Motif ID: HIC1.p2

Z-value: 7.201


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19051040.783.3e-04Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_43671355 10.635 NM_173354
SIK1
salt-inducible kinase 1
chr1_-_48235148 9.233 NM_001194986
LOC388630
UPF0632 protein A
chr6_-_112301123 8.030 NM_002037
FYN
FYN oncogene related to SRC, FGR, YES
chr18_+_7557313 7.580 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr6_+_1556543 7.138 FOXC1
forkhead box C1
chr19_+_10843244 6.907 NM_199141
CARM1
coactivator-associated arginine methyltransferase 1
chr8_+_32525269 6.680 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr22_-_45037882 6.616 NM_006071
PKDREJ
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr8_+_1937711 6.159 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr11_+_101485946 6.050 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chrX_-_151996613 5.923 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr6_+_147871477 5.867 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr6_+_159510416 5.858 NM_032532
FNDC1
fibronectin type III domain containing 1
chr10_-_45488162 5.485 NM_001128324
NM_174890
ANUBL1

AN1, ubiquitin-like, homolog (Xenopus laevis)

chr17_+_75689955 5.478 GAA
glucosidase, alpha; acid
chr19_+_3175700 5.474 NM_021938
NM_001172673
CELF5

CUGBP, Elav-like family member 5

chr11_-_63292688 5.438 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr15_+_89300995 5.380 RCCD1
RCC1 domain containing 1
chr19_+_3175734 5.328 CELF5
CUGBP, Elav-like family member 5
chr12_-_122321640 5.316 CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr15_+_89300973 5.220 RCCD1
RCC1 domain containing 1
chrX_+_9943793 5.206 NM_015691
WWC3
WWC family member 3
chr13_+_97593469 5.188 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr6_-_105691235 5.155 NM_007073
BVES
blood vessel epicardial substance
chr15_+_90198031 5.147 SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr13_+_97593711 5.115 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr17_+_26322081 5.071 NM_001184992
NM_032322
NM_197939
RNF135


ring finger protein 135


chr14_+_63389360 5.064 NM_015180
NM_182914
SYNE2

spectrin repeat containing, nuclear envelope 2

chr17_+_26322168 4.979 RNF135
ring finger protein 135
chr11_+_120828058 4.918 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr8_+_145705253 4.880 NM_138431
MFSD3
major facilitator superfamily domain containing 3
chr17_+_75689985 4.869 GAA
glucosidase, alpha; acid
chr20_-_34925483 4.784 NM_080627
KIAA0889
KIAA0889
chr3_+_198214173 4.717 LOC100507057
MFI2
hypothetical LOC100507057
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr9_-_138454088 4.682 INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr16_-_79395379 4.618 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr11_+_109469296 4.600 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr7_+_3307445 4.582 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chrX_+_151991474 4.561 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr21_+_25856311 4.552 MIR155HG
MIR155 host gene (non-protein coding)
chr1_+_226937732 4.516 RHOU
ras homolog gene family, member U
chr11_+_120828275 4.501 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_108802561 4.498 NM_016433
GLTP
glycolipid transfer protein
chr13_-_94162249 4.414 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr13_-_39075304 4.397 LHFP
lipoma HMGIC fusion partner
chr9_-_138454071 4.375 NM_019892
INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr15_+_66658626 4.373 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr11_+_119887630 4.370 LOC100293636
GRIK4
hypothetical protein LOC100293636
glutamate receptor, ionotropic, kainate 4
chr1_-_6162669 4.357 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr7_+_129918408 4.338 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr9_+_86473273 4.328 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr9_-_138454095 4.323 INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
chr13_+_30672122 4.285 B3GALTL
beta 1,3-galactosyltransferase-like
chr19_+_10843369 4.257 CARM1
coactivator-associated arginine methyltransferase 1
chr17_+_34140030 4.251 NM_001136498
CISD3
CDGSH iron sulfur domain 3
chr8_+_143805595 4.224 NM_016647
C8orf55
chromosome 8 open reading frame 55
chr7_+_156435163 4.219 NM_138400
NOM1
nucleolar protein with MIF4G domain 1
chr13_+_20175481 4.216 NM_138284
IL17D
interleukin 17D
chr20_+_56701224 4.187 NM_024663
NPEPL1
aminopeptidase-like 1
chr9_-_88751923 4.137 NM_002048
GAS1
growth arrest-specific 1
chr13_-_39075355 4.134 NM_005780
LHFP
lipoma HMGIC fusion partner
chr14_-_57688560 4.103 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr8_+_74369647 4.099 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chr14_+_58174489 4.077 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr10_+_71232281 4.069 COL13A1
collagen, type XIII, alpha 1
chr13_+_32488477 4.065 NM_004795
KL
klotho
chr17_+_75689894 4.047 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr1_-_1274618 4.036 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr16_+_82559600 3.970 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr13_+_32058651 3.960 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr12_-_26166485 3.931 BHLHE41
basic helix-loop-helix family, member e41
chr10_+_111975618 3.886 NM_005962
MXI1
MAX interactor 1
chr8_-_143805371 3.882 LOC100288181
hypothetical LOC100288181
chr7_-_27136876 3.865 NM_002141
HOXA4
homeobox A4
chr17_+_15788955 3.840 NM_000676
ADORA2B
adenosine A2b receptor
chr21_-_45786709 3.829 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr1_-_226661089 3.827 NM_145214
TRIM11
tripartite motif containing 11
chr13_-_39075200 3.771 LHFP
lipoma HMGIC fusion partner
chr12_-_122322117 3.725 NM_004642
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr11_+_915899 3.718 AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr11_+_916021 3.713 AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr2_+_29191711 3.699 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr12_-_122201237 3.699 PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr17_+_52026058 3.699 NM_005450
NOG
noggin
chr2_+_23461802 3.676 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chr14_-_104706159 3.643 NM_002226
NM_145159
JAG2

