Motif ID: EVI1.p2

Z-value: 0.890


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1



Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_50342168 1.996 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr9_+_33230165 1.740 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chrX_+_50670474 1.694 NM_005448
BMP15
bone morphogenetic protein 15
chr1_+_202033273 1.645 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr6_-_32892705 1.528 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_-_27126721 1.523 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr11_-_113935789 1.488 NM_152315
FAM55A
family with sequence similarity 55, member A
chr4_+_70928718 1.403 NM_000200
HTN3
histatin 3
chr6_+_126282078 1.360 NCOA7
nuclear receptor coactivator 7
chr5_-_96175560 1.341 NM_001198541
ERAP1
endoplasmic reticulum aminopeptidase 1
chr12_-_55293131 1.340 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr12_-_21649019 1.326 NM_021957
GYS2
glycogen synthase 2 (liver)
chr1_-_110735158 1.303 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr11_-_55815113 1.296 NM_001005199
OR8H1
olfactory receptor, family 8, subfamily H, member 1
chr15_-_100280784 1.294 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr16_+_24475129 1.294 RBBP6
retinoblastoma binding protein 6
chr6_+_52637116 1.288 LOC730101
hypothetical LOC730101
chr6_+_26548678 1.277 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr5_+_140568451 1.277 NM_018932
PCDHB12
protocadherin beta 12
chr9_+_124355211 1.239 NM_001004457
OR1N2
olfactory receptor, family 1, subfamily N, member 2
chr5_-_137502975 1.231 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr15_+_64661560 1.212


chrX_-_11194015 1.194 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr20_-_55368284 1.189 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr1_-_246912227 1.175 NM_001004734
OR14I1
olfactory receptor, family 14, subfamily I, member 1
chr6_+_154373323 1.175 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr6_+_142510034 1.153 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr17_-_35911340 1.151 NM_032865
TNS4
tensin 4
chr9_+_5646582 1.150 NM_020829
KIAA1432
KIAA1432
chr2_-_135498716 1.106 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr12_+_21059896 1.051 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr1_+_200698493 1.049 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr20_+_15125503 1.025 NM_001033087
MACROD2
MACRO domain containing 2
chr1_-_148854503 1.000


chr11_+_12917369 0.988 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr16_+_52037186 0.956 RBL2
retinoblastoma-like 2 (p130)
chr7_+_142053693 0.947 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr3_-_194579207 0.942 NM_198505
ATP13A5
ATPase type 13A5
chr19_+_53189719 0.942 NM_022142
ELSPBP1
epididymal sperm binding protein 1
chr11_-_10487212 0.939 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr3_-_57301749 0.934 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chrX_+_14457340 0.924 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr5_+_132460779 0.923 HSPA4
heat shock 70kDa protein 4
chr6_+_29732736 0.911 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr10_+_90474280 0.908 NM_001080518
LIPK
lipase, family member K
chr4_-_72868598 0.900 NM_000583
GC
group-specific component (vitamin D binding protein)
chr6_-_41276901 0.896 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr2_-_39310176 0.896 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr4_-_70115037 0.887 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr12_-_49708279 0.879 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr12_-_9804682 0.874 NM_001781
CD69
CD69 molecule
chr3_+_133798770 0.873 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_-_58175437 0.869 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr6_+_64289585 0.868 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr5_+_72504778 0.861 NM_153217
TMEM174
transmembrane protein 174
chr6_-_116488458 0.858 NM_002031
FRK
fyn-related kinase
chr6_-_50025115 0.850 NM_001166478
DEFB133
defensin, beta 133
chr1_-_156078115 0.840 NM_005894
CD5L
CD5 molecule-like
chr3_+_85858321 0.836 NM_153184
CADM2
cell adhesion molecule 2
chr15_+_71953020 0.829 NM_153356
TBC1D21
TBC1 domain family, member 21
chr5_+_161045235 0.826 NM_000811
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr5_+_175241449 0.822 CPLX2
complexin 2
chr6_+_123142559 0.815 FABP7
fatty acid binding protein 7, brain
chr11_-_47467094 0.811 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr9_+_676640 0.811


chr3_-_46224791 0.807 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr4_-_40212670 0.805 NM_019027
RBM47
RNA binding motif protein 47
chr4_-_89963177 0.804 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr1_+_19807168 0.800


