Motif ID: ESRRA.p2

Z-value: 1.789


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_638296160.476.4e-02Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_1647617 2.816 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr8_-_139995417 2.655 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr14_-_106084519 2.431 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106084085 2.216 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_+_540849 2.012 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr19_-_4486202 1.723 NM_001013706
PLIN5
perilipin 5
chr17_-_34014390 1.600 SRCIN1
SRC kinase signaling inhibitor 1
chr6_+_44076281 1.563 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chrX_-_21686079 1.560 NM_014332
SMPX
small muscle protein, X-linked
chr6_+_33280396 1.550 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr11_+_73176561 1.549 NM_016055
MRPL48
mitochondrial ribosomal protein L48
chr8_+_86563382 1.541 NM_000067
CA2
carbonic anhydrase II
chr19_+_1358531 1.527 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr1_-_143706265 1.521 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_3013191 1.486 NM_001130
NM_198970
AES

amino-terminal enhancer of split

chr11_-_64284762 1.413 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr10_+_80777248 1.407 PPIF
peptidylprolyl isomerase F
chr20_+_36867708 1.406 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr10_+_44726635 1.343 NM_001123376
TMEM72
transmembrane protein 72
chr16_+_76313909 1.319 NM_001105663
NUDT7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr19_+_1199548 1.310 NM_177401
MIDN
midnolin
chr19_+_1358604 1.294 DAZAP1
DAZ associated protein 1
chr10_+_80777265 1.279 PPIF
peptidylprolyl isomerase F
chr18_-_17538624 1.263 ABHD3
abhydrolase domain containing 3
chr18_-_17538735 1.244 NM_138340
ABHD3
abhydrolase domain containing 3
chr19_-_12028126 1.241 NM_001080404
ZNF878
zinc finger protein 878
chr11_+_63463009 1.205 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr1_-_150065176 1.182 NM_001001523
RORC
RAR-related orphan receptor C
chr17_-_31332568 1.164 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr19_+_1358664 1.153 DAZAP1
DAZ associated protein 1
chr9_-_130006309 1.136 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr9_-_99994704 1.117 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr19_+_1358750 1.112 DAZAP1
DAZ associated protein 1
chr11_+_63750296 1.069 NM_001128612
NM_001128613
NM_032344
NUDT22


nudix (nucleoside diphosphate linked moiety X)-type motif 22


chr15_-_74139123 1.055 NRG4
neuregulin 4
chr15_-_76210611 1.043 NM_006383
CIB2
calcium and integrin binding family member 2
chr19_-_3013441 1.042 AES
amino-terminal enhancer of split
chr7_-_38356100 1.019 TRGV5
T cell receptor gamma variable 5
chr10_-_126097483 0.995 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr14_-_106270497 0.984 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chrX_-_15421279 0.983 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr7_-_38355949 0.966


chrX_+_48505097 0.965 NM_001080489
GLOD5
glyoxalase domain containing 5
chr4_-_7120656 0.962 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr3_-_49701085 0.955 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr10_-_91394881 0.947 PANK1
pantothenate kinase 1
chr6_+_34314545 0.933 NM_145905
HMGA1
high mobility group AT-hook 1
chr20_-_31452964 0.914 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr10_-_126097444 0.910 OAT
ornithine aminotransferase
chr20_-_31452991 0.901 NM_016082
NM_016408
CDK5RAP1

