Motif ID: NKX3-1.p2

Z-value: 2.294


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_23596346-0.302.6e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_58146916 4.445 LOC284757
hypothetical protein LOC284757
chr11_-_62668268 3.710 NM_001136506
SLC22A24
solute carrier family 22, member 24
chr2_+_165858586 3.056 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr17_-_53847937 2.996 RNF43
ring finger protein 43
chr14_-_74669864 2.942 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr6_+_26548678 2.890 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr6_-_52060327 2.876 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_+_119174947 2.756 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr6_+_53043729 2.688 NM_012347
FBXO9
F-box protein 9
chr7_+_141457977 2.590 LOC93432
maltase-glucoamylase-like pseudogene
chr14_+_66901237 2.499 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr12_+_79362256 2.478 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr10_+_116687904 2.463 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr8_+_23157094 2.427 NM_152272
CHMP7
CHMP family, member 7
chr11_-_104332631 2.398 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr5_-_160044844 2.285 ATP10B
ATPase, class V, type 10B
chr12_-_18134319 2.280 NM_024730
RERGL
RERG/RAS-like
chr20_+_29309127 2.231 NM_001037730
DEFB115
defensin, beta 115
chr2_+_114390975 2.221 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr2_+_69974581 2.124 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr12_+_100394787 2.055 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr14_+_38772870 2.021 NM_054024
MIA2
melanoma inhibitory activity 2
chr4_+_71418886 2.005 NM_212557
AMTN
amelotin
chr9_-_35860316 1.998 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr10_+_90336489 1.967 NM_001010939
LIPJ
lipase, family member J
chr1_+_69998445 1.963 NM_020794
LRRC7
leucine rich repeat containing 7
chr17_+_58440629 1.878 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_-_178461710 1.866 NM_001077196
PDE11A
phosphodiesterase 11A
chr9_+_109131814 1.860 RAD23B
RAD23 homolog B (S. cerevisiae)
chr14_+_87541220 1.843 NM_003608
GPR65
G protein-coupled receptor 65
chr5_+_127016605 1.838 NM_001127385
CTXN3
cortexin 3
chr12_-_15757114 1.833 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_177427252 1.769 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr4_-_70861301 1.732 NM_001891
CSN2
casein beta
chr4_-_10295412 1.702 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr6_+_126282078 1.681 NCOA7
nuclear receptor coactivator 7
chr6_+_132000134 1.666 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr5_+_121523769 1.658 NM_001195535
LOC728460
hypothetical LOC728460
chr2_+_165804157 1.613 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr4_+_141484046 1.610 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr8_+_67751007 1.595 NM_019607
C8orf44
chromosome 8 open reading frame 44
chr7_+_50106227 1.569 NM_001161834
C7orf72
chromosome 7 open reading frame 72
chr3_-_121445831 1.561 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr20_+_17622319 1.548 NM_001159495
BANF2
barrier to autointegration factor 2
chr7_-_41709191 1.546 NM_002192
INHBA
inhibin, beta A
chr4_+_47403107 1.527


chr9_+_122923864 1.513 CEP110
centrosomal protein 110kDa
chr20_+_12937616 1.505 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr2_+_228064531 1.499 AGFG1
ArfGAP with FG repeats 1
chr20_-_31055892 1.493 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr15_+_22832198 1.492 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr4_+_73123712 1.471 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr14_-_24148658 1.459 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr14_+_38804226 1.437 NM_203354
CTAGE5
CTAGE family, member 5
chr1_+_200775864 1.434 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr2_-_233349469 1.430 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr12_-_10215942 1.423 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr14_-_101617680 1.422 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr2_+_102320148 1.412 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr9_+_21399132 1.402 NM_002170
IFNA8
interferon, alpha 8
chr18_-_29273979 1.400 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr5_+_156628929 1.397 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_+_9055357 1.387 NM_001040448
DEFB131
defensin, beta 131
chr5_-_137502975 1.382 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr10_-_11614279 1.373 NM_001080491
USP6NL
USP6 N-terminal like
chr10_+_90474280 1.342 NM_001080518
LIPK
lipase, family member K
chr6_+_134800533 1.339 LOC154092
hypothetical LOC154092
chr8_+_24207524 1.336 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr11_+_56224436 1.327 NM_001005213
NM_001013358
OR9G1
OR9G9
olfactory receptor, family 9, subfamily G, member 1
olfactory receptor, family 9, subfamily G, member 9
chr6_-_76838944 1.324 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr6_+_16251260 1.313 MYLIP
myosin regulatory light chain interacting protein
chr1_+_151240846 1.292 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr2_+_151922350 1.282 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr11_+_59804634 1.279 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr4_-_174557191 1.277 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr11_-_30910074 1.244 NM_020869
DCDC5
doublecortin domain containing 5
chr7_-_36730525 1.242 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr9_-_113561613 1.234 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr17_-_7434113 1.233 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr22_-_39587944 1.230 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chrX_-_77801480 1.227 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr9_+_106496480 1.213 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr4_-_69116839 1.208 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr11_-_13474101 1.200 NM_000315
PTH
parathyroid hormone
chr12_+_73217889 1.196 ATXN7L3B
ataxin 7-like 3B
chr2_-_20375497 1.195 PUM2
pumilio homolog 2 (Drosophila)
chr10_+_118340460 1.195 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr10_-_118670968 1.191 KIAA1598
KIAA1598
chr6_-_155818728 1.188 NM_015718
NOX3
NADPH oxidase 3
chr7_-_108311872 1.179 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr10_-_93992982 1.176 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr1_-_111908085 1.175 NM_001081976
ADORA3
adenosine A3 receptor
chr6_+_12622286 1.162