chr1_-_111908085 0.798 NM_001081976
ADORA3
adenosine A3 receptor
chr2_+_165858586 0.793 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chrX_-_65752570 0.793 NM_021783
EDA2R
ectodysplasin A2 receptor
chr9_+_112470871 0.793 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr8_-_81155564 0.786 NM_001025252
TPD52
tumor protein D52
chr18_+_53865455 0.782 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_29081015 0.780 NM_001010877
ZNF311
zinc finger protein 311
chrX_-_131375217 0.778 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr5_-_79982584 0.762 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr12_+_49634048 0.762 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr10_+_18669619 0.747 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chrX_+_135558001 0.746 NM_000074
CD40LG
CD40 ligand
chr11_+_22646229 0.743 NM_177553
GAS2
growth arrest-specific 2
chr5_-_158567411 0.737 NM_144726
RNF145
ring finger protein 145
chr7_-_93027057 0.736 NM_001164738
CALCR
calcitonin receptor
chrX_+_154880439 0.734 NM_002186
IL9R
interleukin 9 receptor
chr8_-_110411283 0.730 NM_001128211
NUDCD1
NudC domain containing 1
chr7_-_87180499 0.728 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr19_+_61624 0.717 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_+_110795271 0.716 NM_032414
PROK1
prokineticin 1
chr4_-_69218909 0.716 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr10_-_116241572 0.715


chrX_+_15435351 0.712 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr13_+_20081940 0.710


chr6_+_168161401 0.698 NM_005355
NM_030615
KIF25

kinesin family member 25

chr11_+_64950074 0.691 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr11_-_56267862 0.688 NM_001005284
OR9G4
olfactory receptor, family 9, subfamily G, member 4
chr12_+_79362256 0.678 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr10_-_48426868 0.677 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr15_-_49184764 0.670 NM_207381
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr11_-_55460451 0.666 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr3_+_63859114 0.662 NM_001177387
ATXN7
ataxin 7
chr11_+_125208420 0.662 NM_001144874
PATE4
prostate and testis expressed 4
chr9_+_83733162 0.657 NM_001145197
FAM75D4
family with sequence similarity 75, member D4
chr8_+_42671718 0.653 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chrX_+_101388810 0.649 NM_022053
NXF2
nuclear RNA export factor 2
chrX_-_55225668 0.643 NM_001190708
MTRNR2L10
MT-RNR2-like 10
chr11_-_119499188 0.634 TRIM29
tripartite motif containing 29
chr7_-_111216180 0.633 DOCK4
dedicator of cytokinesis 4
chrX_-_106129854 0.631 MORC4
MORC family CW-type zinc finger 4
chr22_-_30885200 0.629 NM_001010859
C22orf42
chromosome 22 open reading frame 42
chr12_+_46799279 0.626 NM_000289
PFKM
phosphofructokinase, muscle
chr10_-_64698831 0.625 NM_004241
JMJD1C
jumonji domain containing 1C
chr1_-_196776697 0.625 NM_133262
NM_133326
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr5_+_175444454 0.622 NM_001079529
FAM153B
family with sequence similarity 153, member B
chr12_-_10042956 0.617 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr4_+_123311207 0.617 NM_015312
KIAA1109
KIAA1109
chr13_+_96592051 0.611 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_211166323 0.609 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr19_-_41083288 0.608 NM_139239
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chrX_+_37777730 0.607 NM_001163334
SYTL5
synaptotagmin-like 5
chr11_+_61005160 0.606 NM_001170753
NM_145017
C11orf66

chromosome 11 open reading frame 66

chr8_-_143958234 0.606 NM_000497
NM_001026213
CYP11B1

cytochrome P450, family 11, subfamily B, polypeptide 1

chr16_-_30254189 0.604 LOC595101
PI-3-kinase-related kinase SMG-1 pseudogene
chr7_+_139750311 0.603 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr19_-_40673185 0.597 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr5_+_140583098 0.597 NM_018934
PCDHB14
protocadherin beta 14
chr19_-_52427698 0.594 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr11_+_59564323 0.594 NM_173801
PLAC1L
placenta-specific 1-like
chr6_-_150109324 0.589 NM_198887
NUP43
nucleoporin 43kDa
chr11_-_104274606 0.588 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr9_-_111253484 0.586 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr5_-_160044844 0.584 ATP10B
ATPase, class V, type 10B
chr3_-_153541468 0.579 NM_001123228
TMEM14E
transmembrane protein 14E
chr3_-_45858566 0.577 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr4_+_71235259 0.577 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr19_-_56825400 0.577 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr6_+_46822657 0.574 NM_001162435
LOC100287718
ankyrin repeat domain containing gene
chr4_-_186537145 0.571 NM_018409
LRP2BP
LRP2 binding protein
chr1_+_28134090 0.569 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr21_+_17841297 0.561 CXADR
coxsackie virus and adenovirus receptor
chr5_-_131907071 0.555 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr5_-_134290789 0.555


chr4_+_77214886 0.555 NM_001130016
NM_001179
ART3

ADP-ribosyltransferase 3

chr22_-_37214480 0.554 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr13_-_43101608 0.554 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr17_-_64462976 0.551 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr4_-_77163609 0.550 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_+_44418374 0.549 NM_145026
SPATS1
spermatogenesis associated, serine-rich 1
chr21_-_31041390 0.548 NM_181617
KRTAP21-2
keratin associated protein 21-2
chr3_-_120861959 0.547 NM_022135
POPDC2
popeye domain containing 2
chrX_+_150653873 0.546 NM_005140
CNGA2
cyclic nucleotide gated channel alpha 2
chr1_-_245942679 0.544 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr3_-_27473248 0.541 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr1_-_178100204 0.538


