Motif ID: PATZ1.p2

Z-value: 2.873


Transcription factors associated with PATZ1.p2:

Gene SymbolEntrez IDGene Name
PATZ1 23598 POZ (BTB) and AT hook containing zinc finger 1



Activity profile for motif PATZ1.p2.

activity profile for motif PATZ1.p2


Sorted Z-values histogram for motif PATZ1.p2

Sorted Z-values for motif PATZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PATZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_51644187 3.957 ZNF217
zinc finger protein 217
chr17_+_34114924 3.125 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr22_-_21231421 2.760 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr9_+_132961723 2.686 AIF1L
allograft inflammatory factor 1-like
chr6_+_7052798 2.642 NM_001168344
RREB1
ras responsive element binding protein 1
chr19_-_1966628 2.630 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr11_+_63829616 2.442 NM_004451
ESRRA
estrogen-related receptor alpha
chr6_+_7052985 2.386 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr20_+_1154763 2.232 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr5_-_176671897 2.213 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr1_-_40903897 2.208 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr7_-_150305933 2.200 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr1_-_40903700 2.198 RIMS3
regulating synaptic membrane exocytosis 3
chr9_+_70509925 2.138 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr22_+_18081968 2.104 NM_002688
SEPT5
septin 5
chr17_-_34015631 2.101 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr9_+_132961683 2.065 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr20_-_39680405 2.031 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr2_+_231968578 1.971 NM_145236
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr1_-_32574185 1.965 NM_023009
MARCKSL1
MARCKS-like 1
chr1_-_222688623 1.946 NM_001115113
NM_025160
WDR26

WD repeat domain 26

chr8_+_144706699 1.915 NM_001166237
GSDMD
gasdermin D
chr6_+_44203335 1.837 NM_018426
TMEM63B
transmembrane protein 63B
chr2_+_170298700 1.823 KLHL23
kelch-like 23 (Drosophila)
chr1_-_21868380 1.811 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr12_+_55896844 1.779 NM_007224
NXPH4
neurexophilin 4
chr6_+_34312979 1.756 HMGA1
high mobility group AT-hook 1
chr16_+_29725311 1.736 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr12_-_103055924 1.697 NM_006166
NFYB
nuclear transcription factor Y, beta
chr20_-_49592444 1.687 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr7_-_100077072 1.676 NM_003227
TFR2
transferrin receptor 2
chr2_+_46623396 1.615 RHOQ
ras homolog gene family, member Q
chr19_+_18069596 1.585 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr2_+_112529270 1.581 NM_032824
TMEM87B
transmembrane protein 87B
chr7_-_150306169 1.577 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr9_-_125732005 1.575 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr1_+_172104115 1.573 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr21_+_43267760 1.564 PKNOX1
PBX/knotted 1 homeobox 1
chr20_+_30410447 1.521 ASXL1
additional sex combs like 1 (Drosophila)
chr22_+_20101661 1.511 NM_015094
HIC2
hypermethylated in cancer 2
chr6_+_34313007 1.510 HMGA1
high mobility group AT-hook 1
chr16_+_88422354 1.488 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr1_-_222688337 1.480 WDR26
WD repeat domain 26
chr2_+_170298487 1.457


chr3_+_185580554 1.454 NM_003741
CHRD
chordin
chr8_-_99906944 1.453 NM_006281
STK3
serine/threonine kinase 3
chr3_-_13436802 1.417 NM_024923
NUP210
nucleoporin 210kDa
chr3_-_13436725 1.408 NUP210
nucleoporin 210kDa
chr2_+_69995807 1.407 MXD1
MAX dimerization protein 1
chr9_-_122679387 1.402 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr5_+_140997171 1.389 RELL2
RELT-like 2
chr22_-_17546276 1.387 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_+_210525490 1.367 NM_006243
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr17_+_40192072 1.341 NM_002390
ADAM11
ADAM metallopeptidase domain 11
chr20_-_48980858 1.339 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr6_+_37245860 1.337 NM_002648
PIM1
pim-1 oncogene
chr22_-_17546234 1.335 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_-_17546296 1.333 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_-_48700824 1.329 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr19_-_4017739 1.314 NM_015898
ZBTB7A
zinc finger and BTB domain containing 7A
chr6_-_32265489 1.314 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr21_+_42946719 1.307 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr8_+_144888275 1.306 LOC100128338
hypothetical LOC100128338
chr2_-_68332985 1.299 NM_000945
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr17_-_53420595 1.292 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr8_-_144887876 1.257 NM_198488
FAM83H
family with sequence similarity 83, member H
chr12_+_110328126 1.255 NM_005475
SH2B3
SH2B adaptor protein 3
chr16_+_29725597 1.251


