Motif ID: JUN.p2

Z-value: 1.279


Transcription factors associated with JUN.p2:

Gene SymbolEntrez IDGene Name
JUN 3725 jun oncogene
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
JUNBchr19_+_127632950.683.8e-03Click!
JUNDchr19_-_182530480.514.2e-02Click!
JUNchr1_-_590208750.292.8e-01Click!


Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_42303517 1.982 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr21_-_43671355 1.588 NM_173354
SIK1
salt-inducible kinase 1
chr1_-_703848 1.548 LOC100288069
hypothetical LOC100288069
chr5_+_112877251 1.328 NM_022828
YTHDC2
YTH domain containing 2
chr8_-_95343716 1.244 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr8_-_95343696 1.184 GEM
GTP binding protein overexpressed in skeletal muscle
chr4_+_75699652 1.176 NM_001657
AREG
amphiregulin
chr4_+_75529716 1.149 NM_001657
AREG
amphiregulin
chr1_+_26368969 1.140 NM_015871
ZNF593
zinc finger protein 593
chr22_+_20101661 1.110 NM_015094
HIC2
hypermethylated in cancer 2
chr6_-_53321545 1.093 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chrX_-_151996613 1.060 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr1_+_27591738 1.037 NM_005281
GPR3
G protein-coupled receptor 3
chr6_-_53321658 1.024 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr6_-_53321706 0.998 NM_021814
ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr16_-_3008162 0.978 NM_021195
CLDN6
claudin 6
chrX_+_151991474 0.954 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr2_+_74635354 0.924 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr6_+_44322764 0.914 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr3_-_33734544 0.910 CLASP2
cytoplasmic linker associated protein 2
chr7_+_134483305 0.907 NM_018295
TMEM140
transmembrane protein 140
chrX_-_47364039 0.906


chr22_+_20326572 0.903 SDF2L1
stromal cell-derived factor 2-like 1
chr7_-_158314945 0.897 ESYT2
extended synaptotagmin-like protein 2
chr7_-_45117797 0.892 TBRG4
transforming growth factor beta regulator 4
chr7_-_140270749 0.887 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr11_-_69228286 0.883 NM_005117
FGF19
fibroblast growth factor 19
chr8_+_23442331 0.880 SLC25A37
solute carrier family 25, member 37
chr1_+_29435534 0.879 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr19_-_10202947 0.868 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chrX_-_47364173 0.865 NM_006950
NM_133499
SYN1

synapsin I

chr22_-_18807805 0.860 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr22_+_20326541 0.846 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr7_-_45117822 0.840 NM_004749
NM_030900
NM_199122
TBRG4


transforming growth factor beta regulator 4


chr11_-_85053807 0.837 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr1_-_240228987 0.837 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr6_+_44322831 0.836 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr21_-_38210531 0.827 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr11_-_85053709 0.808 CREBZF
CREB/ATF bZIP transcription factor
chr20_+_31717964 0.800 NM_001024675
C20orf134
chromosome 20 open reading frame 134
chr17_-_13445942 0.799 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr5_-_172130766 0.791 NM_004417
DUSP1
dual specificity phosphatase 1
chr2_-_156897286 0.786 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr22_+_20326591 0.781 SDF2L1
stromal cell-derived factor 2-like 1
chr3_+_197851052 0.777 NM_198565
LRRC33
leucine rich repeat containing 33
chr8_+_23442413 0.773 SLC25A37
solute carrier family 25, member 37
chr7_+_116447527 0.772 ST7
suppression of tumorigenicity 7
chr6_+_39868116 0.756


chr12_-_91063441 0.748 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr6_+_39868126 0.746 DAAM2
dishevelled associated activator of morphogenesis 2
chr7_-_23537968 0.741 NM_013293
TRA2A
transformer 2 alpha homolog (Drosophila)
chr19_-_8670054 0.739 NM_178525
ACTL9
actin-like 9
chr8_-_142586487 0.731 NM_207414
FLJ43860
FLJ43860 protein
chr4_-_186693574 0.724 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr9_+_131291224 0.722 LOC100506190
hypothetical LOC100506190
chr11_-_61341011 0.715 NM_013402
FADS1
fatty acid desaturase 1
chr2_+_74635019 0.708 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chrX_+_48282992 0.697 NM_002536
TBC1D25
TBC1 domain family, member 25
chr1_+_226394626 0.696 GUK1
guanylate kinase 1
chr22_+_20326615 0.693 SDF2L1
stromal cell-derived factor 2-like 1
chr22_-_18484428 0.683 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr1_+_226394605 0.681 GUK1
guanylate kinase 1
chr7_-_152004096 0.681 NM_005431
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr4_-_120595218 0.676


chr20_-_44034346 0.669 ZNF335
zinc finger protein 335
chr6_+_34324322 0.667


chr8_+_23442307 0.665 NM_016612
SLC25A37
solute carrier family 25, member 37
chr11_-_68537243 0.663 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr1_+_226394545 0.663 NM_000858
NM_001159390
GUK1

