Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.438


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX3chr20_-_393621220.828.7e-05Click!
SIX2chr2_-_45090025-0.693.2e-03Click!
SIX5chr19_-_50964336-0.601.3e-02Click!
ZHX1chr8_-_124355670-0.581.9e-02Click!
ZHX2chr8_+_123863224-0.476.6e-02Click!
IRX5chr16_+_53522611-0.214.3e-01Click!
IRX4chr5_-_1935764-0.136.4e-01Click!
ADNPchr20_-_48980858-0.029.5e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_91244422 2.115 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr15_+_91244563 2.100 CHD2
chromodomain helicase DNA binding protein 2
chr18_+_50409387 2.051 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr4_-_72868598 1.854 NM_000583
GC
group-specific component (vitamin D binding protein)
chr4_+_123380569 1.830 KIAA1109
KIAA1109
chr12_+_79362256 1.685 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr11_-_62668268 1.676 NM_001136506
SLC22A24
solute carrier family 22, member 24
chr7_+_106897737 1.550 NM_005295
GPR22
G protein-coupled receptor 22
chr14_+_38772870 1.541 NM_054024
MIA2
melanoma inhibitory activity 2
chr4_-_69218909 1.490 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr10_+_77212524 1.472 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr6_-_50097606 1.349 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr3_+_133798770 1.348 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr2_+_166137091 1.333 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_+_202033273 1.317 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr4_-_163304567 1.309 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr2_+_234490781 1.302 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr10_+_5126556 1.287 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr16_+_2593351 1.236 LOC652276
hypothetical LOC652276
chr16_+_68238460 1.210 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr5_+_140532385 1.202 NM_018940
PCDHB7
protocadherin beta 7
chr5_+_140509803 1.172 NM_018939
PCDHB6
protocadherin beta 6
chr1_-_240679380 1.168 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr10_+_5126589 1.144 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5126613 1.134 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_-_68793928 1.120 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr4_-_69116839 1.104 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr5_-_160044844 1.072 ATP10B
ATPase, class V, type 10B
chr6_-_52060327 1.069 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr7_-_26198673 1.057 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr15_+_46285789 1.055 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr17_+_38306339 1.054 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr7_-_76667045 1.050 NM_006682
FGL2
fibrinogen-like 2
chr2_-_180135559 1.032 NM_001113398
ZNF385B
zinc finger protein 385B
chr1_+_78243181 1.016 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr6_-_33016561 1.015 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_46155937 1.006 NM_001114086
CLIC5
chloride intracellular channel 5
chr11_-_89181390 0.951 NM_020358
TRIM49
tripartite motif containing 49
chr5_-_134291882 0.944


chr9_+_109131814 0.921 RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_+_140605100 0.920 PCDHB15
protocadherin beta 15
chr5_+_161045235 0.909 NM_000811
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr11_-_83071084 0.908 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr15_+_47502666 0.905 NM_002009
FGF7
fibroblast growth factor 7
chr6_+_49575629 0.904 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr11_+_117982422 0.898 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr16_+_7322751 0.893 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr10_-_85975263 0.874 NM_001017924
LRIT2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr8_+_9990471 0.871 NM_001135671
MSRA
methionine sulfoxide reductase A
chr15_-_64108718 0.869


chr7_-_27133163 0.862 NM_153631
HOXA3
homeobox A3
chr4_-_184478920 0.808 NM_001111319
CLDN22
claudin 22
chr1_-_110735158 0.802 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr3_-_33675484 0.801 CLASP2
cytoplasmic linker associated protein 2
chr3_+_162697289 0.793 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr6_-_116488458 0.778 NM_002031
FRK
fyn-related kinase
chr5_-_132228375 0.778 NM_005260
GDF9
growth differentiation factor 9
chr4_+_70831387 0.759 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr6_+_144227265 0.759 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr6_+_45404031 0.757 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr9_+_106496480 0.756 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr11_-_104515670 0.755 NM_021571
CARD18
caspase recruitment domain family, member 18
chr13_+_107753764 0.751


chr11_+_65027721 0.743


chr21_-_36870736 0.739 NM_001146077
CLDN14
claudin 14
chr12_+_43972732 0.736 NM_001142678
ANO6
anoctamin 6
chrX_-_15593074 0.736 NM_020665
TMEM27
transmembrane protein 27
chr7_-_30032649 0.736 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr5_+_140568451 0.730 NM_018932
PCDHB12
protocadherin beta 12
chr5_+_140751666 0.729 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr9_-_94338072 0.725 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chrX_-_119593646 0.722 NM_003588
CUL4B
cullin 4B
chr4_+_141484046 0.722 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr3_+_63859114 0.719 NM_001177387
ATXN7
ataxin 7
chr11_+_64950402 0.716


