Motif ID: GFI1.p2

Z-value: 1.536


Transcription factors associated with GFI1.p2:

Gene SymbolEntrez IDGene Name
GFI1 2672 growth factor independent 1 transcription repressor



Activity profile for motif GFI1.p2.

activity profile for motif GFI1.p2


Sorted Z-values histogram for motif GFI1.p2

Sorted Z-values for motif GFI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_1566566 1.129 NM_001163673
NM_152348
WDR81

WD repeat domain 81

chr14_+_105028614 1.039 NM_001134875
NM_001134876
C14orf80

chromosome 14 open reading frame 80

chr4_+_183302105 1.030 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr17_-_1566223 1.014 C17orf91
chromosome 17 open reading frame 91
chr1_+_161305558 0.997 NM_001113381
RGS4
regulator of G-protein signaling 4
chr1_+_161305188 0.975 NM_005613
RGS4
regulator of G-protein signaling 4
chr7_-_27162688 0.963 NM_006896
HOXA7
homeobox A7
chr5_+_174084137 0.936 NM_002449
MSX2
msh homeobox 2
chr3_+_132583204 0.919 NM_001171905
NM_001171906
NM_152395
NUDT16


nudix (nucleoside diphosphate linked moiety X)-type motif 16


chr3_+_121296290 0.903


chr2_+_149894744 0.856 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr4_-_115120251 0.854 NM_024590
ARSJ
arylsulfatase family, member J
chr10_-_71576458 0.850 NM_001040273
NM_173555
TYSND1

trypsin domain containing 1

chr9_+_136673534 0.840 COL5A1
collagen, type V, alpha 1
chr11_-_47154955 0.840 NM_032389
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr19_-_11352850 0.837 EPOR
erythropoietin receptor
chr3_+_112876212 0.819 NM_001185106
NM_153268
PLCXD2

phosphatidylinositol-specific phospholipase C, X domain containing 2

chr8_-_78074851 0.809 NM_000318
NM_001079867
PEX2

peroxisomal biogenesis factor 2

chr11_-_47154996 0.804 ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr9_-_23816062 0.798 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_33028790 0.796 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr19_-_14108267 0.793 ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr8_+_42129620 0.771 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr14_+_64948332 0.757 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr1_-_148936123 0.757 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr17_-_5330204 0.744 NM_016041
DERL2
Der1-like domain family, member 2
chr19_-_14108400 0.742 NM_018154
ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr6_-_26125939 0.733 NM_005325
HIST1H1A
histone cluster 1, H1a
chr15_+_39032927 0.713 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr3_-_116348780 0.710 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr11_-_85074848 0.692 NM_152723
CCDC89
coiled-coil domain containing 89
chr5_-_73973004 0.685 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr7_-_133794344 0.659 AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr17_-_43328141 0.652


chr7_-_133794404 0.638 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr1_+_66570683 0.631 PDE4B
phosphodiesterase 4B, cAMP-specific
chr10_+_102782156 0.630 SFXN3
sideroflexin 3
chr11_-_19038803 0.624 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr13_-_77391525 0.624


chrX_-_101658297 0.623 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr3_-_64186151 0.622 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr1_+_66570363 0.616 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr9_+_1040600 0.616 NM_181872
DMRT2
doublesex and mab-3 related transcription factor 2
chr5_-_157011665 0.581


chr6_+_26333361 0.580 NM_003532
HIST1H3E
histone cluster 1, H3e
chr10_-_71576415 0.576 TYSND1
trypsin domain containing 1
chr8_-_28403652 0.571 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr9_+_36180885 0.564 CLTA
clathrin, light chain A
chr1_-_68470585 0.556 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_+_36180852 0.556 NM_001076677
NM_001184760
NM_001184761
NM_001184762
NM_001833
NM_007096
CLTA





clathrin, light chain A





chr3_+_173951163 0.555 ECT2
epithelial cell transforming sequence 2 oncogene
chr5_-_92982927 0.546