jagged 2

chr17_+_15789147 3.642 ADORA2B
adenosine A2b receptor
chr10_+_112247614 3.610 NM_004419
DUSP5
dual specificity phosphatase 5
chr22_+_36632242 3.549 NM_033386
MICALL1
MICAL-like 1
chr2_-_198359182 3.527 NM_197970
BOLL
bol, boule-like (Drosophila)
chr20_-_4177519 3.518 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr14_-_57688669 3.513 C14orf37
chromosome 14 open reading frame 37
chr16_+_1696162 3.498 NM_001040439
NM_015133
MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

chr2_-_25418249 3.494 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr11_-_67737275 3.477 NM_016028
NM_017635
SUV420H1

suppressor of variegation 4-20 homolog 1 (Drosophila)

chr17_-_60346042 3.463 LRRC37A3
leucine rich repeat containing 37, member A3
chr21_+_41461962 3.462 BACE2
beta-site APP-cleaving enzyme 2
chr19_-_15204194 3.453 NM_024794
EPHX3
epoxide hydrolase 3
chr6_-_105691675 3.348 BVES
blood vessel epicardial substance
chr4_-_24523605 3.334 NM_001130726
CCDC149
coiled-coil domain containing 149
chr22_-_39964001 3.330 CHADL
chondroadherin-like
chr9_-_71476917 3.311 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr11_-_44928803 3.306 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr9_+_90193807 3.275 SPIN1
spindlin 1
chr5_-_171643399 3.237 NM_152277
UBTD2
ubiquitin domain containing 2
chr7_+_98084531 3.222 NM_002523
NPTX2
neuronal pentraxin II
chr19_+_18391423 3.211