CDK5 regulatory subunit associated protein 1

chr19_-_44518465 0.901 GMFG
glia maturation factor, gamma
chr1_-_143706196 0.893 PDE4DIP
phosphodiesterase 4D interacting protein
chr22_+_35586950 0.886 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr11_-_63750138 0.874 NM_001033678
NM_001160389
NM_001160390
NM_001160392
NM_031472
TRPT1




tRNA phosphotransferase 1




chr19_-_7244876 0.873 NM_000208
NM_001079817
INSR

insulin receptor

chr1_+_234625338 0.871 NM_080738
EDARADD
EDAR-associated death domain
chr14_-_105796665 0.867 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_-_105245959 0.867 IGHA1
immunoglobulin heavy constant alpha 1
chr17_+_45778381 0.866 NM_022167
XYLT2
xylosyltransferase II
chr5_+_176807931 0.859 NM_001174102
PRR7
proline rich 7 (synaptic)
chr16_-_28843955 0.856 NM_024816
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr4_+_44375165 0.855 NM_021927
GUF1
GUF1 GTPase homolog (S. cerevisiae)
chr15_+_74139325 0.853 NM_152335
C15orf27
chromosome 15 open reading frame 27
chr2_+_108604111 0.849 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_-_74682247 0.836 NM_016065
MRPS16
mitochondrial ribosomal protein S16
chr7_+_138859213 0.817 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr19_-_44518516 0.806 NM_004877
GMFG
glia maturation factor, gamma
chrX_-_47374187 0.801 NM_001145252
CFP
complement factor properdin
chr1_-_152431175 0.801 NM_152263
TPM3
tropomyosin 3
chr11_-_18704294 0.798 NM_173588
IGSF22
immunoglobulin superfamily, member 22
chr6_+_31662454 0.796 NM_205837
LST1
leukocyte specific transcript 1
chr11_-_64268841 0.795 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr1_+_46151845 0.787 MAST2
microtubule associated serine/threonine kinase 2
chr11_-_64268126 0.785 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr6_-_33655995 0.776 NM_001188
BAK1
BCL2-antagonist/killer 1
chr2_+_112956192 0.762 TTL
tubulin tyrosine ligase
chr1_+_157824239 0.760 NM_001639
APCS
amyloid P component, serum
chr18_+_42751510 0.760 KATNAL2
katanin p60 subunit A-like 2
chr7_-_38915306 0.757 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr2_+_112956204 0.745 NM_153712
TTL
tubulin tyrosine ligase
chr8_+_145221973 0.742 CYC1
cytochrome c-1
chr12_+_131577229 0.741 NM_001142641
FBRSL1
fibrosin-like 1
chr15_-_38417564 0.739 C15orf52
chromosome 15 open reading frame 52
chr15_-_46890475 0.737 NM_001194998
NM_014985
CEP152

centrosomal protein 152kDa

chr15_-_81526896 0.723 BTBD1
BTB (POZ) domain containing 1
chr11_-_75769514 0.721 NM_004705
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr8_-_124622434 0.719 NM_058229
FBXO32
F-box protein 32
chr1_+_234916376 0.716 NM_001103
ACTN2
actinin, alpha 2
chrX_+_100241453 0.701 NM_006733
CENPI
centromere protein I
chr3_-_50624085 0.699 CISH
cytokine inducible SH2-containing protein
chr1_+_32489426 0.698 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr16_+_30844707 0.693 FBXL19
F-box and leucine-rich repeat protein 19
chr10_+_80777234 0.685 PPIF
peptidylprolyl isomerase F
chr2_+_219453487 0.681 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr10_+_80777199 0.667 NM_005729
PPIF
peptidylprolyl isomerase F
chr19_+_17923110 0.664 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr15_+_41597097 0.663 NM_002373
MAP1A
microtubule-associated protein 1A
chr5_+_271428 0.644 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_-_35266305 0.640 PRLR
prolactin receptor
chr17_+_59933322 0.637 CCDC45
coiled-coil domain containing 45
chr7_-_140270749 0.635 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr5_+_271355 0.634 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr22_+_19651446 0.630 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr22_+_22703107 0.628 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr1_+_29086206 0.627 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr17_-_34015631 0.625 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr19_+_62434188 0.620 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr3_+_161040439 0.607 SCHIP1
schwannomin interacting protein 1
chr1_+_29086156 0.605 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chrX_-_153397566 0.599 NM_001171132
NM_001171133
NM_001171134
NM_021806
FAM3A



