Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 3.127


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene



Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_90456824 10.554 NM_001100111
LOC286238
hypothetical protein LOC286238
chr1_+_181421984 9.712 LAMC2
laminin, gamma 2
chr1_+_181421796 7.570 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_-_115682374 6.660 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr1_+_181422016 6.315 LAMC2
laminin, gamma 2
chr5_+_150000394 5.982 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_-_177378801 5.898 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr4_-_115120251 5.775 NM_024590
ARSJ
arylsulfatase family, member J
chr12_-_68369322 5.758 NM_152439
BEST3
bestrophin 3
chr3_+_11153778 5.349 NM_001098213
HRH1
histamine receptor H1
chr1_+_81544432 5.123 LPHN2
latrophilin 2
chr18_+_19706979 4.887 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr10_-_88720908 4.841 LOC100133190
hypothetical LOC100133190
chr1_-_36589744 4.825


chr1_-_151788341 4.816 NM_002960
S100A3
S100 calcium binding protein A3
chr2_+_36777336 4.729 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr1_+_221955876 4.674 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr17_-_7434113 4.572 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr10_+_123862430 4.546 TACC2
transforming, acidic coiled-coil containing protein 2
chr20_-_17487480 4.491 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr4_+_120276386 4.476 NM_016599
MYOZ2
myozenin 2
chr6_+_31190505 4.386 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr14_+_95792299 4.205 NM_000710
BDKRB1
bradykinin receptor B1
chr9_+_102231616 4.099 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr12_-_56445653 3.978 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr17_+_21131940 3.878 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr20_+_19903778 3.686 RIN2
Ras and Rab interactor 2
chr16_+_56219802 3.595 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr10_+_17310263 3.577 NM_003380
VIM
vimentin
chr18_+_59593591 3.571 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr4_+_183302105 3.445 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr3_-_152517204 3.433 NM_023915
GPR87
G protein-coupled receptor 87
chr12_+_13240868 3.341 NM_001423
EMP1
epithelial membrane protein 1
chr1_+_17719405 3.281 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr8_-_38505331 3.217 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr3_-_150578207 3.128 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr3_-_48576204 3.091 NM_033199
UCN2
urocortin 2
chr1_+_151270301 3.012 NM_003125
SPRR1B
small proline-rich protein 1B
chr13_+_75232797 3.003 NM_015842
LMO7
LIM domain 7
chr3_-_150578103 2.988 TM4SF1
transmembrane 4 L six family member 1
chr3_-_150578148 2.952 TM4SF1
transmembrane 4 L six family member 1
chr14_-_104507862 2.915 AHNAK2
AHNAK nucleoprotein 2
chr17_-_37022465 2.897 NM_005557
KRT16
keratin 16
chr11_-_102156531 2.878 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr10_+_17310475 2.858 VIM
vimentin
chr15_-_53996597 2.855 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr4_+_81325447 2.836 NM_020226
PRDM8
PR domain containing 8
chr15_+_38319326 2.792 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_+_33213111 2.758 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr3_+_64645819 2.734 LOC100507098
hypothetical LOC100507098
chr1_-_45045543 2.724 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr6_-_152744143 2.704 SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_150578023 2.630 TM4SF1
transmembrane 4 L six family member 1
chr9_-_133574928 2.619 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr6_-_169392771 2.596


chr2_+_201830998 2.585 NM_001080125
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr14_+_104218487 2.575


chr3_+_30622905 2.540 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr13_-_85271329 2.501 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr9_+_676640 2.483