chr14_-_21064182 1.247 SALL2
sal-like 2 (Drosophila)
chr17_-_37586716 1.247 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr16_+_80036275 1.243 NM_198390
CMIP
c-Maf-inducing protein
chr20_+_30409649 1.239 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr17_-_34157962 1.236 NM_007144
PCGF2
polycomb group ring finger 2
chr16_+_66676833 1.234 NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr7_-_97868101 1.228 BAIAP2L1
BAI1-associated protein 2-like 1
chr16_+_1143241 1.222 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr1_+_224317036 1.219 NM_002107
H3F3A
H3 histone, family 3A
chr19_-_48835783 1.216 NM_145296
CADM4
cell adhesion molecule 4
chr10_+_86078136 1.215 NM_018999
FAM190B
family with sequence similarity 190, member B
chr19_+_659766 1.214 NM_001040134
NM_002579
PALM

paralemmin

chr16_+_2461500 1.172 NM_006181
NTN3
netrin 3
chr17_+_34115383 1.162 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr6_-_31805547 1.158 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr16_+_2504001 1.157 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr1_+_224317062 1.157 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_+_6767968 1.148 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr17_-_53946899 1.142 MTMR4
myotubularin related protein 4
chr22_-_17545872 1.130 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_+_45996940 1.129 EGLN2
egl nine homolog 2 (C. elegans)
chr7_-_154425510 1.128 NM_007349
PAXIP1
PAX interacting (with transcription-activation domain) protein 1
chr6_+_37895570 1.128 ZFAND3
zinc finger, AN1-type domain 3
chr12_+_56621711 1.121 NM_033276
XRCC6BP1
XRCC6 binding protein 1
chr19_+_13090101 1.114 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr6_+_4081241 1.104 LOC100507506
hypothetical LOC100507506
chr20_+_34357604 1.100 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr6_+_149680747 1.098 TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr7_-_150495799 1.098 NM_001098834
GBX1
gastrulation brain homeobox 1
chr1_+_224317044 1.092 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr16_+_2503676 1.090 NM_001198569
NM_001694
ATP6V0C

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

chr20_+_44083667 1.090 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_-_11636983 1.089 FBXO2
F-box protein 2
chr16_+_2503915 1.089 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr4_+_100135869 1.085 METAP1
methionyl aminopeptidase 1
chr20_+_56318415 1.079 RAB22A
RAB22A, member RAS oncogene family
chr12_+_118911859 1.077 NM_207311
CCDC64
coiled-coil domain containing 64
chr16_+_66676851 1.072 NM_004555
NM_173163
NM_173164
NM_173165
NFATC3



nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3



chr8_-_96350575 1.072 NM_177965
C8orf37
chromosome 8 open reading frame 37
chr19_+_47480445 1.072 NM_015125
CIC
capicua homolog (Drosophila)
chr16_+_87047159 1.065 ZFPM1
zinc finger protein, multitype 1
chr20_-_55533544 1.054 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr21_+_43267703 1.052 NM_004571
PKNOX1
PBX/knotted 1 homeobox 1
chr22_+_18085990 1.050 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr6_+_34312906 1.048 HMGA1
high mobility group AT-hook 1
chr6_-_33393471 1.042 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr4_+_100135810 1.041 NM_015143
METAP1
methionyl aminopeptidase 1
chr9_-_138277467 1.038 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr19_+_40451807 1.038 USF2
upstream transcription factor 2, c-fos interacting
chr20_-_44370537 1.032 CDH22
cadherin 22, type 2
chr19_+_40431359 1.030 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr7_-_105712565 1.029 NAMPT
nicotinamide phosphoribosyltransferase
chr4_+_100135897 1.024 METAP1
methionyl aminopeptidase 1
chrX_-_152749190 1.023 NM_032512
PDZD4
PDZ domain containing 4
chr17_-_34014390 1.019 SRCIN1
SRC kinase signaling inhibitor 1
chr17_-_7434113 1.014 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr19_+_2115119 1.011 NM_032482
DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr22_-_18807805 1.009 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr19_-_14177980 1.005 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr19_+_40451626 1.002 USF2
upstream transcription factor 2, c-fos interacting
chr8_+_1699418 1.002 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr21_-_39642935 1.000 HMGN1
high-mobility group nucleosome binding domain 1
chr22_+_18085891 0.999 SEPT5
septin 5
chr11_-_16992524 0.991 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr1_+_224317056 0.990 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_-_210939820 0.986 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr19_+_40451842 0.983 USF2
upstream transcription factor 2, c-fos interacting
chr20_+_60130963 0.980 LSM14B
LSM14B, SCD6 homolog B (S. cerevisiae)
chr11_+_64705725 0.979 NM_001198869
CAPN1
calpain 1, (mu/I) large subunit
chr9_-_115178969 0.975 HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr10_+_23424383 0.974 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr11_+_64705837 0.970 CAPN1
calpain 1, (mu/I) large subunit
chr11_-_64268841 0.967 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr7_+_100047877 0.956 NM_001040098
NM_001040099
NM_023948
MOSPD3


motile sperm domain containing 3


chr22_-_17489718 0.953 DGCR2
DiGeorge syndrome critical region gene 2
chr1_+_224317030 0.953 H3F3A
H3 histone, family 3A
chr20_-_49592654 0.952 NM_012340
NM_173091
NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

chr16_+_11669736 0.952 NM_003498
SNN
stannin
chr19_-_45642078 0.950 NM_203344
SERTAD3
SERTA domain containing 3
chr12_-_53071285 0.949 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr2_+_218972963 0.946 NM_182642
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr20_+_61841553 0.941 NM_020062
SLC2A4RG
SLC2A4 regulator
chr20_+_48240772 0.936 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr19_-_44034797 0.935 NM_001005335
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr17_-_34209671 0.932 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr22_+_38183480 0.932 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr19_-_48976852 0.929 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr22_-_20551722 0.927 MAPK1
mitogen-activated protein kinase 1
chr6_+_143423656 0.927 NM_016108
AIG1
androgen-induced 1
chr17_+_72880831 0.926 NM_001113493
SEPT9
septin 9
chr12_+_56206692 0.925 MBD6
methyl-CpG binding domain protein 6
chr19_-_6453224 0.925 NM_006087
TUBB4
tubulin, beta 4
chr21_-_37260488 0.924 HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr11_+_64705261 0.924 NM_001198868
CAPN1
calpain 1, (mu/I) large subunit
chr20_+_56900116 0.923 NM_001077488
GNAS
GNAS complex locus
chr19_-_44503328 0.917


chr11_+_117812282 0.916 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr13_+_114065142 0.915 NM_023011
NM_080687
UPF3A

UPF3 regulator of nonsense transcripts homolog A (yeast)

chr11_+_64705855 0.914 NM_001198870
NM_005186
CAPN1

calpain 1, (mu/I) large subunit

chr16_+_2503978 0.912 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr19_-_53950458 0.908 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr1_+_172395277 0.906 RABGAP1L
RAB GTPase activating protein 1-like
chr22_-_17489912 0.901 NM_001173533
NM_001173534
NM_001184781
NM_005137
DGCR2