chr1_+_226937424 3.195 NM_021205
RHOU
ras homolog gene family, member U
chr16_+_19087035 3.165 NM_016524
SYT17
synaptotagmin XVII
chr16_+_65840275 3.155 NM_004594
SLC9A5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
chr6_-_3102690 3.152 NM_001069
TUBB2A
tubulin, beta 2A
chr10_+_134060681 3.144 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr11_+_61352209 3.134 NM_004265
FADS2
fatty acid desaturase 2
chr2_+_6974922 3.124 NM_014746
RNF144A
ring finger protein 144A
chr16_+_51722285 3.113 CHD9
chromodomain helicase DNA binding protein 9
chr9_+_123501186 3.104 DAB2IP
DAB2 interacting protein
chr7_-_81910956 3.095 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr4_+_156899575 3.095 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr18_-_24011349 3.089 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr9_-_21549696 3.076 LOC554202
hypothetical LOC554202
chr20_+_48241334 3.056 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_-_16272523 3.055 NM_182623
FAM131C
family with sequence similarity 131, member C
chr14_+_85069217 3.043


chr10_+_116843108 3.017 NM_207303
ATRNL1
attractin-like 1
chr12_+_20413445 3.013 NM_000921
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr8_-_93184629 3.005 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr1_-_94147616 2.968 GCLM
glutamate-cysteine ligase, modifier subunit
chr19_-_5291700 2.967 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr1_-_1274160 2.951 NM_004421
DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr22_+_36286350 2.944 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr11_+_131285747 2.940 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr21_-_26464931 2.931 APP
amyloid beta (A4) precursor protein
chr13_+_30672087 2.924 NM_194318
B3GALTL
beta 1,3-galactosyltransferase-like
chr21_-_26465005 2.921 NM_000484
NM_001136129
NM_001136130
NM_201413
NM_201414
APP




amyloid beta (A4) precursor protein




chr21_-_26464915 2.916 APP
amyloid beta (A4) precursor protein
chr19_+_18391211 2.909 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr3_-_191321367 2.900 LEPREL1
leprecan-like 1
chr15_+_72861470 2.894 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr11_+_109468734 2.887 ZC3H12C
zinc finger CCCH-type containing 12C
chr10_+_126140330 2.887 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr13_-_109236897 2.887 NM_003749
IRS2
insulin receptor substrate 2
chr2_-_98919109 2.883 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr21_-_26464790 2.882 APP
amyloid beta (A4) precursor protein
chr3_-_53055078 2.882 NM_001005158
NM_016329
SFMBT1

Scm-like with four mbt domains 1

chr7_+_129919134 2.851 MEST
mesoderm specific transcript homolog (mouse)
chr10_+_102749597 2.849 LZTS2
leucine zipper, putative tumor suppressor 2
chr13_-_101366995 2.847 NM_004115
FGF14
fibroblast growth factor 14
chr7_-_11838260 2.841 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr11_+_19691397 2.830 NM_145117
NM_182964
NAV2

neuron navigator 2

chr7_+_154720416 2.826 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr2_-_101370355 2.826 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr14_-_104705753 2.813 JAG2
jagged 2
chr1_-_95165089 2.813 NM_001839
CNN3
calponin 3, acidic
chr10_-_118022707 2.805 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr10_+_72245730 2.798 SGPL1
sphingosine-1-phosphate lyase 1
chr5_+_1061900 2.797 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr9_+_136673534 2.777 COL5A1
collagen, type V, alpha 1
chr11_-_110088330 2.776 NM_020809
ARHGAP20
Rho GTPase activating protein 20
chr2_-_25418856 2.774 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr2_-_233501069 2.762 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr14_+_54104099 2.755 SAMD4A
sterile alpha motif domain containing 4A
chr18_-_27518392 2.754 NM_004775
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr10_-_132999973 2.730 NM_174937
TCERG1L
transcription elongation regulator 1-like
chr17_+_19853200 2.718 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_+_22909916 2.711 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr18_+_19523402 2.701 LAMA3
laminin, alpha 3
chr10_+_129595349 2.698 PTPRE
protein tyrosine phosphatase, receptor type, E
chr3_-_191522886 2.696 NM_021101
CLDN1
claudin 1
chr17_-_77649393 2.691 NM_004104
FASN
fatty acid synthase
chr1_+_33494745 2.678 NM_152493
ZNF362
zinc finger protein 362
chr7_+_6596183 2.668 NM_024067
C7orf26
chromosome 7 open reading frame 26
chr4_+_184257337 2.663 NM_024949
WWC2
WW and C2 domain containing 2
chr10_-_30065760 2.661 SVIL
supervillin
chr15_+_77511912 2.656 NM_015206
KIAA1024
KIAA1024
chr21_+_42807052 2.651 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr3_-_127677400 2.650 ZXDC
ZXD family zinc finger C
chr1_-_145110669 2.649 NM_005399
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr10_-_6059460 2.648 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr7_+_154720547 2.645 INSIG1
insulin induced gene 1
chr21_+_41461924 2.638 BACE2
beta-site APP-cleaving enzyme 2
chr2_-_25418819 2.634 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr7_-_131911808 2.631 NM_001105543
NM_020911
PLXNA4

