Motif ID: FOXA2.p3

Z-value: 1.573


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
FOXA2 3170 forkhead box A2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXA2chr20_-_225130500.611.2e-02Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_69218909 3.916 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr6_+_131190237 2.564 NM_001195597
LOC285733
hypothetical LOC285733
chr20_+_54257194 2.105 NM_019888
MC3R
melanocortin 3 receptor
chr20_+_29492071 1.757 NM_153324
DEFB123
defensin, beta 123
chr3_-_150422474 1.729 NM_000096
CP
ceruloplasmin (ferroxidase)
chr7_-_50596238 1.702 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr14_-_37134050 1.583 FOXA1
forkhead box A1
chr9_+_135276940 1.564 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr9_+_135277264 1.545 ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr3_+_176059763 1.430 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr2_+_11591692 1.394 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr3_-_150569574 1.390 TM4SF1
transmembrane 4 L six family member 1
chr16_-_86527608 1.370 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr17_+_69939130 1.284 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr14_-_93859394 1.278 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr2_-_20390601 1.210 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr17_-_23721430 1.195 VTN
vitronectin
chr4_-_70115037 1.192 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr10_-_21475493 1.166 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr19_-_59003770 1.133 NM_033297
NLRP12
NLR family, pyrin domain containing 12
chr1_-_20682541 1.131


chr7_-_158304062 1.128 ESYT2
extended synaptotagmin-like protein 2
chr20_-_49612745 1.120 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr4_-_152368492 1.115 SH3D19
SH3 domain containing 19
chr17_-_3142625 1.100 NM_002550
OR3A1
olfactory receptor, family 3, subfamily A, member 1
chr5_+_128468785 1.096 ISOC1
isochorismatase domain containing 1
chr8_-_30121741 1.083 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr2_-_165133239 1.075 GRB14
growth factor receptor-bound protein 14
chr5_+_140583098 1.071 NM_018934
PCDHB14
protocadherin beta 14
chr4_+_70896236 1.063 NM_001009181
NM_003154
STATH

statherin

chr2_+_214984705 1.055 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr3_-_191650291 1.020 NM_207316
TMEM207
transmembrane protein 207
chr5_+_173405343 1.009 HMP19
HMP19 protein
chr5_+_173405298 1.006 NM_015980
HMP19
HMP19 protein
chr3_+_173043832 0.993 NM_001164436
TMEM212
transmembrane protein 212
chr2_-_233586145 0.990 NGEF
neuronal guanine nucleotide exchange factor
chrX_-_55037235 0.985 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr1_+_26376611 0.973 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr10_+_102722275 0.957 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr20_+_31334601 0.950 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr20_-_52120421 0.929 BCAS1
breast carcinoma amplified sequence 1
chr4_+_187385618 0.917 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr18_+_30589937 0.912 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr11_+_125258718 0.909 NM_145014
HYLS1
hydrolethalus syndrome 1
chr20_+_31219543 0.906 NM_080574
C20orf70
chromosome 20 open reading frame 70
chr2_-_32344192 0.903 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr17_-_23721420 0.894 VTN
vitronectin
chr5_+_140227951 0.888 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr2_-_233586164 0.886 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr11_+_55319607 0.886 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr3_-_121065112 0.878


chr20_+_31287462 0.877 NM_016583
NM_130852
PLUNC

palate, lung and nasal epithelium associated

chr17_-_23721351 0.870 VTN
vitronectin
chr20_-_49612574 0.866 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr3_-_194579207 0.856 NM_198505
ATP13A5
ATPase type 13A5
chr2_-_169596078 0.854 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr17_-_23721468 0.852 VTN
vitronectin
chr17_-_31332568 0.843 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chrX_-_131375217 0.839 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr12_-_51629874 0.830 KRT8
keratin 8
chrX_+_49718954 0.826 NM_000084
CLCN5
chloride channel 5
chr17_-_23721485 0.812 NM_000638
VTN
vitronectin
chr1_+_34997928 0.808 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr3_+_152970904 0.806 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr17_+_64922420 0.806 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr11_-_121492010 0.804 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr10_-_49152918 0.804 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr14_+_104337923 0.785 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr11_+_124294355 0.782 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr6_+_26548678 0.769 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr6_+_55147029 0.765 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr17_-_46296376 0.765 NM_005749
TOB1
transducer of ERBB2, 1
chr7_+_143402207 0.763 NM_001004488
OR2A25
olfactory receptor, family 2, subfamily A, member 25
chr22_+_19458378 0.763 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr15_+_64661560 0.758


