Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.717


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.204.6e-01Click!
NKX2-3chr10_+_1012826790.048.9e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_79899748 0.936 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr19_-_46504831 0.776


chr13_-_45323757 0.658 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr11_-_40272239 0.582 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr6_+_50789215 0.550 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr7_+_94135384 0.507 PEG10
paternally expressed 10
chr10_-_123346148 0.482 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr13_-_102517196 0.448 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr9_+_12683385 0.441 NM_000550
TYRP1
tyrosinase-related protein 1
chr2_+_102456193 0.422 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr17_+_38412267 0.422 NM_005533
IFI35
interferon-induced protein 35
chrX_-_10504852 0.410 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr13_+_77213295 0.399 NM_144595
SLAIN1
SLAIN motif family, member 1
chr6_+_29187565 0.396 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr8_-_110724594 0.379 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr10_-_105835609 0.374 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr7_-_26202626 0.364 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_-_152368492 0.348 SH3D19
SH3 domain containing 19
chr5_+_140227951 0.346 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr6_-_50045296 0.333 NM_001037729
DEFB113
defensin, beta 113
chr4_-_123761615 0.326 NM_021803
IL21
interleukin 21
chr7_-_26198673 0.325 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr14_-_34252695 0.323 NM_021914
CFL2
cofilin 2 (muscle)
chr17_+_7682355 0.322


chr2_+_37282516 0.307 LOC100505876
hypothetical LOC100505876
chr3_+_85858321 0.307 NM_153184
CADM2
cell adhesion molecule 2
chr2_-_162717159 0.304 NM_002054
GCG
glucagon
chr10_-_105835525 0.302 COL17A1
collagen, type XVII, alpha 1
chr5_+_175041069 0.298 NM_022304
HRH2
histamine receptor H2
chr17_-_1195096 0.282 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr20_-_7869068 0.278 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr20_-_33489383 0.276 NM_000557
GDF5
growth differentiation factor 5
chr5_-_22889487 0.275 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr11_+_128067598 0.275 NM_001167681
FLI1
Friend leukemia virus integration 1
chr12_-_101036407 0.274 NM_024057
NUP37
nucleoporin 37kDa
chr6_-_2696152 0.263 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr14_-_37134050 0.262 FOXA1
forkhead box A1
chr12_-_120725210 0.261 LOC338799
hypothetical LOC338799
chr9_-_14076901 0.260 NFIB
nuclear factor I/B
chr12_-_16652202 0.259 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr21_+_39117064 0.256 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr9_+_108726257 0.255 ZNF462
zinc finger protein 462
chr7_-_96471544 0.254 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr7_+_128802719 0.252 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr10_-_56230953 0.251 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr16_+_68238460 0.250 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr5_-_43326922 0.248 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr15_+_97990705 0.247 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr20_-_43163021 0.243 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr15_-_53996597 0.239 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr17_-_9635325 0.235 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr12_-_16321885 0.233 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr11_-_16380967 0.233 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr1_-_152431175 0.224 NM_152263
TPM3
tropomyosin 3
chr8_-_30826074 0.224 NM_031271
TEX15
testis expressed 15
chr20_+_31713750 0.223 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr14_+_31868229 0.220 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr6_+_155579788 0.220 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_+_143971009 0.220 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr2_-_55053398 0.219


chr20_+_56919233 0.218 GNAS
GNAS complex locus
chr17_-_26648375 0.217 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr5_+_140583098 0.213 NM_018934
PCDHB14
protocadherin beta 14
chr17_-_53849888 0.213 RNF43
ring finger protein 43
chr14_-_37133927 0.213 FOXA1
forkhead box A1
chr11_-_104411065 0.209 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr20_+_62266217 0.207 MYT1
myelin transcription factor 1
chr2_+_102320148 0.206 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr17_+_65582981 0.206 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr20_+_1041905 0.204 NM_178578
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr20_+_62266270 0.204 NM_004535
MYT1
myelin transcription factor 1
chr12_+_49634048 0.203 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr10_-_31328426 0.202 NM_001143769
ZNF438
zinc finger protein 438
chr14_-_37134191 0.201 NM_004496
FOXA1
forkhead box A1
chr20_+_56904042 0.201 GNAS
GNAS complex locus
chr5_-_39255335 0.199 NM_001465
NM_199335
FYB

