Motif ID: IKZF1.p2

Z-value: 1.441


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF1chr7_+_50314801-0.224.2e-01Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_108972048 2.503 EDAR
ectodysplasin A receptor
chr2_-_108972100 2.290 NM_022336
EDAR
ectodysplasin A receptor
chr14_-_23107106 1.440 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr20_-_44370537 1.182 CDH22
cadherin 22, type 2
chr20_-_3097070 1.161 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr14_+_102636233 1.126 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr11_+_111294868 1.108 C11orf52
chromosome 11 open reading frame 52
chr12_-_51585004 1.108 NM_002273
KRT8
keratin 8
chr20_-_49612745 0.996 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr14_+_23527866 0.980 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr17_+_50333021 0.924 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr2_+_197212522 0.920 NM_001080539
CCDC150
coiled-coil domain containing 150
chr16_-_23559978 0.904 NM_024675
PALB2
partner and localizer of BRCA2
chr2_+_201158824 0.900 AOX1
aldehyde oxidase 1
chr16_+_23560187 0.900 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr14_+_19365447 0.891 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr14_-_23493169 0.890 C14orf167
chromosome 14 open reading frame 167
chr4_+_609362 0.880 NM_000283
NM_001145291
PDE6B

phosphodiesterase 6B, cGMP-specific, rod, beta

chr14_-_23106779 0.878 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr14_+_23492780 0.837 NM_021004
DHRS4
dehydrogenase/reductase (SDR family) member 4
chr1_+_1971762 0.828 NM_002744
PRKCZ
protein kinase C, zeta
chr21_-_36774257 0.786 NM_001146079
NM_144492
CLDN14

claudin 14

chr1_+_3378030 0.779 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr14_+_23575460 0.772 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr16_-_65510230 0.740 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr11_+_111294810 0.737 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr2_+_96295751 0.720 CIAO1
cytosolic iron-sulfur protein assembly 1
chr2_-_113310796 0.716 NM_000576
IL1B
interleukin 1, beta
chr20_-_49612574 0.696 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr17_+_38575939 0.695 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr10_-_21825879 0.689 C10orf114
chromosome 10 open reading frame 114
chr17_+_70244945 0.673 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr20_-_32924219 0.663 NM_178026
GGT7
gamma-glutamyltransferase 7
chr14_-_34168911 0.651 SNX6
sorting nexin 6
chr22_-_30018329 0.646 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr9_+_132700462 0.646 ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr1_-_207892420 0.641 NM_000228
LAMB3
laminin, beta 3
chr17_+_71154240 0.625 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr3_+_197427779 0.623 NM_152672
OSTalpha
organic solute transporter alpha
chr16_+_23597735 0.621 PLK1
polo-like kinase 1
chr19_+_40431122 0.618 LSR
lipolysis stimulated lipoprotein receptor
chr1_+_19842309 0.610 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr14_+_23508922 0.609 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr1_+_26728839 0.602 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr11_+_20000938 0.600 NAV2
neuron navigator 2
chr20_-_44612619 0.598 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr16_+_23597691 0.593 PLK1
polo-like kinase 1
chr8_-_125785611 0.586 MTSS1
metastasis suppressor 1
chr20_+_55569542 0.585 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr3_-_12561962 0.578 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr16_+_23597692 0.576 NM_005030
PLK1
polo-like kinase 1
chr6_+_31838751 0.575 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr16_+_23597661 0.573 PLK1
polo-like kinase 1
chr16_+_23597713 0.569 PLK1
polo-like kinase 1
chr19_-_10807866 0.568 NM_006858
TMED1
transmembrane emp24 protein transport domain containing 1
chr1_+_31814672 0.561 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr5_+_140509803 0.558 NM_018939
PCDHB6
protocadherin beta 6
chr5_+_140537554 0.554 NM_019120
PCDHB8
protocadherin beta 8
chr19_-_15451203 0.552 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr1_+_26728827 0.551 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_+_11267823 0.548 NM_012466
TSPAN16
tetraspanin 16
chr5_+_176726918 0.542 RGS14
regulator of G-protein signaling 14
chr2_+_241279934 0.542 NM_198998
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr17_+_41424665 0.540 MAPT
microtubule-associated protein tau
chr20_+_41621119 0.539 SGK2
serum/glucocorticoid regulated kinase 2
chr6_-_33276141 0.534 RXRB
retinoid X receptor, beta
chr19_-_6432765 0.534 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr16_+_88517187 0.533 NM_006086
TUBB3
tubulin, beta 3
chr4_-_176970895 0.533 GPM6A
glycoprotein M6A
chr14_-_106282128 0.530 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_+_126112588 0.530 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr12_-_32940931 0.529 NM_001005242
NM_004572
PKP2