DiGeorge syndrome critical region gene 2



chr20_+_48240867 0.900 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr2_+_154436670 0.895 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr19_-_11169184 0.892 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr22_-_20551937 0.890 MAPK1
mitogen-activated protein kinase 1
chr10_-_79356285 0.887 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chrX_+_153318662 0.886 GDI1
GDP dissociation inhibitor 1
chr17_-_75385371 0.885 NM_020649
CBX8
chromobox homolog 8
chr2_+_11213053 0.885 PQLC3
PQ loop repeat containing 3
chr1_-_39910296 0.884 NM_032526
NT5C1A
5'-nucleotidase, cytosolic IA
chr17_-_72009001 0.883 NM_024599
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr2_+_218896219 0.883 PNKD
paroxysmal nonkinesigenic dyskinesia
chr6_-_44203155 0.881 NM_032111
MRPL14
mitochondrial ribosomal protein L14
chr6_+_33486750 0.880 NM_002636
NM_024165
PHF1

PHD finger protein 1

chr7_+_150414704 0.880 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr20_+_61841662 0.879 SLC2A4RG
SLC2A4 regulator
chr6_+_43151922 0.879 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr16_+_2503994 0.875 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr16_+_87741416 0.871


chr1_-_52791218 0.870 ZCCHC11
zinc finger, CCHC domain containing 11
chr2_-_171725150 0.869 TLK1
tousled-like kinase 1
chr7_+_64975784 0.868 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr6_-_33393696 0.867 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr15_-_91433165 0.867 NM_020211
RGMA
RGM domain family, member A
chr6_+_111911226 0.866 LOC643749
hypothetical LOC643749
chr6_+_44346457 0.861 NM_001137560
TMEM151B
transmembrane protein 151B
chr22_-_20551953 0.859 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr2_-_175741096 0.857 NM_001880
ATF2
activating transcription factor 2
chr5_+_138116972 0.857 NM_001903
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr2_+_46623325 0.856 NM_012249
RHOQ
ras homolog gene family, member Q

