Motif ID: NKX2-1,4.p2

Z-value: 1.088


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-4chr20_-_213260460.322.3e-01Click!
NKX2-1chr14_-_36059084-0.312.5e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_78087484 1.557 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr15_-_81271859 1.278 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr6_+_152053323 1.204 NM_001122742
ESR1
estrogen receptor 1
chr7_+_120416680 1.148 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr14_-_94669547 1.115 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr14_-_19553191 1.046 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr4_-_68793928 1.010 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr5_-_13997588 1.002 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr14_+_38772870 0.995 NM_054024
MIA2
melanoma inhibitory activity 2
chr5_-_22248630 0.953 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr4_-_184478920 0.886 NM_001111319
CLDN22
claudin 22
chr19_-_6621078 0.854 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_180836050 0.846


chr16_-_70306198 0.815 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr2_-_56266408 0.809 LOC100129434
hypothetical LOC100129434
chr12_-_7739591 0.797 NM_020634
GDF3
growth differentiation factor 3
chr19_+_16691786 0.762 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr4_+_86968069 0.752 ARHGAP24
Rho GTPase activating protein 24
chr10_-_11614279 0.751 NM_001080491
USP6NL
USP6 N-terminal like
chr8_-_7308438 0.744 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




SPAG11A
sperm associated antigen 11B




sperm associated antigen 11A
chr8_+_7742811 0.729 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr1_-_12880674 0.717 NM_001039361
PRAMEF10
PRAME family member 10
chr17_+_63338500 0.702 BPTF
bromodomain PHD finger transcription factor
chr12_-_119733062 0.691 SPPL3
signal peptide peptidase 3
chr21_-_14840506 0.660 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_-_108311872 0.638 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr1_+_32489426 0.629 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr2_+_161701711 0.627 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr3_+_2908920 0.609 NM_175613
CNTN4
contactin 4
chr19_-_50688310 0.602 NM_206901
RTN2
reticulon 2
chr5_-_147996769 0.578 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr7_-_7724762 0.571 NM_002947
RPA3
replication protein A3, 14kDa
chrX_+_128966844 0.549 NM_021946
BCORL1
BCL6 corepressor-like 1
chr4_-_174774368 0.535 NM_006792
MORF4
mortality factor 4
chr1_-_21310462 0.531 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr4_-_151993422 0.530


chr1_-_89364273 0.526 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr2_-_133256097 0.512 NCKAP5
NCK-associated protein 5
chrX_-_131989963 0.506 NM_031907
USP26
ubiquitin specific peptidase 26
chr2_+_105320440 0.504 NM_024093
C2orf49
chromosome 2 open reading frame 49
chr11_+_118259684 0.483 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr16_+_11966464 0.483 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_+_31059463 0.475 NM_001010909
MUC21
mucin 21, cell surface associated
chr17_+_7563763 0.475 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr8_+_67201684 0.471 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr10_-_49152918 0.469 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr6_-_155818728 0.468 NM_015718
NOX3
NADPH oxidase 3
chr1_-_143706196 0.466 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_220953351 0.466 BROX
BRO1 domain and CAAX motif containing
chr19_-_6621598 0.460 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr16_-_66558197 0.450 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr16_+_56567839 0.449 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr12_+_76749199 0.446 NM_014903
NAV3
neuron navigator 3
chr1_+_151117421 0.443 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr16_-_31007630 0.442 NM_001039503
PRSS53
protease, serine, 53
chr1_-_58920315 0.440


chr3_+_191588354 0.433 NM_006580
CLDN16
claudin 16
chr15_+_38430517 0.428 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr1_-_143706300 0.422 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr10_+_18669619 0.420 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr13_-_35842289 0.419 NM_001142294
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr1_+_159817752 0.412 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr11_-_102331643 0.407 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr1_-_178100204 0.405