plexin A4

chr7_-_107089387 2.620 LOC286002
hypothetical LOC286002
chr16_+_88169612 2.608 NM_014427
NM_153636
CPNE7

copine VII

chr15_+_90197884 2.607 NM_001145044
NM_013272
SLCO3A1

solute carrier organic anion transporter family, member 3A1

chr18_+_19523526 2.601 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr8_+_142207866 2.599 NM_014957
DENND3
DENN/MADD domain containing 3
chr15_+_88120592 2.599 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr2_+_238200922 2.598 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr14_-_76677711 2.596 ZDHHC22
zinc finger, DHHC-type containing 22
chr9_-_135847106 2.578 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr7_+_79602023 2.578 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr4_+_186301410 2.571 NM_001151
SLC25A4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr13_+_97593411 2.571 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr8_-_145605540 2.563 NM_013291
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr2_+_10969513 2.548 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr2_+_202607554 2.539 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr7_-_81910740 2.534 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr10_-_99521701 2.534 NM_003015
SFRP5
secreted frizzled-related protein 5
chr7_+_26158257 2.526 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 6.52e-21 GO:0007399 nervous system development
1.27 1.56e-18 GO:0007275 multicellular organismal development
1.35 3.40e-17 GO:0030154 cell differentiation
1.34 3.93e-17 GO:0048869 cellular developmental process
1.55 4.00e-17 GO:0022008 neurogenesis
1.39 7.28e-17 GO:0023051 regulation of signaling
1.24 7.77e-17 GO:0032502 developmental process
1.73 3.03e-16 GO:0000904 cell morphogenesis involved in differentiation
1.41 4.08e-16 GO:0009653 anatomical structure morphogenesis
1.54 6.43e-16 GO:0048699 generation of neurons
1.27 8.76e-15 GO:0048731 system development
1.40 1.67e-14 GO:0009966 regulation of signal transduction
1.63 2.47e-14 GO:0000902 cell morphogenesis
1.75 2.85e-14 GO:0007409 axonogenesis
1.74 3.27e-14 GO:0048667 cell morphogenesis involved in neuron differentiation
1.09 4.46e-14 GO:0009987 cellular process
1.73 5.41e-14 GO:0048812 neuron projection morphogenesis
1.14 1.14e-13 GO:0050794 regulation of cellular process
1.24 1.29e-13 GO:0048856 anatomical structure development
1.66 2.65e-13 GO:0032990 cell part morphogenesis
1.59 3.57e-13 GO:0032989 cellular component morphogenesis
1.66 4.24e-13 GO:0048858 cell projection morphogenesis
1.57 6.87e-13 GO:0007167 enzyme linked receptor protein signaling pathway
1.48 8.08e-13 GO:0048468 cell development
1.65 4.06e-12 GO:0031175 neuron projection development
1.13 8.13e-12 GO:0050789 regulation of biological process
1.12 1.58e-11 GO:0065007 biological regulation
1.28 2.05e-11 GO:0048523 negative regulation of cellular process
1.58 3.64e-11 GO:0048666 neuron development
1.54 4.44e-11 GO:0030030 cell projection organization
1.60 7.13e-11 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.51 8.58e-11 GO:0030182 neuron differentiation
1.26 1.62e-10 GO:0048519 negative regulation of biological process
1.73 3.16e-10 GO:0007411 axon guidance
2.40 1.70e-09 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.10 9.42e-09 GO:0030111 regulation of Wnt receptor signaling pathway
1.27 9.78e-09 GO:0048583 regulation of response to stimulus
1.24 1.13e-08 GO:0048522 positive regulation of cellular process
1.19 4.65e-08 GO:0016043 cellular component organization
