Motif ID: SOX{8,9,10}.p2

Z-value: 2.015


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9



Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_183970093 1.805 NM_031935
 HMCN1
hemicentin 1
chr6_+_105511615 1.541 NM_001004317
 LIN28B
lin-28 homolog B (C. elegans)
chr19_-_60369731 1.241 NM_178837
 C19orf51
chromosome 19 open reading frame 51
chr13_+_112704077 1.174 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_+_200449905 1.054 NM_001017404
 LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr5_-_39461054 1.008 NM_001343
 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr7_-_27171600 1.007 HOXA9
homeobox A9
chr4_-_7991992 1.000 NM_001134647
NM_198595
 AFAP1

actin filament associated protein 1

chr11_+_63710206 0.995 STIP1
stress-induced-phosphoprotein 1
chr11_+_63710242 0.970 STIP1
stress-induced-phosphoprotein 1
chr7_-_27171673 0.968 NM_152739
 HOXA9
homeobox A9
chr15_-_38188333 0.962 NM_001003940
 BMF
Bcl2 modifying factor
chr7_-_27171648 0.956 HOXA9
homeobox A9
chr1_-_151910098 0.956 NM_004515
 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_2451543 0.954 NM_001010926
 HES5
hairy and enhancer of split 5 (Drosophila)
chr9_+_126460511 0.944


chr14_-_37795290 0.936 NM_175060
 CLEC14A
C-type lectin domain family 14, member A
chr11_-_69228286 0.933 NM_005117
 FGF19
fibroblast growth factor 19
chr11_+_63710162 0.896 NM_006819
 STIP1
stress-induced-phosphoprotein 1
chr14_-_37795001 0.893 CLEC14A
C-type lectin domain family 14, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
5.42 2.75e-02 GO:0048008 platelet-derived growth factor receptor signaling pathway
2.75 5.94e-03 GO:0006334 nucleosome assembly
2.61 1.66e-02 GO:0031497 chromatin assembly
2.58 1.34e-02 GO:0034728 nucleosome organization
2.49 2.82e-02 GO:0065004 protein-DNA complex assembly
1.84 3.76e-03 GO:0007264 small GTPase mediated signal transduction
1.57 1.79e-02 GO:0030182 neuron differentiation
1.55 5.59e-03 GO:0051128 regulation of cellular component organization
1.54 3.80e-07 GO:0007399 nervous system development
1.53 5.21e-03 GO:0048699 generation of neurons
1.53 2.27e-02 GO:0071844 cellular component assembly at cellular level
1.50 1.21e-02 GO:0022008 neurogenesis
1.40 3.37e-05 GO:0030154 cell differentiation
1.39 6.88e-11 GO:0007275 multicellular organismal development
1.39 4.96e-05 GO:0048869 cellular developmental process
1.38 9.16e-08 GO:0048731 system development
1.37 4.17e-11 GO:0032502 developmental process
1.37 1.37e-02 GO:0009653 anatomical structure morphogenesis
1.35 1.72e-07 GO:0048856 anatomical structure development
1.32 2.57e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
3.47 9.61e-05 GO:0000786 nucleosome
2.56 2.07e-02 GO:0030027 lamellipodium
2.43 2.26e-02 GO:0032993 protein-DNA complex
2.12 4.25e-03 GO:0031252 cell leading edge
1.85 3.47e-02 GO:0000785 chromatin
1.53 2.34e-02 GO:0030054 cell junction
1.28 3.10e-02 GO:0031981 nuclear lumen
1.19 4.45e-05 GO:0005634 nucleus
1.09 3.91e-04 GO:0044424 intracellular part
1.09 4.08e-02 GO:0043227 membrane-bounded organelle
1.09 4.18e-02 GO:0043231 intracellular membrane-bounded organelle
1.08 1.27e-03 GO:0005622 intracellular
1.08 4.21e-02 GO:0043226 organelle
1.08 4.62e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.57 2.15e-05 GO:0001071 nucleic acid binding transcription factor activity
1.57 2.15e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.31 3.50e-04 GO:0003677 DNA binding
1.13 3.12e-03 GO:0005515 protein binding
1.08 1.49e-03 GO:0005488 binding