Motif ID: KLF12.p2

Z-value: 2.216


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_736059140.019.7e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_14121728 3.081 LPHN1
latrophilin 1
chr1_+_200358594 2.166 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr8_-_6407882 1.834 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr16_-_66535457 1.770 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr20_+_34603311 1.597 MYL9
myosin, light chain 9, regulatory
chr6_+_31838751 1.583 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr16_-_66535923 1.487 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr9_+_34642125 1.460 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr1_-_33613729 1.360 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr9_-_138387903 1.288 CARD9
caspase recruitment domain family, member 9
chr20_+_2744947 1.286 NM_001167670
LOC100288797
hypothetical protein LOC100288797
chr9_-_138387926 1.252 NM_052813
NM_052814
CARD9

caspase recruitment domain family, member 9

chr20_+_61394982 1.250 NM_020882
COL20A1
collagen, type XX, alpha 1
chr11_-_118716244 1.238 MFRP
membrane frizzled-related protein
chr20_+_34206070 1.196 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr11_-_70971556 1.115 NM_001005405
KRTAP5-11
keratin associated protein 5-11
chr17_-_36725470 1.112 NM_031964
KRTAP17-1
keratin associated protein 17-1
chr10_-_105410840 1.071


chr20_+_34603290 1.067 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr12_+_105519049 1.054 NM_002920
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr14_-_105681377 1.026 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_-_65860450 1.025 NM_004292
RIN1
Ras and Rab interactor 1
chr9_-_129752687 1.021 NM_203305
FAM102A
family with sequence similarity 102, member A
chr1_-_201321711 1.001 MYOG
myogenin (myogenic factor 4)
chr2_+_32142083 0.999 NM_014946
NM_199436
SPAST

spastin

chr14_-_22891263 0.995 NM_020372
SLC22A17
solute carrier family 22, member 17
chr5_+_31675181 0.989 PDZD2
PDZ domain containing 2
chr7_-_75206152 0.977 HIP1
huntingtin interacting protein 1
chr16_-_47872880 0.976


chr11_-_118716736 0.971 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr15_-_75694674 0.951 LINGO1
leucine rich repeat and Ig domain containing 1
chr10_+_94439658 0.932 NM_002729
HHEX
hematopoietically expressed homeobox
chr11_-_117589283 0.912 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_+_6767968 0.905 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr8_+_37672427 0.897 NM_025069
ZNF703
zinc finger protein 703
chr15_-_62460622 0.893 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr1_+_157441824 0.892 NM_001122951
DARC
Duffy blood group, chemokine receptor
chrX_+_135079461 0.882 NM_001167819
FHL1
four and a half LIM domains 1
chr16_+_65918220 0.869 NM_018296
LRRC36
leucine rich repeat containing 36
chr11_-_116691574 0.866 BACE1
beta-site APP-cleaving enzyme 1
chr1_-_201321999 0.864 NM_002479
MYOG
myogenin (myogenic factor 4)
chr17_-_71352090 0.863 UNC13D
unc-13 homolog D (C. elegans)
chr1_+_1099145 0.853 NM_001130045
TTLL10
tubulin tyrosine ligase-like family, member 10
chr1_-_199348316 0.845 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr17_-_38081967 0.842 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr14_+_62740878 0.840 NM_020663
RHOJ
ras homolog gene family, member J
chr5_+_140709907 0.837 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr2_+_69995656 0.830 NM_002357
MXD1
MAX dimerization protein 1
chr9_+_136673464 0.815 NM_000093
COL5A1
collagen, type V, alpha 1
chr7_-_27669029 0.807 NM_152740
HIBADH
3-hydroxyisobutyrate dehydrogenase
chr19_-_14447122 0.795 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr17_-_34084682 0.794 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr7_-_75206212 0.794 NM_005338
HIP1
huntingtin interacting protein 1
chr17_-_8474733 0.793 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr2_+_69995740 0.793 MXD1
MAX dimerization protein 1
chr15_+_88120592 0.769 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr19_+_50004134 0.741 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr12_+_46133 0.736 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr20_-_1921451 0.733 NM_001190892
PDYN
prodynorphin
chr16_-_47872973 0.730 CBLN1
cerebellin 1 precursor
chr10_+_76256305 0.724 NM_012330
MYST4
MYST histone acetyltransferase (monocytic leukemia) 4
chr11_-_64520964 0.702 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr11_-_116692128 0.697 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr17_+_35471971 0.695 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr16_+_2503676 0.694 NM_001198569
NM_001694
ATP6V0C

