Motif ID: MZF1.p2

Z-value: 2.702


Transcription factors associated with MZF1.p2:

Gene SymbolEntrez IDGene Name
MZF1 7593 myeloid zinc finger 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MZF1chr19_-_63776740-0.273.1e-01Click!


Activity profile for motif MZF1.p2.

activity profile for motif MZF1.p2


Sorted Z-values histogram for motif MZF1.p2

Sorted Z-values for motif MZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_108665168 7.560 NM_021224
ZNF462
zinc finger protein 462
chr18_-_22382497 6.039 NM_001142730
KCTD1
potassium channel tetramerisation domain containing 1
chr8_+_22513043 4.099 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr13_+_113574925 3.963 NM_001143945
GAS6
growth arrest-specific 6
chr10_-_105604942 3.596 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr4_-_158111916 3.079 PDGFC
platelet derived growth factor C
chr13_-_39075200 3.011 LHFP
lipoma HMGIC fusion partner
chr4_-_158111995 2.977 NM_016205
PDGFC
platelet derived growth factor C
chr4_-_11039600 2.940 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chrX_-_1291526 2.929 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr15_+_66658626 2.517 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr5_+_17270474 2.433 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr7_-_27136876 2.373 NM_002141
HOXA4
homeobox A4
chr1_-_72521079 2.347


chr21_-_27261276 2.335 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr11_-_68537243 2.332 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr13_-_43259032 2.183 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr5_+_92944680 2.177 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr11_+_61352209 2.158 NM_004265
FADS2
fatty acid desaturase 2
chr6_-_10523203 2.157 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr3_-_189354510 2.147 LOC339929
hypothetical LOC339929
chr6_-_75972473 2.093 COL12A1
collagen, type XII, alpha 1
chr17_-_20886680 2.038 NM_015276
USP22
ubiquitin specific peptidase 22
chr11_+_61352348 2.037 FADS2
fatty acid desaturase 2
chr1_+_2975590 2.026 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr8_-_11096257 2.009 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr6_-_72187168 1.965 C6orf155
chromosome 6 open reading frame 155
chr12_-_51912101 1.949 NM_000966
RARG
retinoic acid receptor, gamma
chrX_-_74062005 1.930 NM_001008537
KIAA2022
KIAA2022
chr10_+_119292699 1.928


chr3_+_195889845 1.927 FAM43A
family with sequence similarity 43, member A
chr16_-_71650034 1.920 NM_001164766
ZFHX3
zinc finger homeobox 3
chr4_+_145786622 1.884 NM_022475
HHIP
hedgehog interacting protein
chrX_+_12066505 1.824 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr5_-_92942680 1.819 FLJ42709
hypothetical LOC441094
chr9_+_33807213 1.808 UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr20_+_8060762 1.806 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr11_-_132318741 1.804 OPCML
opioid binding protein/cell adhesion molecule-like
chr13_-_39075355 1.789 NM_005780
LHFP
lipoma HMGIC fusion partner
chr20_+_19141282 1.764 NM_020689
SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr12_+_74071145 1.746 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr9_-_4289574 1.729 GLIS3
GLIS family zinc finger 3
chr1_-_72520735 1.725 NM_173808
NEGR1
neuronal growth regulator 1
chr9_+_8848130 1.720


chr2_-_174537021 1.712 NM_001017371
SP3
Sp3 transcription factor
chr4_-_158111504 1.681 PDGFC
platelet derived growth factor C
chr11_+_131286513 1.670 NTM
neurotrimin
chrX_+_73557809 1.668 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr10_-_79067210 1.654 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr13_-_39075304 1.640 LHFP
lipoma HMGIC fusion partner
chr12_+_74071116 1.627 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr12_-_52179462 1.607 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr4_+_183302105 1.593 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr3_+_189354167 1.572 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_+_98016114 1.550 NM_001080448
EPHA6
EPH receptor A6
chr12_+_64504835 1.549 HMGA2
high mobility group AT-hook 2
chr5_+_82803248 1.532 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr14_+_85069217 1.516


