Motif ID: FOXL1.p2

Z-value: 1.784


Transcription factors associated with FOXL1.p2:

Gene SymbolEntrez IDGene Name
FOXL1 2300 forkhead box L1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXL1chr16_+_85169615-0.058.5e-01Click!


Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_53847937 4.092 RNF43
ring finger protein 43
chr13_+_75232797 3.766 NM_015842
LMO7
LIM domain 7
chrX_-_117003310 3.684 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr7_-_113346284 2.844 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr4_-_152368492 2.661 SH3D19
SH3 domain containing 19
chr3_-_150422474 2.401 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_+_165804157 2.182 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr14_-_94669547 2.150 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr10_+_90511142 1.950 NM_001102469
LIPN
lipase, family member N
chr3_-_78749633 1.851 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr14_-_30927931 1.805 NM_015473
HEATR5A
HEAT repeat containing 5A
chr3_-_57301749 1.803 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr8_+_54926920 1.782 NM_170587
RGS20
regulator of G-protein signaling 20
chr1_-_181540631 1.765 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr20_+_58146916 1.763 LOC284757
hypothetical protein LOC284757
chr10_+_35524835 1.749 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr4_+_169654742 1.731 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr4_+_73123712 1.727 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr12_+_79625538 1.638 NM_002469
MYF6
myogenic factor 6 (herculin)
chr12_+_79362256 1.629 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr1_+_150997129 1.622 NM_001025231
KPRP
keratinocyte proline-rich protein
chr6_-_48186868 1.605 C6orf138
chromosome 6 open reading frame 138
chr8_-_82522175 1.590 NM_002677
PMP2
peripheral myelin protein 2
chr22_-_14829803 1.572 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr1_+_62835759 1.570 NM_014495
ANGPTL3
angiopoietin-like 3
chr5_-_94250357 1.556 MCTP1
multiple C2 domains, transmembrane 1
chr20_-_14266200 1.556 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr5_-_16561936 1.458 NM_019000
FAM134B
family with sequence similarity 134, member B
chr18_-_49944986 1.429 MBD2
methyl-CpG binding domain protein 2
chrX_-_77801480 1.401 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr4_+_86968069 1.395 ARHGAP24
Rho GTPase activating protein 24
chr2_-_162717159 1.391 NM_002054
GCG
glucagon
chr7_+_106897737 1.383 NM_005295
GPR22
G protein-coupled receptor 22
chr3_+_44667504 1.355 ZNF35
zinc finger protein 35
chr9_-_21472311 1.315 NM_176891
IFNE
interferon, epsilon
chr20_+_9406460 1.302 PLCB4
phospholipase C, beta 4
chr17_-_8004671 1.296 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr5_+_140568451 1.249 NM_018932
PCDHB12
protocadherin beta 12
chr6_+_127940011 1.240 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr1_-_150328153 1.235 NM_001008536
TCHHL1
trichohyalin-like 1
chr5_+_139485703 1.227 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr4_+_88748704 1.212 NM_014208
DSPP
dentin sialophosphoprotein
chr6_-_116553918 1.209 NM_000493
COL10A1
collagen, type X, alpha 1
chr11_+_36546138 1.197 NM_000448
RAG1
recombination activating gene 1
chr17_-_36436979 1.188 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr10_+_94584449 1.187 NM_001013848
EXOC6
exocyst complex component 6
chr1_-_27604656 1.184 WASF2
WAS protein family, member 2
chr5_+_128468785 1.136 ISOC1
isochorismatase domain containing 1
chr2_+_211129567 1.118 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr3_-_95230143 1.110 NM_001001850
STX19
syntaxin 19
chr4_+_53975597 1.100 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr10_-_69125932 1.095 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr6_+_131190237 1.092 NM_001195597
LOC285733
hypothetical LOC285733
chrX_-_33139349 1.091 NM_004006
DMD
dystrophin
chr1_+_246195157 1.087 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr14_+_18447521 1.068 NM_001013354
OR11H12
olfactory receptor, family 11, subfamily H, member 12
chr3_+_153014550 1.056 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr1_+_50344550 1.054 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr6_-_32892705 1.053 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr2_+_61243132 1.053 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr10_-_95231933 1.036 NM_013451
NM_133337
MYOF

myoferlin

chr7_+_90176647 1.018 NM_012395
CDK14
cyclin-dependent kinase 14
chr7_-_108311872 1.018 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr3_-_102194938 0.996 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_+_15862887 0.974


chr18_-_39111243 0.973 NM_020783
SYT4
synaptotagmin IV
chr3_-_150533948 0.959 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr6_-_123999640 0.956 NM_006073
TRDN
triadin
chr1_-_197173159 0.951 LOC100131234
familial acute myelogenous leukemia related factor
chr10_-_93992982 0.950 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr6_+_73133152 0.949 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr6_-_117256890 0.947 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr3_-_58175437 0.940 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr5_+_86712376 0.936