1.36 8.84e-08 GO:0010646 regulation of cell communication
1.21 1.03e-07 GO:0048518 positive regulation of biological process
1.21 1.10e-07 GO:0071842 cellular component organization at cellular level
1.39 1.50e-07 GO:0040011 locomotion
1.65 3.50e-07 GO:0060284 regulation of cell development
1.76 7.64e-07 GO:0048011 nerve growth factor receptor signaling pathway
2.11 9.99e-07 GO:0010720 positive regulation of cell development
1.58 1.11e-06 GO:0048598 embryonic morphogenesis
1.42 2.78e-06 GO:0045595 regulation of cell differentiation
1.17 3.49e-06 GO:0071840 cellular component organization or biogenesis
1.60 4.67e-06 GO:0001501 skeletal system development
1.40 5.36e-06 GO:0009790 embryo development
1.16 5.63e-06 GO:0023052 signaling
1.35 6.72e-06 GO:0050793 regulation of developmental process
1.38 6.86e-06 GO:2000026 regulation of multicellular organismal development
1.53 7.19e-06 GO:0009968 negative regulation of signal transduction
1.19 7.46e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.49 1.26e-05 GO:0048646 anatomical structure formation involved in morphogenesis
1.46 1.55e-05 GO:0007417 central nervous system development
1.60 2.15e-05 GO:0048729 tissue morphogenesis
1.49 2.29e-05 GO:0023057 negative regulation of signaling
2.44 2.74e-05 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
1.49 2.82e-05 GO:0010648 negative regulation of cell communication
1.56 2.90e-05 GO:0045597 positive regulation of cell differentiation
1.32 3.34e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.15 3.44e-05 GO:0031323 regulation of cellular metabolic process
1.16 3.86e-05 GO:0007165 signal transduction
1.27 4.14e-05 GO:0051239 regulation of multicellular organismal process
1.23 4.42e-05 GO:0007166 cell surface receptor linked signaling pathway
1.34 5.80e-05 GO:0051128 regulation of cellular component organization
1.47 6.36e-05 GO:0051094 positive regulation of developmental process
1.40 9.33e-05 GO:0009887 organ morphogenesis
1.38 9.36e-05 GO:0051254 positive regulation of RNA metabolic process
1.51 1.08e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.47 1.16e-04 GO:0008285 negative regulation of cell proliferation
1.21 1.47e-04 GO:0048513 organ development
1.31 1.55e-04 GO:0042127 regulation of cell proliferation
1.43 1.87e-04 GO:0048585 negative regulation of response to stimulus
1.61 2.31e-04 GO:0050767 regulation of neurogenesis
1.36 2.40e-04 GO:0010628 positive regulation of gene expression
2.06 2.47e-04 GO:0060485 mesenchyme development
1.57 2.53e-04 GO:0051960 regulation of nervous system development
1.46 3.15e-04 GO:0016477 cell migration
1.37 3.81e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.60 3.92e-04 GO:0046578 regulation of Ras protein signal transduction
1.14 4.17e-04 GO:0080090 regulation of primary metabolic process
1.41 4.45e-04 GO:0006935 chemotaxis
1.41 4.45e-04 GO:0042330 taxis
2.08 4.84e-04 GO:0016331 morphogenesis of embryonic epithelium
1.56 5.12e-04 GO:0035295 tube development
1.48 5.73e-04 GO:0009792 embryo development ending in birth or egg hatching
1.61 6.56e-04 GO:0002009 morphogenesis of an epithelium
1.39 7.45e-04 GO:0006928 cellular component movement
1.47 8.58e-04 GO:0043009 chordate embryonic development
1.44 1.00e-03 GO:0040008 regulation of growth
1.14 1.04e-03 GO:0051179 localization
2.02 1.06e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.14 1.13e-03 GO:0060255 regulation of macromolecule metabolic process
1.30 1.20e-03 GO:0009888 tissue development
1.30 1.23e-03 GO:0006351 transcription, DNA-dependent