chr6_-_10520592 1.513 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr4_-_115120251 1.507 NM_024590
ARSJ
arylsulfatase family, member J
chr2_+_69093641 1.504 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr12_-_6585785 1.489 CHD4
chromodomain helicase DNA binding protein 4
chr6_-_10523424 1.484 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr12_+_52653176 1.482 NM_014212
HOXC11
homeobox C11
chr12_-_116890410 1.481 NM_173598
KSR2
kinase suppressor of ras 2
chr18_-_55515623 1.479 NM_133459
CCBE1
collagen and calcium binding EGF domains 1
chr4_-_86106567 1.477 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr8_+_30361485 1.472 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr5_+_129268352 1.464 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr10_-_103593529 1.450 NM_014591
NM_173191
NM_173192
NM_173193
NM_173195
NM_173197
KCNIP2





Kv channel interacting protein 2





chr19_-_13478037 1.417 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr12_+_56406296 1.417 LOC100130776
hypothetical LOC100130776
chr18_-_55515552 1.407 CCBE1
collagen and calcium binding EGF domains 1
chr5_-_9599157 1.406 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr17_-_44047299 1.405 NM_024016
HOXB8
homeobox B8
chr21_+_46226072 1.404 NM_001848
COL6A1
collagen, type VI, alpha 1
chr11_+_124539814 1.395 PKNOX2
PBX/knotted 1 homeobox 2
chr9_+_136673534 1.393 COL5A1
collagen, type V, alpha 1
chr22_-_28972683 1.380 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr1_-_212791597 1.370 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr1_-_29321599 1.355 NM_001171868
TMEM200B
transmembrane protein 200B
chr4_+_37569093 1.355 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr10_-_33663984 1.342 NRP1
neuropilin 1
chr8_+_123863224 1.340 ZHX2
zinc fingers and homeoboxes 2
chr19_-_41215380 1.335 CLIP3
CAP-GLY domain containing linker protein 3
chr20_+_19141364 1.323 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr8_+_121206478 1.305 NM_021110
COL14A1
collagen, type XIV, alpha 1
chr12_-_131816604 1.302 ANKLE2
ankyrin repeat and LEM domain containing 2
chr6_-_10520264 1.293 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr3_-_121652183 1.285 NM_007085
FSTL1
follistatin-like 1
chr8_+_120497732 1.284 NM_002514
NOV
nephroblastoma overexpressed gene
chr22_-_26527469 1.283 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr2_-_216944911 1.281 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr10_-_79067296 1.273 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr4_+_30330963 1.272 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr5_-_159478967 1.267 NM_001130864
NM_052927
PWWP2A

PWWP domain containing 2A

chr17_-_24068759 1.265 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr2_+_209996913 1.262 NM_001039538
MAP2
microtubule-associated protein 2
chr12_-_6668880 1.256 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr2_-_61551403 1.237 USP34
ubiquitin specific peptidase 34
chr19_-_53365371 1.233 NM_000234
LIG1
ligase I, DNA, ATP-dependent
chrX_-_103060777 1.229 LOC100128594
hypothetical LOC100128594
chr12_-_6668680 1.228 ZNF384
zinc finger protein 384
chr7_-_27120015 1.225 HOXA3
homeobox A3
chr9_+_2611740 1.219 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chr5_-_127901633 1.203 NM_001999
FBN2
fibrillin 2
chr10_+_71231693 1.198 COL13A1
collagen, type XIII, alpha 1
chr2_-_127580975 1.194 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr2_-_161058120 1.191 RBMS1
RNA binding motif, single stranded interacting protein 1
chr17_-_24069299 1.185 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr19_-_36531958 1.185 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr2_-_110230642 1.184 MALL
mal, T-cell differentiation protein-like
chr7_-_19123765 1.179 TWIST1
twist homolog 1 (Drosophila)
chr3_-_121445831 1.174 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr2_+_5750229 1.174 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr11_+_8059267 1.171 NM_177972
TUB
tubby homolog (mouse)
chr16_-_3225360 1.167 NM_001145448
NM_198088
NM_001145446
NM_198087
ZNF200



