Motif ID: HIF1A.p2

Z-value: 1.447


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_612317950.467.1e-02Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_174803768 1.881 NM_000794
DRD1
dopamine receptor D1
chr3_-_185025989 1.552 NM_024871
MAP6D1
MAP6 domain containing 1
chr2_-_97016027 1.297 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr21_+_25856311 1.278 MIR155HG
MIR155 host gene (non-protein coding)
chr1_-_77921681 1.270 ZZZ3
zinc finger, ZZ-type containing 3
chr13_-_110365282 1.222


chr10_-_64248932 0.953 NM_001136178
EGR2
early growth response 2
chr12_+_105873803 0.914 C12orf23
chromosome 12 open reading frame 23
chr1_+_191357788 0.851 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr13_-_43259032 0.849 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr17_+_32924110 0.849 DUSP14
dual specificity phosphatase 14
chr11_+_122936145 0.848 GRAMD1B
GRAM domain containing 1B
chr1_+_191357843 0.848 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr12_+_120635021 0.844 NM_001080825
TMEM120B
transmembrane protein 120B
chr1_+_243384868 0.821 NM_018012
KIF26B
kinesin family member 26B
chr2_-_227371698 0.813 NM_005544
IRS1
insulin receptor substrate 1
chr1_+_191357680 0.804 NM_024529
CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr10_+_35456393 0.803 NM_181571
NM_183060
CREM

cAMP responsive element modulator

chr9_+_99785405 0.799 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_-_47492421 0.775 NM_012235
SCAP
SREBF chaperone
chr3_-_73756668 0.756 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr16_+_51722285 0.751 CHD9
chromodomain helicase DNA binding protein 9
chr2_-_225615556 0.743 NM_014689
DOCK10
dedicator of cytokinesis 10
chr17_-_77421980 0.731 NM_001185077
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr5_+_110587546 0.729 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr12_+_105873669 0.727 NM_152261
C12orf23
chromosome 12 open reading frame 23
chr1_+_191357819 0.727 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr7_+_156624370 0.721 UBE3C
ubiquitin protein ligase E3C
chr3_-_47492320 0.716 SCAP
SREBF chaperone
chr1_-_77920914 0.714 NM_015534
ZZZ3
zinc finger, ZZ-type containing 3
chr1_+_191357906 0.707 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_-_9046460 0.696 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr11_+_13646806 0.680 FAR1
fatty acyl CoA reductase 1
chr11_+_32808045 0.676 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr13_+_97426713 0.664 IPO5
importin 5
chr10_-_43390014 0.661 NM_001099282
NM_001099283
NM_001099284
ZNF239


zinc finger protein 239


chr11_+_13646727 0.658 NM_032228
FAR1
fatty acyl CoA reductase 1
chr9_+_137532294 0.653 NM_016034
MRPS2
mitochondrial ribosomal protein S2
chr5_+_159276317 0.643 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr22_-_30072329 0.642 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr5_-_142763418 0.634 NM_000176
NM_001020825
NM_001024094
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr12_-_57600336 0.629 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr15_-_90999606 0.626 NM_207446
FAM174B
family with sequence similarity 174, member B
chr15_-_72922482 0.618 ULK3
unc-51-like kinase 3 (C. elegans)
chr6_+_73388713 0.615 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr5_-_49772940 0.615 EMB
embigin
chr3_-_48698244 0.608 NM_016453
NM_184231
NCKIPSD

NCK interacting protein with SH3 domain

chr5_-_49772973 0.602 NM_198449
EMB
embigin
chr9_+_6747636 0.596 NM_001146694
NM_001146695
NM_015061
KDM4C


lysine (K)-specific demethylase 4C


chr4_-_166253374 0.590 TMEM192
transmembrane protein 192
chr7_+_156624392 0.589 NM_014671
UBE3C
ubiquitin protein ligase E3C
chr19_-_12747263 0.587 HOOK2
hook homolog 2 (Drosophila)
chr1_+_12046020 0.582 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr10_+_35455806 0.582 NM_001881
NM_182850
NM_182853
NM_183013
CREM



