Motif ID: PAX5.p2

Z-value: 1.537


Transcription factors associated with PAX5.p2:

Gene SymbolEntrez IDGene Name
PAX5 5079 paired box 5



Activity profile for motif PAX5.p2.

activity profile for motif PAX5.p2


Sorted Z-values histogram for motif PAX5.p2

Sorted Z-values for motif PAX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_133923758 6.937 NCRNA00119
non-protein coding RNA 119
chr3_-_133923992 5.837 NPHP3-ACAD11
NPHP3-ACAD11 read-through transcript
chr3_-_133923906 5.802 NM_153240
NPHP3
nephronophthisis 3 (adolescent)
chrX_+_43399101 4.344 MAOA
monoamine oxidase A
chr21_-_43671355 3.621 NM_173354
SIK1
salt-inducible kinase 1
chr12_-_93568336 3.236 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr19_+_61742111 2.983 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr4_+_7245218 2.514 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr9_+_139566129 2.468 NM_032477
MRPL41
mitochondrial ribosomal protein L41
chr17_-_59131194 2.440 LIMD2
LIM domain containing 2
chrX_+_118486390 2.357 NM_001152
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr14_+_102128741 2.322 RCOR1
REST corepressor 1
chr14_+_99329198 2.280 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr14_+_102128844 2.276 NM_015156
RCOR1
REST corepressor 1
chr17_+_40565492 2.105 NM_001135704
ACBD4
acyl-CoA binding domain containing 4
chrX_+_118486419 2.086 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr4_-_186629841 2.027 NM_001145411
NM_152775
CCDC110

coiled-coil domain containing 110

chr16_+_65790514 2.004 NM_024712
ELMO3
engulfment and cell motility 3
chr10_+_129595349 1.982 PTPRE
protein tyrosine phosphatase, receptor type, E
chr1_-_233879617 1.943 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr22_-_41913076 1.897 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr4_-_170428564 1.882 SH3RF1
SH3 domain containing ring finger 1
chr10_+_171410 1.848 ZMYND11
zinc finger, MYND-type containing 11
chr22_-_41913002 1.824 TTLL12
tubulin tyrosine ligase-like family, member 12
chr1_+_243200251 1.790 NM_001143943
EFCAB2
EF-hand calcium binding domain 2
chr15_-_76210611 1.776 NM_006383
CIB2
calcium and integrin binding family member 2
chr22_-_41913075 1.774 TTLL12
tubulin tyrosine ligase-like family, member 12
chr3_+_58452560 1.759 NM_001128214
KCTD6
potassium channel tetramerisation domain containing 6
chr4_-_170428681 1.753 SH3RF1
SH3 domain containing ring finger 1
chr18_+_7557313 1.723 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr15_+_97009194 1.717 IGF1R
insulin-like growth factor 1 receptor
chr10_-_105604942 1.698 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr1_+_243200275 1.690 EFCAB2
EF-hand calcium binding domain 2
chr18_-_59138192 1.673 BCL2
B-cell CLL/lymphoma 2
chr8_+_1909437 1.655 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr3_-_127677451 1.636 NM_001040653
NM_025112
ZXDC

ZXD family zinc finger C

chr5_+_17270474 1.619 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr21_+_41461962 1.566 BACE2
beta-site APP-cleaving enzyme 2
chr17_+_41217391 1.534 NM_001145146
NM_001145147
NM_001145148
NM_004382
CRHR1



corticotropin releasing hormone receptor 1



chr8_-_80842452 1.531 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr10_-_30064600 1.525 NM_003174
SVIL
supervillin
chr2_+_238265519 1.479 NM_001137551
NM_001137552
NM_001137553
NM_004735
LRRFIP1



leucine rich repeat (in FLII) interacting protein 1



chr7_+_72720093 1.469 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr17_-_26175764 1.450 CRLF3
cytokine receptor-like factor 3
chr8_+_22513043 1.441 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr21_+_32706615 1.431 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr1_+_208178198 1.418 SYT14
synaptotagmin XIV
chr2_-_158440587 1.415 NM_001111067
ACVR1
activin A receptor, type I
chr19_+_3175700 1.414 NM_021938
NM_001172673
CELF5