chr14_-_106282128 0.749 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_+_132237253 0.732 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr12_-_119249938 0.732 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr3_+_70131572 0.724


chr14_-_105542441 0.724 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr5_+_140460240 0.709 NM_018937
PCDHB3
protocadherin beta 3
chr7_+_116238309 0.704 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr2_+_38009405 0.703 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr7_+_94953148 0.703 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr2_-_172458970 0.703 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr14_+_22136968 0.699 NM_022060
ABHD4
abhydrolase domain containing 4
chr4_+_70180805 0.697 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr15_-_23204887 0.694 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr17_+_7732759 0.694 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr6_+_154449334 0.689 NM_001145287
OPRM1
opioid receptor, mu 1
chr7_+_28305464 0.686 NM_182899
CREB5
cAMP responsive element binding protein 5
chr1_-_150070849 0.678 NM_005060
RORC
RAR-related orphan receptor C
chr5_-_13997588 0.675 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr2_+_71016503 0.674 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr1_-_176205672 0.670 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr6_+_112481970 0.668 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr14_+_38772870 0.667 NM_054024
MIA2
melanoma inhibitory activity 2
chr18_+_28023984 0.659 NM_005925
MEP1B
meprin A, beta
chr14_+_87560646 0.655 LOC283587
hypothetical protein LOC283587
chr2_+_241776596 0.651 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr20_-_14266200 0.647 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr2_-_39201631 0.647 SOS1
son of sevenless homolog 1 (Drosophila)
chr6_-_41823056 0.639 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr14_-_105589467 0.639 LOC100126583
IGHA1
IGHG1
IGHG2
IGHM
hypothetical LOC100126583
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr10_+_18729518 0.638 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr22_+_33792125 0.632 NM_001008494
ISX
intestine-specific homeobox
chr2_+_113591940 0.615 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr4_-_69852090 0.611 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr20_+_9406460 0.611 PLCB4
phospholipase C, beta 4
chr3_-_49434874 0.609 AMT
aminomethyltransferase
chr6_+_154373323 0.599 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr6_+_144227265 0.599 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr5_+_140509803 0.595 NM_018939
PCDHB6
protocadherin beta 6
chr18_+_27425727 0.593 NM_000371
TTR
transthyretin
chr2_-_21081694 0.593 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_-_135498716 0.592 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr19_-_45424403 0.582 NM_024877
CNTD2
cyclin N-terminal domain containing 2
chr12_+_119900931 0.581 NM_000545
HNF1A
HNF1 homeobox A
chr4_-_70861301 0.579 NM_001891
CSN2
casein beta
chr12_-_10464308 0.577 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr6_+_31698447 0.574


chr12_-_18134319 0.572 NM_024730
RERGL
RERG/RAS-like
chr11_+_3622933 0.572 NM_004314
ART1
ADP-ribosyltransferase 1
chr6_-_47030492 0.570 NM_015234
GPR116
G protein-coupled receptor 116
chr2_+_170149348 0.565 PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr6_-_31953425 0.563 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr3_+_52786642 0.560 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr7_+_129693938 0.559 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr11_+_22646229 0.549 NM_177553
GAS2
growth arrest-specific 2
chrX_-_15198093 0.547 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr11_-_104332631 0.544 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr3_-_25658829 0.537 TOP2B
topoisomerase (DNA) II beta 180kDa
chr1_-_150079656 0.536 NM_001136003
C2CD4D
C2 calcium-dependent domain containing 4D
chr6_-_76838944 0.534 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr11_-_104411065 0.532 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr21_-_42608531 0.530 TFF3
trefoil factor 3 (intestinal)
chr5_-_135729062 0.528 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr20_-_52120710 0.525 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr12_-_6356783 0.522 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_-_57204208 0.514 NM_000066
C8B
complement component 8, beta polypeptide
chr19_-_63715135 0.508 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr2_+_170149092 0.506 NM_004792
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr14_-_57133361 0.505 NM_001080455
SLC35F4
solute carrier family 35, member F4
chr1_-_167822334 0.502 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr6_+_127940011 0.502 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr6_-_155818728 0.498 NM_015718
NOX3
NADPH oxidase 3
chr3_-_71376919 0.494 FOXP1
forkhead box P1
chr20_-_31055892 0.491 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr1_+_153232685 0.486 NM_018655
LENEP
lens epithelial protein
chr10_+_101532544 0.486 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_167822248 0.485 F5
coagulation factor V (proaccelerin, labile factor)
chr12_+_32578513 0.484 FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_+_99334230 0.480 NM_001005338
OR5H1
olfactory receptor, family 5, subfamily H, member 1
chr18_+_50409387 0.479 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr5_-_36337756 0.477 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr17_+_38259620 0.477 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_+_55842358 0.474 NM_001005202
OR8K3
olfactory receptor, family 8, subfamily K, member 3
chr6_+_32003180 0.471 NM_000063
NM_001145903
C2