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

chr7_-_110989582 0.690 NM_032549
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr6_-_33375106 0.687 NM_004761
RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr2_+_161980865 0.679 NM_006593
TBR1
T-box, brain, 1
chr7_+_100047877 0.678 NM_001040098
NM_001040099
NM_023948
MOSPD3


motile sperm domain containing 3


chr20_+_61967078 0.675 TPD52L2
tumor protein D52-like 2
chr15_-_88148177 0.674 ANPEP
alanyl (membrane) aminopeptidase
chr5_+_137829065 0.673 EGR1
early growth response 1
chr12_+_56135353 0.672 NM_031479
INHBE
inhibin, beta E
chr16_+_65869558 0.669 NM_001129727
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr2_+_48395271 0.668 NM_002158
FOXN2
forkhead box N2
chr16_+_24709922 0.660 TNRC6A
trinucleotide repeat containing 6A
chrX_+_151837064 0.659 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr6_-_44341222 0.654 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr7_-_75461868 0.652 TMEM120A
transmembrane protein 120A
chr12_+_109390586 0.651 NM_013300
C12orf24
chromosome 12 open reading frame 24
chr2_+_46623325 0.648 NM_012249
RHOQ
ras homolog gene family, member Q
chr11_-_118471385 0.648 NM_002105
H2AFX
H2A histone family, member X
chr1_+_53300410 0.645 NM_153703
PODN
podocan
chr7_+_100113664 0.644 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr16_+_2503915 0.644 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr19_-_41034734 0.643 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr9_-_126991857 0.642 NM_001123355
NM_001123369
NM_002721
PPP6C


protein phosphatase 6, catalytic subunit


chr11_-_118471313 0.641 H2AFX
H2A histone family, member X
chrX_+_152454773 0.640 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr3_+_171619346 0.640 NM_005602
CLDN11
claudin 11
chr22_+_18499354 0.639 NM_001185024
NM_013373
ZDHHC8

zinc finger, DHHC-type containing 8

chr7_-_38341697 0.637 TRGV7
T cell receptor gamma variable 7 pseudogene
chr20_+_1154763 0.631 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr2_-_27446670 0.626 EIF2B4
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
chr19_-_43926953 0.625 NM_144691
CAPN12
calpain 12
chr19_+_40534284 0.622 NM_005303
FFAR1
free fatty acid receptor 1
chr16_-_30992574 0.621 ZNF668
zinc finger protein 668
chr9_+_139292094 0.621 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr6_+_32057779 0.620 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr1_+_199259664 0.612


chr4_-_176970407 0.603 GPM6A
glycoprotein M6A
chr16_-_10183244 0.596 NM_001134408
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr5_+_34692352 0.596 NM_001145520
RAI14
retinoic acid induced 14
chr9_-_126991805 0.596 PPP6C
protein phosphatase 6, catalytic subunit
chr7_-_75461814 0.596 TMEM120A
transmembrane protein 120A
chr2_-_192767494 0.591 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr11_+_116575249 0.587 NM_001001522
NM_003186
TAGLN