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.66e-28 GO:0009987 cellular process
1.14 4.62e-24 GO:0044237 cellular metabolic process
1.17 4.45e-20 GO:0044260 cellular macromolecule metabolic process
1.11 4.23e-17 GO:0050794 regulation of cellular process
1.10 1.75e-16 GO:0065007 biological regulation
1.18 2.70e-16 GO:0031323 regulation of cellular metabolic process
1.11 1.07e-15 GO:0050789 regulation of biological process
1.11 1.60e-15 GO:0008152 metabolic process
1.12 1.98e-15 GO:0044238 primary metabolic process
1.17 1.72e-14 GO:0080090 regulation of primary metabolic process
1.16 2.58e-14 GO:0019222 regulation of metabolic process
1.17 4.83e-14 GO:0060255 regulation of macromolecule metabolic process
1.13 8.57e-14 GO:0043170 macromolecule metabolic process
1.20 6.68e-13 GO:0010468 regulation of gene expression
1.20 2.89e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.23 3.03e-12 GO:0006464 protein modification process
1.19 1.70e-11 GO:0010556 regulation of macromolecule biosynthetic process
1.16 2.27e-11 GO:0016043 cellular component organization
1.18 3.27e-11 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 4.27e-11 GO:0071842 cellular component organization at cellular level
1.50 5.49e-11 GO:0016568 chromatin modification
1.20 6.86e-11 GO:0051252 regulation of RNA metabolic process
1.17 1.25e-10 GO:0009889 regulation of biosynthetic process
1.23 1.26e-10 GO:0006996 organelle organization
1.17 1.37e-10 GO:0051171 regulation of nitrogen compound metabolic process
1.17 1.80e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 1.82e-10 GO:0031326 regulation of cellular biosynthetic process
1.15 3.11e-10 GO:0006807 nitrogen compound metabolic process
1.30 5.30e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.19 9.90e-10 GO:0048523 negative regulation of cellular process
1.14 1.42e-09 GO:0071840 cellular component organization or biogenesis
1.20 1.80e-09 GO:0043412 macromolecule modification
1.15 1.85e-09 GO:0034641 cellular nitrogen compound metabolic process
1.19 2.67e-09 GO:0006355 regulation of transcription, DNA-dependent
1.16 3.61e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.16 1.50e-08 GO:0048518 positive regulation of biological process
1.17 1.53e-08 GO:0044267 cellular protein metabolic process
1.17 1.78e-08 GO:0048522 positive regulation of cellular process
1.17 6.33e-08 GO:0048519 negative regulation of biological process
1.16 8.24e-08 GO:0009058 biosynthetic process
1.16 9.28e-08 GO:0044249 cellular biosynthetic process
1.28 1.76e-07 GO:0006351 transcription, DNA-dependent
1.22 7.46e-07 GO:0033036 macromolecule localization
1.23 1.26e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.52 1.44e-06 GO:0048011 nerve growth factor receptor signaling pathway
1.57 1.76e-06 GO:0016569 covalent chromatin modification
1.30 2.01e-06 GO:0010628 positive regulation of gene expression
1.12 2.42e-06 GO:0051179 localization
1.57 2.65e-06 GO:0016570 histone modification
1.18 2.82e-06 GO:0009059 macromolecule biosynthetic process
1.18 3.93e-06 GO:0034645 cellular macromolecule biosynthetic process
1.24 5.37e-06 GO:0007049 cell cycle
1.31 5.38e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.21 7.64e-06 GO:0009893 positive regulation of metabolic process
1.18 8.88e-06 GO:0023051 regulation of signaling
1.15 9.70e-06 GO:0090304 nucleic acid metabolic process
1.21 1.38e-05 GO:0031325 positive regulation of cellular metabolic process
1.30 1.53e-05 GO:0051276 chromosome organization
1.27 1.79e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.19 1.99e-05 GO:0007399 nervous system development
1.21 2.31e-05 GO:0044248 cellular catabolic process
1.33 3.43e-05 GO:0006325 chromatin organization
1.28 4.51e-05 GO:0051254 positive regulation of RNA metabolic process
1.19 5.35e-05 GO:0009966 regulation of signal transduction
1.22 7.07e-05 GO:0009892 negative regulation of metabolic process
1.33 8.12e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.23 8.65e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.26 9.11e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 1.22e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.22 1.24e-04 GO:0006793 phosphorus metabolic process