zinc finger protein 200



chr6_+_17389752 1.165 NM_001143942
RBM24
RNA binding motif protein 24
chr3_+_152287365 1.163 NM_053002
MED12L
mediator complex subunit 12-like
chr20_+_17498507 1.163 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr10_-_33663777 1.162 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr9_+_2612134 1.158 VLDLR
very low density lipoprotein receptor
chr4_-_96689137 1.155 UNC5C
unc-5 homolog C (C. elegans)
chr12_-_93568336 1.152 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr9_+_2612099 1.151 VLDLR
very low density lipoprotein receptor
chr2_-_110230822 1.147 MALL
mal, T-cell differentiation protein-like
chr3_-_151904408 1.139 NM_152394
FAM194A
family with sequence similarity 194, member A
chr16_-_63713485 1.132 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr18_+_17076166 1.131 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr15_-_86600658 1.127 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr7_+_55054152 1.127 NM_005228
NM_201282
NM_201283
NM_201284
EGFR



epidermal growth factor receptor



chr16_+_31390567 1.124 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr2_-_197883569 1.123 ANKRD44
ankyrin repeat domain 44
chr17_+_58058783 1.116 MRC2
mannose receptor, C type 2
chr3_+_106568243 1.111 ALCAM
activated leukocyte cell adhesion molecule
chr1_-_56817823 1.102 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr5_-_111120929 1.100 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr9_-_10602722 1.097 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr6_+_127481740 1.090 NM_032784
RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr14_-_62581656 1.089 NM_139318
NM_172375
KCNH5

potassium voltage-gated channel, subfamily H (eag-related), member 5

chr10_-_76829857 1.074 ZNF503
zinc finger protein 503
chr7_-_127458231 1.069 NM_022143
LRRC4
leucine rich repeat containing 4
chr11_+_124539768 1.068 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr12_-_105056577 1.068 NUAK1
NUAK family, SNF1-like kinase, 1
chr9_+_2612052 1.061 VLDLR
very low density lipoprotein receptor
chr4_+_30331289 1.061 PCDH7
protocadherin 7
chr8_+_32525269 1.058 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr10_-_79067400 1.056 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr2_-_75641535 1.056 FAM176A
family with sequence similarity 176, member A
chr9_-_4290028 1.051 NM_001042413
GLIS3
GLIS family zinc finger 3
chr5_-_111120764 1.043 C5orf13
chromosome 5 open reading frame 13
chr1_+_181259317 1.039


chr17_+_7096095 1.038 NM_203415
NM_015362
NM_203413
NM_203414
C17orf81



chromosome 17 open reading frame 81



chr3_+_182113125 1.038 FXR1
fragile X mental retardation, autosomal homolog 1
chr13_+_87122778 1.035 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr16_-_63713466 1.033 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_-_158440587 1.032 NM_001111067
ACVR1
activin A receptor, type I
chr18_-_27518392 1.025 NM_004775
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr19_-_11352850 1.023 EPOR
erythropoietin receptor
chr18_-_22383066 1.020 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr11_-_27697768 1.016 NM_001143807
BDNF
brain-derived neurotrophic factor
chr10_-_79067476 1.014 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr18_-_24010944 1.007 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr9_+_33807590 1.007 UBE2R2
ubiquitin-conjugating enzyme E2R 2
chr11_+_17714070 1.004 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr7_+_78920846 0.995 LOC100505881
hypothetical LOC100505881
chr1_-_194844299 0.994 KCNT2
potassium channel, subfamily T, member 2
chr2_-_75641587 0.988 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr12_-_6668787 0.987 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr2_-_56004366 0.986 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr7_+_114349376 0.983 NM_001166345
NM_001166346
NM_199072
MDFIC