CUGBP, Elav-like family member 5

chr22_+_36632242 1.410 NM_033386
MICALL1
MICAL-like 1
chr19_+_3175734 1.401 CELF5
CUGBP, Elav-like family member 5
chr18_+_12298242 1.395 NM_032525
TUBB6
tubulin, beta 6
chr14_-_104705753 1.388 JAG2
jagged 2
chr6_+_159510416 1.387 NM_032532
FNDC1
fibronectin type III domain containing 1
chr11_+_1925075 1.384 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr9_+_138680064 1.382 EGFL7
EGF-like-domain, multiple 7
chr17_-_53387493 1.378 CUEDC1
CUE domain containing 1
chr7_-_107883929 1.375 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr11_+_109468734 1.363 ZC3H12C
zinc finger CCCH-type containing 12C
chr7_+_89678935 1.361 NM_152999
NM_001040665
STEAP2

six transmembrane epithelial antigen of the prostate 2

chr21_+_41461597 1.359 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr11_+_66643311 1.346 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chr16_-_342399 1.343 NM_003502
NM_181050
AXIN1

axin 1

chr12_+_13044604 1.343 HTR7P1
5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
chr4_-_7991992 1.342 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr13_+_43845977 1.321 NM_001010897
SERP2
stress-associated endoplasmic reticulum protein family member 2
chr15_+_73281288 1.320 C15orf39
chromosome 15 open reading frame 39
chr5_-_14924555 1.306 NM_054027
ANKH
ankylosis, progressive homolog (mouse)
chr18_+_12298236 1.303 TUBB6
tubulin, beta 6
chr7_-_138316393 1.296 NM_001164665
NM_020910
KIAA1549

KIAA1549

chr17_-_24068759 1.291 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr12_+_131000455 1.285 NM_015409
EP400
E1A binding protein p400
chr17_+_63713171 1.285


chr15_+_73281249 1.284 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr6_+_17389752 1.284 NM_001143942
RBM24
RNA binding motif protein 24
chr2_+_238265617 1.273 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr14_-_94855848 1.259 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr18_+_12298189 1.255 TUBB6
tubulin, beta 6
chr7_+_99919485 1.250 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr2_+_27163114 1.242 NM_000221
NM_006488
KHK

ketohexokinase (fructokinase)

chr21_+_45118353 1.237


chr11_-_63292688 1.233 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr19_-_7896974 1.232 NM_206833
CTXN1
cortexin 1
chr22_-_30071565 1.229 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chrX_-_1532648 1.226 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr15_+_73281286 1.215 C15orf39
chromosome 15 open reading frame 39
chr18_-_59137948 1.215 BCL2
B-cell CLL/lymphoma 2
chr10_+_135042684 1.208 NM_152911
NM_207127
NM_207128
PAOX


polyamine oxidase (exo-N4-amino)


chr11_-_17367439 1.208 NM_001166290
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr4_-_170428768 1.196 NM_020870
SH3RF1
SH3 domain containing ring finger 1
chr8_+_136538739 1.185 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr8_-_144722141 1.181 C8orf73
chromosome 8 open reading frame 73
chr11_+_120828058 1.178 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr16_+_65196125 1.173 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr8_+_60194328 1.172


