Motif ID: MSX1,2.p2

Z-value: 0.460


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX2chr5_+_174084137-0.204.6e-01Click!
MSX1chr4_+_4912272-0.009.9e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_36774257 0.924 NM_001146079
NM_144492
CLDN14

claudin 14

chr6_-_52060327 0.724 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr19_-_40696393 0.633 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr3_-_150422474 0.368 NM_000096
CP
ceruloplasmin (ferroxidase)
chr9_+_135491305 0.324 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr5_-_160211623 0.314 NM_025153
ATP10B
ATPase, class V, type 10B
chr2_+_114916368 0.301 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr14_-_93324518 0.300 NM_178013
PRIMA1
proline rich membrane anchor 1
chr2_-_77602843 0.297 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr10_-_74384569 0.295 PLA2G12B
phospholipase A2, group XIIB
chr11_-_40272239 0.290 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr2_+_84597087 0.289 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chr14_-_64479198 0.283 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr5_+_140509803 0.282 NM_018939
PCDHB6
protocadherin beta 6
chr9_-_115880372 0.281 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_74384485 0.269 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr2_-_192420168 0.254 NM_004657
SDPR
serum deprivation response
chr3_+_52803823 0.214 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chrX_-_11194015 0.213 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr14_+_22375632 0.211 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr9_+_119506446 0.210 TLR4
toll-like receptor 4
chr16_-_29817841 0.203 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr7_+_80145461 0.200 CD36
CD36 molecule (thrombospondin receptor)
chrX_-_19598912 0.200 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr4_+_47403107 0.199


chr11_+_101693403 0.189 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr4_-_159311959 0.187 FAM198B
family with sequence similarity 198, member B
chr4_+_89115825 0.175 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr20_+_43283423 0.173 NM_003008
SEMG2
semenogelin II
chr2_+_233633348 0.169 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr6_-_48186868 0.168 C6orf138
chromosome 6 open reading frame 138
chr4_+_89115862 0.168 SPP1
secreted phosphoprotein 1
chr17_+_72380323 0.166 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr14_+_20595820 0.165 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr9_-_115880281 0.165 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_+_65582981 0.163 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr9_+_110664366 0.155 NM_006687
ACTL7A
actin-like 7A
chr12_-_6354818 0.152 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr6_+_127940011 0.149 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr9_-_115880425 0.149 AMBP
alpha-1-microglobulin/bikunin precursor
chr5_+_139856688 0.148 ANKHD1
ankyrin repeat and KH domain containing 1
chr16_+_52037186 0.148 RBL2
retinoblastoma-like 2 (p130)
chr4_+_89115892 0.147 SPP1
secreted phosphoprotein 1
chr2_-_192419896 0.146 SDPR
serum deprivation response
chr3_-_115380539 0.145 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr17_-_36113502 0.143 NM_019016
KRT24
keratin 24
chr13_+_51496679 0.142 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr12_+_70119785 0.137 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr4_+_155703581 0.135 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr22_+_33792125 0.134 NM_001008494
ISX
intestine-specific homeobox
chr13_-_98708549 0.133 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr6_-_46155937 0.133 NM_001114086
CLIC5
chloride intracellular channel 5
chr14_-_104330982 0.131 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr2_-_180135559 0.131 NM_001113398
ZNF385B
zinc finger protein 385B
chr16_-_67943157 0.126 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr11_+_6823458 0.125 NM_178168
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr12_-_9252227 0.125 NM_002864
PZP
pregnancy-zone protein
chr12_+_49634048 0.124 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr10_-_44794146 0.119 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr16_-_88656092 0.119 NM_052996
PRDM7
PR domain containing 7
chr9_-_96395828 0.117 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr14_-_106282128 0.117 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_55042924 0.115 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr7_+_132588359 0.111 NM_001037126
NM_021807
EXOC4

