Motif ID: NANOG.p2

Z-value: 0.923


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_7833292-0.621.0e-02Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_177106702 1.356 NM_004673
ANGPTL1
angiopoietin-like 1
chr14_+_100365162 1.313 MEG3
maternally expressed 3 (non-protein coding)
chrX_+_28515479 1.265 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr7_-_13996166 1.205 NM_001163147
NM_004956
ETV1

ets variant 1

chr2_-_144994038 1.077 ZEB2
zinc finger E-box binding homeobox 2
chr2_-_110665188 1.043 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr4_+_114190233 0.928 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr9_+_117955890 0.916 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr5_+_176744037 0.889 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr4_-_186815116 0.884 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr9_-_8723893 0.881 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr1_+_168898898 0.865 PRRX1
paired related homeobox 1
chr16_+_51690564 0.839 CHD9
chromodomain helicase DNA binding protein 9
chr21_-_30836051 0.823 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr5_+_155686333 0.791 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr13_+_100902942 0.739 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr3_+_161040343 0.698 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr3_+_116824840 0.689 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr4_-_138673014 0.671 PCDH18
protocadherin 18
chr4_+_114433551 0.647 ANK2
ankyrin 2, neuronal
chr6_+_129245978 0.635 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr9_+_108665168 0.635 NM_021224
ZNF462
zinc finger protein 462
chr6_-_112034166 0.634 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr4_-_40631397 0.619 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr5_+_152850276 0.592 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr2_+_210152399 0.572 MAP2
microtubule-associated protein 2
chr3_-_11598829 0.562 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr13_+_112825113 0.557 NM_000504
F10
coagulation factor X
chr7_-_13992351 0.550 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr14_+_100365390 0.534 MEG3
maternally expressed 3 (non-protein coding)
chr5_-_112658200 0.534 MCC
mutated in colorectal cancers
chrX_+_55951280 0.534


chr3_-_113842652 0.531 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr2_+_157822355 0.522 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr3_+_161040439 0.521 SCHIP1
schwannomin interacting protein 1
chr6_+_39868116 0.520


chr3_+_16191159 0.520 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr13_+_23042722 0.515 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr7_+_18501876 0.515 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr1_-_42156957 0.500 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr19_+_3713650 0.499 NM_172251
MRPL54
mitochondrial ribosomal protein L54
chr10_-_13789628 0.493 FRMD4A
FERM domain containing 4A
chr7_-_25234582 0.479 NM_022150
NPVF
neuropeptide VF precursor
chr6_-_136889302 0.463 MAP7
microtubule-associated protein 7
chr5_-_112658456 0.462 NM_002387
MCC
mutated in colorectal cancers
chr1_+_196874839 0.459 PTPRC
protein tyrosine phosphatase, receptor type, C
chr6_-_136888771 0.457 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr5_+_125786717 0.456 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr5_+_140790141 0.455 PCDHGA12
protocadherin gamma subfamily A, 12
chr7_+_2524022 0.452 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_-_42157077 0.451 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr2_+_161980865 0.450 NM_006593
TBR1
T-box, brain, 1
chr2_+_36777336 0.447 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr4_-_138673078 0.445 NM_019035
PCDH18
protocadherin 18
chr11_-_85107569 0.444 NM_206929
SYTL2
synaptotagmin-like 2
chr9_-_132759045 0.441 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr1_+_559618 0.433


chr1_-_42156913 0.433


chr14_-_79748273 0.429 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr17_-_46479127 0.426 SPAG9
sperm associated antigen 9
chr12_-_120725210 0.425 LOC338799
hypothetical LOC338799
chr3_+_35697432 0.422 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_+_18502342 0.404 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr9_-_4656665 0.401 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr7_+_63411813 0.400 ZNF736
zinc finger protein 736
chr3_-_12916547 0.399 IQSEC1
IQ motif and Sec7 domain 1
chr8_+_26206648 0.399 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_196874759 0.395 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_+_36777406 0.388 VIT
vitrin
chr2_+_210152609 0.386 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr2_+_108637916 0.373 LIMS1
LIMS3
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 3
chr3_-_21767819 0.371 NM_024697
ZNF385D
zinc finger protein 385D
chr1_-_109957195 0.367 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr2_-_158439868 0.367 NM_001105
ACVR1
activin A receptor, type I
chr4_-_123761615 0.362 NM_021803
IL21
interleukin 21
chrX_+_21960841 0.362 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr13_+_48923688 0.360 NM_001160308
SETDB2
SET domain, bifurcated 2
chr10_-_93659164 0.358 NM_152429
FGFBP3
fibroblast growth factor binding protein 3
chr3_-_139960874 0.357 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr18_+_13601664 0.351 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr22_+_44828338 0.351