chr15_+_38849450 2.469 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chrX_-_33139349 2.441 NM_004006
DMD
dystrophin
chr22_+_35586950 2.430 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr17_-_36996611 2.418 NM_000526
KRT14
keratin 14
chr12_+_13240983 2.409 EMP1
epithelial membrane protein 1
chr1_+_34993234 2.391 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr12_+_13240987 2.361 EMP1
epithelial membrane protein 1
chr5_+_73145098 2.353 RGNEF
190 kDa guanine nucleotide exchange factor
chr10_-_118022965 2.312 NM_005264
GFRA1
GDNF family receptor alpha 1
chr1_-_43523825 2.299 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr16_+_14187965 2.298 MKL2
MKL/myocardin-like 2
chr4_+_76700281 2.283 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr7_-_104696678 2.248 NM_182691
SRPK2
SRSF protein kinase 2
chr19_-_3920736 2.242 NM_001348
DAPK3
death-associated protein kinase 3
chr10_+_5126589 2.217 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_-_24068759 2.211 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr1_-_151296611 2.186 NM_005988
SPRR2A
small proline-rich protein 2A
chr15_+_38318528 2.183 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr3_-_58175437 2.181 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr18_+_59295123 2.128 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr10_+_24795446 2.093 KIAA1217
KIAA1217
chr3_+_190147633 2.088 TPRG1
tumor protein p63 regulated 1
chr13_-_35327798 2.087 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr1_+_34997928 2.081 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr13_-_59223074 2.079


chr2_+_113591940 2.056 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr19_-_52427698 2.033 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr3_-_121445831 2.027 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr11_-_117640166 2.024 MPZL2
myelin protein zero-like 2
chr17_-_36928604 2.019 NM_002275
KRT15
keratin 15
chr10_-_62002672 1.997 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_+_48482213 1.995 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr10_+_68355797 1.989 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr1_+_151025376 1.983 NM_178353
LCE1E
late cornified envelope 1E
chr7_+_90176647 1.981 NM_012395
CDK14
cyclin-dependent kinase 14
chr17_-_24069299 1.974 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr6_-_152744022 1.954 SYNE1
spectrin repeat containing, nuclear envelope 1
chr2_+_169634330 1.951 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr2_+_202379442 1.948 NM_139158
CDK15
cyclin-dependent kinase 15
chr5_-_54317102 1.943 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr11_-_117640078 1.942


chr1_+_114298021 1.933 NM_181358
HIPK1
homeodomain interacting protein kinase 1
chr3_-_114947330 1.932 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_+_28637247 1.916 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr10_-_90601655 1.913 NM_144590
ANKRD22
ankyrin repeat domain 22
chr2_+_219180862 1.901 PLCD4
phospholipase C, delta 4
chr4_-_74307637 1.892 ANKRD17
ankyrin repeat domain 17
chr21_+_25856311 1.889 MIR155HG
MIR155 host gene (non-protein coding)
chr18_-_45630154 1.883 MYO5B
myosin VB
chr10_-_93382837 1.880 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr7_+_838663 1.874 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr9_-_116920232 1.862 NM_002160
TNC
tenascin C
chr10_+_24795465 1.862 KIAA1217
KIAA1217
chr19_-_43955984 1.850 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr3_+_106568334 1.847 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr4_+_108965167 1.840 NM_001136258
SGMS2
sphingomyelin synthase 2
chr11_-_117640196 1.839 MPZL2
myelin protein zero-like 2
chr11_-_6298284 1.837 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_-_111908085 1.836 NM_001081976
ADORA3
adenosine A3 receptor
chr12_+_7233025 1.835 NM_001131026
PEX5
peroxisomal biogenesis factor 5
chrX_+_99785818 1.826 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr18_+_50646616 1.826 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr22_+_48927610 1.824 NM_001164106
MOV10L1
Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
chr10_+_5126613 1.800 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr20_-_22978141 1.782 NM_000361
THBD
thrombomodulin
chr3_-_48607596 1.772 NM_000094
COL7A1
collagen, type VII, alpha 1
chr3_+_30623376 1.767 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr11_-_117640407 1.759 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr19_-_48866111 1.744 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr10_-_93382779 1.742 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr3_+_48482625 1.736 TREX1
three prime repair exonuclease 1
chr1_-_205290921 1.729 NM_018566
YOD1
YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
chr10_+_5126556 1.722 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_+_145297490 1.720 SH3RF2
SH3 domain containing ring finger 2
chr1_-_205272619 1.716 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr9_-_34652629 1.709 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr21_+_29439768 1.691 C21orf7
chromosome 21 open reading frame 7
chr3_+_106568243 1.647 ALCAM
activated leukocyte cell adhesion molecule
chr19_+_49866563 1.632 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr18_+_59705918 1.621 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr10_-_93382735 1.615 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr14_-_20642214 1.600