MyoD family inhibitor domain containing


chr16_-_63713382 0.981 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr18_-_24011349 0.979 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr19_-_242335 0.969 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr1_+_201711578 0.966 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr10_-_79067552 0.966 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr12_-_105165805 0.960 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr5_-_111120817 0.957 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr20_-_17986520 0.951 NM_021220
OVOL2
ovo-like 2 (Drosophila)
chr11_-_62445587 0.950 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr17_+_67628749 0.949 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr17_-_43470134 0.949 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chrX_+_66680593 0.948 NM_000044
AR
androgen receptor
chr11_-_64167361 0.943 NM_138734
NRXN2
neurexin 2
chr16_+_65790514 0.939 NM_024712
ELMO3
engulfment and cell motility 3
chr1_-_68470585 0.930 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr2_+_54537842 0.928 SPTBN1
spectrin, beta, non-erythrocytic 1
chr11_+_69165119 0.927 CCND1
cyclin D1
chr19_+_12996830 0.925 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_-_20791907 0.922


chr11_+_74629597 0.921 NM_001195528
LOC441617
hypothetical LOC441617
chr1_-_20684858 0.920 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr17_+_2443983 0.917 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_-_132318080 0.915 NM_002545
OPCML
opioid binding protein/cell adhesion molecule-like
chr17_-_7083321 0.914 NM_024297
PHF23
PHD finger protein 23
chr11_-_72986738 0.912 NM_015159
FAM168A
family with sequence similarity 168, member A
chr10_+_71231649 0.911 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr17_-_959007 0.910 NM_001092
ABR
active BCR-related gene
chr5_-_73972055 0.910 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr9_+_33807168 0.908 NM_017811
UBE2R2
ubiquitin-conjugating enzyme E2R 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 5.19e-29 GO:0050794 regulation of cellular process
1.15 8.33e-29 GO:0065007 biological regulation
1.43 6.16e-28 GO:0007399 nervous system development
1.15 6.37e-28 GO:0050789 regulation of biological process
1.39 1.52e-22 GO:0009653 anatomical structure morphogenesis
1.25 2.85e-22 GO:0048856 anatomical structure development
1.22 4.96e-22 GO:0032502 developmental process
1.26 7.41e-22 GO:0048731 system development
1.23 1.86e-21 GO:0007275 multicellular organismal development
1.28 1.59e-20 GO:0048522 positive regulation of cellular process
1.26 2.14e-20 GO:0048518 positive regulation of biological process
1.08 1.33e-19 GO:0009987 cellular process
1.30 2.59e-19 GO:0030154 cell differentiation
1.47 5.30e-19 GO:0022008 neurogenesis
1.29 5.68e-19 GO:0048869 cellular developmental process
1.21 7.19e-19 GO:0031323 regulation of cellular metabolic process
1.47 8.64e-18 GO:0048699 generation of neurons
1.21 5.78e-17 GO:0080090 regulation of primary metabolic process
1.28 6.94e-17 GO:0048523 negative regulation of cellular process
1.19 1.13e-16 GO:0019222 regulation of metabolic process
1.48 3.55e-15 GO:0030182 neuron differentiation
1.25 4.19e-15 GO:0048519 negative regulation of biological process
1.42 5.79e-15 GO:0048468 cell development
1.20 6.65e-15 GO:0060255 regulation of macromolecule metabolic process
1.19 8.02e-15 GO:0023052 signaling
1.30 4.81e-14 GO:0023051 regulation of signaling
1.49 1.36e-13 GO:0032989 cellular component morphogenesis