chr2_-_1925880 0.935 MYT1L
myelin transcription factor 1-like
chr6_+_90660906 0.935 NM_032602
GJA10
gap junction protein, alpha 10, 62kDa
chr18_+_59593591 0.922 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr6_+_72979234 0.919 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr1_+_151240846 0.918 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr7_-_41709191 0.908 NM_002192
INHBA
inhibin, beta A
chr15_-_78050515 0.906 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr2_+_151922350 0.901 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr15_+_22832198 0.880 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr15_+_47502666 0.879 NM_002009
FGF7
fibroblast growth factor 7
chr12_-_18134319 0.873 NM_024730
RERGL
RERG/RAS-like
chr2_-_98646367 0.871 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr4_+_68107039 0.863 NM_012108
STAP1
signal transducing adaptor family member 1
chr14_-_76958984 0.863 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr2_-_224175293 0.860 SCG2
secretogranin II
chr8_-_28403652 0.856 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chrX_-_131989963 0.847 NM_031907
USP26
ubiquitin specific peptidase 26
chr11_+_6854431 0.844 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr4_+_71418886 0.841 NM_212557
AMTN
amelotin
chr7_+_111908143 0.840 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr2_+_33592445 0.839 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr9_-_94338072 0.839 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr3_+_49522871 0.838 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr3_-_52688768 0.827 NM_018165
NM_181042
PBRM1

polybromo 1

chr21_-_35174742 0.827 RUNX1
runt-related transcription factor 1
chr12_+_63510481 0.827


chr3_-_135131207 0.825 NM_025041
C3orf36
chromosome 3 open reading frame 36
chr2_-_224175386 0.822 NM_003469
SCG2
secretogranin II
chr19_+_60879802 0.814 NM_001130071
EPN1
epsin 1
chr20_+_56369012 0.813


chr8_+_50147455 0.810 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr9_+_124321239 0.809 NM_001004452
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr14_-_105785639 0.801


chr6_+_131613196 0.799 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chrX_+_41468351 0.799 NM_080817
GPR82
G protein-coupled receptor 82
chr21_-_26294332 0.794 APP
amyloid beta (A4) precursor protein
chr15_+_91244422 0.788 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr5_+_161045235 0.787 NM_000811
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr1_+_69998445 0.780 NM_020794
LRRC7
leucine rich repeat containing 7
chr8_-_62764839 0.778 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr7_+_141054621 0.778 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr4_+_77214886 0.778 NM_001130016
NM_001179
ART3

ADP-ribosyltransferase 3

chr8_+_24297742 0.766 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr17_+_58440629 0.766 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_-_171796069 0.765 NM_001136554
TLK1
tousled-like kinase 1
chr9_-_36365965 0.765 RNF38
ring finger protein 38
chr15_+_91244563 0.765 CHD2
chromodomain helicase DNA binding protein 2
chr9_+_122923864 0.760 CEP110
centrosomal protein 110kDa
chr1_-_9925412 0.758 NM_032368
LZIC
leucine zipper and CTNNBIP1 domain containing
chr3_+_133798770 0.755 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr13_+_49487390 0.753 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr1_+_97033103 0.750


chr11_-_13474101 0.746 NM_000315
PTH
parathyroid hormone
chr9_+_124477135 0.745 NM_001005234
OR1L3
olfactory receptor, family 1, subfamily L, member 3
chr2_-_224175339 0.744 SCG2
secretogranin II
chr17_-_53973177 0.741 NM_001198713
SEPT4
septin 4
chrX_+_37750778 0.741 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chr4_+_120276386 0.737 NM_016599
MYOZ2
myozenin 2
chr15_+_38296920 0.734 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr17_+_3326045 0.734 NM_000049
ASPA
aspartoacylase
chr7_+_50106227 0.730 NM_001161834
C7orf72
chromosome 7 open reading frame 72
chr5_-_83052606 0.730 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr8_-_102005697 0.728 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_-_110735158 0.728 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr5_+_121523769 0.726 NM_001195535
LOC728460
hypothetical LOC728460
chr12_-_101115677 0.725 NM_002674
PMCH
pro-melanin-concentrating hormone
chr6_+_55147029 0.721 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr1_+_93072947 0.720 RPL5
ribosomal protein L5
chr10_-_45350804 0.717 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr1_-_214963279 0.710 NM_001438
ESRRG
estrogen-related receptor gamma
chr1_+_103898844 0.709 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr3_+_44665220 0.708 NM_003420
ZNF35
zinc finger protein 35
chr12_-_9123126 0.707 A2M
alpha-2-macroglobulin
chr10_-_116408046 0.707 NM_002313
ABLIM1
actin binding LIM protein 1
chr13_-_44673174 0.705 NM_198404
KCTD4
potassium channel tetramerisation domain containing 4
chr1_+_114295289 0.704 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr2_-_179623030 0.699 NM_173648
CCDC141
coiled-coil domain containing 141
chr4_-_157006827 0.699 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr10_+_5478521 0.691 NM_005863
NET1
neuroepithelial cell transforming 1
chr2_-_165133239 0.687 GRB14
growth factor receptor-bound protein 14
chr4_-_64957595 0.685 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr15_+_19883745 0.684 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr17_-_26648375 0.683 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr5_+_156540425 0.680 NM_005546
ITK
IL2-inducible T-cell kinase
chr2_-_55090759 0.670 NM_007008
RTN4
reticulon 4
chr1_+_151117421 0.669 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr11_-_56137553 0.669 NM_001004740
OR5M1
olfactory receptor, family 5, subfamily M, member 1
chrX_-_21686079 0.665 NM_014332
SMPX
small muscle protein, X-linked
chr14_-_106270497 0.664 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr10_-_14090459 0.664 FRMD4A
FERM domain containing 4A
chr10_-_98021144 0.662 NM_001114094
NM_013314
BLNK

