronan synthase 3
chr12_-_115660017 1.142 NM_024738
 C12orf49
chromosome 12 open reading frame 49
chr8_-_111056099 0.985 NM_014379
 KCNV1
potassium channel, subfamily V, member 1
chr11_-_117628211 0.802 NM_198275
 MPZL3
myelin protein zero-like 3
chr2_-_21106291 0.780 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_-_15875932 0.780 NM_015199
 ANKRD28
ankyrin repeat domain 28
chr17_+_2443652 0.765 NM_000430
 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr17_-_70901303 0.742 GRB2
growth factor receptor-bound protein 2
chr12_-_115660227 0.738 C12orf49
chromosome 12 open reading frame 49
chr14_+_22845851 0.684 NM_004050
 BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr17_+_2443983 0.677 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_26491302 0.614 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
 BTN2A2





butyrophilin, subfamily 2, member A2





chr17_-_31146660 0.573 NM_001032278
NM_024302
 MMP28

matrix metallopeptidase 28

chr10_-_103864579 0.556 LDB1
LIM domain binding 1
chr6_-_10520592 0.537 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_-_180297372 0.531 NM_001009992
 ZNF648
zinc finger protein 648
chrX_-_148394570 0.527 NM_000202
NM_001166550
NM_006123
 IDS


iduronate 2-sulfatase


chr19_-_1966628 0.512 NM_017797
 BTBD2
BTB (POZ) domain containing 2
chr12_+_54947180 0.491 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr1_-_167947301 0.491 NM_000655
 SELL
selectin L

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
9.30 8.23e-03 GO:0042734 presynaptic membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
15.29 2.63e-02 GO:0008200 ion channel inhibitor activity
14.33 3.46e-02 GO:0016248 channel inhibitor activity
7.57 8.78e-03 GO:0016247 channel regulator activity