chr11_-_47502115 1.597 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr1_+_185064654 1.581 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr20_-_43370333 1.566 NM_003833
NM_030590
NM_030592
MATN4


matrilin 4


chr14_-_90780604 1.561 NM_001177676
GPR68
G protein-coupled receptor 68
chr12_+_120055013 1.561 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr14_+_62740878 1.560 NM_020663
RHOJ
ras homolog gene family, member J
chr14_+_51025604 1.549 NM_001042481
FRMD6
FERM domain containing 6
chr7_-_142816019 1.549 NM_005232
EPHA1
EPH receptor A1
chr12_+_7038240 1.537 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr12_+_10256682 1.533 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr3_+_57718067 1.532 NM_007159
SLMAP
sarcolemma associated protein
chr6_-_116488458 1.525 NM_002031
FRK
fyn-related kinase
chr1_-_94779727 1.524 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr13_+_42034871 1.509 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr15_-_43458247 1.495 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_+_110494654 1.473 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr12_-_51912101 1.473 NM_000966
RARG
retinoic acid receptor, gamma
chr3_+_57069508 1.472 NM_181727
SPATA12
spermatogenesis associated 12
chr9_-_90983501 1.461 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr1_-_202387767 1.452 NM_018208
ETNK2
ethanolamine kinase 2
chr2_-_166359016 1.446 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr17_-_51155073 1.431 NM_018286
TMEM100
transmembrane protein 100
chr3_+_101720753 1.430 TMEM45A
transmembrane protein 45A
chr13_-_109236897 1.419 NM_003749
IRS2
insulin receptor substrate 2
chr15_+_38923470 1.407 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr11_-_64906683 1.399 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr7_+_116099648 1.398 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr5_-_134942346 1.387 CXCL14
chemokine (C-X-C motif) ligand 14
chr3_+_161877640 1.387 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr11_+_20005704 1.386 NAV2
neuron navigator 2
chr7_-_42243318 1.383 GLI3
GLI family zinc finger 3
chr16_+_2023279 1.379 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr5_+_145296313 1.373 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr6_+_64339869 1.366 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_+_101423378 1.365 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr12_+_73217889 1.350 ATXN7L3B
ataxin 7-like 3B
chr5_+_180348450 1.336 NM_197975
BTNL3
butyrophilin-like 3
chr12_-_51173238 1.336 NM_005554
KRT6A
keratin 6A
chrX_+_135079461 1.322 NM_001167819
FHL1
four and a half LIM domains 1
chr7_-_42243142 1.322 NM_000168
GLI3
GLI family zinc finger 3
chr12_-_55316350 1.317 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr9_+_130942029 1.302 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr17_-_7064092 1.302 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr11_+_10434056 1.293 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr20_+_19815075 1.292 RIN2
Ras and Rab interactor 2
chrX_+_99786044 1.287 SRPX2
sushi-repeat containing protein, X-linked 2
chr14_+_63752424 1.281 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr11_-_76676110 1.279 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr8_-_68821131 1.276 NM_020361
CPA6
carboxypeptidase A6
chr11_-_102174102 1.272 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr12_+_6514645 1.269 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr11_-_102174032 1.269 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr12_+_73217817 1.268 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr6_+_108593907 1.266 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chrX_-_19598912 1.260 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr21_+_46226072 1.256 NM_001848
COL6A1
collagen, type VI, alpha 1
chr1_-_84237316 1.255 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr12_+_54832470 1.255 NM_002475
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.33 8.16e-03 GO:0008544 epidermis development
8.28 1.04e-02 GO:0031581 hemidesmosome assembly
1.58 1.88e-02 GO:0009888 tissue development
4.03 2.57e-02 GO:0031424 keratinization
10.85 3.98e-02 GO:0002548 monocyte chemotaxis
1.53 4.73e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.20 4.43e-04 GO:0001533 cornified envelope
1.36 2.43e-02 GO:0005856 cytoskeleton
1.44 2.83e-02 GO:0044421 extracellular region part

Nothing significant found in function category.