chr6_-_31215089 0.350 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr7_-_92615593 0.346 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr12_-_101398451 0.342 IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_116185215 0.342 NM_005599
NHLH2
nescient helix loop helix 2
chr11_-_40272239 0.339 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr5_-_43326922 0.339 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr5_+_140790310 0.331 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr8_-_142333339 0.330 SLC45A4
solute carrier family 45, member 4
chr13_-_59223074 0.330


chr7_+_113842470 0.325 FOXP2
forkhead box P2
chr3_+_171183203 0.323 SEC62
SEC62 homolog (S. cerevisiae)
chr12_-_101398470 0.321 IGF1
insulin-like growth factor 1 (somatomedin C)
chr3_+_153074118 0.316 NM_033050
SUCNR1
succinate receptor 1
chr5_-_88215034 0.315 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chrX_+_135058402 0.312 NM_001159700
FHL1
four and a half LIM domains 1
chr11_-_118405288 0.310 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr12_-_101398429 0.309 IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_+_40117751 0.309 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr12_-_101398503 0.308 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr8_-_6407882 0.306 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr12_+_47205681 0.305 NM_001005203
OR8S1
olfactory receptor, family 8, subfamily S, member 1
chr11_+_101488380 0.302 NM_001195045
YAP1
Yes-associated protein 1
chr3_-_46043982 0.298 NM_001024644
NM_005283
XCR1

chemokine (C motif) receptor 1

chr17_-_10313600 0.298 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr14_-_80934523 0.297 NM_033104
STON2
stonin 2
chr2_+_161981046 0.296 TBR1
T-box, brain, 1
chr10_-_52315436 0.294 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_-_115960807 0.294 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr5_+_125786975 0.290 GRAMD3
GRAM domain containing 3
chr2_+_161981138 0.290 TBR1
T-box, brain, 1
chr12_-_4358968 0.287 NM_020638
FGF23
fibroblast growth factor 23
chr17_+_56843893 0.284 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr5_-_96504216 0.282 LIX1
Lix1 homolog (chicken)
chr3_+_130014957 0.279 RAB7A
RAB7A, member RAS oncogene family
chr5_+_140848905 0.276 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr5_+_140790365 0.274 PCDHGA12
protocadherin gamma subfamily A, 12
chr1_-_20682541 0.273


chr6_-_32605898 0.272 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr10_+_11246934 0.270 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr11_+_7574992 0.269 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_-_101398288 0.268 IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_-_114490701 0.267 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr11_-_104421240 0.267 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr4_+_71806538 0.263 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr5_-_96504194 0.263 LIX1
Lix1 homolog (chicken)
chr2_-_224175386 0.263 NM_003469
SCG2
secretogranin II
chr15_-_68177283 0.262 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr6_-_112033775 0.262 TRAF3IP2
TRAF3 interacting protein 2
chrX_+_114701432 0.260 NM_005032
PLS3
plastin 3
chr17_-_45629401 0.259


chr22_-_37211467 0.257 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr3_-_69254226 0.254 NM_198271
LMOD3
leiomodin 3 (fetal)
chr7_+_28692122 0.254 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr12_+_54700955 0.253 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr11_-_85108030 0.252 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr11_-_66976775 0.251 NM_206997
GPR152
G protein-coupled receptor 152
chr7_-_13995811 0.249 ETV1
ets variant 1
chr18_+_71051713 0.248 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr18_+_54039779 0.248 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_-_45621571 0.247 COL1A1
collagen, type I, alpha 1
chr7_+_116447527 0.246 ST7
suppression of tumorigenicity 7
chr8_-_82557956 0.243 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr3_+_2528272 0.240 CNTN4
contactin 4
chr8_+_26569709 0.240 DPYSL2
dihydropyrimidinase-like 2
chr3_-_121445831 0.239 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr12_-_69434330 0.239 PTPRR
protein tyrosine phosphatase, receptor type, R
chr5_+_53787187 0.237 NM_006308
HSPB3
heat shock 27kDa protein 3
chr3_-_113842553 0.237 CCDC80
coiled-coil domain containing 80
chr12_+_54838408 0.236 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr2_-_224175339 0.235 SCG2
secretogranin II
chr12_-_89922888 0.234 NM_004950
EPYC
epiphycan
chr7_+_113853790 0.231 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr3_-_55489973 0.229 WNT5A
wingless-type MMTV integration site family, member 5A
chr11_-_128217550 0.227 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr18_+_54039818 0.227 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_99309688 0.227 EML1
echinoderm microtubule associated protein like 1
chr4_+_169250281 0.224 NM_007193
ANXA10
annexin A10
chrX_+_102918409 0.224 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr15_-_91078307 0.223 FAM174B
family with sequence similarity 174, member B
chr9_+_81377289 0.222 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_50347188 0.221 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_-_36418869 0.221 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr12_+_25096755 0.221 LRMP
lymphoid-restricted membrane protein
chr18_+_30812205 0.218 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr11_-_85074848 0.218 NM_152723
CCDC89
coiled-coil domain containing 89
chrX_+_134482387 0.217 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr12_-_14740694 0.216 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr5_-_96504258 0.216 NM_153234
LIX1
Lix1 homolog (chicken)
chr4_+_15038726 0.216 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr1_-_149004916 0.215 NM_004079
CTSS
cathepsin S
chrX_+_41433169 0.215 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr17_-_45621312 0.214 COL1A1
collagen, type I, alpha 1
chr1_-_149004852 0.214 CTSS
cathepsin S
chr17_+_51585834 0.213 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr7_-_136679045 0.212 NM_002825
PTN
pleiotrophin
chr2_+_108637698 0.212 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr9_+_123369219 0.209 NM_032552
DAB2IP
DAB2 interacting protein
chr1_-_203579932 0.208 KLHDC8A
kelch domain containing 8A
chr2_-_224175293 0.208 SCG2
secretogranin II
chr1_+_194887630 0.206 NM_000186
NM_001014975
CFH