plakophilin 2

chr17_+_46067114 0.529 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr20_+_41621079 0.528 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr3_-_185578621 0.527 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr17_+_21249040 0.525 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr17_-_76720342 0.519 AATK
apoptosis-associated tyrosine kinase
chr2_-_218516950 0.517 NM_022648
TNS1
tensin 1
chr20_-_1257782 0.516 SDCBP2
syndecan binding protein (syntenin) 2
chr17_-_40344203 0.503 GFAP
glial fibrillary acidic protein
chr17_+_35728039 0.492 RARA
retinoic acid receptor, alpha
chr1_-_228916559 0.490 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_238164042 0.484 RAB17
RAB17, member RAS oncogene family
chr1_-_228916486 0.483 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_64108331 0.481 FAM20A
family with sequence similarity 20, member A
chr15_-_40236061 0.479 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr2_-_152538694 0.478 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr16_+_21518633 0.473 METTL9
methyltransferase like 9
chr6_-_33276426 0.472 RXRB
retinoid X receptor, beta
chr2_+_96295715 0.469 CIAO1
cytosolic iron-sulfur protein assembly 1
chr19_+_50004134 0.469 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr2_+_32142083 0.468 NM_014946
NM_199436
SPAST

spastin

chr1_+_31814709 0.467 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_-_39877883 0.466 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr16_+_4654710 0.465 MGRN1
mahogunin, ring finger 1
chr6_-_33276416 0.459 RXRB
retinoid X receptor, beta
chr1_-_39877928 0.458 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr1_+_246591505 0.458 NM_001004696
OR2T4
olfactory receptor, family 2, subfamily T, member 4
chr6_+_28357292 0.457 NM_001184743
NM_032507
PGBD1

piggyBac transposable element derived 1

chr1_+_113064711 0.454 NM_001004440
NM_182759
FAM19A3

family with sequence similarity 19 (chemokine (C-C motif)-like), member A3

chr22_+_21065134 0.454 LOC100290481
immunoglobulin lambda light chain-like
chr7_-_96471544 0.453 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr16_-_10581944 0.451 NM_001424
EMP2
epithelial membrane protein 2
chr10_+_44726635 0.450 NM_001123376
TMEM72
transmembrane protein 72
chr2_+_30523586 0.449 NM_182551
NM_001002257
LCLAT1

lysocardiolipin acyltransferase 1

chr9_+_129951552 0.441 NM_005564
LCN2
lipocalin 2
chr20_-_1257809 0.441 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr9_+_34636608 0.440 NM_000155
GALT
galactose-1-phosphate uridylyltransferase
chr11_-_16992524 0.437 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr10_+_102881050 0.437 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr3_+_51992339 0.436 NM_000666
NM_001198895
NM_001198896
NM_001198897
NM_001198898
ACY1




aminoacylase 1




chr17_-_38575737 0.434 BRCA1
breast cancer 1, early onset
chr22_+_21065202 0.433


chr19_-_18913032 0.433 NM_004838
HOMER3
homer homolog 3 (Drosophila)
chr2_-_21120398 0.430 APOB
apolipoprotein B (including Ag(x) antigen)
chr18_-_26935883 0.427 NM_004949
NM_024422
DSC2

desmocollin 2

chr6_-_33276131 0.425 RXRB
retinoid X receptor, beta
chr9_-_15297148 0.424 TTC39B
tetratricopeptide repeat domain 39B
chr5_-_125958503 0.423 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr7_-_103417198 0.422 NM_005045
NM_173054
RELN

reelin

chr1_+_45046740 0.421 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr3_+_143925904 0.421 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr5_-_45731588 0.420 HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr4_-_176970407 0.418 GPM6A
glycoprotein M6A
chr2_-_220144254 0.417 OBSL1
obscurin-like 1
chr17_+_35728070 0.416 RARA
retinoic acid receptor, alpha
chr9_+_132700567 0.416 NM_005157
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr11_+_6216905 0.415 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr6_-_27548438 0.413 NM_007149
ZNF184
zinc finger protein 184
chr17_+_24394043 0.412 NM_016518
PIPOX
pipecolic acid oxidase
chr1_-_228916470 0.411 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_+_225982862 0.410 LOC100130093
hypothetical LOC100130093
chr22_+_44059491 0.408 NM_001167574
NM_006953
UPK3A

uroplakin 3A

chr19_-_18913017 0.407 HOMER3
homer homolog 3 (Drosophila)
chr2_-_165406173 0.403 NM_014900
COBLL1
COBL-like 1
chr1_-_31942206 0.402 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr17_-_77411803 0.402 NM_000918
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr5_+_176807931 0.399 NM_001174102
PRR7
proline rich 7 (synaptic)
chr2_-_96295471 0.399 NM_001193304
NM_017849
TMEM127