chr4_-_68793928 1.160 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr5_+_147423727 1.157 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr18_-_62422195 1.148 NM_021153
CDH19
cadherin 19, type 2
chr8_-_18710575 1.128 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr17_-_15914485 1.124 NCOR1
nuclear receptor corepressor 1
chr21_-_35174742 1.118 RUNX1
runt-related transcription factor 1
chrX_-_131089552 1.116 NM_194277
FRMD7
FERM domain containing 7
chr11_-_102156531 1.111 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr2_+_102456193 1.110 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr3_-_153541468 1.110 NM_001123228
TMEM14E
transmembrane protein 14E
chr4_+_120029426 1.109 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr9_+_104797413 1.107 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr1_-_118123033 1.097


chr9_-_21177529 1.096 NM_021068
IFNA4
interferon, alpha 4
chr4_+_186587537 1.093 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr14_+_74353417 1.092 YLPM1
YLP motif containing 1
chr1_-_103269356 1.087 COL11A1
collagen, type XI, alpha 1
chr14_-_46882144 1.085 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr6_-_122807439 1.085 SERINC1
serine incorporator 1
chr5_+_140757787 1.077 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr12_+_32578513 1.074 FGD4
FYVE, RhoGEF and PH domain containing 4
chr12_+_63510481 1.073


chr4_-_163304567 1.068 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr15_-_54175954 1.053 RFX7
regulatory factor X, 7
chr3_+_99484421 1.051 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr3_-_57301749 1.043 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr5_+_54491702 1.041 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr2_-_61566477 1.025 XPO1
exportin 1 (CRM1 homolog, yeast)
chr2_+_135312655 1.019 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr3_-_152541129 1.014 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr20_+_15125503 1.011 NM_001033087
MACROD2
MACRO domain containing 2
chr6_-_50097606 1.010 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr3_+_188397967 1.004 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr6_-_33016561 1.004 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr11_-_16953135 1.002 RPL36A
ribosomal protein L36a
chr2_-_144768529 0.997 NM_001006636
GTDC1
glycosyltransferase-like domain containing 1
chr2_+_207512522 0.992 NM_173077
CPO
carboxypeptidase O
chr7_+_94377145 0.985 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr2_+_119416214 0.985 NM_006770
MARCO
macrophage receptor with collagenous structure
chr12_-_55990512 0.967 NM_014925
R3HDM2
R3H domain containing 2
chr3_-_69183926 0.962 NM_007114
TMF1
TATA element modulatory factor 1
chrX_-_131989963 0.959 NM_031907
USP26
ubiquitin specific peptidase 26
chr14_-_19553191 0.955 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr20_+_43269051 0.949 NM_003007
SEMG1
semenogelin I
chr1_-_110735158 0.945 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr12_-_10433852 0.942 NM_007360
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr4_-_69852090 0.936 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_+_166350620 0.933 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr19_-_14813688 0.932 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr11_+_56512922 0.926 NM_001005323
OR5AK2
olfactory receptor, family 5, subfamily AK, member 2
chr20_-_44494961 0.926 ELMO2
engulfment and cell motility 2
chr18_+_59705918 0.925 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr3_+_88270951 0.923 NM_018293
ZNF654
zinc finger protein 654
chr5_-_119768430 0.921