chr4_-_174557191 0.397 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr1_-_143706265 0.393 PDE4DIP
phosphodiesterase 4D interacting protein
chr15_+_38437703 0.392 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr6_-_11887265 0.387 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr3_+_188397967 0.387 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr1_-_242073094 0.382 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chrX_+_46967360 0.376 NM_001170460
CDK16
cyclin-dependent kinase 16
chr11_+_22646229 0.356 NM_177553
GAS2
growth arrest-specific 2
chr6_+_73133152 0.353 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr9_+_114671635 0.352 SNX30
sorting nexin family member 30
chr3_-_51971915 0.349 NM_033010
PCBP4
poly(rC) binding protein 4
chr6_-_119137923 0.347 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr12_-_10846435 0.345 NM_023919
TAS2R7
taste receptor, type 2, member 7
chrX_-_100920493 0.338 GK
glycerol kinase
chr18_-_44723116 0.336 NM_001190823
SMAD7
SMAD family member 7
chr16_-_69876262 0.336 FTSJD1
FtsJ methyltransferase domain containing 1
chr10_+_126620681 0.333 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr10_+_102212787 0.332 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr17_+_20048890 0.329 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr3_+_68136056 0.328 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr6_+_126282078 0.322 NCOA7
nuclear receptor coactivator 7
chr2_-_242205556 0.321 NM_001164356
THAP4
THAP domain containing 4
chr12_-_110410730 0.321 ATXN2
ataxin 2
chr7_-_99170651 0.321 NM_000765
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chr10_-_69125932 0.320 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr12_+_12769985 0.319 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chrX_+_41468351 0.318 NM_080817
GPR82
G protein-coupled receptor 82
chr3_+_63403792 0.317 NM_144642
SYNPR
synaptoporin
chr7_-_16471817 0.307 NM_015464
SOSTDC1
sclerostin domain containing 1
chr1_+_169747788 0.304 PRRC2C
proline-rich coiled-coil 2C
chr20_-_33706532 0.303 RBM12
RNA binding motif protein 12
chr5_+_66160359 0.297 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_-_101115677 0.296 NM_002674
PMCH
pro-melanin-concentrating hormone
chr2_+_38009405 0.293 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr11_+_59979857 0.291 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_-_13325242 0.286 NM_001099854
PRAMEF14
PRAME family member 14
chr5_-_131907071 0.285 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr5_-_121842680 0.284


chr13_-_25687062 0.283 RNF6
ring finger protein (C3H2C3 type) 6
chr11_+_55899675 0.282 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr5_+_147423727 0.277 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr10_-_75005421 0.275 NM_152586
USP54
ubiquitin specific peptidase 54
chr8_-_110726921 0.272 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr11_-_4782185 0.269 NM_001005177
OR52R1
olfactory receptor, family 52, subfamily R, member 1
chr7_+_129634935 0.269 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr17_+_7846636 0.269 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr1_-_33585848 0.269


chr20_+_2224612 0.267 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr20_+_31287462 0.267 NM_016583
NM_130852
PLUNC

palate, lung and nasal epithelium associated

chr4_+_70896236 0.263 NM_001009181
NM_003154
STATH

statherin

chr12_-_10853940 0.262 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr21_-_31049566 0.262 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr3_+_190831909 0.262 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr4_+_37638450 0.262 NM_006607
PTTG2
pituitary tumor-transforming 2
chr2_-_100125402 0.261 NM_002285
AFF3
AF4/FMR2 family, member 3
chr9_+_122923864 0.260 CEP110
centrosomal protein 110kDa
chr4_+_111053488 0.259 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr15_-_23201740 0.257 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr14_-_20694023 0.256 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr3_-_180460372 0.254 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr8_-_7207899 0.254 NM_001164457
ZNF705G
zinc finger protein 705G
chr15_+_79304694 0.248 NM_172217
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr1_+_163780063 0.246 NM_001005214
LRRC52
leucine rich repeat containing 52
chrX_-_84250629 0.245 NM_001012980
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr9_-_21472311 0.244 NM_176891
IFNE
interferon, epsilon
chr4_-_100359353 0.244 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr3_+_98641143 0.241 NM_173655
EPHA6
EPH receptor A6
chr17_-_32730804 0.239 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr13_-_74799898 0.238 TBC1D4
TBC1 domain family, member 4
chr5_+_139485703 0.234 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chrX_+_71280758 0.234 NM_207422
FLJ44635
TPT1-like protein
chr1_+_50344550 0.233 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_51340487 0.230 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr21_+_37714470 0.229 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr1_-_12813849 0.225 NM_001146344
PRAMEF11
PRAME family member 11
chr11_-_89181390 0.222 NM_020358
TRIM49
tripartite motif containing 49
chr5_+_156752739 0.221 CYFIP2
cytoplasmic FMR1 interacting protein 2
chrX_+_69371229 0.220 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr7_-_113346284 0.219 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr9_+_126158935 0.218