transgelin

chr15_+_71763674 0.585 NM_001024736
NM_025240
CD276

CD276 molecule

chr5_-_148422799 0.585 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr20_-_29896981 0.583 NM_004118
FOXS1
forkhead box S1
chr2_+_112372671 0.582 MERTK
c-mer proto-oncogene tyrosine kinase
chr11_+_69872033 0.578 PPFIA1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr17_-_45620911 0.577 COL1A1
collagen, type I, alpha 1
chr22_+_39404940 0.577 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr2_+_234209838 0.576 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr2_-_188127294 0.573 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr20_-_44034194 0.572 NM_022095
ZNF335
zinc finger protein 335
chr1_-_53380709 0.572 NM_006671
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr7_-_38356100 0.571 TRGV5
T cell receptor gamma variable 5
chr2_-_73152323 0.571 NM_144579
SFXN5
sideroflexin 5
chr17_-_71352017 0.570 UNC13D
unc-13 homolog D (C. elegans)
chr13_+_57105859 0.562 PCDH17
protocadherin 17
chr12_+_109391042 0.559 C12orf24
chromosome 12 open reading frame 24
chr14_+_36196523 0.557 NM_006194
PAX9
paired box 9
chr2_-_224974954 0.557 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr17_+_59205289 0.556 NM_007372
NM_203499
DDX42

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

chr2_-_74563542 0.555 CCDC142
coiled-coil domain containing 142
chr4_-_176970372 0.553 GPM6A
glycoprotein M6A
chr12_-_92489652 0.552 LOC144481
hypothetical protein LOC144481
chr6_+_20510019 0.552 NM_001949
E2F3
E2F transcription factor 3
chr4_+_2783764 0.551 SH3BP2
SH3-domain binding protein 2
chr4_-_83566246 0.551 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr20_-_3713509 0.551 CENPB
centromere protein B, 80kDa
chr2_+_161981046 0.550 TBR1
T-box, brain, 1
chr5_+_140871107 0.550


chr2_-_236741352 0.542 NM_001485
GBX2
gastrulation brain homeobox 2
chr11_-_62231636 0.541 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr16_+_82490230 0.541 NM_012213
MLYCD
malonyl-CoA decarboxylase
chr10_+_123913094 0.537 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr4_-_176970895 0.535 GPM6A
glycoprotein M6A
chr16_+_68765428 0.534 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr15_-_72446979 0.534 NM_000781
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr4_+_3413457 0.534 HGFAC
HGF activator
chr1_-_177106702 0.532 NM_004673
ANGPTL1
angiopoietin-like 1
chr17_-_36418869 0.530 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr17_+_18796202 0.529 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr16_-_47873183 0.528 NM_004352
CBLN1
cerebellin 1 precursor
chr11_+_59580630 0.524 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr12_+_6363482 0.523 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr2_+_161981138 0.523 TBR1
T-box, brain, 1
chr2_+_88966170 0.522


chr15_-_87257595 0.520 NM_001114614
NM_005928
MFGE8

milk fat globule-EGF factor 8 protein

chr9_+_130231027 0.519 CERCAM
cerebral endothelial cell adhesion molecule
chr20_+_30409649 0.519 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr11_+_62231689 0.518 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr7_+_127015650 0.517 NM_001662
ARF5
ADP-ribosylation factor 5
chr1_-_201583989 0.515 FMOD
fibromodulin
chr11_-_64368616 0.514 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr22_+_37407921 0.513 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr12_+_109390915 0.513 C12orf24
chromosome 12 open reading frame 24
chr17_+_59205244 0.512


chr4_-_75123193 0.511 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr7_-_38355949 0.509


chr6_+_17708483 0.509 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr11_+_65162114 0.508 NM_006747
SIPA1
signal-induced proliferation-associated 1
chr9_+_132874324 0.508 NM_006059
LAMC3
laminin, gamma 3
chr1_-_1840564 0.507 NM_178545
TMEM52
transmembrane protein 52
chr2_-_178645718 0.506 NM_016953
PDE11A
phosphodiesterase 11A
chr7_-_44547382 0.505 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr22_+_37407925 0.504 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr12_-_46499834 0.501 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr17_+_19255083 0.501 NM_007148
RNF112
ring finger protein 112
chr6_+_35881048 0.500 NM_182548
LHFPL5
lipoma HMGIC fusion partner-like 5
chr13_+_50694364 0.497 NM_145019
FAM124A
family with sequence similarity 124A
chr16_-_87878249 0.497 ANKRD11
ankyrin repeat domain 11
chr9_+_130056513 0.496