chr7_+_119700924 0.920 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr5_+_92944680 0.916 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr12_-_78608873 0.916 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr8_+_67201684 0.912 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr2_+_64534774 0.912 NM_014181
HSPC159
galectin-related protein
chr14_+_19655405 0.911 NM_001004715
OR4K17
olfactory receptor, family 4, subfamily K, member 17
chr14_+_88130482 0.907 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr6_-_22410993 0.907 NM_001163558
PRL
prolactin
chr9_-_25668855 0.904 NM_001004125
TUSC1
tumor suppressor candidate 1
chr18_+_19826734 0.902 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr2_+_234490781 0.897 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr7_-_93027057 0.893 NM_001164738
CALCR
calcitonin receptor
chr6_+_64344307 0.892 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_246682699 0.890 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr6_+_152053323 0.880 NM_001122742
ESR1
estrogen receptor 1
chr15_-_100280784 0.871 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr5_+_76470829 0.866


chr1_+_15862887 0.860


chr11_+_111551417 0.858 NM_031938
BCO2
beta-carotene oxygenase 2
chr4_-_103464491 0.858 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_-_47502115 0.857 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr1_-_205012348 0.855 NM_000572
IL10
interleukin 10
chr17_-_16038607 0.848 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr15_-_63069280 0.847 NM_001127890
NM_016630
SPG21

spastic paraplegia 21 (autosomal recessive, Mast syndrome)

chr2_-_202271598 0.839 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr13_-_40604587 0.838 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr3_-_115380539 0.837 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr1_-_148174722 0.836 NM_181873
MTMR11
myotubularin related protein 11
chr15_+_100163424 0.831 NM_001005326
OR4F6
olfactory receptor, family 4, subfamily F, member 6
chr3_-_113495763 0.831 NM_183061
SLC9A10
solute carrier family 9, member 10
chr4_+_78651929 0.829 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr3_+_85858321 0.824 NM_153184
CADM2
cell adhesion molecule 2
chr3_+_123279439 0.824 NM_006889
CD86
CD86 molecule
chr3_+_50119261 0.824 RBM5
RNA binding motif protein 5
chr11_-_77730573 0.813 NM_012296
GAB2
GRB2-associated binding protein 2
chr1_+_103898844 0.812 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr6_+_144654565 0.806 NM_007124
UTRN
utrophin
chr9_+_4829763 0.804 RCL1
RNA terminal phosphate cyclase-like 1
chr4_+_88748704 0.799 NM_014208
DSPP
dentin sialophosphoprotein
chr3_-_150569574 0.793 TM4SF1
transmembrane 4 L six family member 1
chr19_-_47623340 0.786 NM_005357
LIPE
lipase, hormone-sensitive
chr1_+_24713396 0.782 RCAN3
RCAN family member 3
chr2_-_21106291 0.777 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_+_69465107 0.772 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr12_-_86947276 0.770 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr1_-_151630168 0.766 NM_002964
S100A8
S100 calcium binding protein A8
chr19_+_62844143 0.765 ZNF211
zinc finger protein 211
chr10_+_90552466 0.760 NM_001128215
LIPM
lipase, family member M
chr1_+_169421011 0.759 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chrX_+_56772391 0.756 LOC550643
hypothetical LOC550643
chr11_+_125258718 0.756 NM_145014
HYLS1
hydrolethalus syndrome 1
chr9_+_126158935 0.755


chr18_+_74957475 0.750



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.16 9.05e-16 GO:0007606 sensory perception of chemical stimulus
3.29 1.36e-15 GO:0007608 sensory perception of smell
2.33 1.35e-11 GO:0007600 sensory perception
1.78 7.01e-07 GO:0050877 neurological system process
1.68 1.10e-06 GO:0003008 system process
1.31 7.65e-06 GO:0032501 multicellular organismal process
1.25 1.13e-04 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 2.14e-07 GO:0005886 plasma membrane
1.37 2.59e-07 GO:0071944 cell periphery
1.52 8.52e-06 GO:0005576 extracellular region
1.21 1.04e-03 GO:0044425 membrane part
1.17 3.26e-03 GO:0016020 membrane
1.21 1.02e-02 GO:0016021 integral to membrane
1.20 1.23e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.40 8.90e-17 GO:0004984 olfactory receptor activity
2.43 9.54e-15 GO:0004930 G-protein coupled receptor activity
1.94 1.26e-10 GO:0004888 transmembrane receptor activity
1.74 3.76e-09 GO:0004872 receptor activity
1.60 1.08e-07 GO:0004871 signal transducer activity
1.60 1.08e-07 GO:0060089 molecular transducer activity
16.09 5.16e-06 GO:0005132 interferon-alpha/beta receptor binding
3.13 3.66e-02 GO:0004867 serine-type endopeptidase inhibitor activity