chr10_+_102782151 0.544 SFXN3
sideroflexin 3
chr7_+_129918408 0.543 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr9_+_1040367 0.542 DMRT2
doublesex and mab-3 related transcription factor 2
chr9_+_1040333 0.536 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr9_+_36180927 0.533 CLTA
clathrin, light chain A
chr9_+_136673464 0.532 NM_000093
COL5A1
collagen, type V, alpha 1
chr4_-_159313613 0.530 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr11_-_72111027 0.528 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr2_+_149895274 0.514 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr4_-_122063118 0.514 NM_018699
PRDM5
PR domain containing 5
chr10_-_101680645 0.512 DNMBP
dynamin binding protein
chr10_-_71576335 0.510


chr9_+_36180936 0.508 CLTA
clathrin, light chain A
chr6_-_119512035 0.504 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr12_+_94776901 0.501 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr5_+_140772691 0.499 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr3_-_130385454 0.483 NM_001127192
NM_001127193
NM_001127194
NM_001127195
NM_001127196
NM_003418
CNBP





CCHC-type zinc finger, nucleic acid binding protein





chr6_+_26128656 0.481 NM_003529
HIST1H3A
histone cluster 1, H3a
chr9_+_36180956 0.480 CLTA
clathrin, light chain A
chr12_+_94776836 0.479 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr17_+_5330439 0.479 MIS12
MIS12, MIND kinetochore complex component, homolog (S. pombe)
chr8_-_71743908 0.477 LACTB2
lactamase, beta 2
chr7_-_121571472 0.476 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr5_-_100266769 0.468 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr10_-_93382735 0.465 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr8_+_74083615 0.456 NM_003218
NM_017489
TERF1

telomeric repeat binding factor (NIMA-interacting) 1

chr6_-_134540666 0.454 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_6473207 0.454 MRPL51
mitochondrial ribosomal protein L51
chr3_-_69517913 0.449 FRMD4B
FERM domain containing 4B
chr6_+_137185441 0.448 PEX7
peroxisomal biogenesis factor 7
chr18_+_42780784 0.448 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr6_+_137185376 0.445 NM_000288
PEX7
peroxisomal biogenesis factor 7
chr11_-_59140192 0.444 NM_002556
OSBP
oxysterol binding protein
chr11_+_13255836 0.438 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr7_-_93357881 0.437 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr3_-_147361626 0.437 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr3_+_50248652 0.437 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr7_-_44129661 0.433 POLD2
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
chr16_+_81218074 0.431 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr12_+_46878406 0.430 DKFZP779L1853
hypothetical LOC643162
chr3_+_50248579 0.429 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chrX_+_53128207 0.429 NM_022117
TSPYL2
TSPY-like 2
chr3_+_50248639 0.424 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr9_+_91115924 0.423 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr12_-_22378833 0.422 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr2_-_192767494 0.419 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr2_-_241146040 0.412 ANKMY1
ankyrin repeat and MYND domain containing 1
chr3_+_50248649 0.412 NM_002070
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr5_-_112658456 0.411 NM_002387
MCC
mutated in colorectal cancers
chr10_-_93382779 0.410 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr3_-_130385444 0.404 CNBP
CCHC-type zinc finger, nucleic acid binding protein
chr19_-_44112920 0.402 NM_001145901
NM_017827
SARS2

seryl-tRNA synthetase 2, mitochondrial

chr19_-_12128528 0.402 NM_145233
ZNF625-ZNF20
ZNF625
ZNF625-ZNF20 read-through transcript
zinc finger protein 625
chr17_-_30783631 0.401 NM_018042
SLFN12
schlafen family member 12
chr6_+_46205777 0.401 ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr15_+_96304911 0.401 NM_183376
ARRDC4
arrestin domain containing 4
chr2_-_45090025 0.397 NM_016932
SIX2
SIX homeobox 2
chr10_-_93382837 0.396 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr8_-_49996353 0.394 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr3_+_50248678 0.389 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_-_95165037 0.385 CNN3
calponin 3, acidic
chr11_-_67032125 0.384 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr17_-_45427565 0.384 NM_005220
DLX3
distal-less homeobox 3
chr1_-_95165089 0.384 NM_001839
CNN3
calponin 3, acidic
chr14_-_52487558 0.383 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr2_-_241146077 0.380 NM_016552
NM_017844
ANKMY1

ankyrin repeat and MYND domain containing 1

chr1_-_27211913 0.378 NM_052943
FAM46B
family with sequence similarity 46, member B
chr4_+_95898098 0.377 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_172060563 0.376 DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr19_+_18164989 0.375 NM_032683
MPV17L2
MPV17 mitochondrial membrane protein-like 2
chr12_-_55013987 0.375 NM_001166279
NM_014871
PAN2