complement component 2

chr12_-_21379098 0.466 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr6_+_26359805 0.462 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr2_+_183316574 0.461 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr12_+_119900677 0.460 HNF1A
HNF1 homeobox A
chr14_-_105644300 0.460 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr4_+_86615275 0.460 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr15_-_88578195 0.459 NM_006384
CIB1
calcium and integrin binding 1 (calmyrin)
chr13_+_110653407 0.459 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr14_-_106270497 0.459 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr15_-_48198697 0.457 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr2_+_102456193 0.456 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr4_-_185963859 0.455 ACSL1
acyl-CoA synthetase long-chain family member 1
chr2_-_21079145 0.455 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_36418869 0.454 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr21_-_30510113 0.454 NM_199328
CLDN8
claudin 8
chr11_-_128399218 0.453 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr14_+_20226762 0.451 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr9_-_14900992 0.451 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr11_-_16953135 0.450 RPL36A
ribosomal protein L36a
chr11_-_102156531 0.450 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr6_+_154402135 0.449 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145285
NM_001145286
NM_001145284
OPRM1








opioid receptor, mu 1








chr4_+_72321113 0.447 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr5_+_150138489 0.446 C5orf62
chromosome 5 open reading frame 62
chr1_+_40635058 0.443 NM_001198980
SMAP2
small ArfGAP2
chr2_+_191009265 0.441 MFSD6
major facilitator superfamily domain containing 6
chr8_+_18072250 0.439 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr17_-_36409632 0.438 NM_031959
KRTAP3-2
keratin associated protein 3-2
chrX_+_26066380 0.437 NM_173699
MAGEB18
melanoma antigen family B, 18
chr6_-_159386007 0.437 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr6_+_31838751 0.436 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr2_-_167058829 0.435 SCN7A
sodium channel, voltage-gated, type VII, alpha
chr17_-_52393364 0.434 NM_004645
COIL
coilin
chr4_-_40211324 0.434 RBM47
RNA binding motif protein 47
chr17_+_36647795 0.433 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr14_+_36200815 0.433 PAX9
paired box 9
chr5_+_52892217 0.432 NM_002495
NDUFS4
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr1_+_154855709 0.430 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr20_+_16676997 0.429 NM_020157
OTOR
otoraplin
chr12_+_5473558 0.428 NM_002527
NTF3
neurotrophin 3
chr10_+_123738678 0.425 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr5_+_76150637 0.424 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr7_+_45899621 0.423



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.14 4.67e-05 GO:0007606 sensory perception of chemical stimulus
1.76 4.13e-04 GO:0007600 sensory perception
1.50 5.97e-04 GO:0003008 system process
1.21 1.25e-03 GO:0050896 response to stimulus
1.23 4.58e-03 GO:0032501 multicellular organismal process
1.99 5.97e-03 GO:0007608 sensory perception of smell
4.63 3.15e-02 GO:0008206 bile acid metabolic process
1.47 3.36e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 8.86e-06 GO:0005576 extracellular region
1.26 3.57e-04 GO:0071944 cell periphery
1.61 3.95e-04 GO:0044421 extracellular region part
1.26 7.37e-04 GO:0005886 plasma membrane
1.65 2.04e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.86 1.86e-06 GO:0004930 G-protein coupled receptor activity
1.54 7.31e-04 GO:0004888 transmembrane receptor activity
1.44 1.52e-03 GO:0004872 receptor activity
2.00 1.87e-03 GO:0004984 olfactory receptor activity
1.38 2.90e-03 GO:0004871 signal transducer activity
1.38 2.90e-03 GO:0060089 molecular transducer activity