family with sequence similarity 3, member A



chr20_+_60558104 0.599 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr12_+_100615530 0.599 NM_020244
CHPT1
choline phosphotransferase 1
chr14_-_23106372 0.596 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_+_55237193 0.595 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr6_-_33655811 0.595 BAK1
BCL2-antagonist/killer 1
chr14_-_23107106 0.594 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_-_172153087 0.592 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr8_-_131097856 0.591 FAM49B
family with sequence similarity 49, member B
chr15_+_74139378 0.589 C15orf27
chromosome 15 open reading frame 27
chr17_+_35471971 0.586 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr15_+_72540655 0.583 LOC440288
similar to FLJ16518 protein
chr19_-_44135166 0.571 NM_148169
FBXO17
F-box protein 17
chr16_-_83602587 0.571 ZDHHC7
zinc finger, DHHC-type containing 7
chr11_-_84311867 0.569 DLG2
discs, large homolog 2 (Drosophila)
chr22_+_22529058 0.563 NM_001024938
NM_030807
SLC2A11

solute carrier family 2 (facilitated glucose transporter), member 11

chr1_-_29381223 0.553 NM_005626
SRSF4
serine/arginine-rich splicing factor 4
chr12_-_52356375 0.551 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr11_+_47227009 0.551 NM_001130102
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr5_+_271447 0.551 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr12_+_119647953 0.550 NM_000017
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr17_+_71586857 0.548 NM_180990
ZACN
zinc activated ligand-gated ion channel
chr1_-_226661089 0.546 NM_145214
TRIM11
tripartite motif containing 11
chr4_-_40327396 0.545 RBM47
RNA binding motif protein 47
chr7_+_37926687 0.545 NM_017549
EPDR1
ependymin related protein 1 (zebrafish)
chr11_+_120399966 0.544 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr7_+_128795280 0.543 AHCYL2
adenosylhomocysteinase-like 2
chr8_+_110415725 0.537 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr19_-_1464187 0.536 NM_213604
ADAMTSL5
ADAMTS-like 5
chr15_+_97009194 0.536 IGF1R
insulin-like growth factor 1 receptor
chr11_-_63749916 0.536 NM_001160393
TRPT1
tRNA phosphotransferase 1
chr1_-_202726068 0.532 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr6_-_34468076 0.528 NUDT3
nudix (nucleoside diphosphate linked moiety X)-type motif 3
chr22_+_29848923 0.527 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr14_+_104523660 0.522 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr14_-_105712630 0.521 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_2785682 0.514 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr4_-_1827475 0.513 NM_012318
LETM1
leucine zipper-EF-hand containing transmembrane protein 1
chr1_-_239749683 0.511 NM_000143
FH
fumarate hydratase
chr16_-_56886380 0.510 NM_001080492
PRSS54
protease, serine, 54
chr16_-_83602620 0.509 NM_001145548
NM_017740
ZDHHC7

zinc finger, DHHC-type containing 7

chr9_-_32540818 0.507 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr1_+_205293217 0.505 NM_001018053
NM_006212
PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

chr1_-_209818675 0.503 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr6_-_109810354 0.503 CD164
CD164 molecule, sialomucin
chr5_+_175902117 0.502 NM_001171976
CDHR2
cadherin-related family member 2
chr1_-_27582368 0.496 NM_207397
CD164L2
CD164 sialomucin-like 2
chr17_-_70430839 0.495 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr1_-_27689129 0.492 WASF2
WAS protein family, member 2
chr7_+_128099581 0.490 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr2_-_26320967 0.488 HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr12_-_56496107 0.487 NM_006576
AVIL
advillin
chr6_+_37081387 0.487 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr7_-_102576570 0.486 NM_001122838
NM_198990
NAPEPLD