cAMP responsive element modulator



chr4_-_90251571 0.579 FAM13A
family with sequence similarity 13, member A
chr4_-_83570318 0.578 NM_031372
HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr15_-_72922577 0.570 NM_001099436
ULK3
unc-51-like kinase 3 (C. elegans)
chr5_+_17270474 0.568 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr19_+_16083549 0.567 RAB8A
RAB8A, member RAS oncogene family
chr19_+_5638287 0.562


chr10_+_112247614 0.560 NM_004419
DUSP5
dual specificity phosphatase 5
chr1_-_153560532 0.559 NM_001039517
C1orf104
chromosome 1 open reading frame 104
chr19_-_12747421 0.558 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr8_+_98725505 0.556 NM_178812
MTDH
metadherin
chr5_+_1061900 0.550 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr10_+_35455986 0.548 CREM
cAMP responsive element modulator
chr12_-_48963505 0.547 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr4_-_166253453 0.544 NM_001100389
TMEM192
transmembrane protein 192
chr3_-_129024665 0.543 NM_001003794
MGLL
monoglyceride lipase
chr16_+_88169612 0.540 NM_014427
NM_153636
CPNE7

copine VII

chr15_-_72922533 0.538 ULK3
unc-51-like kinase 3 (C. elegans)
chr2_-_213724577 0.533 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_+_28717349 0.526 RCC1
regulator of chromosome condensation 1
chr21_+_44033871 0.521 RRP1
ribosomal RNA processing 1 homolog (S. cerevisiae)
chr1_+_153560351 0.518 NM_001105205
RUSC1
RUN and SH3 domain containing 1
chr8_-_72918697 0.511 MSC
musculin
chr14_+_101297887 0.508 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr7_+_156624424 0.505 UBE3C
ubiquitin protein ligase E3C
chr18_+_40513889 0.503 NM_001130110
SETBP1
SET binding protein 1
chr2_-_39040981 0.501 LOC375196
hypothetical LOC375196
chr15_-_72922532 0.499 ULK3
unc-51-like kinase 3 (C. elegans)
chr5_-_88215034 0.498 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr17_+_75689955 0.494 GAA
glucosidase, alpha; acid
chr12_-_62348506 0.494 NM_173812
DPY19L2
dpy-19-like 2 (C. elegans)
chr3_+_145173585 0.489 C3orf58
chromosome 3 open reading frame 58
chr19_-_60587414 0.487 NM_001190764
LOC388564
hypothetical protein LOC388564
chr1_+_45565126 0.483 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr3_-_16529996 0.482 RFTN1
raftlin, lipid raft linker 1
chr19_-_19599973 0.479 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr19_-_5671158 0.477 NM_004793
LONP1
lon peptidase 1, mitochondrial
chr14_+_54104099 0.476 SAMD4A
sterile alpha motif domain containing 4A
chr10_-_88720908 0.474 LOC100133190
hypothetical LOC100133190
chr17_+_75689985 0.474 GAA
glucosidase, alpha; acid
chr6_-_83832139 0.471 NM_198920
UBE2CBP
ubiquitin-conjugating enzyme E2C binding protein
chr15_+_89300973 0.468 RCCD1
RCC1 domain containing 1
chr12_+_38905053 0.467 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr4_-_122063118 0.460 NM_018699
PRDM5
PR domain containing 5
chr17_-_40263124 0.459 NM_005497
GJC1
gap junction protein, gamma 1, 45kDa
chr12_-_54938385 0.458 NM_173595
ANKRD52
ankyrin repeat domain 52
chr19_-_8803916 0.455 ZNF558
zinc finger protein 558
chr9_-_139316523 0.449 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr19_-_63550712 0.449 A1BG
alpha-1-B glycoprotein
chr5_+_134122359 0.448 NM_014829
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr9_+_111582317 0.443 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr4_-_186629841 0.443 NM_001145411
NM_152775
CCDC110