chr3_-_53054999 1.171 SFMBT1
Scm-like with four mbt domains 1
chr8_-_145640604 1.167 NM_013432
TONSL
tonsoku-like, DNA repair protein
chr9_+_36126710 1.165 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr11_+_67107852 1.160 GSTP1
glutathione S-transferase pi 1
chr16_+_65196133 1.154 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr2_-_20714303 1.153 NM_022460
HS1BP3
HCLS1 binding protein 3
chr9_+_136673534 1.145 COL5A1
collagen, type V, alpha 1
chr1_+_86943074 1.133 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr1_+_208178160 1.132 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr1_+_86942874 1.120 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr14_-_104718565 1.115 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr7_+_72720256 1.115 VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr4_+_110574420 1.111 SEC24B
SEC24 family, member B (S. cerevisiae)
chr8_+_25097983 1.109 DOCK5
dedicator of cytokinesis 5
chr8_-_145640579 1.109 TONSL
tonsoku-like, DNA repair protein
chr15_-_76890626 1.103 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr1_+_86943103 1.094 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr11_-_64247230 1.093 NM_015080
NM_138732
NRXN2

neurexin 2

chr22_+_47350781 1.086 NM_015381
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr12_+_130878870 1.075 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr22_-_30072217 1.070 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr19_-_52426055 1.058 NM_014417
BBC3
BCL2 binding component 3
chr7_-_35044177 1.053 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr16_+_65196031 1.053 NM_181553
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr1_-_115433570 1.051 NM_005725
TSPAN2
tetraspanin 2
chr16_+_65196153 1.049 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr11_+_915795 1.047 NM_012305
AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr7_+_55999559 1.046 NM_001483
GBAS
glioblastoma amplified sequence
chr1_+_226937732 1.035 RHOU
ras homolog gene family, member U
chr12_-_13044448 1.026 HEBP1
heme binding protein 1
chr1_-_42274160 1.021


chr11_-_67737275 1.020 NM_016028
NM_017635
SUV420H1

suppressor of variegation 4-20 homolog 1 (Drosophila)

chr22_-_49413326 1.020 NM_000487
NM_001085425
NM_001085426
NM_001085427
NM_001085428
ARSA




arylsulfatase A




chr3_+_198214173 1.019 LOC100507057
MFI2
hypothetical LOC100507057
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr17_-_26175850 1.015 NM_015986
CRLF3
cytokine receptor-like factor 3
chr13_-_105985313 1.012 NM_004093
EFNB2
ephrin-B2
chr11_+_120828275 1.008 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr4_-_158111995 1.008 NM_016205
PDGFC
platelet derived growth factor C
chr9_+_133259330 1.007 PRRC2B
proline-rich coiled-coil 2B
chr17_+_41217435 0.998 CRHR1
corticotropin releasing hormone receptor 1
chr4_+_186368277 0.996 NM_031953
SNX25
sorting nexin 25
chr9_+_135991064 0.995 WDR5
WD repeat domain 5
chr16_+_65195702 0.990 NM_001048251
NM_144601
NM_181554
CMTM3


CKLF-like MARVEL transmembrane domain containing 3


chr10_+_129595289 0.987 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr22_+_42651018 0.986 PNPLA3
patatin-like phospholipase domain containing 3
chr2_-_219960813 0.980 DNPEP
aspartyl aminopeptidase
chr13_+_97593411 0.971 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr22_-_30071761 0.970 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr13_+_97593469 0.970 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr11_+_109469296 0.968 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr12_-_13044467 0.968 NM_015987
HEBP1
heme binding protein 1
chr5_-_179712920 0.966 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr10_-_15250616 0.963 NM_004808
NMT2
N-myristoyltransferase 2
chr1_-_48235148 0.960 NM_001194986
LOC388630
UPF0632 protein A
chr8_+_31616809 0.955 NM_013962
NRG1
neuregulin 1
chr22_+_42651007 0.954 PNPLA3
patatin-like phospholipase domain containing 3
chr18_+_17076166 0.945 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr9_-_137992967 0.941 NM_016172
UBAC1
UBA domain containing 1
chr11_+_109805799 0.938 NM_004109
FDX1
ferredoxin 1
chr1_+_43769065 0.930 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr9_-_139593176 0.927 NM_138778
WDR85
WD repeat domain 85
chr1_-_3437834 0.923 MEGF6
multiple EGF-like-domains 6
chr4_+_7096043 0.918 NM_152293
TADA2B
transcriptional adaptor 2B
chr3_-_53055078 0.917 NM_001005158
NM_016329
SFMBT1