exocyst complex component 4

chr20_+_31613800 0.111 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr2_+_113542017 0.110 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr2_-_21087435 0.106 APOB
apolipoprotein B (including Ag(x) antigen)
chr9_-_21472311 0.104 NM_176891
IFNE
interferon, epsilon
chr16_+_55042936 0.102 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr8_-_145613058 0.101 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr9_+_119506428 0.101 TLR4
toll-like receptor 4
chr2_+_234209838 0.099 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr8_-_8276598 0.099 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr4_-_44348414 0.099 NM_182592
YIPF7
Yip1 domain family, member 7
chr4_+_89115923 0.098 SPP1
secreted phosphoprotein 1
chr2_+_233029076 0.098 NM_001631
ALPI
alkaline phosphatase, intestinal
chr20_-_48686832 0.098 NM_080829
FAM65C
family with sequence similarity 65, member C
chr8_-_145613034 0.098 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr1_+_31654998 0.094 NM_001199038
SERINC2
serine incorporator 2
chr14_-_23752875 0.094 NM_014169
CHMP4A
chromatin modifying protein 4A
chr1_-_240679380 0.093 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr1_-_150328153 0.092 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_+_162908828 0.092 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr3_+_9919295 0.090 NM_153483
IL17RE
interleukin 17 receptor E
chr9_-_126309510 0.089 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr14_+_19458580 0.089 NM_001005483
OR4K5
olfactory receptor, family 4, subfamily K, member 5
chr12_+_56114724 0.089 NM_005538
INHBC
inhibin, beta C
chr3_+_25445071 0.086 RARB
retinoic acid receptor, beta
chr3_-_11660395 0.084 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr9_-_115880366 0.083 AMBP
alpha-1-microglobulin/bikunin precursor
chr12_+_52105131 0.083 AMHR2
anti-Mullerian hormone receptor, type II
chr14_+_22375656 0.082 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr7_+_111850367 0.080 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr17_-_15109315 0.078 NM_000304
PMP22
peripheral myelin protein 22
chr2_+_137464931 0.078 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr6_-_31215089 0.078 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr2_+_228064531 0.076 AGFG1
ArfGAP with FG repeats 1
chr1_-_149245503 0.074 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr17_-_1195096 0.074 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr3_+_69895310 0.074 NM_001184967
MITF
microphthalmia-associated transcription factor
chr6_-_33028790 0.073 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr11_+_55869996 0.073 NM_001002907
OR8K1
olfactory receptor, family 8, subfamily K, member 1
chr6_+_154373323 0.072 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr11_-_114593838 0.071 CADM1
cell adhesion molecule 1
chr17_+_38306339 0.069 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr2_-_68952006 0.069 NM_014482
BMP10
bone morphogenetic protein 10
chr4_-_68793928 0.067 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr17_+_7732759 0.066 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr4_-_89963177 0.066 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr3_-_194579207 0.065 NM_198505
ATP13A5
ATPase type 13A5
chr3_+_9919511 0.065 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr21_-_18697829 0.064 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr16_+_64958025 0.063 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr15_-_64644758 0.062 NM_207338
LCTL
lactase-like
chr3_+_50119261 0.062 RBM5
RNA binding motif protein 5
chrX_-_15530112 0.061 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr20_+_2224612 0.061 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr3_+_187866464 0.061 NM_000412
HRG
histidine-rich glycoprotein
chr6_-_55848346 0.060 BMP5
bone morphogenetic protein 5
chr7_-_96471544 0.059 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr2_-_162808123 0.059 NM_004460
FAP
fibroblast activation protein, alpha
chr12_+_79362256 0.059 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr1_-_188713324 0.058 NM_199051
FAM5C
family with sequence similarity 5, member C
chr6_-_130578110 0.058 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr2_-_165133239 0.058 GRB14
growth factor receptor-bound protein 14
chr19_-_51109875 0.058 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr4_+_106851415 0.057 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr8_-_15140162 0.057 NM_139167
SGCZ
sarcoglycan, zeta
chr20_+_18070867 0.056 NM_020536
CSRP2BP
CSRP2 binding protein
chr2_+_165804157 0.056 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr20_+_71230 0.055 NM_030931
DEFB126
defensin, beta 126
chr2_+_61243132 0.055 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr10_+_7785331 0.055 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_+_138438277 0.054 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr20_-_34707971 0.052 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr6_+_139136349 0.052 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr3_+_16191159 0.052 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr1_-_118273701 0.051 GDAP2