B-cell linker

chr1_+_200775864 0.662 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr17_-_10362583 0.661 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr8_-_82606104 0.660 NM_001105281
FABP12
fatty acid binding protein 12
chr7_-_84589182 0.660 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr1_+_242281199 0.656 ZNF238
zinc finger protein 238
chr15_-_42756377 0.655 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr8_+_24207524 0.652 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr10_-_97190885 0.648 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr6_+_54281161 0.648 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr2_+_227900471 0.647 NM_020194
MFF
mitochondrial fission factor
chr14_+_38772870 0.642 NM_054024
MIA2
melanoma inhibitory activity 2
chr7_+_80069439 0.641 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr20_-_42561725 0.640


chr12_-_54150188 0.636 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr12_+_9713472 0.635 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr10_+_96512447 0.631 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr18_+_30589937 0.623 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr13_-_74799898 0.623 TBC1D4
TBC1 domain family, member 4
chr6_-_132980901 0.623 NM_014626
TAAR2
trace amine associated receptor 2
chr6_+_147568795 0.621 STXBP5
syntaxin binding protein 5 (tomosyn)
chr5_+_140757787 0.621 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr11_+_4885138 0.617 NM_001004749
OR51A7
olfactory receptor, family 51, subfamily A, member 7
chr11_+_123625632 0.614 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr1_+_246682699 0.613 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr10_+_5228756 0.613 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr22_-_34564611 0.612 RPL41P5
ribosomal protein L41 pseudogene 5
chr6_-_29451042 0.609 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr17_-_1195096 0.607 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr13_+_110653407 0.603 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_+_4571844 0.598 NM_001005169
OR52I1
olfactory receptor, family 52, subfamily I, member 1
chr1_-_246554492 0.597 NM_001004691
OR2M7
olfactory receptor, family 2, subfamily M, member 7
chr1_-_31251315 0.592 PUM1
pumilio homolog 1 (Drosophila)
chr9_+_5646582 0.588 NM_020829
KIAA1432
KIAA1432
chr6_+_154449334 0.587 NM_001145287
OPRM1
opioid receptor, mu 1
chr9_-_74757735 0.582 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.76 6.10e-32 GO:0007608 sensory perception of smell
3.43 1.44e-28 GO:0007606 sensory perception of chemical stimulus
2.01 2.61e-23 GO:0003008 system process
2.54 8.86e-23 GO:0007600 sensory perception
2.09 1.40e-20 GO:0050877 neurological system process
1.44 1.29e-19 GO:0032501 multicellular organismal process
1.26 8.01e-08 GO:0050896 response to stimulus
2.49 1.51e-03 GO:0007517 muscle organ development
2.61 5.95e-03 GO:0043062 extracellular structure organization
2.84 4.28e-02 GO:0030198 extracellular matrix organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.50 6.34e-20 GO:0071944 cell periphery
1.50 4.78e-19 GO:0005886 plasma membrane
1.73 2.43e-07 GO:0044421 extracellular region part
1.47 1.01e-06 GO:0005576 extracellular region
1.74 1.68e-05 GO:0005615 extracellular space
1.19 4.50e-05 GO:0044425 membrane part
1.22 9.49e-05 GO:0016021 integral to membrane
1.21 1.17e-04 GO:0031224 intrinsic to membrane
1.73 9.24e-04 GO:0030054 cell junction
1.14 1.34e-03 GO:0016020 membrane
1.99 2.38e-03 GO:0005578 proteinaceous extracellular matrix
2.68 4.04e-03 GO:0030016 myofibril
1.83 9.42e-03 GO:0031012 extracellular matrix
1.31 1.03e-02 GO:0044459 plasma membrane part
2.52 1.09e-02 GO:0043292 contractile fiber

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.94 1.20e-34 GO:0004984 olfactory receptor activity
2.64 2.57e-27 GO:0004930 G-protein coupled receptor activity
2.11 7.46e-21 GO:0004888 transmembrane receptor activity
1.81 4.89e-16 GO:0004872 receptor activity
1.69 7.38e-15 GO:0004871 signal transducer activity
1.69 7.38e-15 GO:0060089 molecular transducer activity
2.01 2.01e-03 GO:0003779 actin binding
4.08 4.91e-03 GO:0008307 structural constituent of muscle
2.17 1.49e-02 GO:0005125 cytokine activity