chr6_-_10523424 0.712 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr10_+_18589589 0.710 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr10_-_50402148 0.705 NM_170753
PGBD3
piggyBac transposable element derived 3
chr7_-_26202626 0.705 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr14_-_34252695 0.701 NM_021914
CFL2
cofilin 2 (muscle)
chr18_-_55136673 0.697 NM_181654
CPLX4
complexin 4
chrX_-_18600108 0.696 NM_000330
RS1
retinoschisin 1
chr21_-_14840506 0.692 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr20_-_7869068 0.691 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr7_-_87180499 0.685 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr3_+_173043832 0.683 NM_001164436
TMEM212
transmembrane protein 212
chr6_-_29163027 0.680 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chrX_-_65752570 0.679 NM_021783
EDA2R
ectodysplasin A2 receptor
chr1_+_556968 0.676


chr12_+_53699995 0.670 NM_021191
NEUROD4
neurogenic differentiation 4
chr15_+_100163424 0.666 NM_001005326
OR4F6
olfactory receptor, family 4, subfamily F, member 6
chr21_-_35174742 0.659 RUNX1
runt-related transcription factor 1
chr4_+_109033868 0.659 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr5_+_128468785 0.658 ISOC1
isochorismatase domain containing 1
chr12_+_54172413 0.657 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr5_-_131907071 0.656 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr5_+_140573692 0.655 NM_018933
PCDHB13
protocadherin beta 13
chr4_+_110968594 0.654 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr6_+_55300225 0.652 NM_207410
GFRAL
GDNF family receptor alpha like
chr3_-_115960807 0.648 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr20_-_33706532 0.645 RBM12
RNA binding motif protein 12
chr8_+_18123456 0.643 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr6_-_155818728 0.639 NM_015718
NOX3
NADPH oxidase 3
chr5_-_88235624 0.639 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr5_+_140698537 0.638 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr12_-_10497195 0.632 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr4_+_120029426 0.629 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr9_+_27514311 0.628 NM_020124
IFNK
interferon, kappa
chr21_+_24722913 0.627 FLJ42200
FLJ42200 protein
chr11_+_59564323 0.622 NM_173801
PLAC1L
placenta-specific 1-like
chr3_-_197726587 0.621 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr22_+_21006814 0.615


chr9_-_74757735 0.611 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_-_133008834 0.606 NM_138327
TAAR1
trace amine associated receptor 1
chr19_-_3936460 0.605 NM_001961
EEF2
eukaryotic translation elongation factor 2
chr10_-_62002672 0.604 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_140605330 0.593 NM_018935
PCDHB15
protocadherin beta 15
chr5_+_140733664 0.593 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr12_-_16652202 0.587 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_+_148711419 0.582 GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr5_-_9683462 0.582 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr5_+_125828685 0.582 NM_001146322
GRAMD3
GRAM domain containing 3
chr2_+_234245243 0.581 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr1_+_205344200 0.580 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr2_+_167468220 0.580 NM_001079810
NM_152381
XIRP2

xin actin-binding repeat containing 2

chr13_-_85271329 0.578 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr2_-_10860093 0.577 PDIA6
protein disulfide isomerase family A, member 6
chr13_+_97856148 0.572


chr3_+_99484421 0.568 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr14_-_64479198 0.568 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr5_+_147775652 0.567 FBXO38
F-box protein 38
chr4_-_152368492 0.567 SH3D19
SH3 domain containing 19
chr7_-_92693716 0.565 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_+_35623688 0.565 ZMYM4
zinc finger, MYM-type 4
chr12_-_9252227 0.564 NM_002864
PZP
pregnancy-zone protein
chr5_+_140460240 0.564 NM_018937
PCDHB3
protocadherin beta 3
chr18_+_28023984 0.560 NM_005925
MEP1B
meprin A, beta
chr3_+_176059763 0.557 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr16_+_68284252 0.556 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr14_+_19458580 0.556 NM_001005483
OR4K5
olfactory receptor, family 4, subfamily K, member 5
chr12_+_14429499 0.554 ATF7IP
activating transcription factor 7 interacting protein
chr16_+_24475129 0.553 RBBP6
retinoblastoma binding protein 6
chr12_-_10453409 0.553 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr1_+_84402962 0.550 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_-_138581319 0.545 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr4_-_54152480 0.537 NM_001126328
LNX1
ligand of numb-protein X 1
chr1_+_198263352 0.525 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr4_-_79322295 0.523