Scm-like with four mbt domains 1

chr17_-_17340219 0.917 NM_016084
RASD1
RAS, dexamethasone-induced 1
chr22_-_40652724 0.911 NM_052945
TNFRSF13C
tumor necrosis factor receptor superfamily, member 13C
chr2_-_31214868 0.910


chrX_+_151991474 0.910 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr3_-_127677400 0.910 ZXDC
ZXD family zinc finger C
chr8_+_145274906 0.898 NM_001099280
NM_001099281
NM_032450
HEATR7A


HEAT repeat containing 7A


chr17_-_77512346 0.896 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr13_-_110365416 0.895 NM_017664
ANKRD10
ankyrin repeat domain 10
chr13_-_109236897 0.889 NM_003749
IRS2
insulin receptor substrate 2
chr5_+_118632316 0.881 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr16_-_65742323 0.880 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr22_+_42650951 0.879 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr4_+_77446906 0.877 STBD1
starch binding domain 1
chr17_-_59131210 0.876 NM_030576
LIMD2
LIM domain containing 2
chr3_+_49211936 0.876 NM_001135197
CCDC36
coiled-coil domain containing 36
chr11_+_67107641 0.874 NM_000852
GSTP1
glutathione S-transferase pi 1
chr14_-_52487386 0.873 FERMT2
fermitin family member 2
chr17_-_43470134 0.872 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr9_+_135991037 0.870 WDR5
WD repeat domain 5
chr7_-_19123787 0.869 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr1_+_9217444 0.867 NM_004285
H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr8_-_145881968 0.864 ARHGAP39
Rho GTPase activating protein 39
chr4_+_77446700 0.863 NM_003943
STBD1
starch binding domain 1
chr10_-_128884411 0.860 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr13_-_110365336 0.855 ANKRD10
ankyrin repeat domain 10
chr22_+_29938284 0.844 LIMK2
LIM domain kinase 2
chr12_-_13044314 0.842 HEBP1
heme binding protein 1
chr6_+_1556543 0.841 FOXC1
forkhead box C1
chr9_-_131422842 0.840 NM_199350
C9orf50
chromosome 9 open reading frame 50
chr3_+_49034050 0.839 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr2_+_27163583 0.839 KHK
ketohexokinase (fructokinase)
chr10_-_135036805 0.835 NM_004092
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr7_-_148825760 0.832 ZNF746
zinc finger protein 746
chr10_+_102746819 0.829 NM_032429
LZTS2
leucine zipper, putative tumor suppressor 2
chr19_+_447453 0.820 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr6_-_105734535 0.817 NM_022361
POPDC3
popeye domain containing 3
chr9_+_130223046 0.816 CERCAM
cerebral endothelial cell adhesion molecule
chr1_-_199704773 0.815 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr7_-_117300763 0.815 NM_033427
CTTNBP2
cortactin binding protein 2
chr16_-_69271428 0.813 MTSS1L
metastasis suppressor 1-like
chr2_-_31214788 0.813 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.14 5.96e-18 GO:0050794 regulation of cellular process
1.13 3.54e-15 GO:0050789 regulation of biological process
1.12 5.50e-15 GO:0065007 biological regulation
1.26 1.21e-12 GO:0048523 negative regulation of cellular process
1.07 1.40e-11 GO:0009987 cellular process
1.29 1.87e-11 GO:0023051 regulation of signaling
1.31 5.13e-11 GO:0009966 regulation of signal transduction
1.22 2.62e-09 GO:0048519 negative regulation of biological process
1.56 2.98e-09 GO:0009968 negative regulation of signal transduction
1.27 1.96e-08 GO:0007399 nervous system development
1.46 6.64e-08 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.16 1.10e-07 GO:0016043 cellular component organization
1.58 1.73e-07 GO:0060284 regulation of cell development
1.31 3.87e-07 GO:0010646 regulation of cell communication
1.19 5.28e-07 GO:0048522 positive regulation of cellular process
