Motif ID: EWSR1-FLI1.p2

Z-value: 0.595


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1



Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_67697622 1.168 NM_138612
HAS3
hyaluronan synthase 3
chr12_-_115660017 1.142 NM_024738
C12orf49
chromosome 12 open reading frame 49
chr8_-_111056099 0.985 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr11_-_117628211 0.802 NM_198275
MPZL3
myelin protein zero-like 3
chr2_-_21106291 0.780 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_-_15875932 0.780 NM_015199
ANKRD28
ankyrin repeat domain 28
chr17_+_2443652 0.765 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr17_-_70901303 0.742 GRB2
growth factor receptor-bound protein 2
chr12_-_115660227 0.738 C12orf49
chromosome 12 open reading frame 49
chr14_+_22845851 0.684 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr17_+_2443983 0.677 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_26491302 0.614 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr17_-_31146660 0.573 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr10_-_103864579 0.556 LDB1
LIM domain binding 1
chr6_-_10520592 0.537 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_-_180297372 0.531 NM_001009992
ZNF648
zinc finger protein 648
chrX_-_148394570 0.527 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr19_-_1966628 0.512 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr12_+_54947180 0.491 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr1_-_167947301 0.491 NM_000655
SELL
selectin L
chr3_-_120878910 0.487 NM_005694
COX17
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr3_-_166397142 0.486 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr5_+_156819782 0.479 NIPAL4
NIPA-like domain containing 4
chr4_-_44145580 0.471 NM_198353
KCTD8
potassium channel tetramerisation domain containing 8
chr12_+_54946815 0.466 NM_144576
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr12_+_14409875 0.449 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr12_+_54947293 0.448 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr7_-_127458231 0.435 NM_022143
LRRC4
leucine rich repeat containing 4
chrX_+_56606686 0.426 NM_013444
UBQLN2
ubiquilin 2
chr10_+_23424383 0.409 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr12_+_54946991 0.407 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr1_+_165866127 0.404 RCSD1
RCSD domain containing 1
chrX_+_505078 0.400 NM_000451
NM_006883
SHOX

short stature homeobox

chr20_+_43691797 0.399 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr6_-_10520264 0.397 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr11_-_65244718 0.395 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr1_-_224563461 0.387 LIN9
lin-9 homolog (C. elegans)
chrX_+_24077649 0.382 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr10_+_119292699 0.381


chr4_+_110956085 0.377 NM_018983
NM_032993
GAR1

GAR1 ribonucleoprotein homolog (yeast)

chr1_-_26070330 0.360 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr5_+_156819604 0.360 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr8_-_95556460 0.360 NM_012415
RAD54B
RAD54 homolog B (S. cerevisiae)
chr2_+_182464910 0.356 SSFA2
sperm specific antigen 2
chr6_-_25940247 0.356 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr21_+_39099624 0.346 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr21_+_39099717 0.339 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr1_-_224563820 0.333 NM_173083
LIN9
lin-9 homolog (C. elegans)
chr10_-_103864651 0.330 NM_003893
LDB1
LIM domain binding 1
chr7_+_24290331 0.323 NM_000905
NPY
neuropeptide Y
chr3_-_193928038 0.320 NM_004113
FGF12
fibroblast growth factor 12
chr2_+_37425240 0.320 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr10_-_90601655 0.319 NM_144590
ANKRD22
ankyrin repeat domain 22
chr12_+_107797985 0.317 NM_001917
DAO
D-amino-acid oxidase
chr19_+_57592913 0.313 NM_032423
ZNF528
zinc finger protein 528
chr2_-_55349851 0.302 NM_002453
MTIF2
mitochondrial translational initiation factor 2
chr11_-_62213946 0.300 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr1_-_224564038 0.298 LIN9
lin-9 homolog (C. elegans)
chr1_-_6468600 0.297 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr18_+_41659542 0.297 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr1_+_165865953 0.289 NM_052862
RCSD1
RCSD domain containing 1
chr8_-_37943143 0.285 NM_000025
ADRB3
adrenergic, beta-3-, receptor
chr16_-_2848106 0.276 NM_022119
PRSS22
protease, serine, 22
chr4_+_183302105 0.276 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr9_-_124715392 0.269 NM_006626
ZBTB6
zinc finger and BTB domain containing 6
chr18_+_54682261 0.266 ZNF532
zinc finger protein 532
chr3_-_50353209 0.266 NM_007182
NM_170714
RASSF1