FYN binding protein

chr17_-_36209672 0.198 NM_181535
KRT28
keratin 28
chr2_+_172530120 0.195 HAT1
histone acetyltransferase 1
chr22_-_16127520 0.194 CECR3
cat eye syndrome chromosome region, candidate 3
chr2_+_101874765 0.194 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr7_+_139175420 0.193 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr2_+_101874809 0.191 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr5_+_140215778 0.190 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr9_+_115303527 0.190 NM_130795
RGS3
regulator of G-protein signaling 3
chrX_+_28515479 0.190 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr14_+_22059212 0.189


chr15_+_34720097 0.186 NM_032499
C15orf41
chromosome 15 open reading frame 41
chr2_-_39310176 0.185 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr1_-_181826633 0.185 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr4_+_123380569 0.183 KIAA1109
KIAA1109
chr6_+_118976134 0.183 NM_002667
PLN
phospholamban
chr11_+_55554470 0.183 NM_001001921
OR5AS1
olfactory receptor, family 5, subfamily AS, member 1
chr17_+_72065440 0.183 LOC100507246
hypothetical LOC100507246
chr21_-_14840506 0.181 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr1_+_50342168 0.178 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr6_+_105511615 0.178 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_+_50119261 0.176 RBM5
RNA binding motif protein 5
chr6_-_25679197 0.174


chr17_+_36642240 0.174 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr6_-_39398293 0.172 NM_001135105
NM_001135106
NM_001135107
NM_032115
KCNK16



potassium channel, subfamily K, member 16



chr6_-_39180390 0.171 C6orf64
chromosome 6 open reading frame 64
chr1_+_63861474 0.171 NM_001172818
PGM1
phosphoglucomutase 1
chr4_+_68995761 0.171 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr17_-_36346240 0.170 KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_142605739 0.170 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr17_+_55269974 0.170


chr12_-_10853940 0.170 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr20_+_30160952 0.169 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr5_+_140166842 0.169 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr17_-_39191658 0.167 NM_025237
SOST
sclerostin
chr6_-_66473790 0.165 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr5_-_160211623 0.165 NM_025153
ATP10B
ATPase, class V, type 10B
chr12_+_12829807 0.163 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr10_+_124660206 0.161 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr14_-_105712630 0.160 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_-_92693716 0.160 NM_001039372
HEPACAM2
HEPACAM family member 2
chr2_-_175170674 0.160 WIPF1
WAS/WASL interacting protein family, member 1
chr14_+_30161285 0.159 SCFD1
sec1 family domain containing 1
chr12_-_4358968 0.159 NM_020638
FGF23
fibroblast growth factor 23
chr11_-_57964221 0.158 NM_001004733
OR5B12
olfactory receptor, family 5, subfamily B, member 12
chr2_-_40593074 0.158 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr13_-_37070862 0.157 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr13_+_51933228 0.156 CKAP2
cytoskeleton associated protein 2
chr16_+_7322751 0.156 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr14_+_22059174 0.156


chr5_-_58331515 0.155 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_51200347 0.155 NM_000424
KRT5
keratin 5
chr2_+_225973845 0.154 NM_020864
KIAA1486
KIAA1486
chr2_+_174907914 0.154 NM_001145250
SP9
Sp9 transcription factor homolog (mouse)
chr1_+_556968 0.154


chr2_-_162072492 0.153 AHCTF1P1
AT hook containing transcription factor 1 pseudogene 1
chr3_+_174598937 0.152 NM_014932
NLGN1
neuroligin 1
chr16_-_20246309 0.151 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr14_-_46882144 0.151 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr2_+_165804157 0.150 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr1_+_100089118 0.150 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr2_-_215953818 0.150 FN1
fibronectin 1
chr14_-_106289751 0.149 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr20_+_19985289 0.148 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr5_+_140703784 0.148 NM_018916
NM_032011
PCDHGA3

protocadherin gamma subfamily A, 3

chr19_+_50100843 0.147 NM_000041
APOE
apolipoprotein E
chr20_-_49747397 0.146 ATP9A
ATPase, class II, type 9A
chr20_-_55368284 0.145 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr9_-_103185621 0.144 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr16_-_20323533 0.144 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr11_-_57173823 0.143 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr3_+_2528272 0.143 CNTN4
contactin 4
chr12_-_6355165 0.141 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_-_74652952 0.140 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr21_+_30734467 0.140 NM_181623
KRTAP15-1
keratin associated protein 15-1
chr10_+_102722275 0.140 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr3_-_121883647 0.140 HGD
homogentisate 1,2-dioxygenase
chr14_+_38772870 0.140 NM_054024
MIA2
melanoma inhibitory activity 2
chr2_-_207291364 0.139 NM_001093730
DYTN
dystrotelin
chr8_+_104900591 0.139 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr10_+_115302767 0.139 NM_004132
HABP2
hyaluronan binding protein 2
chr4_+_75393053 0.138 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr8_-_20084892 0.138 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr10_-_98326435 0.137 TM9SF3
transmembrane 9 superfamily member 3
chr12_+_15590552 0.137 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr5_-_168204430 0.137