1.39 7.06e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.33 7.09e-07 GO:0022008 neurogenesis
1.22 7.51e-07 GO:0048583 regulation of response to stimulus
1.14 7.99e-07 GO:0051716 cellular response to stimulus
1.47 8.25e-07 GO:0010648 negative regulation of cell communication
1.15 1.09e-06 GO:0023052 signaling
1.47 1.23e-06 GO:0023057 negative regulation of signaling
1.15 1.61e-06 GO:0007165 signal transduction
1.15 2.12e-06 GO:0071840 cellular component organization or biogenesis
1.39 2.47e-06 GO:0000902 cell morphogenesis
1.38 5.06e-06 GO:0032989 cellular component morphogenesis
1.42 5.69e-06 GO:0048585 negative regulation of response to stimulus
1.17 6.15e-06 GO:0048518 positive regulation of biological process
1.24 7.46e-06 GO:0009653 anatomical structure morphogenesis
1.17 8.40e-06 GO:0071842 cellular component organization at cellular level
1.36 1.45e-05 GO:0030030 cell projection organization
1.19 1.79e-05 GO:0048869 cellular developmental process
1.61 2.34e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.40 4.28e-05 GO:0000904 cell morphogenesis involved in differentiation
1.30 6.33e-05 GO:0048699 generation of neurons
1.16 6.75e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.18 8.19e-05 GO:0030154 cell differentiation
1.28 1.09e-04 GO:0048468 cell development
1.38 1.31e-04 GO:0032990 cell part morphogenesis
1.38 1.72e-04 GO:0048858 cell projection morphogenesis
1.14 1.72e-04 GO:0060255 regulation of macromolecule metabolic process
1.40 2.58e-04 GO:0048812 neuron projection morphogenesis
1.41 2.83e-04 GO:0008285 negative regulation of cell proliferation
1.31 4.58e-04 GO:0009790 embryo development
1.31 5.12e-04 GO:0045595 regulation of cell differentiation
1.72 6.42e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.12 7.89e-04 GO:0032502 developmental process
1.39 8.14e-04 GO:0007409 axonogenesis
1.12 8.41e-04 GO:0031323 regulation of cellular metabolic process
1.87 8.92e-04 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.19 9.41e-04 GO:0006996 organelle organization
1.71 9.73e-04 GO:0022604 regulation of cell morphogenesis
1.25 1.01e-03 GO:0032879 regulation of localization
1.36 1.17e-03 GO:0031175 neuron projection development
1.69 1.27e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.25 1.29e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.12 1.39e-03 GO:0080090 regulation of primary metabolic process
1.41 1.48e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.77 1.61e-03 GO:0010720 positive regulation of cell development
1.38 1.64e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.47 2.22e-03 GO:0035295 tube development
1.40 2.29e-03 GO:0009792 embryo development ending in birth or egg hatching
1.11 2.89e-03 GO:0019222 regulation of metabolic process
1.40 3.01e-03 GO:0043009 chordate embryonic development
1.49 3.42e-03 GO:0050767 regulation of neurogenesis
1.34 3.51e-03 GO:0007417 central nervous system development
1.13 3.53e-03 GO:0048731 system development
1.31 3.75e-03 GO:0010629 negative regulation of gene expression
1.32 4.31e-03 GO:0051253 negative regulation of RNA metabolic process
1.12 4.93e-03 GO:0007275 multicellular organismal development
1.33 5.02e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.50 5.53e-03 GO:0002009 morphogenesis of an epithelium
1.20 5.65e-03 GO:0051641 cellular localization
1.55 5.81e-03 GO:0035239 tube morphogenesis
1.07 5.91e-03 GO:0008152 metabolic process
1.21 6.21e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.35 6.25e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.08 6.51e-03 GO:0044237 cellular metabolic process
1.43 6.58e-03 GO:0051130 positive regulation of cellular component organization