chr19_+_9347991 0.523 NM_001172651
ZNF177
zinc finger protein 177
chr6_-_49820030 0.521 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr6_-_29503468 0.518 NM_013937
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr5_-_134290789 0.516


chr9_+_101628829 0.516 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr10_-_11614279 0.513 NM_001080491
USP6NL
USP6 N-terminal like
chr1_+_67404756 0.513 NM_144701
IL23R
interleukin 23 receptor
chr18_-_44723116 0.509 NM_001190823
SMAD7
SMAD family member 7
chr1_-_197173159 0.506 LOC100131234
familial acute myelogenous leukemia related factor
chr1_+_557269 0.502


chr9_+_104797413 0.501 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr3_+_88270951 0.501 NM_018293
ZNF654
zinc finger protein 654
chr19_-_51236113 0.497 NM_001002923
IGFL4
IGF-like family member 4
chr13_-_40604587 0.496 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr8_+_92330691 0.496 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr9_+_102380156 0.495 NM_001018116
MURC
muscle-related coiled-coil protein
chr12_-_9123126 0.493 A2M
alpha-2-macroglobulin
chr1_+_61642287 0.492 NFIA
nuclear factor I/A
chr5_-_124108672 0.492 NM_020747
ZNF608
zinc finger protein 608
chr5_+_44844724 0.492 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr4_-_74307637 0.490 ANKRD17
ankyrin repeat domain 17
chr11_-_33870411 0.490 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_-_202449659 0.489 NM_198447
GOLT1A
golgi transport 1A
chr7_+_129771865 0.488 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr9_+_122923864 0.486 CEP110
centrosomal protein 110kDa
chr4_-_54152385 0.482 LNX1
ligand of numb-protein X 1
chr15_+_32048380 0.482 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr7_+_123083096 0.480 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr2_-_215953818 0.479 FN1
fibronectin 1
chr16_-_11270619 0.478 NM_005425
TNP2
transition protein 2 (during histone to protamine replacement)
chr2_+_220087135 0.472 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr11_-_5835507 0.472 NM_001005168
OR52E8
olfactory receptor, family 52, subfamily E, member 8
chr1_+_63861474 0.472 NM_001172818
PGM1
phosphoglucomutase 1
chr4_-_69570919 0.470 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr2_+_173794692 0.469 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr1_-_9925412 0.468 NM_032368
LZIC
leucine zipper and CTNNBIP1 domain containing
chr4_+_70896236 0.468 NM_001009181
NM_003154
STATH

statherin

chr13_+_48582389 0.468 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr2_+_201806410 0.468 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr7_-_84589182 0.466 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr5_+_6799100 0.466 NM_001171806
PAPD7
PAP associated domain containing 7
chr6_-_76838944 0.462 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr3_-_57653634 0.460 NM_152678
FAM116A
family with sequence similarity 116, member A
chr11_-_71424614 0.456


chr11_+_89403921 0.454 NM_001195234
TRIM49
TRIM49L2
tripartite motif containing 49
tripartite motif containing 49-like 2
chr17_-_1195096 0.453 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_-_102156531 0.451 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr22_-_34564611 0.448 RPL41P5
ribosomal protein L41 pseudogene 5
chr2_+_225973845 0.447 NM_020864
KIAA1486
KIAA1486
chr5_-_160211623 0.446 NM_025153
ATP10B
ATPase, class V, type 10B
chr3_-_12858006 0.445 NM_000994
NM_001007073
RPL32

ribosomal protein L32

chr7_+_94135384 0.443 PEG10
paternally expressed 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.60 1.27e-16 GO:0007606 sensory perception of chemical stimulus
2.14 5.63e-16 GO:0007600 sensory perception
2.60 1.52e-14 GO:0007608 sensory perception of smell
1.68 5.88e-10 GO:0050877 neurological system process
1.59 1.24e-09 GO:0003008 system process
1.24 3.04e-06 GO:0032501 multicellular organismal process
1.16 5.11e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 3.25e-04 GO:0071944 cell periphery
1.22 3.85e-04 GO:0005886 plasma membrane
1.29 1.17e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.66 1.51e-15 GO:0004984 olfactory receptor activity
1.87 4.99e-10 GO:0004930 G-protein coupled receptor activity
1.50 1.63e-07 GO:0004872 receptor activity
1.59 1.82e-07 GO:0004888 transmembrane receptor activity
1.41 2.94e-06 GO:0004871 signal transducer activity
1.41 2.94e-06 GO:0060089 molecular transducer activity