Motif ID: IRF1,2,7.p3

Z-value: 2.522


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF1chr5_-_131854325-0.467.1e-02Click!
IRF7chr11_-_605649-0.214.4e-01Click!
IRF2chr4_-_185632610-0.175.3e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_78858675 2.937 NM_006820
IFI44L
interferon-induced protein 44-like
chr17_+_75851984 2.821


chr12_+_93066370 2.718 NM_005761
PLXNC1
plexin C1
chr10_+_91077581 2.091 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91082218 2.042 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_+_230900121 1.940 NM_138402
SP140L
SP140 nuclear body protein-like
chr17_+_38719371 1.868 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr6_+_26548678 1.832 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr10_+_91142301 1.788 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr12_+_111900650 1.727 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr4_+_142777172 1.694 NM_000585
NM_172174
IL15

interleukin 15

chr2_+_6935246 1.641 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr15_+_42790951 1.621 NM_004048
B2M
beta-2-microglobulin
chr6_-_27948065 1.615 NM_003533
HIST1H3I
histone cluster 1, H3i
chrX_+_77041612 1.605 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr2_-_175337386 1.578 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr16_-_88358946 1.566 FANCA
Fanconi anemia, complementation group A
chr12_+_27568311 1.559 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr11_-_104274606 1.554 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr19_+_49361054 1.513 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr18_-_6404900 1.506 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr4_+_187227302 1.488 NM_003265
TLR3
toll-like receptor 3
chr7_-_76883642 1.441 NM_017439
PION
pigeon homolog (Drosophila)
chr3_+_120904555 1.419 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr19_-_52427698 1.419 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr1_+_97033103 1.401


chr14_+_31100330 1.399 NM_025152
NUBPL
nucleotide binding protein-like
chr9_+_5500544 1.390 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr11_-_60880799 1.385 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr9_-_21197141 1.384 NM_002171
IFNA10
interferon, alpha 10
chr2_-_230792844 1.364 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr15_+_68971835 1.322 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr9_-_21295311 1.318 NM_002169
IFNA5
interferon, alpha 5
chr11_+_1830763 1.308 NM_002339
LSP1
lymphocyte-specific protein 1
chr16_+_10878539 1.300 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr13_-_42464301 1.274 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr12_-_9252227 1.252 NM_002864
PZP
pregnancy-zone protein
chr4_+_37569093 1.235 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr2_-_101134146 1.226 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr4_-_157094443 1.224 NM_001334
CTSO
cathepsin O
chr11_-_104477367 1.201 NM_001007232
CARD17
caspase recruitment domain family, member 17
chr3_-_152641248 1.158 NM_001178145
NM_001178146
IGSF10

immunoglobulin superfamily, member 10

chr9_-_21375258 1.149 NM_000605
IFNA2
interferon, alpha 2
chr8_-_145132551 1.148 PARP10
poly (ADP-ribose) polymerase family, member 10
chr9_-_21132143 1.146 NM_002177
IFNW1
interferon, omega 1
chr2_-_6923215 1.146 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_+_124438217 1.136 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr8_-_145132582 1.136 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr12_-_15265490 1.134 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr3_+_114733907 1.128 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr1_+_78888064 1.125 NM_006417
IFI44
interferon-induced protein 44
chr2_+_143351695 1.118 KYNU
kynureninase
chr8_+_54926920 1.117 NM_170587
RGS20
regulator of G-protein signaling 20
chr9_-_21229975 1.107 NM_002172
IFNA14
interferon, alpha 14
chr14_-_106184988 1.095 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_159334774 1.084 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr3_+_48482625 1.081 TREX1
three prime repair exonuclease 1
chr16_+_55580910 1.070 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr11_-_60475558 1.065 NM_016582
SLC15A3
solute carrier family 15, member 3
chr14_+_90650466 1.055 C14orf159
chromosome 14 open reading frame 159
chr3_-_173723754 1.030 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr3_+_109504021 1.027 NM_007072
HHLA2
HERV-H LTR-associating 2
chr14_+_94160046 1.023