N-acyl phosphatidylethanolamine phospholipase D

chr20_+_19946542 0.484 NM_181527
NAA20
N(alpha)-acetyltransferase 20, NatB catalytic subunit
chr2_+_26321119 0.483 NM_000183
HADHB
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
chr1_-_27689254 0.483 NM_006990
WASF2
WAS protein family, member 2
chr7_+_128795178 0.481 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr5_+_271441 0.481 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr10_-_27026559 0.481


chr10_-_105146176 0.480 NM_032747
USMG5
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr15_-_89276657 0.479 NM_198527
HDDC3
HD domain containing 3
chr3_-_49798976 0.478 NM_001006115
NM_153273
IP6K1

inositol hexakisphosphate kinase 1

chr20_-_61600834 0.476 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr2_-_26321005 0.475 NM_000182
HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
chr14_-_73296643 0.471 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr15_-_79403494 0.469 NM_181900
STARD5
StAR-related lipid transfer (START) domain containing 5
chr17_+_27493618 0.469 RHOT1
ras homolog gene family, member T1
chr7_+_44802834 0.467 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr19_-_60360768 0.465 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr20_-_34807882 0.464 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr1_+_38032045 0.462 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr19_-_15451203 0.461 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr11_-_64459910 0.455 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr17_+_78070853 0.452 NM_004514
FOXK2
forkhead box K2
chr6_+_89847019 0.449 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr16_+_716936 0.449 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr17_+_37247568 0.448 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr15_-_32446537 0.447 NM_153613
LPCAT4
lysophosphatidylcholine acyltransferase 4
chr17_+_27493654 0.446 RHOT1
ras homolog gene family, member T1
chr14_-_102500694 0.445 CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr1_+_32530298 0.440 HDAC1
histone deacetylase 1
chr14_-_102045849 0.440 NM_152326
ANKRD9
ankyrin repeat domain 9
chr7_+_38984133 0.435 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr11_-_47226915 0.435 NM_001131064
NM_001610
ACP2

acid phosphatase 2, lysosomal

chr17_+_35472566 0.435 NM_001190918
NM_003250
NM_199334
THRA


thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)


chr1_+_119851348 0.432 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr7_+_28497272 0.428 CREB5
cAMP responsive element binding protein 5
chr19_+_51542085 0.428 NM_006247
PPP5C
protein phosphatase 5, catalytic subunit
chr19_+_50693570 0.427 NM_001080401
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chrX_+_38305634 0.426 NM_004615
TSPAN7
tetraspanin 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 1.67e-04 GO:0006810 transport
1.38 5.46e-04 GO:0051234 establishment of localization
1.73 1.70e-03 GO:0055114 oxidation-reduction process
2.14 3.18e-03 GO:0006091 generation of precursor metabolites and energy
1.31 4.23e-03 GO:0051179 localization
2.88 3.52e-02 GO:0045333 cellular respiration
2.21 4.41e-02 GO:0015980 energy derivation by oxidation of organic compounds

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.11 2.09e-11 GO:0005743 mitochondrial inner membrane
2.97 5.87e-11 GO:0019866 organelle inner membrane
2.50 3.06e-09 GO:0005740 mitochondrial envelope
2.53 4.00e-09 GO:0031966 mitochondrial membrane
2.15 2.53e-08 GO:0044429 mitochondrial part
2.07 6.96e-08 GO:0031975 envelope
2.08 7.05e-08 GO:0031967 organelle envelope
1.66 6.22e-06 GO:0005739 mitochondrion
1.23 7.00e-05 GO:0044444 cytoplasmic part
3.17 4.46e-04 GO:0044455 mitochondrial membrane part
1.15 9.41e-04 GO:0005737 cytoplasm
3.73 5.64e-03 GO:0070469 respiratory chain
1.37 1.03e-02 GO:0005829 cytosol
5.11 1.36e-02 GO:0000932 cytoplasmic mRNA processing body
3.46 4.88e-02 GO:0005746 mitochondrial respiratory chain

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.28 7.68e-04 GO:0003823 antigen binding
1.14 4.93e-02 GO:0005515 protein binding