Ras association (RalGDS/AF-6) domain family member 1

chr2_+_79593679 0.264 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr19_-_57592778 0.261 LOC284373
hypothetical protein LOC284373
chr9_-_125732005 0.257 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr19_-_38408449 0.253 NM_019849
SLC7A10
solute carrier family 7, (neutral amino acid transporter, y+ system) member 10
chr16_+_510732 0.247 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr9_+_35528890 0.244 RUSC2
RUN and SH3 domain containing 2
chr5_+_150020595 0.243 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr1_+_151596953 0.237 NM_002965
S100A9
S100 calcium binding protein A9
chr1_-_231498081 0.233 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr3_+_33130563 0.233 CRTAP
cartilage associated protein
chr4_+_110956360 0.228 GAR1
GAR1 ribonucleoprotein homolog (yeast)
chr11_+_10433241 0.228 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr13_+_56613052 0.228 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr1_-_68071635 0.219 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr12_+_10222823 0.217 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr11_-_76800525 0.217 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_-_223907283 0.216 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr5_-_141981083 0.215 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr2_-_55349818 0.213 NM_001005369
MTIF2
mitochondrial translational initiation factor 2
chrX_-_78509367 0.209 ITM2A
integral membrane protein 2A
chr11_+_10434056 0.207 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr16_-_45565068 0.206 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr17_+_45706786 0.203 NM_153229
TMEM92
transmembrane protein 92
chr6_+_31746706 0.203 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr18_+_12938004 0.197 SEH1L
SEH1-like (S. cerevisiae)
chrX_-_78509662 0.194 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr17_-_34607257 0.188 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chrX_+_107569671 0.186 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr5_-_71838875 0.186 NM_152625
ZNF366
zinc finger protein 366
chr2_+_79593567 0.181 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr19_+_12996745 0.180 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_+_33130451 0.178 NM_006371
CRTAP
cartilage associated protein
chr9_-_83494198 0.175 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr1_+_87153025 0.172 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr17_-_8004671 0.171 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr9_+_77695334 0.168 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr20_-_47238310 0.167 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr8_-_145530639 0.166 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr15_+_39310757 0.166 CHP
calcium binding protein P22
chr17_+_582406 0.163 NM_024792
FAM57A
family with sequence similarity 57, member A
chr10_+_75211810 0.161 NM_203298
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr18_+_12937972 0.152 NM_001013437
NM_031216
SEH1L

SEH1-like (S. cerevisiae)

chr17_-_11841413 0.150 NM_144680
ZNF18
zinc finger protein 18
chr3_-_48446405 0.149 NM_001130082
PLXNB1
plexin B1
chr4_-_57217226 0.147 NM_001145459
NM_139211
HOPX

HOP homeobox

chr6_+_139055244 0.145 FLJ46906
hypothetical LOC441172
chr12_-_40918249 0.144 NM_001190977
YAF2
YY1 associated factor 2
chr5_+_86599350 0.144 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr1_+_242691295 0.143 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr3_-_48516486 0.142 NM_016479
SHISA5
shisa homolog 5 (Xenopus laevis)
chr10_+_114700775 0.141 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr5_+_65258139 0.139 NM_001006600
NM_018695
ERBB2IP

erbb2 interacting protein

chr20_+_6696744 0.139 NM_001200
BMP2
bone morphogenetic protein 2
chr19_-_44060729 0.137 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr15_+_81906983 0.136 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr14_-_63079299 0.133 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr2_-_114230455 0.133 SLC35F5
solute carrier family 35, member F5
chr11_+_101485946 0.133 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chrX_-_102870207 0.132 NM_001024452
NM_001172285
GLRA4

glycine receptor, alpha 4

chr19_+_61798434 0.131 NM_021216
ZNF71
zinc finger protein 71
chr4_+_166519392 0.129 NM_001873
CPE
carboxypeptidase E
chr18_+_75388522 0.129 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr7_+_21434097 0.126 NM_003112
SP4
Sp4 transcription factor
chr18_-_5620629 0.124 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chrX_+_152252738 0.124 NM_001080485
ZNF275
zinc finger protein 275
chr5_+_86599575 0.121


chr1_+_109036431 0.120 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr15_+_39310693 0.119 NM_007236
CHP
calcium binding protein P22
chr2_+_182464713 0.119 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr1_+_228269589 0.115 GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr1_-_155281785 0.115 NM_014784
NM_198236
ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11

chr1_-_184684478 0.114 NM_022576
PDC
phosducin
chr3_-_109292444 0.113 NM_001777
NM_198793
CD47