1.22 1.24e-04 GO:0006796 phosphate metabolic process
1.24 1.31e-04 GO:0048699 generation of neurons
1.22 1.56e-04 GO:0032774 RNA biosynthetic process
1.23 1.56e-04 GO:0022008 neurogenesis
1.35 1.58e-04 GO:0007264 small GTPase mediated signal transduction
1.30 1.89e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.18 1.95e-04 GO:0009056 catabolic process
1.23 2.33e-04 GO:0031324 negative regulation of cellular metabolic process
1.31 2.33e-04 GO:0000904 cell morphogenesis involved in differentiation
1.12 3.07e-04 GO:0051234 establishment of localization
1.26 3.17e-04 GO:0009890 negative regulation of biosynthetic process
1.26 3.88e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.21 3.95e-04 GO:0032268 regulation of cellular protein metabolic process
1.11 4.30e-04 GO:0048856 anatomical structure development
1.17 4.65e-04 GO:0009653 anatomical structure morphogenesis
1.23 4.87e-04 GO:0022402 cell cycle process
1.12 5.27e-04 GO:0006810 transport
1.30 5.51e-04 GO:0031175 neuron projection development
1.16 5.66e-04 GO:0016070 RNA metabolic process
1.27 6.03e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.26 7.78e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.27 8.18e-04 GO:0010629 negative regulation of gene expression
1.26 8.31e-04 GO:0032989 cellular component morphogenesis
1.20 8.42e-04 GO:0051246 regulation of protein metabolic process
1.26 8.60e-04 GO:0051726 regulation of cell cycle
1.27 8.75e-04 GO:0000902 cell morphogenesis
1.26 9.15e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 9.85e-04 GO:0048666 neuron development
1.11 1.05e-03 GO:0019538 protein metabolic process
1.22 1.13e-03 GO:0016310 phosphorylation
1.25 1.19e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.14 1.45e-03 GO:0030154 cell differentiation
1.31 1.50e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.22 1.55e-03 GO:0009891 positive regulation of biosynthetic process
1.26 1.60e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.21 1.63e-03 GO:0048468 cell development
1.13 2.21e-03 GO:0048869 cellular developmental process
1.22 2.36e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.27 2.43e-03 GO:0051253 negative regulation of RNA metabolic process
1.23 2.54e-03 GO:0006468 protein phosphorylation
1.09 2.85e-03 GO:0032502 developmental process
1.30 2.94e-03 GO:0048812 neuron projection morphogenesis
1.21 3.47e-03 GO:0016265 death
1.21 3.72e-03 GO:0008219 cell death
1.19 3.82e-03 GO:0008104 protein localization
1.14 4.49e-03 GO:0010467 gene expression
1.27 4.58e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.17 4.85e-03 GO:0051641 cellular localization
1.37 6.06e-03 GO:0045596 negative regulation of cell differentiation
1.23 7.67e-03 GO:0045595 regulation of cell differentiation
1.15 8.04e-03 GO:0065009 regulation of molecular function
1.29 8.71e-03 GO:0007409 axonogenesis
1.32 9.10e-03 GO:0070647 protein modification by small protein conjugation or removal
1.25 9.67e-03 GO:0000278 mitotic cell cycle
1.11 1.03e-02 GO:0048731 system development
1.26 1.05e-02 GO:0032990 cell part morphogenesis
1.39 1.06e-02 GO:0051129 negative regulation of cellular component organization
1.26 1.12e-02 GO:0048858 cell projection morphogenesis
1.20 1.13e-02 GO:0051128 regulation of cellular component organization
1.23 1.45e-02 GO:0030030 cell projection organization
1.18 1.73e-02 GO:0010646 regulation of cell communication
1.09 2.48e-02 GO:0007275 multicellular organismal development
1.37 2.65e-02 GO:0007507 heart development
1.21 2.84e-02 GO:0030182 neuron differentiation
1.31 2.86e-02 GO:0007411 axon guidance
1.31 4.02e-02 GO:0051098 regulation of binding
1.31 4.14e-02 GO:0051093 negative regulation of developmental process
1.43 4.21e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 2.54e-48 GO:0005622 intracellular
1.10 1.16e-47 GO:0044424 intracellular part
1.13 1.56e-40 GO:0043227 membrane-bounded organelle
1.13 2.72e-40 GO:0043231 intracellular membrane-bounded organelle
1.11 4.11e-37 GO:0043226 organelle
1.11 5.06e-37 GO:0043229 intracellular organelle
1.17 2.32e-31 GO:0005634 nucleus