ganglioside induced differentiation associated protein 2
chr16_-_21197072 0.049 CRYM
crystallin, mu
chr6_-_28591542 0.048 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr20_-_5879036 0.048 NM_015939
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr3_-_74652952 0.048 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr10_+_114123828 0.048 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_21081694 0.046 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_-_11918019 0.045 NM_001130007
GSPT1
G1 to S phase transition 1
chr17_-_64462976 0.045 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr20_+_43269051 0.045 NM_003007
SEMG1
semenogelin I
chr14_-_94669547 0.045 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr11_-_104344473 0.044 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chrX_-_24600661 0.043 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr10_+_98730977 0.043 NM_015652
C10orf12
chromosome 10 open reading frame 12
chr7_+_116238309 0.042 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr5_-_13997588 0.042 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr4_+_110968594 0.042 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr6_-_24491498 0.042 NM_001195610
DCDC2
doublecortin domain containing 2
chr12_-_110410730 0.040 ATXN2
ataxin 2
chr8_+_67096344 0.040 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr10_+_115501202 0.040 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr4_-_186970366 0.039 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_-_123999640 0.039 NM_006073
TRDN
triadin
chr16_+_64958060 0.039 CDH5
cadherin 5, type 2 (vascular endothelium)
chr10_+_685887 0.039 C10orf108
chromosome 10 open reading frame 108
chr3_+_189425886 0.039 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr12_-_51457371 0.038 NM_015848
KRT76
keratin 76
chr5_-_148738980 0.038 NM_014443
IL17B
interleukin 17B
chr11_-_6870306 0.038 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr2_+_102744921 0.038 NM_144632
TMEM182
transmembrane protein 182
chr17_+_39213328 0.038 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr11_-_55460451 0.038 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr6_-_49862858 0.037 NM_138733
PGK2
phosphoglycerate kinase 2
chr9_-_115880494 0.037 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr7_+_90176647 0.037 NM_012395
CDK14
cyclin-dependent kinase 14
chr11_+_114054409 0.037 NM_182495
FAM55B
family with sequence similarity 55, member B
chr2_+_219453487 0.036 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr19_-_17236522 0.036 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr1_-_229071957 0.036 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr1_+_118273869 0.036 WDR3
WD repeat domain 3
chr8_-_102005697 0.036 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr13_-_45577144 0.036 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr14_-_23653965 0.035 NRL
neural retina leucine zipper
chr12_-_89922875 0.035 EPYC
epiphycan
chrX_-_62891730 0.035 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr9_+_1040333 0.035 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr3_-_121884091 0.035 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr6_+_64289585 0.035 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_-_150578148 0.035 TM4SF1
transmembrane 4 L six family member 1
chr5_+_109053034 0.034 NM_002372
MAN2A1
mannosidase, alpha, class 2A, member 1
chr16_-_55042614 0.034 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr4_-_66218777 0.034 EPHA5
EPH receptor A5
chr12_+_108038774 0.034 ACACB
acetyl-CoA carboxylase beta
chr11_-_72141064 0.034 NM_001040118
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr8_-_114518194 0.034 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr2_-_96238234 0.033 STARD7
StAR-related lipid transfer (START) domain containing 7
chr7_+_21434818 0.033


chr6_-_119512035 0.033 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr5_+_109052984 0.033


chr10_+_94823636 0.032 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr12_-_89922888 0.032 NM_004950
EPYC
epiphycan
chr7_-_86433139 0.032 NM_152748
KIAA1324L
KIAA1324-like
chr5_-_42847716 0.031 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1



Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.34 9.46e-04 GO:0005626 insoluble fraction
1.30 1.21e-03 GO:0016020 membrane
2.34 1.26e-03 GO:0005624 membrane fraction
1.46 3.05e-03 GO:0071944 cell periphery
2.04 4.31e-03 GO:0000267 cell fraction
1.33 6.23e-03 GO:0044425 membrane part
2.30 6.61e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
2.26 9.28e-03 GO:0031988 membrane-bounded vesicle
7.33 9.88e-03 GO:0031983 vesicle lumen
2.17 1.95e-02 GO:0031410 cytoplasmic vesicle
1.41 2.29e-02 GO:0005886 plasma membrane
2.10 3.41e-02 GO:0031982 vesicle
23.31 4.56e-02 GO:0005577 fibrinogen complex

Nothing significant found in function category.