coiled-coil domain containing 110

chr19_-_5671136 0.442 LONP1
lon peptidase 1, mitochondrial
chr6_-_114399005 0.441 NM_001527
HDAC2
histone deacetylase 2
chrX_-_47394808 0.439 ELK1
ELK1, member of ETS oncogene family
chr4_+_17188202 0.437 LAP3
leucine aminopeptidase 3
chr19_+_13124889 0.436 IER2
immediate early response 2
chr14_+_89597860 0.435 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr19_-_5671155 0.435 LONP1
lon peptidase 1, mitochondrial
chr15_-_68177244 0.433 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr14_-_104718565 0.431 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr4_-_39655944 0.427 NM_001100399
NM_001100400
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr10_+_102746819 0.425 NM_032429
LZTS2
leucine zipper, putative tumor suppressor 2
chr10_+_35456095 0.425 CREM
cAMP responsive element modulator
chr11_+_69602055 0.422 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr11_-_787955 0.422 NM_001191060
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr19_+_1156773 0.422 NM_000455
STK11
serine/threonine kinase 11
chr5_+_10494979 0.422 NM_031916
ROPN1L
rhophilin associated tail protein 1-like
chr17_+_5126275 0.420 NM_001083585
NM_004703
RABEP1

rabaptin, RAB GTPase binding effector protein 1

chr8_+_26296439 0.419 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr21_-_29179482 0.418 NM_013240
NM_182749
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr19_+_16083434 0.418 NM_005370
RAB8A
RAB8A, member RAS oncogene family
chr16_-_3049336 0.416


chr4_-_83569572 0.414 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr7_-_35044177 0.414 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr7_+_148590152 0.413 NM_001195220
ZNF783
zinc finger family member 783
chrX_-_47394937 0.412 NM_001114123
NM_005229
ELK1

ELK1, member of ETS oncogene family

chr3_+_113534710 0.412 CD200
CD200 molecule
chr5_+_148941228 0.412 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr15_-_68177280 0.409 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr22_-_30071565 0.408 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr17_-_60345364 0.406 NM_199340
LRRC37A3
leucine rich repeat containing 37, member A3
chrX_-_131919896 0.404 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr22_-_22511173 0.400 NM_001002862
NM_001135751
NM_198440
DERL3


Der1-like domain family, member 3


chr1_+_13899272 0.399 NM_001135610
PRDM2
PR domain containing 2, with ZNF domain
chr9_-_76757555 0.399 NM_017998
C9orf40
chromosome 9 open reading frame 40
chr4_-_83569476 0.398 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr22_-_30071761 0.398 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr13_+_78068246 0.396 LOC780529
hypothetical LOC780529
chr15_-_68177283 0.395 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr14_+_54104383 0.393 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr12_+_129922589 0.392 RAN
RAN, member RAS oncogene family
chr22_-_49311439 0.391 NM_001169110
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr6_-_114398946 0.390 HDAC2
histone deacetylase 2
chrX_+_24077649 0.389 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr17_-_8643163 0.389 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr11_-_76059435 0.387 NM_001128922
LRRC32
leucine rich repeat containing 32
chr10_-_45410197 0.387 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr4_+_183302105 0.387 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr12_+_129922570 0.387 RAN
RAN, member RAS oncogene family
chr12_-_57600564 0.387 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr17_+_1905104 0.382 NM_006497
HIC1
hypermethylated in cancer 1
chr15_+_61356801 0.382 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr5_-_127447197 0.380 FLJ33630
hypothetical LOC644873
chr22_-_30016707 0.379 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr4_+_17187936 0.378 NM_015907
LAP3
leucine aminopeptidase 3
chrX_+_24077782 0.378 ZFX
zinc finger protein, X-linked
chr20_-_62186155 0.377 NM_001007125
C20orf201
chromosome 20 open reading frame 201
chr5_-_159730196 0.376 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr19_+_54872220 0.374 PRMT1
protein arginine methyltransferase 1
chr5_+_10495065 0.370 ROPN1L
rhophilin associated tail protein 1-like
chr5_+_49998677 0.370 PARP8
poly (ADP-ribose) polymerase family, member 8
chr1_+_65386559 0.367 AK4
adenylate kinase 4
chr7_-_148788799 0.367 NM_015694
ZNF777
zinc finger protein 777
chrX_+_16714452 0.366 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr1_+_88922424 0.366 NM_006256
PKN2
protein kinase N2
chr9_+_99785277 0.363 NM_006401
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr3_+_32123004 0.362 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr6_-_132764257 0.361 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr12_+_52806103 0.360 LOC400043
hypothetical LOC400043
chr5_-_1547872 0.359 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr2_-_144991386 0.359 ZEB2
zinc finger E-box binding homeobox 2
chr5_+_138637687 0.358 SNHG4
MATR3
small nucleolar RNA host gene 4 (non-protein coding)
matrin 3
chr5_+_176806401 0.357 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr17_+_32924049 0.356 NM_007026
DUSP14
dual specificity phosphatase 14
chr10_-_119795663 0.355 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr11_+_65049552 0.355 SCYL1
SCY1-like 1 (S. cerevisiae)
chr2_+_26768894 0.355 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr22_-_30072217 0.355 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr4_-_83569853 0.355 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr6_-_97452481 0.354 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr2_-_74915722 0.354