chr20_+_5935897 0.137 NM_001127458
CRLS1
cardiolipin synthase 1
chr2_+_234266250 0.136 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr10_-_21475493 0.135 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr6_+_31731667 0.135 APOM
apolipoprotein M
chr17_-_64649608 0.135 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_+_31731647 0.135 NM_019101
APOM
apolipoprotein M
chr20_-_29441946 0.135 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr2_+_137464931 0.133 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr1_-_32157845 0.132 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr20_-_13919256 0.131 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr3_-_52269467 0.130 WDR82
WD repeat domain 82
chr3_-_115960807 0.130 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr7_-_36991189 0.130 NM_001039459
ELMO1
engulfment and cell motility 1
chr6_-_50039776 0.130 NM_001037499
DEFB114
defensin, beta 114
chr2_-_20375497 0.130 PUM2
pumilio homolog 2 (Drosophila)
chr12_-_23995109 0.129 SOX5
SRY (sex determining region Y)-box 5
chrX_-_114158388 0.129 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr10_-_75071205 0.129 MYOZ1
myozenin 1
chr19_+_4442610 0.129 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr4_+_53986759 0.129 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr13_-_40454188 0.129 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_171280046 0.128 NM_001003845
SP5
Sp5 transcription factor
chr4_-_69218909 0.128 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr3_+_171560104 0.128 NM_001145097
SKIL
SKI-like oncogene
chr11_+_89032112 0.128 NM_153696
FOLH1B
folate hydrolase 1B
chr2_-_74460933 0.128 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr4_-_69852090 0.127 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr8_+_9990471 0.127 NM_001135671
MSRA
methionine sulfoxide reductase A
chr9_+_135491305 0.127 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr8_-_122722674 0.126 NM_005328
HAS2
hyaluronan synthase 2
chr1_+_157526127 0.126 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr2_+_171280182 0.125


chr11_+_20001130 0.125 NM_001111019
NAV2
neuron navigator 2
chr6_-_49712483 0.125 NM_000324
RHAG
Rh-associated glycoprotein
chr6_+_16251260 0.124 MYLIP
myosin regulatory light chain interacting protein
chr11_-_123319754 0.123 NM_001005187
OR6T1
olfactory receptor, family 6, subfamily T, member 1
chr12_-_27815475 0.123 NM_001146221
LOC100287284
MANSC domain-containing protein ENSP00000370673
chr10_+_118340460 0.123 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr12_-_6103945 0.122 NM_000552
VWF
von Willebrand factor

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 1.66e-06 GO:0032501 multicellular organismal process
2.19 3.11e-05 GO:0007606 sensory perception of chemical stimulus
2.11 9.90e-04 GO:0007608 sensory perception of smell
1.21 2.96e-03 GO:0050896 response to stimulus
1.68 1.21e-02 GO:0007600 sensory perception
1.44 1.66e-02 GO:0003008 system process
2.77 2.71e-02 GO:0007156 homophilic cell adhesion
1.66 4.73e-02 GO:0007155 cell adhesion
1.66 4.73e-02 GO:0022610 biological adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 9.30e-06 GO:0005576 extracellular region
1.27 3.96e-04 GO:0071944 cell periphery
1.26 1.27e-03 GO:0005886 plasma membrane
1.67 2.45e-03 GO:0005615 extracellular space
1.56 4.40e-03 GO:0044421 extracellular region part
2.47 8.16e-03 GO:0005882 intermediate filament
3.81 1.63e-02 GO:0031983 vesicle lumen
1.18 2.36e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.17 1.38e-04 GO:0004984 olfactory receptor activity
1.36 1.77e-02 GO:0004871 signal transducer activity
1.36 1.77e-02 GO:0060089 molecular transducer activity
1.40 2.05e-02 GO:0004872 receptor activity