1.42 1.52e-13 GO:0051128 regulation of cellular component organization
1.54 2.84e-13 GO:0000904 cell morphogenesis involved in differentiation
1.21 3.64e-13 GO:0051171 regulation of nitrogen compound metabolic process
1.22 8.11e-13 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.48 1.26e-12 GO:0000902 cell morphogenesis
1.30 1.68e-12 GO:0009966 regulation of signal transduction
1.49 2.48e-12 GO:0048666 neuron development
1.18 4.32e-12 GO:0007165 signal transduction
1.16 1.19e-11 GO:0051716 cellular response to stimulus
1.51 1.25e-11 GO:0031175 neuron projection development
1.21 1.52e-11 GO:0031326 regulation of cellular biosynthetic process
1.20 2.39e-11 GO:0009889 regulation of biosynthetic process
1.25 2.93e-11 GO:0048583 regulation of response to stimulus
1.37 3.96e-11 GO:0050793 regulation of developmental process
1.21 7.58e-11 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.53 8.86e-11 GO:0048667 cell morphogenesis involved in neuron differentiation
1.21 1.63e-10 GO:0010556 regulation of macromolecule biosynthetic process
1.52 2.04e-10 GO:0048812 neuron projection morphogenesis
1.43 3.43e-10 GO:0030030 cell projection organization
1.39 5.59e-10 GO:2000026 regulation of multicellular organismal development
1.35 6.65e-10 GO:0031324 negative regulation of cellular metabolic process
1.17 6.99e-10 GO:0016043 cellular component organization
1.52 8.20e-10 GO:0007409 axonogenesis
1.35 1.19e-09 GO:0010605 negative regulation of macromolecule metabolic process
1.40 1.28e-09 GO:0045595 regulation of cell differentiation
1.19 1.48e-09 GO:0071842 cellular component organization at cellular level
1.47 1.94e-09 GO:0048858 cell projection morphogenesis
1.28 2.18e-09 GO:0051239 regulation of multicellular organismal process
1.19 2.45e-09 GO:0010468 regulation of gene expression
1.16 2.56e-09 GO:0071840 cellular component organization or biogenesis
1.33 2.95e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.21 3.02e-09 GO:0051252 regulation of RNA metabolic process
1.46 3.19e-09 GO:0032990 cell part morphogenesis
1.29 8.36e-09 GO:0010604 positive regulation of macromolecule metabolic process
1.32 9.97e-09 GO:0009892 negative regulation of metabolic process
1.39 1.58e-08 GO:0010558 negative regulation of macromolecule biosynthetic process
1.40 1.75e-08 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.22 2.24e-08 GO:0048513 organ development
1.27 2.30e-08 GO:0009893 positive regulation of metabolic process
1.38 3.51e-08 GO:0031327 negative regulation of cellular biosynthetic process
1.18 3.52e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.39 7.89e-08 GO:0010629 negative regulation of gene expression
1.19 1.31e-07 GO:0006355 regulation of transcription, DNA-dependent
1.36 1.32e-07 GO:0009890 negative regulation of biosynthetic process
1.37 2.26e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.60 2.43e-07 GO:0030036 actin cytoskeleton organization
1.27 3.26e-07 GO:0031325 positive regulation of cellular metabolic process
1.41 3.68e-07 GO:0045892 negative regulation of transcription, DNA-dependent
1.11 5.66e-07 GO:0043170 macromolecule metabolic process
1.39 7.47e-07 GO:0051253 negative regulation of RNA metabolic process
1.37 7.64e-07 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 8.78e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
1.36 1.25e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.12 1.32e-06 GO:0044260 cellular macromolecule metabolic process
1.40 1.42e-06 GO:0007417 central nervous system development
1.50 1.52e-06 GO:0007411 axon guidance