complement factor H

chr2_-_200033445 0.205 SATB2
SATB homeobox 2
chr14_-_104330982 0.204 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr5_-_148738980 0.204 NM_014443
IL17B
interleukin 17B
chr18_-_3864252 0.203 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr3_-_102194938 0.203 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr3_+_157877146 0.201 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr9_-_4289574 0.200 GLIS3
GLIS family zinc finger 3
chr12_+_54838733 0.200 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr5_-_24535386 0.195 NM_001190450
CDH10
cadherin 10, type 2 (T2-cadherin)
chr15_+_100175888 0.195 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr20_+_42463279 0.194 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr2_-_217268492 0.194 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr19_-_38052481 0.193 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr1_-_115060956 0.193 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr5_-_168204430 0.192


chr1_-_115060857 0.192 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr17_-_37590910 0.191 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr7_+_113842284 0.191 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr12_-_89922875 0.191 EPYC
epiphycan

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.09e-06 GO:0032501 multicellular organismal process
2.39 2.01e-06 GO:0045595 regulation of cell differentiation
1.48 2.56e-06 GO:0032502 developmental process
1.74 3.10e-06 GO:0048513 organ development
1.57 3.75e-06 GO:0048731 system development
3.27 4.01e-06 GO:0061061 muscle structure development
1.53 5.23e-06 GO:0048856 anatomical structure development
3.77 5.51e-06 GO:0007517 muscle organ development
2.13 6.05e-06 GO:0050793 regulation of developmental process
1.46 7.22e-05 GO:0007275 multicellular organismal development
2.05 1.19e-04 GO:0009888 tissue development
1.61 2.44e-04 GO:0030154 cell differentiation
1.58 5.88e-04 GO:0048869 cellular developmental process
3.84 9.07e-04 GO:0001503 ossification
2.05 9.42e-04 GO:2000026 regulation of multicellular organismal development
1.59 5.37e-03 GO:0003008 system process
2.53 8.67e-03 GO:0060284 regulation of cell development
1.69 8.89e-03 GO:0051239 regulation of multicellular organismal process
1.21 9.49e-03 GO:0050789 regulation of biological process
1.44 1.03e-02 GO:0048518 positive regulation of biological process
1.61 1.68e-02 GO:0009653 anatomical structure morphogenesis
3.39 2.10e-02 GO:0060537 muscle tissue development
2.42 2.14e-02 GO:0045597 positive regulation of cell differentiation
1.24 2.15e-02 GO:0050896 response to stimulus
2.20 2.25e-02 GO:0051094 positive regulation of developmental process
1.21 2.55e-02 GO:0050794 regulation of cellular process
3.03 3.27e-02 GO:0030155 regulation of cell adhesion
1.59 3.49e-02 GO:0007399 nervous system development
5.78 3.54e-02 GO:0051149 positive regulation of muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 4.57e-03 GO:0005886 plasma membrane
1.30 5.31e-03 GO:0071944 cell periphery
1.45 1.08e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.81 8.01e-04 GO:0001071 nucleic acid binding transcription factor activity
1.81 8.01e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.94 2.94e-03 GO:0043565 sequence-specific DNA binding