chr10_+_63478974 1.018 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_-_9052170 1.011 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr12_+_12115668 1.004 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr13_+_48967746 1.002 NM_001040443
PHF11
PHD finger protein 11
chr17_+_6599879 0.968 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr10_+_115429415 0.958 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr3_-_102888090 0.954 NM_000986
RPL24
ribosomal protein L24
chr2_-_55090759 0.951 NM_007008
RTN4
reticulon 4
chr10_+_115429622 0.937 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr11_+_7463175 0.929 NM_198474
OLFML1
olfactomedin-like 1
chr1_+_157246305 0.927 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr1_-_89303478 0.927 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr4_-_100359353 0.923 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr1_+_208568811 0.917 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr2_+_73911477 0.907 STAMBP
STAM binding protein
chr12_+_6431437 0.903 NM_018009
TAPBPL
TAP binding protein-like
chr14_+_90650220 0.899 C14orf159
chromosome 14 open reading frame 159
chr6_+_37081387 0.898 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr6_-_30289092 0.896 NM_003449
TRIM26
tripartite motif containing 26
chr8_+_79740813 0.890 NM_016010
FAM164A
family with sequence similarity 164, member A
chr6_+_6533932 0.886 NM_004271
LY86
lymphocyte antigen 86
chr6_-_110843432 0.882 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr15_+_76619842 0.875 PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr10_+_22765996 0.867 LOC100289455
hypothetical LOC100289455
chr22_-_48604455 0.865 NM_014577
BRD1
bromodomain containing 1
chr14_+_31868229 0.863 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr20_-_55628852 0.855 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr13_-_33148899 0.854 STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_9052207 0.853 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr22_-_16080265 0.852 CECR1
cat eye syndrome chromosome region, candidate 1
chr20_+_336693 0.851 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr14_+_34521854 0.847 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr14_-_69953433 0.846 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr7_+_139750311 0.845 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr9_-_32516164 0.841 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr20_+_336717 0.835 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr3_+_188568861 0.834 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chrX_+_14457340 0.833 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr4_+_89597257 0.822 NM_016323
HERC5
hect domain and RLD 5
chr13_-_43101608 0.820 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr2_+_69822609 0.805 NM_001153
ANXA4
annexin A4
chr1_-_9052253 0.802 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr11_-_104421240 0.799 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr2_+_218641982 0.797 NM_198483
RUFY4
RUN and FYVE domain containing 4
chr3_-_115825742 0.796 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_102269580 0.789 NM_015490
SEC31B
SEC31 homolog B (S. cerevisiae)
chr21_+_37514925 0.788 DSCR9
Down syndrome critical region gene 9 (non-protein coding)
chr1_+_245646080 0.780 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr16_-_46823682 0.772 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr2_-_68143618 0.770 C1D
C1D nuclear receptor corepressor
chr16_-_49272617 0.760 SNX20
sorting nexin 20
chr17_+_6600080 0.755 XAF1
XIAP associated factor 1
chr4_-_130233855 0.755 NM_144643
SCLT1
sodium channel and clathrin linker 1
chr19_-_51909416 0.754 NM_001079882
PRKD2
protein kinase D2
chr10_+_91051685 0.750 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr14_-_106202262 0.743 IGLJ3
IGHA1
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
chr3_-_115960807 0.733 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr3_+_133798770 0.732 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr17_-_36409632 0.732 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr20_+_5055393 0.729 NM_003818
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr19_-_7672978 0.727 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr20_+_336941 0.725 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_+_15843418 0.724 NM_017775
TTC19
tetratricopeptide repeat domain 19
chr9_-_113561613 0.720 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr20_+_226200 0.717 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr9_+_5440455 0.717 NM_014143
CD274
CD274 molecule
chr2_-_227737009 0.713 COL4A4
collagen, type IV, alpha 4
chr20_-_24986501 0.706 ACSS1
acyl-CoA synthetase short-chain family member 1
chr4_-_53926764 0.703 NM_152540
SCFD2
sec1 family domain containing 2
chr3_+_48482213 0.700 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr2_+_173794692 0.695 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr7_+_12217343 0.693 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr22_-_34965498 0.693 APOL2
apolipoprotein L, 2
chr2_-_27210792 0.689 PREB
prolactin regulatory element binding
chr15_-_42790805 0.676


chr9_-_21207303 0.666 NM_002173
IFNA16
interferon, alpha 16
chr3_+_106568243 0.663 ALCAM
activated leukocyte cell adhesion molecule
chr2_+_114935623 0.660 NM_001178036
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr13_-_47899043 0.656 NM_001162497
LPAR6
lysophosphatidic acid receptor 6
chr9_-_33254458 0.653 NM_001172415
NM_004323
BAG1

BCL2-associated athanogene

chr11_-_88962426 0.651 NM_001143837
NOX4
NADPH oxidase 4
chr3_+_139388770 0.649 NM_014154
NM_015396
NM_213654
ARMC8


armadillo repeat containing 8


chr12_-_57600336 0.647 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr20_+_60906605 0.647 NM_007346
OGFR
opioid growth factor receptor
chr7_+_154351087 0.647 LOC100132707
hypothetical LOC100132707
chr11_-_4371463 0.640 NM_003141
TRIM21
tripartite motif containing 21
chr9_-_21358005 0.635 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr12_-_116983276 0.632 NM_018639
WSB2
WD repeat and SOCS box containing 2
chr2_+_201806410 0.630 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr17_-_41018291 0.628


chr5_-_75044001 0.627 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr7_+_134483305 0.627 NM_018295
TMEM140
transmembrane protein 140
chr9_+_21399132 0.625 NM_002170
IFNA8
interferon, alpha 8
chr12_-_8584658 0.619 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr19_-_18058632 0.619 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr9_-_34700062 0.617 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr21_-_42219849 0.616 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr2_+_122229590 0.607 NM_004622
TSN
translin
chr15_+_76619801 0.605 NM_001102667
NM_001102668
NM_002789
PSMA4