CD47 molecule

chr1_+_233558863 0.113 GGPS1
geranylgeranyl diphosphate synthase 1
chr16_-_73198416 0.112 GLG1
golgi glycoprotein 1
chr8_-_22606653 0.110 NM_004430
EGR3
early growth response 3
chr13_+_56639331 0.110 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr7_+_16759845 0.109 NM_014399
TSPAN13
tetraspanin 13
chr9_+_124836666 0.109 NM_005294
GPR21
G protein-coupled receptor 21
chr7_+_138133236 0.109 NM_001085429
TMEM213
transmembrane protein 213
chr9_+_134843918 0.108 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr2_-_25418249 0.108 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr18_+_12938010 0.107 SEH1L
SEH1-like (S. cerevisiae)
chrX_-_131918905 0.106 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr17_+_27288253 0.106 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr12_-_120502483 0.105 NM_001005366
KDM2B
lysine (K)-specific demethylase 2B
chr16_+_55777739 0.105 NM_133368
RSPRY1
ring finger and SPRY domain containing 1
chrX_+_134674850 0.104 NM_001017417
CT45A3
CT45A4
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A1
chrX_+_122923279 0.104 STAG2
stromal antigen 2
chr3_-_133236447 0.104 NM_130808
CPNE4
copine IV
chr11_-_67163600 0.104 NM_005995
TBX10
T-box 10
chr10_-_103869923 0.103 NM_001113407
LDB1
LIM domain binding 1
chr1_-_10964680 0.103 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr17_+_24598000 0.103 NM_005208
CRYBA1
crystallin, beta A1
chr8_-_133562185 0.101 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr3_-_58497913 0.100 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chrX_+_122923236 0.100 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr19_-_56164628 0.099 NM_002774
KLK6
kallikrein-related peptidase 6
chr10_-_13429397 0.099 SEPHS1
selenophosphate synthetase 1
chr17_+_7252225 0.097 NM_020795
NLGN2
neuroligin 2
chr7_+_128218685 0.097 CCDC136
coiled-coil domain containing 136
chr21_+_38550533 0.096 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_48235148 0.095 NM_001194986
LOC388630
UPF0632 protein A
chr8_-_22982435 0.095 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr2_+_179053512 0.093 PLEKHA3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr12_+_121803255 0.093 NM_003677
DENR
density-regulated protein
chr14_-_93665668 0.092 IFI27L2
interferon, alpha-inducible protein 27-like 2
chr19_+_60487345 0.090 NM_032430
BRSK1
BR serine/threonine kinase 1
chr19_+_12996830 0.088 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_177827647 0.088 NM_173533
TDRD5
tudor domain containing 5
chr12_+_2774550 0.088 FKBP4
FK506 binding protein 4, 59kDa
chr20_-_47238082 0.088 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr19_-_18220009 0.087 NM_000923
PDE4C
phosphodiesterase 4C, cAMP-specific
chr14_-_93665678 0.087 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr17_+_27288374 0.087


chr2_-_114230666 0.085 NM_025181
SLC35F5
solute carrier family 35, member F5
chr16_+_65579988 0.084 NM_173815
CES4A
carboxylesterase 4A
chr7_-_75256999 0.083 NM_006072
CCL26
chemokine (C-C motif) ligand 26
chr13_+_56632766 0.082 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr1_-_154737162 0.080 MEF2D
myocyte enhancer factor 2D
chr9_+_34169023 0.079 UBAP1
ubiquitin associated protein 1
chr9_+_34169036 0.079 UBAP1
ubiquitin associated protein 1
chr8_-_29262240 0.078 NM_057158
DUSP4
dual specificity phosphatase 4
chr9_+_35528628 0.077 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr1_-_154737130 0.077 NM_005920
MEF2D
myocyte enhancer factor 2D
chr8_+_133948384 0.075 NM_003235
TG
thyroglobulin
chr3_-_129852182 0.075 RPN1
ribophorin I
chr4_-_57216816 0.074 HOPX
HOP homeobox
chr3_-_56477404 0.072 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr9_-_103397023 0.072 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr8_-_145671947 0.072 FOXH1
forkhead box H1
chr9_+_34169002 0.071 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chr1_+_228269551 0.070 NM_004481
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
9.30 8.23e-03 GO:0042734 presynaptic membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.57 8.78e-03 GO:0016247 channel regulator activity
15.29 2.63e-02 GO:0008200 ion channel inhibitor activity
14.33 3.46e-02 GO:0016248 channel inhibitor activity