chr4_+_78298326 0.354 CCNG2
cyclin G2
chr9_+_129199204 0.352 NM_014580
SLC2A8
solute carrier family 2 (facilitated glucose transporter), member 8
chr19_-_18252440 0.352


chr2_+_74502364 0.352 NM_032118
WDR54
WD repeat domain 54
chr1_+_109963950 0.352 NM_139156
AMPD2
adenosine monophosphate deaminase 2
chr22_+_39072448 0.349 NM_000026
NM_001123378
ADSL

adenylosuccinate lyase

chr13_+_114098045 0.348 NM_001164144
NM_001164145
NM_032436
ZNF828


zinc finger protein 828


chr4_+_17188155 0.348 LAP3
leucine aminopeptidase 3
chr3_-_16530132 0.347 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr8_+_49083522 0.347 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr19_+_5671687 0.346 NM_152784
TMEM146
transmembrane protein 146
chrX_+_64804235 0.343 NM_002444
MSN
moesin
chr5_-_142762947 0.341 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr12_+_6514228 0.339 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr9_-_138378061 0.338 NM_001080849
DNLZ
DNL-type zinc finger

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 7.85e-04 GO:0044260 cellular macromolecule metabolic process
1.16 1.56e-03 GO:0044237 cellular metabolic process
1.14 4.73e-03 GO:0008152 metabolic process
2.98 9.16e-03 GO:0050770 regulation of axonogenesis
1.47 1.12e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.41 1.18e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.39 1.41e-02 GO:0022604 regulation of cell morphogenesis
2.13 2.10e-02 GO:0006913 nucleocytoplasmic transport
1.44 2.32e-02 GO:0006793 phosphorus metabolic process
1.44 2.32e-02 GO:0006796 phosphate metabolic process
2.37 2.45e-02 GO:0010975 regulation of neuron projection development
1.31 2.56e-02 GO:0043412 macromolecule modification
2.11 2.78e-02 GO:0051169 nuclear transport
1.08 2.90e-02 GO:0009987 cellular process
1.30 4.73e-02 GO:0006464 protein modification process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.49e-22 GO:0044424 intracellular part
1.16 1.46e-19 GO:0005622 intracellular
1.17 2.02e-14 GO:0043226 organelle
1.17 2.42e-14 GO:0043229 intracellular organelle
1.21 2.70e-14 GO:0005737 cytoplasm
1.19 4.76e-14 GO:0043231 intracellular membrane-bounded organelle
1.19 7.02e-14 GO:0043227 membrane-bounded organelle
1.23 7.56e-10 GO:0044444 cytoplasmic part
1.05 1.11e-06 GO:0044464 cell part
1.05 1.15e-06 GO:0005623 cell
1.36 1.32e-05 GO:0031090 organelle membrane
1.42 2.36e-05 GO:0012505 endomembrane system
1.18 5.28e-05 GO:0005634 nucleus
1.18 9.14e-05 GO:0044446 intracellular organelle part
1.17 2.76e-04 GO:0044422 organelle part
1.31 7.71e-04 GO:0005829 cytosol
1.52 1.85e-03 GO:0044432 endoplasmic reticulum part
1.45 4.09e-02 GO:0031967 organelle envelope
1.79 4.50e-02 GO:0005635 nuclear envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 9.20e-08 GO:0005515 protein binding
1.08 6.25e-05 GO:0005488 binding
1.28 3.27e-03 GO:0000166 nucleotide binding
1.21 7.78e-03 GO:0003676 nucleic acid binding
2.10 1.87e-02 GO:0004721 phosphoprotein phosphatase activity
1.39 3.80e-02 GO:0030528 transcription regulator activity