chr2_+_138438277 0.533 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr8_-_110724594 0.528 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr3_+_42825957 0.528 NM_001296
CCBP2
chemokine binding protein 2
chr17_+_21946563 0.527 NM_001190452
MTRNR2L1
MT-RNR2-like 1
chrX_+_129301493 0.527 NM_003951
NM_022810
SLC25A14

solute carrier family 25 (mitochondrial carrier, brain), member 14

chr12_-_14024187 0.525 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chrX_-_114158388 0.523 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr19_-_48401532 0.523 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr12_-_9976173 0.520 NM_001130711
CLEC2A
C-type lectin domain family 2, member A
chr8_+_134272463 0.518 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr1_+_181028016 0.517 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr2_+_201755865 0.514 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr3_+_23904086 0.505 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr12_-_14858358 0.505 NM_001013698
C12orf69
chromosome 12 open reading frame 69
chr14_+_98247702 0.504 NM_182560
C14orf177
chromosome 14 open reading frame 177
chr2_-_113526910 0.502 NM_014438
NM_173178
IL1F8

interleukin 1 family, member 8 (eta)

chr1_+_151147646 0.502 NM_005547
IVL
involucrin
chr5_-_39400319 0.501 NM_001737
C9
complement component 9
chr2_+_170259195 0.496 NM_144711
NM_001008489
PHOSPHO2-KLHL23
KLHL23
PHOSPHO2
PHOSPHO2-KLHL23 read-through transcript
kelch-like 23 (Drosophila)
phosphatase, orphan 2
chr6_-_56515640 0.496


chr2_+_206847658 0.494 NM_020923
ZDBF2
zinc finger, DBF-type containing 2
chr1_+_152229861 0.493 NM_001030
RPS27
ribosomal protein S27
chr2_-_229844198 0.491 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr10_-_98315090 0.490 TM9SF3
transmembrane 9 superfamily member 3
chr2_-_21106291 0.490 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_-_22410993 0.489 NM_001163558
PRL
prolactin
chr4_+_189297591 0.487 NM_178556
TRIML1
tripartite motif family-like 1
chr4_+_71418886 0.487 NM_212557
AMTN
amelotin
chr6_+_37030186 0.484 NM_153370
PI16
peptidase inhibitor 16
chr1_+_239762179 0.483 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_+_40522533 0.483 NM_175888
ZNF620
zinc finger protein 620
chr12_-_15757114 0.482 EPS8
epidermal growth factor receptor pathway substrate 8
chr6_-_32482877 0.482 NM_019602
BTNL2
butyrophilin-like 2 (MHC class II associated)
chr12_+_54796640 0.478 NM_001035267
NM_021104
RPL41

ribosomal protein L41

chr5_-_36337756 0.478 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr19_-_39777329 0.478 NM_001025591
SCGBL
secretoglobin-like
chr2_-_26395420 0.477 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr1_+_207668787 0.476 NM_001104548
LOC642587
NPC-A-5
chr3_-_152478843 0.476 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr19_+_14982538 0.475 NM_173482
CCDC105
coiled-coil domain containing 105
chr1_-_165112157 0.473 NM_053053
TADA1
transcriptional adaptor 1
chr10_+_35575958 0.473 NM_181698
CCNY
cyclin Y
chr7_+_137411717 0.473 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr21_+_29322100 0.471 USP16
ubiquitin specific peptidase 16
chr20_+_57966865 0.471 NM_177980
CDH26
cadherin 26
chr3_+_98641143 0.470 NM_173655
EPHA6
EPH receptor A6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.84 4.31e-15 GO:0007608 sensory perception of smell
2.63 1.43e-13 GO:0007606 sensory perception of chemical stimulus
1.99 2.04e-09 GO:0007600 sensory perception
1.58 3.12e-07 GO:0003008 system process
1.55 1.20e-04 GO:0050877 neurological system process
1.22 1.28e-03 GO:0032501 multicellular organismal process
1.64 4.68e-03 GO:0006952 defense response
2.75 1.88e-02 GO:0051606 detection of stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 5.18e-10 GO:0071944 cell periphery
1.36 6.08e-10 GO:0005886 plasma membrane
1.21 3.37e-06 GO:0044425 membrane part
1.23 1.96e-05 GO:0031224 intrinsic to membrane
1.23 2.13e-05 GO:0016021 integral to membrane
1.16 1.04e-04 GO:0016020 membrane
1.32 5.04e-03 GO:0044459 plasma membrane part
1.31 1.81e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.91 6.53e-16 GO:0004984 olfactory receptor activity
2.07 2.85e-12 GO:0004930 G-protein coupled receptor activity
1.80 5.87e-11 GO:0004888 transmembrane receptor activity
1.65 2.39e-10 GO:0004872 receptor activity
1.54 6.85e-09 GO:0004871 signal transducer activity
1.54 6.85e-09 GO:0060089 molecular transducer activity