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

chr1_+_172060440 0.373 DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr4_-_24590867 0.372 NM_173463
CCDC149
coiled-coil domain containing 149
chr17_+_59933541 0.371 NM_138363
CCDC45
coiled-coil domain containing 45
chr1_+_172060389 0.366 NM_018122
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr5_-_112658200 0.365 MCC
mutated in colorectal cancers
chr14_-_52487386 0.364 FERMT2
fermitin family member 2
chr19_-_52709975 0.364 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr20_+_4650499 0.363 NM_012409
PRND
prion protein 2 (dublet)
chr1_-_27212035 0.362 FAM46B
family with sequence similarity 46, member B
chr15_+_98960277 0.362 NM_024708
NM_198243
ASB7

ankyrin repeat and SOCS box containing 7

chr10_+_92621221 0.359 RPP30
ribonuclease P/MRP 30kDa subunit
chr22_-_26645214 0.358 NM_012399
PITPNB
phosphatidylinositol transfer protein, beta
chr4_-_138673014 0.358 PCDH18
protocadherin 18
chr15_-_98699628 0.358 NM_139057
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr11_-_40272239 0.358 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr19_-_54646837 0.356 NM_017916
PIH1D1
PIH1 domain containing 1
chr10_-_16604009 0.355 NM_001010908
C1QL3
complement component 1, q subcomponent-like 3
chr10_+_102123589 0.355 NCRNA00263
non-protein coding RNA 263
chr3_-_102878301 0.355 NM_014415
ZBTB11
zinc finger and BTB domain containing 11
chr11_+_118710424 0.354 NM_032015
RNF26
ring finger protein 26
chr5_+_140742585 0.353 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr8_+_42247954 0.352 NM_001190722
NM_001556
IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

chr16_+_31391998 0.350 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr17_+_40089270 0.350 NM_001145080
C17orf104
chromosome 17 open reading frame 104
chr15_+_96304942 0.348 ARRDC4
arrestin domain containing 4
chr11_-_8849485 0.348 ST5
suppression of tumorigenicity 5
chr16_+_55836480 0.346 NM_012106
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr12_+_27568311 0.345 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr8_-_71743973 0.341 NM_016027
LACTB2
lactamase, beta 2
chr7_-_42243318 0.338 GLI3
GLI family zinc finger 3
chr3_+_185537969 0.338 NM_144635
FAM131A
family with sequence similarity 131, member A
chr22_-_26527469 0.337 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr3_+_50248749 0.335 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr22_+_31080871 0.334 NM_006604
RFPL3
ret finger protein-like 3
chr19_+_44113402 0.334 NM_021107
NM_033363
MRPS12

mitochondrial ribosomal protein S12

chr19_-_1993022 0.334 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr12_+_53534565 0.334 NM_058173
MUCL1
mucin-like 1
chr16_+_28798735 0.333 ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr4_-_83938920 0.333 NM_001037582
NM_024906
SCD5

stearoyl-CoA desaturase 5

chr1_+_101475149 0.332 S1PR1
sphingosine-1-phosphate receptor 1
chr17_+_59933646 0.330 CCDC45
coiled-coil domain containing 45
chr5_-_88215034 0.329 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr1_+_179324260 0.329 NM_016545
IER5
immediate early response 5
chr3_+_56566222 0.328 NM_001012506
NM_001141947
CCDC66

coiled-coil domain containing 66

chr14_-_75196911 0.327 C14orf1
chromosome 14 open reading frame 1
chr19_+_20049800 0.327 NM_007138
ZNF90
zinc finger protein 90
chr1_-_7998265 0.326 ERRFI1
ERBB receptor feedback inhibitor 1
chr8_+_42247991 0.326 NM_001190720
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr5_+_140835788 0.325 PCDHGC3
protocadherin gamma subfamily C, 3
chr14_-_103383483 0.324 NM_015316
PPP1R13B
protein phosphatase 1, regulatory (inhibitor) subunit 13B
chr17_-_76827479 0.324 NM_144679
C17orf56
chromosome 17 open reading frame 56
chr8_-_124477639 0.323 ATAD2
ATPase family, AAA domain containing 2
chr1_+_112740378 0.322