1.31 1.87e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.32 1.87e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53 1.88e-06 GO:0030029 actin filament-based process
1.30 2.06e-06 GO:0009891 positive regulation of biosynthetic process
1.30 2.07e-06 GO:0006351 transcription, DNA-dependent
1.34 2.51e-06 GO:0010628 positive regulation of gene expression
1.51 2.78e-06 GO:0051130 positive regulation of cellular component organization
1.41 3.06e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.53 3.30e-06 GO:0035295 tube development
1.20 5.62e-06 GO:0007166 cell surface receptor linked signaling pathway
1.57 6.40e-06 GO:0051129 negative regulation of cellular component organization
1.31 8.87e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.33 9.41e-06 GO:0051254 positive regulation of RNA metabolic process
1.22 1.00e-05 GO:0065009 regulation of molecular function
1.18 1.10e-05 GO:0065008 regulation of biological quality
1.09 1.26e-05 GO:0044238 primary metabolic process
1.60 1.34e-05 GO:0044087 regulation of cellular component biogenesis
1.35 1.40e-05 GO:0009887 organ morphogenesis
1.37 1.56e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.43 1.56e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.32 1.81e-05 GO:0009790 embryo development
1.26 2.35e-05 GO:0032879 regulation of localization
1.39 2.68e-05 GO:0051094 positive regulation of developmental process
1.25 2.82e-05 GO:0010646 regulation of cell communication
1.43 3.55e-05 GO:0043009 chordate embryonic development
1.48 3.82e-05 GO:0048729 tissue morphogenesis
1.33 5.20e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.70 5.41e-05 GO:0060537 muscle tissue development
1.42 5.52e-05 GO:0009792 embryo development ending in birth or egg hatching
1.25 6.09e-05 GO:0009605 response to external stimulus
1.45 6.98e-05 GO:0060284 regulation of cell development
1.47 8.46e-05 GO:0051270 regulation of cellular component movement
1.24 9.18e-05 GO:0010941 regulation of cell death
1.39 1.24e-04 GO:0007243 intracellular protein kinase cascade
1.39 1.24e-04 GO:0023014 signal transduction via phosphorylation event
1.72 1.26e-04 GO:0014706 striated muscle tissue development
1.48 1.38e-04 GO:0061061 muscle structure development
1.21 1.41e-04 GO:0035556 intracellular signal transduction
1.27 1.47e-04 GO:0040011 locomotion
1.43 1.69e-04 GO:0007389 pattern specification process
1.24 2.09e-04 GO:0043067 regulation of programmed cell death
1.48 2.21e-04 GO:0030334 regulation of cell migration
1.25 2.29e-04 GO:0032774 RNA biosynthetic process
1.26 2.43e-04 GO:0009888 tissue development
1.09 2.58e-04 GO:0032501 multicellular organismal process
1.08 2.64e-04 GO:0044237 cellular metabolic process
1.24 2.92e-04 GO:0042981 regulation of apoptosis
1.07 3.15e-04 GO:0008152 metabolic process
1.08 3.83e-04 GO:0050896 response to stimulus
1.63 4.19e-04 GO:0001655 urogenital system development
1.40 4.27e-04 GO:0048598 embryonic morphogenesis
1.42 4.74e-04 GO:0045597 positive regulation of cell differentiation
1.17 5.49e-04 GO:0006464 protein modification process
1.47 5.53e-04 GO:0045596 negative regulation of cell differentiation
1.47 5.53e-04 GO:2000145 regulation of cell motility
1.49 5.85e-04 GO:0003002 regionalization
1.27 5.90e-04 GO:0031399 regulation of protein modification process
1.34 8.00e-04 GO:0072358 cardiovascular system development
1.34 8.00e-04 GO:0072359 circulatory system development
1.25 9.27e-04 GO:0016265 death
1.23 9.48e-04 GO:0032268 regulation of cellular protein metabolic process
1.44 9.59e-04 GO:0040012 regulation of locomotion
1.23 1.14e-03 GO:0006793 phosphorus metabolic process