chr22_+_37407906 0.495 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr15_+_63948823 0.493 NM_004663
RAB11A
RAB11A, member RAS oncogene family
chr8_+_20099169 0.488 ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr1_+_162795538 0.487 PBX1
pre-B-cell leukemia homeobox 1
chr4_-_1980473 0.486 WHSC2
Wolf-Hirschhorn syndrome candidate 2
chr2_+_112372651 0.486 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr5_+_34692239 0.486 RAI14
retinoic acid induced 14
chr15_-_87257553 0.483 MFGE8
milk fat globule-EGF factor 8 protein
chr5_+_139473873 0.482 NM_005859
PURA
purine-rich element binding protein A
chr16_-_30445548 0.482


chr19_+_2173415 0.481 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr2_+_27573206 0.476 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr7_-_75461897 0.476 NM_031925
TMEM120A
transmembrane protein 120A
chr22_-_37598115 0.471 CBX6
chromobox homolog 6
chr19_+_1158129 0.471 EFNA2
ephrin-A2
chr19_-_60369731 0.470 NM_178837
C19orf51
chromosome 19 open reading frame 51
chr6_-_34324739 0.469 C6orf1
chromosome 6 open reading frame 1
chr11_-_76058542 0.468 NM_005512
LRRC32
leucine rich repeat containing 32
chr17_-_33753218 0.467 NM_001004334
GPR179
G protein-coupled receptor 179
chr9_-_98421894 0.466 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr19_+_38867273 0.466 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr6_+_34590624 0.465 PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr20_-_36227060 0.464 NM_004613
NM_198951
TGM2

transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

chr5_-_176857207 0.463 NM_005451
NM_203352
NM_213636
PDLIM7


PDZ and LIM domain 7 (enigma)



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 2.12e-07 GO:0065007 biological regulation
1.18 2.69e-07 GO:0032502 developmental process
1.31 3.60e-07 GO:0007399 nervous system development
1.19 9.29e-07 GO:0007275 multicellular organismal development
1.07 2.34e-06 GO:0009987 cellular process
1.19 3.13e-06 GO:0048856 anatomical structure development
1.10 1.58e-05 GO:0050794 regulation of cellular process
1.19 2.08e-05 GO:0048731 system development
1.10 3.02e-05 GO:0050789 regulation of biological process
1.21 1.79e-04 GO:0048523 negative regulation of cellular process
1.20 3.63e-04 GO:0048519 negative regulation of biological process
1.20 5.21e-04 GO:0065008 regulation of biological quality
1.43 1.60e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.14 2.17e-03 GO:0023052 signaling
1.11 2.43e-03 GO:0032501 multicellular organismal process
1.23 3.59e-03 GO:0009653 anatomical structure morphogenesis
1.19 5.42e-03 GO:0030154 cell differentiation
1.19 5.94e-03 GO:0048869 cellular developmental process
1.25 6.28e-03 GO:0051239 regulation of multicellular organismal process
1.14 9.10e-03 GO:0016043 cellular component organization
1.34 1.40e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.33 1.66e-02 GO:0045595 regulation of cell differentiation
1.28 1.67e-02 GO:0022008 neurogenesis
1.49 1.74e-02 GO:0060284 regulation of cell development
1.51 2.21e-02 GO:0001944 vasculature development
1.41 3.12e-02 GO:0032583 regulation of gene-specific transcription
1.40 3.49e-02 GO:0061024 membrane organization
1.15 3.60e-02 GO:0048518 positive regulation of biological process
1.31 4.28e-02 GO:0009890 negative regulation of biosynthetic process
1.13 4.78e-02 GO:0060255 regulation of macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 2.32e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 7.66e-08 GO:0005515 protein binding
1.31 7.92e-05 GO:0001071 nucleic acid binding transcription factor activity
1.31 7.92e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.05 1.08e-04 GO:0005488 binding
1.33 2.13e-03 GO:0043565 sequence-specific DNA binding