1.36 1.57e-03 GO:0010629 negative regulation of gene expression
1.60 1.61e-03 GO:0045786 negative regulation of cell cycle
1.73 2.20e-03 GO:0016311 dephosphorylation
1.09 2.31e-03 GO:0044237 cellular metabolic process
1.23 2.38e-03 GO:0035556 intracellular signal transduction
1.51 2.62e-03 GO:0051270 regulation of cellular component movement
2.33 2.64e-03 GO:0001704 formation of primary germ layer
1.64 2.76e-03 GO:0035239 tube morphogenesis
1.27 3.18e-03 GO:0032879 regulation of localization
2.01 3.44e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.12 3.85e-03 GO:0051716 cellular response to stimulus
1.32 3.85e-03 GO:0009890 negative regulation of biosynthetic process
1.30 3.92e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.12 4.02e-03 GO:0019222 regulation of metabolic process
1.53 4.48e-03 GO:0030334 regulation of cell migration
1.40 4.51e-03 GO:0048870 cell motility
1.40 4.51e-03 GO:0051674 localization of cell
1.53 4.55e-03 GO:2000145 regulation of cell motility
1.37 5.21e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.32 5.72e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.73 6.58e-03 GO:0006470 protein dephosphorylation
1.34 6.99e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.49 7.55e-03 GO:0040012 regulation of locomotion
1.26 7.58e-03 GO:0009605 response to external stimulus
1.74 7.61e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.45 7.61e-03 GO:0007389 pattern specification process
1.33 8.64e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.03 8.70e-03 GO:0014031 mesenchymal cell development
1.35 9.18e-03 GO:0051253 negative regulation of RNA metabolic process
1.32 9.37e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.58 9.54e-03 GO:0045664 regulation of neuron differentiation
1.73 1.06e-02 GO:0022604 regulation of cell morphogenesis
1.93 1.06e-02 GO:0050769 positive regulation of neurogenesis
1.24 1.08e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.25 1.16e-02 GO:0006793 phosphorus metabolic process
1.25 1.16e-02 GO:0006796 phosphate metabolic process
1.33 1.20e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
2.27 1.44e-02 GO:0030177 positive regulation of Wnt receptor signaling pathway
2.17 1.44e-02 GO:0001841 neural tube formation
1.52 1.55e-02 GO:0001558 regulation of cell growth
1.29 1.58e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.22 1.67e-02 GO:0009893 positive regulation of metabolic process
1.23 1.69e-02 GO:0031325 positive regulation of cellular metabolic process
1.08 1.72e-02 GO:0008152 metabolic process
1.27 1.74e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.27 1.74e-02 GO:0009891 positive regulation of biosynthetic process
2.05 1.74e-02 GO:0001838 embryonic epithelial tube formation
1.29 1.77e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.40 1.97e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.70 2.00e-02 GO:0048705 skeletal system morphogenesis
1.15 2.04e-02 GO:0010468 regulation of gene expression
1.45 2.08e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.41 2.15e-02 GO:0090066 regulation of anatomical structure size
1.72 2.16e-02 GO:0007050 cell cycle arrest
1.36 2.62e-02 GO:0072358 cardiovascular system development
1.36 2.62e-02 GO:0072359 circulatory system development
2.22 2.69e-02 GO:0045995 regulation of embryonic development
1.94 2.77e-02 GO:0031346 positive regulation of cell projection organization
1.94 2.77e-02 GO:0048762 mesenchymal cell differentiation
2.02 2.85e-02 GO:0072175 epithelial tube formation
1.64 2.94e-02 GO:0060562 epithelial tube morphogenesis