guanylate kinase 1

chr1_+_226394589 0.662 GUK1
guanylate kinase 1
chr1_-_1283770 0.662 NM_032348
MXRA8
matrix-remodelling associated 8
chr19_+_13124889 0.651 IER2
immediate early response 2
chr19_-_5291700 0.644 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr4_-_111777651 0.641 PITX2
paired-like homeodomain 2
chr19_-_10375242 0.630 NM_007065
CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr19_+_13124870 0.628 IER2
immediate early response 2
chr7_+_116447499 0.627 ST7
suppression of tumorigenicity 7
chr2_-_96899396 0.624 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr7_+_120378052 0.615 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chrX_+_48283106 0.604 TBC1D25
TBC1 domain family, member 25
chr6_+_43319199 0.603 NM_032538
TTBK1
tau tubulin kinase 1
chr16_-_3707450 0.602 NM_016292
TRAP1
TNF receptor-associated protein 1
chr9_+_131291144 0.592


chr6_+_47553399 0.589 NM_012120
CD2AP
CD2-associated protein
chr18_-_257987 0.587 NM_005131
THOC1
THO complex 1
chr1_+_226394638 0.576 GUK1
guanylate kinase 1
chr9_-_139473606 0.571 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
NELF




nasal embryonic LHRH factor




chr19_-_48791967 0.571 NM_001007561
IRGQ
immunity-related GTPase family, Q
chr11_-_118693021 0.570 NM_006500
MCAM
melanoma cell adhesion molecule
chr2_+_30307900 0.569 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr4_-_111777584 0.557 PITX2
paired-like homeodomain 2
chr7_-_158314963 0.551 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr3_+_42165740 0.549 TRAK1
trafficking protein, kinesin binding 1
chrX_+_148671394 0.548 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr14_+_104290511 0.547 NM_006427
NM_021709
SIVA1

SIVA1, apoptosis-inducing factor

chr11_+_117362272 0.546 NM_001558
IL10RA
interleukin 10 receptor, alpha
chr1_+_240078167 0.544 EXO1
exonuclease 1
chr2_-_74634569 0.527 NM_032603
LOXL3
lysyl oxidase-like 3
chr6_+_41997212 0.527 BYSL
bystin-like
chr16_-_4837266 0.526 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr14_+_104290561 0.521 SIVA1
SIVA1, apoptosis-inducing factor
chr6_+_41997169 0.518 BYSL
bystin-like
chr15_-_89338728 0.517 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr1_-_152394215 0.509 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr11_-_5487728 0.508 NM_017481
UBQLN3
ubiquilin 3
chr3_-_188946168 0.506 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr4_+_119732338 0.505 LOC729218
hypothetical LOC729218
chr3_+_158026769 0.505 NM_001004316
NM_001193283
LEKR1

leucine, glutamate and lysine rich 1

chr3_+_9950474 0.505 CRELD1
cysteine-rich with EGF-like domains 1
chr16_+_25030595 0.503 LCMT1
leucine carboxyl methyltransferase 1
chr10_-_7491204 0.500 NM_001018039
SFMBT2
Scm-like with four mbt domains 2
chr7_+_65596078 0.497


chr9_+_133154896 0.497 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr10_-_62373828 0.492 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr7_+_111877699 0.491 NM_001550
IFRD1
interferon-related developmental regulator 1
chr17_+_1580504 0.491 WDR81
WD repeat domain 81
chr4_-_23500706 0.490 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr8_-_41641881 0.489 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr19_+_44591589 0.489


chr3_+_9950513 0.489 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr3_-_143426986 0.487 GK5
glycerol kinase 5 (putative)
chr5_-_95323353 0.486 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr17_+_22645232 0.484 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr9_-_139473569 0.481 NELF
nasal embryonic LHRH factor
chr19_-_55706156 0.481 NM_138334
JOSD2
Josephin domain containing 2
chr5_+_139534874 0.478 C5orf32
chromosome 5 open reading frame 32
chr19_-_10375185 0.477 CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr20_+_43854013 0.477 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr19_-_45611110 0.475 NM_020956
NM_181882
PRX

periaxin

chr4_-_140696740 0.467 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr22_-_17512174 0.467 NM_022719
DGCR14
DiGeorge syndrome critical region gene 14
chr7_+_105304445 0.464 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr5_+_175807978 0.462 FAF2
Fas associated factor family member 2
chr7_-_137337354 0.461 NM_194071
CREB3L2
cAMP responsive element binding protein 3-like 2
chr18_+_258147 0.460


chr1_-_23367934 0.458 NM_001142546
NM_033631
LUZP1

leucine zipper protein 1

chr19_-_10375150 0.458 CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr20_-_44034194 0.456 NM_022095
ZNF335
zinc finger protein 335
chr5_+_175807986 0.454 FAF2
Fas associated factor family member 2
chr3_+_42165829 0.454 TRAK1
trafficking protein, kinesin binding 1
chr22_-_17512097 0.452 DGCR14
DiGeorge syndrome critical region gene 14
chr1_-_180822686 0.452 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr6_-_166321516 0.451 C6orf176
chromosome 6 open reading frame 176
chr20_+_43854017 0.450 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr6_-_127822227 0.448 NM_014702
KIAA0408
KIAA0408
chr1_+_166414706 0.445 NM_001031800
NM_152902
TIPRL

