Motif ID: TFAP2{A,C}.p2

Z-value: 1.179


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)



Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_63292688 6.832 NM_001144936
 C11orf95
chromosome 11 open reading frame 95
chr16_-_87535106 6.006 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr9_+_136673534 5.786 COL5A1
collagen, type V, alpha 1
chr2_+_96845704 5.667 NM_017623
NM_199078
 CNNM3

cyclin M3

chr1_+_33494745 4.555 NM_152493
 ZNF362
zinc finger protein 362
chr1_-_39815002 4.211 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr11_+_62136788 3.923 NM_000327
 ROM1
retinal outer segment membrane protein 1
chr3_-_124650081 3.854 NM_183357
 ADCY5
adenylate cyclase 5
chr17_+_17525571 3.827


chr9_+_136673464 3.764 NM_000093
 COL5A1
collagen, type V, alpha 1
chr1_-_39815048 3.673 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr17_-_19711580 3.607 NM_001142610
NM_014683
 ULK2

unc-51-like kinase 2 (C. elegans)

chr6_+_157141565 3.339 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr15_+_66658626 3.309 NM_006091
 CORO2B
coronin, actin binding protein, 2B
chr5_-_138758783 3.309 NM_001161546
 LOC389333
hypothetical protein LOC389333
chr2_+_171280944 3.180 SP5
Sp5 transcription factor
chr8_-_80842452 3.115 NM_001040708
NM_012258
 HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr9_-_139316523 3.108 NM_001004354
 NRARP
NOTCH-regulated ankyrin repeat protein
chr17_+_17525497 3.106 NM_030665
 RAI1
retinoic acid induced 1
chr17_-_59131194 3.086 LIMD2
LIM domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 90 entries
enrichment   p-value GO term description
1.55 2.00e-02 GO:0030278 regulation of ossification
1.42 2.23e-06 GO:0051325 interphase
1.41 1.33e-05 GO:0051329 interphase of mitotic cell cycle
1.38 2.77e-02 GO:0044087 regulation of cellular component biogenesis
1.36 3.02e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.30 1.90e-04 GO:0000904 cell morphogenesis involved in differentiation
1.30 1.44e-02 GO:0010564 regulation of cell cycle process
1.29 5.78e-06 GO:0051726 regulation of cell cycle
1.29 2.02e-05 GO:0000278 mitotic cell cycle
1.29 2.30e-02 GO:0044419 interspecies interaction between organisms
1.27 1.35e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.27 9.36e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.27 1.68e-02 GO:0007409 axonogenesis
1.26 8.25e-09 GO:0007049 cell cycle
1.26 2.94e-02 GO:0048812 neuron projection morphogenesis
1.25 9.56e-06 GO:0022402 cell cycle process
1.25 3.79e-04 GO:0022403 cell cycle phase
1.25 5.29e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.24 4.31e-05 GO:0051128 regulation of cellular component organization
1.24 2.90e-03 GO:0032989 cellular component morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
1.67 1.85e-02 GO:0005793 ER-Golgi intermediate compartment
1.44 3.57e-03 GO:0031965 nuclear membrane
1.33 8.26e-03 GO:0005635 nuclear envelope
1.26 8.11e-03 GO:0043005 neuron projection
1.20 4.24e-13 GO:0005829 cytosol
1.19 6.54e-03 GO:0031967 organelle envelope
1.19 9.93e-03 GO:0015630 microtubule cytoskeleton
1.18 8.65e-11 GO:0044428 nuclear part
1.18 1.61e-02 GO:0031975 envelope
1.17 4.28e-07 GO:0031981 nuclear lumen
1.17 2.60e-06 GO:0012505 endomembrane system
1.16 2.68e-04 GO:0005654 nucleoplasm
1.16 1.43e-02 GO:0005794 Golgi apparatus
1.15 4.20e-07 GO:0031974 membrane-enclosed lumen
1.15 5.35e-07 GO:0070013 intracellular organelle lumen
1.15 1.43e-04 GO:0005856 cytoskeleton
1.14 1.33e-06 GO:0043233 organelle lumen
1.13 5.86e-07 GO:0043228 non-membrane-bounded organelle
1.13 5.86e-07 GO:0043232 intracellular non-membrane-bounded organelle
1.12 1.64e-17 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
1.37 1.13e-02 GO:0010843 promoter binding
1.35 2.20e-02 GO:0000975 regulatory region DNA binding
1.35 2.20e-02 GO:0001067 regulatory region nucleic acid binding
1.35 2.20e-02 GO:0044212 transcription regulatory region DNA binding
1.26 3.44e-06 GO:0019899 enzyme binding
1.25 9.25e-03 GO:0019904 protein domain specific binding
1.24 1.68e-03 GO:0008092 cytoskeletal protein binding
1.23 3.11e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.23 3.49e-02 GO:0030695 GTPase regulator activity
1.19 2.66e-04 GO:0030528 transcription regulator activity
1.19 1.92e-02 GO:0043565 sequence-specific DNA binding
1.13 9.42e-30 GO:0005515 protein binding
1.12 2.67e-04 GO:0000166 nucleotide binding
1.12 5.55e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.12 5.72e-03 GO:0032553 ribonucleotide binding
1.12 5.72e-03 GO:0032555 purine ribonucleotide binding
1.12 6.47e-03 GO:0017076 purine nucleotide binding
1.12 3.52e-02 GO:0030554 adenyl nucleotide binding
1.12 3.85e-02 GO:0032559 adenyl ribonucleotide binding
1.12 4.90e-02 GO:0005524 ATP binding