Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.625


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_96592051 3.326 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_90176647 2.094 NM_012395
CDK14
cyclin-dependent kinase 14
chr20_+_18742369 1.728 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr17_+_3326045 1.506 NM_000049
ASPA
aspartoacylase
chr1_-_150328153 1.451 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_-_45648608 1.438 SRBD1
S1 RNA binding domain 1
chr12_+_102859354 1.375 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr17_+_57811645 1.343 NM_173503
EFCAB3
EF-hand calcium binding domain 3
chr12_-_66839589 1.319 NM_000619
IFNG
interferon, gamma
chr6_-_66346417 1.298 NM_198283
EYS
eyes shut homolog (Drosophila)
chr2_+_166034402 1.214 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_+_93072947 1.172 RPL5
ribosomal protein L5
chr12_-_10846435 1.081 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr10_+_91127792 1.061 NM_001010987
IFIT1B
interferon-induced protein with tetratricopeptide repeats 1B
chr1_+_245835478 1.055 NM_001001914
OR2G3
olfactory receptor, family 2, subfamily G, member 3
chr4_-_151993422 1.017


chr14_-_106154332 1.007 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_24394281 1.000 PIPOX
pipecolic acid oxidase
chr9_+_6205804 0.976 IL33
interleukin 33
chrX_+_135397790 0.944 NM_001727
BRS3
bombesin-like receptor 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
4.34 2.92e-02 GO:0001959 regulation of cytokine-mediated signaling pathway
4.34 2.92e-02 GO:0060337 type I interferon-mediated signaling pathway
4.34 2.92e-02 GO:0071357 cellular response to type I interferon
4.27 3.46e-02 GO:0034340 response to type I interferon
4.27 3.46e-02 GO:0060759 regulation of response to cytokine stimulus
2.98 2.79e-09 GO:0007608 sensory perception of smell
2.92 5.15e-10 GO:0007606 sensory perception of chemical stimulus
2.27 1.04e-02 GO:0045087 innate immune response
2.24 5.45e-03 GO:0051707 response to other organism
2.21 1.07e-06 GO:0006955 immune response
2.16 7.65e-07 GO:0007600 sensory perception
2.03 2.05e-02 GO:0009607 response to biotic stimulus
1.99 1.24e-04 GO:0006952 defense response
1.72 2.22e-04 GO:0050877 neurological system process
1.67 3.79e-03 GO:0002376 immune system process
1.58 1.67e-03 GO:0003008 system process
1.33 1.77e-07 GO:0050896 response to stimulus
1.29 1.06e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.76 4.62e-03 GO:0005615 extracellular space
1.72 6.63e-04 GO:0044421 extracellular region part
1.65 1.93e-07 GO:0005576 extracellular region
1.44 1.72e-08 GO:0005886 plasma membrane
1.43 4.54e-08 GO:0071944 cell periphery
1.22 1.08e-02 GO:0031224 intrinsic to membrane
1.22 1.69e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
3.06 3.53e-10 GO:0004984 olfactory receptor activity
2.48 3.42e-02 GO:0005125 cytokine activity
2.28 1.42e-09 GO:0004930 G-protein coupled receptor activity
2.12 3.65e-12 GO:0004888 transmembrane receptor activity
1.91 2.94e-11 GO:0004872 receptor activity
1.89 2.48e-03 GO:0005509 calcium ion binding
1.84 2.58e-12 GO:0004871 signal transducer activity
1.84 2.58e-12 GO:0060089 molecular transducer activity