TIP41, TOR signaling pathway regulator-like (S. cerevisiae)

chr1_-_1274618 0.444 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr22_+_40286957 0.441 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr11_-_8982107 0.440 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr7_+_151353707 0.437 NM_022087
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr1_-_23367871 0.437 LUZP1
leucine zipper protein 1
chr5_+_175807961 0.435 NM_014613
FAF2
Fas associated factor family member 2
chr16_+_27320983 0.432 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr6_-_91063181 0.429 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr3_+_38181972 0.428 NM_005109
OXSR1
oxidative-stress responsive 1
chr6_-_135860479 0.424 AHI1
Abelson helper integration site 1
chr3_+_129690735 0.421


chr5_+_175807992 0.421 FAF2
Fas associated factor family member 2
chr10_+_50177192 0.420 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr22_-_18484695 0.419 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr7_+_107007858 0.418 BCAP29
B-cell receptor-associated protein 29
chr19_+_48912053 0.415 NM_019612
IRGC
immunity-related GTPase family, cinema
chr19_-_6432765 0.415 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr9_-_129564517 0.414 NM_001142532
NM_001142531
SH2D3C

SH2 domain containing 3C

chr1_-_21982256 0.413 NM_001032730
NM_032236
USP48

ubiquitin specific peptidase 48

chr20_+_43853982 0.412 NM_052951
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr9_+_132990760 0.412 NM_005085
NUP214
nucleoporin 214kDa
chr7_+_30927439 0.409 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr1_-_23367918 0.409 LUZP1
leucine zipper protein 1
chr7_+_127015650 0.404 NM_001662
ARF5
ADP-ribosylation factor 5
chr11_-_1549719 0.404 NM_004420
DUSP8
dual specificity phosphatase 8
chr7_-_129379947 0.403 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr6_-_31779068 0.402 ABHD16A
abhydrolase domain containing 16A
chr1_+_210848763 0.400 ATF3
activating transcription factor 3
chr7_-_137337352 0.398 CREB3L2
cAMP responsive element binding protein 3-like 2
chr12_-_49076658 0.397 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr1_+_226420437 0.397 C1orf69
chromosome 1 open reading frame 69
chr2_-_96899326 0.397 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr1_+_240078094 0.396 NM_130398
EXO1
exonuclease 1
chr7_+_100111712 0.396 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr1_-_31883051 0.395 PEF1
penta-EF-hand domain containing 1
chr21_+_44033871 0.395 RRP1
ribosomal RNA processing 1 homolog (S. cerevisiae)
chr8_-_103945521 0.394 AZIN1
antizyme inhibitor 1
chr19_-_18253259 0.394


chr6_-_31779082 0.394 ABHD16A
abhydrolase domain containing 16A
chr7_-_105304159 0.393 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr12_+_131194967 0.393 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr7_+_142346724 0.392 NM_178829
C7orf34
chromosome 7 open reading frame 34
chr10_+_24023680 0.392 NM_001098500
KIAA1217
KIAA1217
chr6_-_91063301 0.392 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr13_-_47916803 0.390 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr14_+_104337923 0.389 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr12_+_120635021 0.387 NM_001080825
TMEM120B
transmembrane protein 120B
chr1_+_51855343 0.384 OSBPL9
oxysterol binding protein-like 9
chr21_+_44033821 0.384 NM_003683
RRP1
ribosomal RNA processing 1 homolog (S. cerevisiae)
chr3_+_197851034 0.384 LRRC33
leucine rich repeat containing 33
chr6_+_105511615 0.384 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr1_+_210848726 0.383 ATF3
activating transcription factor 3
chr11_-_61340804 0.383 FADS1
fatty acid desaturase 1
chr7_+_65307691 0.382 NM_003596
TPST1
tyrosylprotein sulfotransferase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.25 1.82e-05 GO:0043170 macromolecule metabolic process
1.26 1.02e-04 GO:0044260 cellular macromolecule metabolic process
1.45 2.67e-04 GO:0016070 RNA metabolic process
1.42 6.03e-04 GO:0010467 gene expression
1.28 2.54e-03 GO:0006807 nitrogen compound metabolic process
1.18 2.60e-03 GO:0044237 cellular metabolic process
1.28 5.73e-03 GO:0034641 cellular nitrogen compound metabolic process
1.34 6.68e-03 GO:0090304 nucleic acid metabolic process
1.16 8.21e-03 GO:0044238 primary metabolic process
1.29 9.43e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.56 1.39e-02 GO:0006351 transcription, DNA-dependent
1.15 1.75e-02 GO:0050794 regulation of cellular process
1.14 4.31e-02 GO:0008152 metabolic process
1.29 4.56e-02 GO:0048522 positive regulation of cellular process
1.49 4.85e-02 GO:0032774 RNA biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 2.50e-04 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 3.68e-06 GO:0005515 protein binding
1.48 9.73e-03 GO:0001071 nucleic acid binding transcription factor activity
1.48 9.73e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.61 4.84e-02 GO:0008092 cytoskeletal protein binding