proteasome (prosome, macropain) subunit, alpha type, 4


chr4_-_95482994 0.604 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr2_-_242449662 0.601 NM_005018
PDCD1
programmed cell death 1
chr2_+_190014403 0.601 NM_032168
WDR75
WD repeat domain 75
chr4_-_77163609 0.601 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr4_+_160408447 0.595 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr9_-_21340885 0.595 NM_021002
IFNA6
interferon, alpha 6
chr22_+_34979118 0.595 APOL1
apolipoprotein L, 1
chr11_+_58146721 0.591 NM_000614
CNTF
ciliary neurotrophic factor
chr1_+_81544432 0.588 LPHN2
latrophilin 2
chr7_+_128367961 0.587 NM_001098627
IRF5
interferon regulatory factor 5
chr4_+_130234278 0.587 NM_173487
C4orf33
chromosome 4 open reading frame 33
chr22_+_37683472 0.586 NM_001193289
NM_145699
APOBEC3A

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

chr1_+_156416360 0.584 NM_001766
CD1D
CD1d molecule
chr6_-_149847718 0.584 ZC3H12D
zinc finger CCCH-type containing 12D
chr2_+_190014432 0.581 WDR75
WD repeat domain 75
chr4_-_89963177 0.577 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr5_+_140719773 0.577 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr6_+_131498540 0.573 AKAP7
A kinase (PRKA) anchor protein 7
chr19_+_44450993 0.573 NM_172138
IL28A
interleukin 28A (interferon, lambda 2)
chr10_+_97505398 0.570 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_+_2975590 0.569 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr16_-_49272741 0.569 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr11_-_47226754 0.566 ACP2
acid phosphatase 2, lysosomal
chr14_-_34252695 0.558 NM_021914
CFL2
cofilin 2 (muscle)
chr12_+_95825131 0.557 NM_001135176
NM_001135177
NM_152905
NEDD1


neural precursor cell expressed, developmentally down-regulated 1


chr6_+_17501589 0.557 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr17_-_30783631 0.555 NM_018042
SLFN12
schlafen family member 12
chr17_-_40695216 0.554 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr19_-_62348381 0.554 NM_052882
ZIM3
zinc finger, imprinted 3
chr1_-_2486313 0.552 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr9_-_21192201 0.552 NM_021057
IFNA7
interferon, alpha 7
chr22_-_34965612 0.549 NM_030882
APOL2
apolipoprotein L, 2
chr14_+_21203136 0.548 NM_001001912
OR4E2
olfactory receptor, family 4, subfamily E, member 2
chr22_-_34886727 0.548 NM_145640
APOL3
apolipoprotein L, 3
chr6_-_121697305 0.544 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr2_+_33554824 0.541 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr9_-_21177529 0.540 NM_021068
IFNA4
interferon, alpha 4
chr10_-_5436781 0.538 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.57 2.64e-17 GO:0060337 type I interferon-mediated signaling pathway
7.57 2.64e-17 GO:0071357 cellular response to type I interferon
7.45 4.87e-17 GO:0034340 response to type I interferon
3.02 1.65e-13 GO:0045087 innate immune response
2.31 8.29e-13 GO:0006955 immune response
4.13 2.57e-12 GO:0009615 response to virus
1.95 4.45e-12 GO:0002376 immune system process
3.46 1.97e-09 GO:0019221 cytokine-mediated signaling pathway
2.08 2.06e-09 GO:0006952 defense response
3.27 4.53e-09 GO:0071345 cellular response to cytokine stimulus
8.08 1.68e-08 GO:0060338 regulation of type I interferon-mediated signaling pathway
2.68 3.32e-07 GO:0034097 response to cytokine stimulus
2.31 4.11e-06 GO:0051707 response to other organism
2.16 6.10e-06 GO:0009607 response to biotic stimulus
1.83 7.23e-06 GO:0051704 multi-organism process
4.64 2.15e-05 GO:0001959 regulation of cytokine-mediated signaling pathway
4.57 2.89e-05 GO:0060759 regulation of response to cytokine stimulus
1.92 3.24e-05 GO:0002682 regulation of immune system process
1.22 3.97e-04 GO:0050896 response to stimulus
2.05 5.13e-04 GO:0050776 regulation of immune response
2.26 5.58e-04 GO:0031347 regulation of defense response
1.85 8.57e-04 GO:0071310 cellular response to organic substance
2.08 4.34e-03 GO:0044419 interspecies interaction between organisms
1.36 8.82e-03 GO:0006950 response to stress
1.40 1.61e-02 GO:0048583 regulation of response to stimulus
1.83 1.67e-02 GO:0080134 regulation of response to stress
1.58 2.96e-02 GO:0070887 cellular response to chemical stimulus
2.68 3.03e-02 GO:0001819 positive regulation of cytokine production
2.42 3.93e-02 GO:0045088 regulation of innate immune response

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.03 5.90e-07 GO:0005126 cytokine receptor binding
13.25 2.26e-05 GO:0005132 interferon-alpha/beta receptor binding
2.44 1.38e-03 GO:0005125 cytokine activity