1.14 6.66e-03 GO:0010468 regulation of gene expression
1.12 6.75e-03 GO:0048856 anatomical structure development
1.52 7.84e-03 GO:0045664 regulation of neuron differentiation
1.85 9.49e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.25 1.01e-02 GO:0051128 regulation of cellular component organization
1.19 1.07e-02 GO:0035556 intracellular signal transduction
1.20 1.11e-02 GO:0009893 positive regulation of metabolic process
1.24 1.15e-02 GO:0016265 death
1.40 1.22e-02 GO:0045597 positive regulation of cell differentiation
1.43 1.46e-02 GO:0051960 regulation of nervous system development
1.20 1.54e-02 GO:0031325 positive regulation of cellular metabolic process
1.16 1.84e-02 GO:0007166 cell surface receptor linked signaling pathway
1.24 2.03e-02 GO:0008219 cell death
1.28 2.04e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.13 2.05e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 2.10e-02 GO:0046578 regulation of Ras protein signal transduction
1.35 2.12e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.18 2.22e-02 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
1.25 2.28e-02 GO:2000026 regulation of multicellular organismal development
1.26 2.38e-02 GO:0030182 neuron differentiation
1.26 2.65e-02 GO:0009890 negative regulation of biosynthetic process
1.26 3.03e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.29 3.18e-02 GO:0048666 neuron development
1.09 3.26e-02 GO:0044260 cellular macromolecule metabolic process
2.75 3.47e-02 GO:0002040 sprouting angiogenesis
1.27 3.96e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.28 4.02e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.12 4.29e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.26 4.34e-02 GO:0010628 positive regulation of gene expression
1.91 4.47e-02 GO:0042058 regulation of epidermal growth factor receptor signaling pathway
1.12 4.80e-02 GO:0031326 regulation of cellular biosynthetic process
1.27 4.95e-02 GO:0051172 negative regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.67e-24 GO:0005622 intracellular
1.09 1.12e-22 GO:0044424 intracellular part
1.13 1.30e-22 GO:0005737 cytoplasm
1.11 4.54e-17 GO:0043227 membrane-bounded organelle
1.11 6.38e-17 GO:0043231 intracellular membrane-bounded organelle
1.14 7.99e-15 GO:0044444 cytoplasmic part
1.09 8.96e-15 GO:0043226 organelle
1.09 1.17e-14 GO:0043229 intracellular organelle
1.12 4.87e-10 GO:0005634 nucleus
1.22 2.81e-09 GO:0005829 cytosol
1.03 1.17e-07 GO:0005623 cell
1.03 1.46e-07 GO:0044464 cell part
1.27 1.13e-05 GO:0005794 Golgi apparatus
1.09 3.60e-05 GO:0044446 intracellular organelle part
1.20 3.95e-05 GO:0012505 endomembrane system
1.09 4.01e-05 GO:0044422 organelle part
1.60 7.30e-04 GO:0005912 adherens junction
1.15 1.34e-03 GO:0031090 organelle membrane
1.15 1.75e-03 GO:0044428 nuclear part
1.32 2.23e-03 GO:0000139 Golgi membrane
1.27 6.10e-03 GO:0044431 Golgi apparatus part
1.25 8.52e-03 GO:0015630 microtubule cytoskeleton
1.50 9.98e-03 GO:0070161 anchoring junction
1.62 2.97e-02 GO:0005925 focal adhesion
1.38 4.02e-02 GO:0005635 nuclear envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 1.80e-20 GO:0005515 protein binding
1.07 3.65e-15 GO:0005488 binding
1.43 2.76e-06 GO:0019904 protein domain specific binding
1.39 2.84e-05 GO:0030695 GTPase regulator activity
1.27 2.97e-05 GO:0030234 enzyme regulator activity
1.38 3.80e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.26 2.74e-03 GO:0042802 identical protein binding
1.65 6.80e-03 GO:0017124 SH3 domain binding
1.54 6.97e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.23 3.71e-02 GO:0019899 enzyme binding