chr22_-_35502059 0.322 NM_001177701
NM_006860
IFT27

intraflagellar transport 27 homolog (Chlamydomonas)

chr6_+_46205659 0.321 NM_014936
ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
chr9_+_36181015 0.321 CLTA
clathrin, light chain A
chr11_-_55492514 0.321 NM_001005491
OR10AG1
olfactory receptor, family 10, subfamily AG, member 1
chr5_-_92942680 0.319 FLJ42709
hypothetical LOC441094
chr3_-_130385362 0.319 CNBP
CCHC-type zinc finger, nucleic acid binding protein
chr12_-_8656705 0.318 NM_020661
AICDA
activation-induced cytidine deaminase
chrX_-_103060777 0.318 LOC100128594
hypothetical LOC100128594
chr17_+_43480674 0.318 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr4_+_6322459 0.317 NM_001145853
NM_006005
WFS1

Wolfram syndrome 1 (wolframin)

chr4_-_138673078 0.316 NM_019035
PCDH18
protocadherin 18
chr3_-_87122958 0.316 VGLL3
vestigial like 3 (Drosophila)
chr1_-_172060399 0.316 NM_001127181
NM_033319
CENPL

centromere protein L

chr14_+_73775927 0.315 NM_182894
VSX2
visual system homeobox 2
chr1_+_101474892 0.315 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr17_-_57295451 0.314 NM_032043
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr12_+_6473519 0.312 NCAPD2
non-SMC condensin I complex, subunit D2
chr17_+_5330588 0.312 MIS12
MIS12, MIND kinetochore complex component, homolog (S. pombe)
chr7_+_87095640 0.311 NM_001134405
NM_001134406
NM_138290
RUNDC3B


RUN domain containing 3B


chr1_+_112740380 0.310 LOC100129406
CTTNBP2NL
hypothetical protein LOC100129406
CTTNBP2 N-terminal like
chr10_-_99436889 0.310 NM_021732
AVPI1
arginine vasopressin-induced 1
chr5_+_140835727 0.310 NM_002588
NM_032402
NM_032403
PCDHGC3


protocadherin gamma subfamily C, 3


chr1_+_169549996 0.309 NM_002022
FMO4
flavin containing monooxygenase 4
chr1_+_160868932 0.308 DDR2
discoidin domain receptor tyrosine kinase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.53 8.56e-04 GO:0071824 protein-DNA complex subunit organization
2.51 2.36e-03 GO:0065004 protein-DNA complex assembly
1.25 6.56e-03 GO:0071842 cellular component organization at cellular level
1.22 1.18e-02 GO:0048856 anatomical structure development
1.73 1.22e-02 GO:0034622 cellular macromolecular complex assembly
1.19 1.61e-02 GO:0032502 developmental process
1.26 2.37e-02 GO:0090304 nucleic acid metabolic process
2.36 3.07e-02 GO:0034728 nucleosome organization
1.17 3.32e-02 GO:0044260 cellular macromolecule metabolic process
2.39 3.36e-02 GO:0031497 chromatin assembly
2.43 3.65e-02 GO:0006334 nucleosome assembly
1.12 4.37e-02 GO:0050794 regulation of cellular process
1.07 4.78e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 9.12e-14 GO:0005634 nucleus
1.13 1.43e-09 GO:0043226 organelle
1.13 1.53e-09 GO:0043229 intracellular organelle
1.10 3.50e-09 GO:0005622 intracellular
1.11 4.06e-09 GO:0044424 intracellular part
1.14 5.48e-08 GO:0043231 intracellular membrane-bounded organelle
1.14 7.57e-08 GO:0043227 membrane-bounded organelle
2.51 1.35e-03 GO:0032993 protein-DNA complex
2.94 1.44e-03 GO:0000786 nucleosome
1.58 1.63e-03 GO:0005694 chromosome
1.22 8.61e-03 GO:0043228 non-membrane-bounded organelle
1.22 8.61e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.55 2.35e-02 GO:0044427 chromosomal part
1.23 3.80e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.06 1.04e-02 GO:0005488 binding