Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.588


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7



Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_113853790 7.977 NM_001172767
NM_148899
 FOXP2

forkhead box P2

chr13_-_101852028 7.040 NM_175929
 FGF14
fibroblast growth factor 14
chr1_+_168898898 6.667 PRRX1
paired related homeobox 1
chrX_+_135079461 6.526 NM_001167819
 FHL1
four and a half LIM domains 1
chr9_-_14076901 6.138 NFIB
nuclear factor I/B
chr14_+_100365162 6.054 MEG3
maternally expressed 3 (non-protein coding)
chr3_+_174598937 5.987 NM_014932
 NLGN1
neuroligin 1
chr1_+_81544432 5.758 LPHN2
latrophilin 2
chrX_+_28515479 4.859 NM_014271
 IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr7_-_27149750 4.840 NM_019102
 HOXA5
homeobox A5
chr4_+_119174947 4.782 NM_004784
 NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr3_-_64186151 4.752 NM_198859
 PRICKLE2
prickle homolog 2 (Drosophila)
chr9_+_108665168 4.401 NM_021224
 ZNF462
zinc finger protein 462
chr4_-_41579325 3.786


chr12_-_48902692 3.225 NM_001113547
 LIMA1
LIM domain and actin binding 1
chr20_+_56369012 3.163


chr1_-_27604656 3.131 WASF2
WAS protein family, member 2
chr2_+_36777336 3.093 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
 VIT




vitrin




chr18_+_30544193 3.067 NM_001198941
NM_032978
 DTNA

dystrobrevin, alpha

chr5_-_124108672 3.059 NM_020747
 ZNF608
zinc finger protein 608

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 166 entries
enrichment   p-value GO term description
4.22 2.98e-02 GO:0060428 lung epithelium development
3.74 1.69e-03 GO:0002053 positive regulation of mesenchymal cell proliferation
3.43 8.90e-03 GO:0010464 regulation of mesenchymal cell proliferation
3.13 2.14e-02 GO:0060688 regulation of morphogenesis of a branching structure
2.74 6.34e-05 GO:0007519 skeletal muscle tissue development
2.74 1.84e-04 GO:0048634 regulation of muscle organ development
2.74 3.14e-04 GO:0016202 regulation of striated muscle tissue development
2.66 9.68e-05 GO:0060538 skeletal muscle organ development
2.56 1.98e-03 GO:0051592 response to calcium ion
2.55 3.37e-03 GO:0048704 embryonic skeletal system morphogenesis
2.50 1.03e-04 GO:0048706 embryonic skeletal system development
2.44 1.24e-03 GO:0022612 gland morphogenesis
2.32 1.06e-02 GO:2000027 regulation of organ morphogenesis
2.28 4.88e-02 GO:0051147 regulation of muscle cell differentiation
2.22 1.14e-05 GO:0007156 homophilic cell adhesion
2.14 4.75e-04 GO:0014706 striated muscle tissue development
2.12 1.69e-04 GO:0060537 muscle tissue development
2.08 9.36e-07 GO:0007517 muscle organ development
2.06 4.94e-05 GO:0009952 anterior/posterior pattern formation
2.06 3.13e-02 GO:0030323 respiratory tube development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
1.94 5.62e-03 GO:0030016 myofibril
1.89 1.71e-02 GO:0044449 contractile fiber part
1.83 2.72e-02 GO:0043292 contractile fiber
1.80 2.32e-03 GO:0005882 intermediate filament
1.76 1.49e-03 GO:0045111 intermediate filament cytoskeleton
1.67 3.19e-02 GO:0030424 axon
1.65 1.70e-04 GO:0005578 proteinaceous extracellular matrix
1.58 3.52e-04 GO:0031012 extracellular matrix
1.56 3.69e-02 GO:0005667 transcription factor complex
1.53 1.14e-03 GO:0045202 synapse
1.44 3.45e-02 GO:0043005 neuron projection
1.42 2.35e-03 GO:0030054 cell junction
1.36 7.75e-05 GO:0044421 extracellular region part
1.36 1.93e-03 GO:0005615 extracellular space
1.31 1.58e-02 GO:0042995 cell projection
1.24 2.60e-02 GO:0005654 nucleoplasm
1.22 1.79e-02 GO:0005856 cytoskeleton
1.20 6.26e-03 GO:0044459 plasma membrane part
1.20 1.01e-02 GO:0005576 extracellular region
1.17 4.10e-05 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.94 2.82e-02 GO:0004435 phosphatidylinositol phospholipase C activity
1.95 5.05e-04 GO:0003714 transcription corepressor activity
1.76 1.39e-03 GO:0000975 regulatory region DNA binding
1.76 1.39e-03 GO:0001067 regulatory region nucleic acid binding
1.76 1.39e-03 GO:0044212 transcription regulatory region DNA binding
1.76 2.00e-02 GO:0008083 growth factor activity
1.75 3.10e-03 GO:0010843 promoter binding
1.73 1.28e-13 GO:0043565 sequence-specific DNA binding
1.63 1.80e-15 GO:0001071 nucleic acid binding transcription factor activity
1.63 1.80e-15 GO:0003700 sequence-specific DNA binding transcription factor activity
1.63 5.96e-05 GO:0000988 protein binding transcription factor activity
1.63 5.96e-05 GO:0000989 transcription factor binding transcription factor activity
1.62 9.88e-05 GO:0003712 transcription cofactor activity
1.58 2.08e-13 GO:0030528 transcription regulator activity
1.57 4.45e-03 GO:0016563 transcription activator activity
1.51 3.25e-02 GO:0003779 actin binding
1.49 1.31e-05 GO:0005509 calcium ion binding
1.32 1.96e-03 GO:0005102 receptor binding
1.12 3.85e-06 GO:0005515 protein binding