1.23 1.14e-03 GO:0006796 phosphate metabolic process
1.27 1.19e-03 GO:0006468 protein phosphorylation
1.54 1.25e-03 GO:0035239 tube morphogenesis
1.25 1.27e-03 GO:0044093 positive regulation of molecular function
1.53 1.34e-03 GO:0048732 gland development
1.38 1.46e-03 GO:0007420 brain development
1.24 1.62e-03 GO:0008219 cell death
1.44 1.77e-03 GO:0001568 blood vessel development
1.43 1.83e-03 GO:0001944 vasculature development
1.23 1.84e-03 GO:0042127 regulation of cell proliferation
1.29 1.91e-03 GO:0001932 regulation of protein phosphorylation
1.21 2.25e-03 GO:0051246 regulation of protein metabolic process
1.40 2.40e-03 GO:0051093 negative regulation of developmental process
1.50 2.75e-03 GO:0045664 regulation of neuron differentiation
1.31 2.95e-03 GO:0043068 positive regulation of programmed cell death
1.57 3.11e-03 GO:0030335 positive regulation of cell migration
1.57 3.11e-03 GO:2000147 positive regulation of cell motility
1.92 3.30e-03 GO:0048738 cardiac muscle tissue development
1.28 3.61e-03 GO:0009725 response to hormone stimulus
1.50 3.67e-03 GO:0007517 muscle organ development
1.31 4.32e-03 GO:0043065 positive regulation of apoptosis
1.68 4.49e-03 GO:0001822 kidney development
1.55 4.52e-03 GO:0051272 positive regulation of cellular component movement
1.26 4.64e-03 GO:0006915 apoptosis
1.30 5.27e-03 GO:0010942 positive regulation of cell death
1.45 5.31e-03 GO:0048568 embryonic organ development
1.57 5.41e-03 GO:0045165 cell fate commitment
1.26 6.56e-03 GO:0009719 response to endogenous stimulus
1.25 6.75e-03 GO:0012501 programmed cell death
1.38 7.04e-03 GO:0033043 regulation of organelle organization
1.45 7.15e-03 GO:0002009 morphogenesis of an epithelium
1.41 7.35e-03 GO:0051960 regulation of nervous system development
1.31 7.35e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.19 7.83e-03 GO:0050790 regulation of catalytic activity
1.54 8.51e-03 GO:0040017 positive regulation of locomotion
1.38 8.57e-03 GO:0051050 positive regulation of transport
1.30 9.16e-03 GO:0006935 chemotaxis
1.30 9.16e-03 GO:0042330 taxis
1.14 9.67e-03 GO:0090304 nucleic acid metabolic process
1.69 1.01e-02 GO:0030278 regulation of ossification
1.16 1.02e-02 GO:0016070 RNA metabolic process
1.64 1.02e-02 GO:0072001 renal system development
1.13 1.03e-02 GO:0042221 response to chemical stimulus
1.26 1.06e-02 GO:0042325 regulation of phosphorylation
1.43 1.09e-02 GO:0000165 MAPKKK cascade
1.25 1.10e-02 GO:0019220 regulation of phosphate metabolic process
1.25 1.10e-02 GO:0051174 regulation of phosphorus metabolic process
1.80 1.12e-02 GO:0001657 ureteric bud development
1.12 1.19e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38 1.22e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.25 1.60e-02 GO:0043085 positive regulation of catalytic activity
1.32 1.66e-02 GO:0032583 regulation of gene-specific transcription
1.32 2.18e-02 GO:0008285 negative regulation of cell proliferation
1.41 2.27e-02 GO:0050767 regulation of neurogenesis
1.59 2.74e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.28 2.96e-02 GO:0051338 regulation of transferase activity
1.57 3.07e-02 GO:0001763 morphogenesis of a branching structure
1.67 3.12e-02 GO:0030326 embryonic limb morphogenesis
1.67 3.12e-02 GO:0035113 embryonic appendage morphogenesis
1.32 3.15e-02 GO:0009968 negative regulation of signal transduction
1.50 3.30e-02 GO:0009952 anterior/posterior pattern formation
1.49 3.39e-02 GO:0051493 regulation of cytoskeleton organization
1.77 3.68e-02 GO:0042326 negative regulation of phosphorylation