chr15_+_36014748 0.214 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr17_-_74244539 0.214


chr20_-_42561725 0.213


chr14_+_55148488 0.212 KTN1
kinectin 1 (kinesin receptor)
chr10_+_90511142 0.212 NM_001102469
LIPN
lipase, family member N
chr11_+_36546138 0.210 NM_000448
RAG1
recombination activating gene 1
chr1_-_118123033 0.209


chr14_+_63752424 0.208 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr10_+_70650064 0.208 NM_025130
HKDC1
hexokinase domain containing 1
chr5_+_86712376 0.207


chr1_-_240679380 0.204 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr4_-_107508040 0.204 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr1_-_238842011 0.203 GREM2
gremlin 2
chr2_-_217433018 0.203 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr6_-_66473790 0.202 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr9_+_130485926 0.201 SET
SET nuclear oncogene
chrX_-_117003310 0.194 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr15_-_40537002 0.193 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr4_+_166350620 0.193 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr17_-_64462976 0.192 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr9_+_6231677 0.189 NM_033439
IL33
interleukin 33
chr1_+_159899528 0.189 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chrX_+_111005934 0.186 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chrX_+_105823723 0.184 NM_024539
RNF128
ring finger protein 128
chr1_+_146827470 0.184 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chr4_-_21155376 0.180 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr11_+_61732715 0.177 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr19_-_53950458 0.176 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chrX_-_154216929 0.175 NM_001289
CLIC2
chloride intracellular channel 2
chr11_+_55776251 0.175 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr8_-_6901661 0.173 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr2_-_21079145 0.172 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_-_13584950 0.171 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr2_-_37727472 0.170 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr6_+_45404031 0.170 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr11_-_119499188 0.168 TRIM29
tripartite motif containing 29
chr9_+_115246831 0.167 NM_144488
RGS3
regulator of G-protein signaling 3
chr2_+_207512522 0.166 NM_173077
CPO
carboxypeptidase O
chr7_+_38984133 0.165 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr9_+_108726257 0.165 ZNF462
zinc finger protein 462
chr12_+_117067214 0.164 PEBP1
phosphatidylethanolamine binding protein 1
chr5_+_150020595 0.164 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr6_+_31782618 0.161 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr3_+_109498082 0.160 HHLA2
HERV-H LTR-associating 2
chr3_+_171112053 0.160 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr2_+_207115060 0.160 ADAM23
ADAM metallopeptidase domain 23
chr4_+_78172966 0.160 SEPT11
septin 11
chr6_-_29451042 0.160 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr4_+_71298187 0.159 NM_021225
PROL1
proline rich, lacrimal 1
chr1_-_41398126 0.158 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr2_-_37397669 0.157 NM_005813
PRKD3
protein kinase D3
chr3_-_188492163 0.157 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr11_-_1586190 0.155 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chr21_-_33785649 0.155 NM_017833
DNAJC28
DnaJ (Hsp40) homolog, subfamily C, member 28
chr17_-_53761119 0.154 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr1_+_151498802 0.154 NM_000427
LOR
loricrin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.35 2.20e-02 GO:0001775 cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 2.21e-03 GO:0071944 cell periphery
1.37 3.93e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.00 3.87e-03 GO:0004930 G-protein coupled receptor activity
1.57 6.64e-03 GO:0004871 signal transducer activity
1.57 6.64e-03 GO:0060089 molecular transducer activity
1.71 1.92e-02 GO:0004888 transmembrane receptor activity
1.58 3.28e-02 GO:0004872 receptor activity