1.12 9.09e-29 GO:0005737 cytoplasm
1.25 3.74e-20 GO:0044428 nuclear part
1.13 4.15e-20 GO:0044444 cytoplasmic part
1.14 1.21e-18 GO:0044446 intracellular organelle part
1.13 2.29e-18 GO:0044422 organelle part
1.26 6.80e-17 GO:0031981 nuclear lumen
1.21 1.40e-14 GO:0070013 intracellular organelle lumen
1.21 2.87e-14 GO:0043233 organelle lumen
1.20 3.72e-13 GO:0031974 membrane-enclosed lumen
1.20 3.68e-12 GO:0005829 cytosol
1.26 7.48e-12 GO:0005654 nucleoplasm
1.03 7.73e-10 GO:0044464 cell part
1.03 8.78e-10 GO:0005623 cell
1.20 1.98e-08 GO:0012505 endomembrane system
1.14 3.57e-08 GO:0043234 protein complex
1.27 1.38e-06 GO:0044451 nucleoplasm part
1.23 2.70e-06 GO:0005794 Golgi apparatus
1.11 2.90e-06 GO:0032991 macromolecular complex
1.15 3.50e-06 GO:0031090 organelle membrane
1.26 1.91e-04 GO:0044431 Golgi apparatus part
1.65 2.42e-04 GO:0016585 chromatin remodeling complex
1.40 7.83e-04 GO:0016604 nuclear body
1.39 1.64e-03 GO:0000228 nuclear chromosome
1.30 2.44e-03 GO:0048471 perinuclear region of cytoplasm
1.40 5.57e-03 GO:0031252 cell leading edge
1.25 6.23e-03 GO:0000139 Golgi membrane
1.10 9.23e-03 GO:0043228 non-membrane-bounded organelle
1.10 9.23e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.20 1.30e-02 GO:0015630 microtubule cytoskeleton
1.39 1.64e-02 GO:0044454 nuclear chromosome part
1.50 2.57e-02 GO:0005925 focal adhesion
1.42 2.77e-02 GO:0000151 ubiquitin ligase complex
1.18 3.57e-02 GO:0044432 endoplasmic reticulum part
1.18 3.71e-02 GO:0031410 cytoplasmic vesicle
1.47 4.12e-02 GO:0030055 cell-substrate junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 4.39e-35 GO:0005515 protein binding
1.08 1.37e-30 GO:0005488 binding
1.30 9.85e-12 GO:0030528 transcription regulator activity
1.18 1.16e-09 GO:0000166 nucleotide binding
1.41 2.83e-09 GO:0019904 protein domain specific binding
1.32 1.32e-08 GO:0043565 sequence-specific DNA binding
1.26 3.40e-08 GO:0001071 nucleic acid binding transcription factor activity
1.26 3.40e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.28 6.81e-07 GO:0019899 enzyme binding
1.15 7.10e-07 GO:0003677 DNA binding
1.12 8.19e-07 GO:0003676 nucleic acid binding
1.43 1.42e-06 GO:0008134 transcription factor binding
1.09 2.72e-06 GO:0003824 catalytic activity
1.16 2.87e-06 GO:0017076 purine nucleotide binding
1.24 2.91e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.16 3.44e-06 GO:0032553 ribonucleotide binding
1.16 3.44e-06 GO:0032555 purine ribonucleotide binding
1.16 4.98e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.34 9.34e-06 GO:0004674 protein serine/threonine kinase activity
1.18 1.29e-05 GO:0030554 adenyl nucleotide binding
1.25 1.55e-05 GO:0016301 kinase activity
1.17 2.05e-05 GO:0032559 adenyl ribonucleotide binding
1.30 2.56e-05 GO:0008092 cytoskeletal protein binding
1.25 3.86e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.17 4.16e-05 GO:0005524 ATP binding
1.15 1.78e-04 GO:0016740 transferase activity
1.32 3.12e-04 GO:0003712 transcription cofactor activity
1.35 3.55e-04 GO:0016563 transcription activator activity
1.32 4.06e-04 GO:0000988 protein binding transcription factor activity
1.32 4.06e-04 GO:0000989 transcription factor binding transcription factor activity
1.45 6.01e-04 GO:0003682 chromatin binding
1.25 6.53e-04 GO:0004672 protein kinase activity
1.40 7.44e-04 GO:0019787 small conjugating protein ligase activity
1.41 7.97e-04 GO:0003713 transcription coactivator activity
1.34 1.96e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.36 2.04e-03 GO:0016881 acid-amino acid ligase activity
1.39 2.23e-03 GO:0004842 ubiquitin-protein ligase activity
1.09 2.50e-03 GO:0043169 cation binding
1.08 2.90e-03 GO:0043167 ion binding
1.32 3.27e-03 GO:0003779 actin binding
1.67 3.47e-03 GO:0042393 histone binding
1.08 5.74e-03 GO:0046872 metal ion binding
1.40 2.43e-02 GO:0000287 magnesium ion binding
1.36 2.45e-02 GO:0000975 regulatory region DNA binding
1.36 2.45e-02 GO:0001067 regulatory region nucleic acid binding
1.36 2.45e-02 GO:0044212 transcription regulatory region DNA binding
1.24 2.52e-02 GO:0016874 ligase activity
1.29 3.40e-02 GO:0016564 transcription repressor activity