1.57 3.68e-02 GO:0043254 regulation of protein complex assembly
1.15 3.75e-02 GO:0006996 organelle organization
1.52 3.84e-02 GO:0060562 epithelial tube morphogenesis
1.14 3.91e-02 GO:0043412 macromolecule modification
1.32 4.49e-02 GO:0007264 small GTPase mediated signal transduction
1.22 4.62e-02 GO:0033554 cellular response to stress
1.28 4.64e-02 GO:0007010 cytoskeleton organization
1.56 4.88e-02 GO:0010639 negative regulation of organelle organization
1.61 4.99e-02 GO:0035107 appendage morphogenesis
1.61 4.99e-02 GO:0035108 limb morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 5.97e-13 GO:0044424 intracellular part
1.06 8.26e-12 GO:0005622 intracellular
1.12 1.43e-11 GO:0005634 nucleus
1.07 3.43e-10 GO:0043226 organelle
1.07 3.80e-10 GO:0043229 intracellular organelle
1.07 1.80e-07 GO:0043231 intracellular membrane-bounded organelle
1.07 2.27e-07 GO:0005737 cytoplasm
1.07 2.28e-07 GO:0043227 membrane-bounded organelle
1.41 3.45e-06 GO:0045202 synapse
1.32 9.34e-06 GO:0030054 cell junction
1.79 1.66e-05 GO:0005925 focal adhesion
1.02 1.68e-05 GO:0044464 cell part
1.02 1.84e-05 GO:0005623 cell
1.49 4.19e-05 GO:0016323 basolateral plasma membrane
1.72 6.97e-05 GO:0030055 cell-substrate junction
1.73 7.80e-05 GO:0005924 cell-substrate adherens junction
1.37 1.00e-04 GO:0043005 neuron projection
1.15 2.72e-04 GO:0005829 cytosol
1.16 3.58e-04 GO:0031981 nuclear lumen
1.14 6.47e-04 GO:0044459 plasma membrane part
1.55 8.63e-04 GO:0005912 adherens junction
1.39 8.92e-04 GO:0044456 synapse part
1.18 1.51e-03 GO:0005654 nucleoplasm
1.37 3.94e-03 GO:0015629 actin cytoskeleton
1.47 4.14e-03 GO:0031252 cell leading edge
1.13 4.34e-03 GO:0044428 nuclear part
1.22 4.38e-03 GO:0031982 vesicle
2.00 5.66e-03 GO:0000781 chromosome, telomeric region
1.22 7.96e-03 GO:0031410 cytoplasmic vesicle
1.47 8.27e-03 GO:0070161 anchoring junction
2.07 9.10e-03 GO:0042641 actomyosin
1.12 1.18e-02 GO:0043233 organelle lumen
1.15 1.20e-02 GO:0005856 cytoskeleton
1.22 1.28e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.22 1.29e-02 GO:0031988 membrane-bounded vesicle
1.46 1.50e-02 GO:0030136 clathrin-coated vesicle
2.09 1.72e-02 GO:0032432 actin filament bundle
1.43 1.77e-02 GO:0030424 axon
1.41 1.78e-02 GO:0030135 coated vesicle
1.92 2.33e-02 GO:0043679 axon terminus
1.90 2.36e-02 GO:0044306 neuron projection terminus
1.11 2.45e-02 GO:0070013 intracellular organelle lumen
1.65 3.16e-02 GO:0033267 axon part
1.11 3.89e-02 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 8.87e-23 GO:0005515 protein binding
1.07 2.69e-17 GO:0005488 binding
1.43 2.70e-12 GO:0043565 sequence-specific DNA binding
1.34 4.82e-12 GO:0030528 transcription regulator activity
1.34 2.01e-11 GO:0001071 nucleic acid binding transcription factor activity
1.34 2.01e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 3.62e-07 GO:0008092 cytoskeletal protein binding
1.46 3.27e-06 GO:0003779 actin binding
1.26 3.79e-04 GO:0019899 enzyme binding
1.40 8.44e-04 GO:0008134 transcription factor binding
1.48 1.30e-03 GO:0010843 promoter binding
1.32 1.49e-03 GO:0019904 protein domain specific binding
1.47 1.79e-03 GO:0000975 regulatory region DNA binding
1.47 1.79e-03 GO:0001067 regulatory region nucleic acid binding
1.47 1.79e-03 GO:0044212 transcription regulatory region DNA binding
1.33 4.70e-03 GO:0000988 protein binding transcription factor activity
1.33 4.70e-03 GO:0000989 transcription factor binding transcription factor activity
1.13 5.70e-03 GO:0003677 DNA binding
1.32 6.33e-03 GO:0003712 transcription cofactor activity
1.35 6.95e-03 GO:0016563 transcription activator activity