transmembrane protein 127

chr12_-_56445653 0.398 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr19_-_50779914 0.396 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr20_+_34635362 0.396 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr1_+_27062215 0.396 NM_006142
SFN
stratifin
chr17_+_4621924 0.394 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr14_+_23675206 0.392 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr2_-_165406098 0.392 COBLL1
COBL-like 1
chr17_-_40344322 0.390


chr9_+_137593420 0.389 NM_001018049
NM_002571
PAEP

progestagen-associated endometrial protein

chr10_-_21826192 0.389 C10orf114
chromosome 10 open reading frame 114
chr2_-_96295443 0.388 TMEM127
transmembrane protein 127
chr10_-_21826211 0.387 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr15_-_88578118 0.387 CIB1
calcium and integrin binding 1 (calmyrin)
chr5_+_140166842 0.386 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr7_-_100078270 0.386 TFR2
transferrin receptor 2
chr6_+_126112431 0.385 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr1_+_26728846 0.384 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr9_+_4975082 0.384 JAK2
Janus kinase 2
chr5_+_175231144 0.383 CPLX2
complexin 2
chr1_-_199635057 0.382 LAD1
ladinin 1
chr1_-_159257486 0.381 F11R
F11 receptor
chr15_+_88578467 0.381 NM_001013657
C15orf58
chromosome 15 open reading frame 58
chr2_+_96295608 0.380 NM_004804
CIAO1
cytosolic iron-sulfur protein assembly 1
chr14_+_22633728 0.380 C14orf119
chromosome 14 open reading frame 119
chrX_+_152252738 0.379 NM_001080485
ZNF275
zinc finger protein 275
chr4_-_176971175 0.379 NM_201591
GPM6A
glycoprotein M6A
chr2_-_74583850 0.379 NM_001009812
LBX2
ladybird homeobox 2
chr17_+_35390607 0.379 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr16_+_55217085 0.378 NM_175617
MT1E
metallothionein 1E
chr2_-_104834344 0.378 LOC100506421
hypothetical LOC100506421
chr8_+_7332600 0.377 NM_152250
NM_001040703
DEFB105A
DEFB105B
defensin, beta 105A
defensin, beta 105B
chr2_-_171998681 0.377 METTL8
methyltransferase like 8
chr2_+_96295680 0.375 CIAO1
cytosolic iron-sulfur protein assembly 1
chr16_+_29726931 0.375 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_+_33276580 0.374 NM_001077516
NM_006979
SLC39A7

solute carrier family 39 (zinc transporter), member 7

chr6_-_33276347 0.371 NM_021976
RXRB
retinoid X receptor, beta
chr17_-_53950191 0.370 NM_004687
MTMR4
myotubularin related protein 4
chr8_-_87311624 0.368 NM_138817
SLC7A13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr12_-_192990 0.367 NM_001122847
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr17_+_35390579 0.367 NM_002809
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr10_-_74384485 0.367 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr20_+_61842880 0.365 SLC2A4RG
SLC2A4 regulator
chr1_-_207892296 0.364 NM_001127641
LAMB3
laminin, beta 3
chr2_-_128285214 0.364 NM_001006622
NM_001006623
NM_018383
WDR33


WD repeat domain 33


chr7_+_1543644 0.364 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr16_-_11587647 0.363 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr19_-_14771947 0.362 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr9_+_114953048 0.361 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr17_-_7095982 0.361 NM_015343
CTDNEP1
CTD nuclear envelope phosphatase 1
chr20_-_697127 0.361 NM_033409
C20orf54
chromosome 20 open reading frame 54
chr5_+_175231210 0.360 CPLX2
complexin 2
chr2_-_24869718 0.359 NM_001013663
C2orf79
chromosome 2 open reading frame 79
chr17_-_77411659 0.359 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr11_-_65860450 0.359 NM_004292
RIN1
Ras and Rab interactor 1
chr16_+_55217180 0.359 MT1E
metallothionein 1E
chr17_+_35390641 0.358 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr19_-_40995564 0.357 PRODH2
proline dehydrogenase (oxidase) 2
chr14_+_23590939 0.356 NM_138360
LRRC16B
leucine rich repeat containing 16B
chr16_+_24985721 0.355 LOC283887
hypothetical protein LOC283887
chr16_-_2848106 0.355 NM_022119
PRSS22
protease, serine, 22
chr1_-_150653351 0.354 NM_016190
CRNN
cornulin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 1.15e-05 GO:0009987 cellular process
1.42 1.19e-02 GO:0042981 regulation of apoptosis
1.42 1.24e-02 GO:0043067 regulation of programmed cell death
1.40 3.05e-02 GO:0010941 regulation of cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.02e-02 GO:0005737 cytoplasm
1.26 1.05e-02 GO:0005829 cytosol
1.12 1.89e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 8.60e-04 GO:0005515 protein binding
1.06 4.42e-02 GO:0005488 binding