1.24 3.26e-02 GO:0009892 negative regulation of metabolic process
1.72 3.47e-02 GO:0006469 negative regulation of protein kinase activity
1.45 3.74e-02 GO:0051130 positive regulation of cellular component organization
1.35 3.78e-02 GO:0043549 regulation of kinase activity
1.69 4.06e-02 GO:0033673 negative regulation of kinase activity
1.14 4.22e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.14 4.22e-02 GO:0031326 regulation of cellular biosynthetic process
1.91 4.27e-02 GO:0007498 mesoderm development
1.35 4.29e-02 GO:0045859 regulation of protein kinase activity
1.14 4.30e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.15 4.35e-02 GO:0051252 regulation of RNA metabolic process
1.15 4.66e-02 GO:0042221 response to chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 6.95e-16 GO:0005622 intracellular
1.09 1.41e-15 GO:0044424 intracellular part
1.12 1.53e-14 GO:0005737 cytoplasm
1.08 5.84e-09 GO:0043226 organelle
1.08 8.67e-09 GO:0043229 intracellular organelle
1.12 2.74e-08 GO:0044444 cytoplasmic part
1.09 4.46e-08 GO:0043227 membrane-bounded organelle
1.09 6.30e-08 GO:0043231 intracellular membrane-bounded organelle
1.48 1.32e-05 GO:0045202 synapse
1.03 2.80e-05 GO:0044464 cell part
1.03 3.01e-05 GO:0005623 cell
1.19 4.36e-05 GO:0005829 cytosol
1.67 9.07e-04 GO:0005912 adherens junction
1.09 1.29e-03 GO:0005634 nucleus
1.33 1.32e-03 GO:0030054 cell junction
1.27 1.53e-03 GO:0005626 insoluble fraction
1.27 3.60e-03 GO:0005624 membrane fraction
1.24 5.25e-03 GO:0005794 Golgi apparatus
1.56 6.35e-03 GO:0031252 cell leading edge
1.42 1.29e-02 GO:0044456 synapse part
1.56 1.45e-02 GO:0070161 anchoring junction
1.32 2.45e-02 GO:0000139 Golgi membrane
1.70 2.54e-02 GO:0005925 focal adhesion
1.28 2.61e-02 GO:0044431 Golgi apparatus part
1.14 3.20e-02 GO:0044459 plasma membrane part
1.24 3.74e-02 GO:0031982 vesicle
1.24 4.56e-02 GO:0031988 membrane-bounded vesicle
1.24 4.74e-02 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.08 1.78e-14 GO:0005488 binding
1.11 6.81e-10 GO:0005515 protein binding
1.48 2.29e-06 GO:0030695 GTPase regulator activity
1.47 2.30e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.32 2.36e-06 GO:0001071 nucleic acid binding transcription factor activity
1.32 2.36e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.30 1.66e-05 GO:0030528 transcription regulator activity
1.63 1.47e-04 GO:0000975 regulatory region DNA binding
1.63 1.47e-04 GO:0001067 regulatory region nucleic acid binding
1.63 1.47e-04 GO:0044212 transcription regulatory region DNA binding
1.64 1.66e-04 GO:0010843 promoter binding
1.34 1.71e-04 GO:0043565 sequence-specific DNA binding
1.47 3.44e-04 GO:0042578 phosphoric ester hydrolase activity
1.68 5.47e-04 GO:0005085 guanyl-nucleotide exchange factor activity
2.01 9.24e-04 GO:0005089 Rho guanyl-nucleotide exchange factor activity
1.46 2.06e-03 GO:0016563 transcription activator activity
1.38 3.29e-03 GO:0019904 protein domain specific binding
1.77 3.43e-03 GO:0017124 SH3 domain binding
1.45 5.59e-03 GO:0005083 small GTPase regulator activity
1.49 6.75e-03 GO:0016791 phosphatase activity
1.81 8.04e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.59 1.28e-02 GO:0004721 phosphoprotein phosphatase activity
1.11 1.51e-02 GO:0043169 cation binding
1.11 1.67e-02 GO:0043167 ion binding
1.36 2.20e-02 GO:0008047 enzyme activator activity
1.10 2.32e-02 GO:0046872 metal ion binding
1.44 3.34e-02 GO:0005096 GTPase activator activity
1.22 4.64e-02 GO:0030234 enzyme regulator activity