Motif ID: PBX1.p2

Z-value: 0.855


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PBX1chr1_+_163084707-0.214.4e-01Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_42780784 1.479 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr6_-_26125939 1.285 NM_005325
HIST1H1A
histone cluster 1, H1a
chr5_+_162797149 1.107 NM_004060
NM_199246
CCNG1

cyclin G1

chr2_+_20510312 1.094 NM_004040
RHOB
ras homolog gene family, member B
chr14_+_23008742 1.023 NGDN
neuroguidin, EIF4E binding protein
chr12_-_54409710 0.972 CD63
CD63 molecule
chr14_+_23008723 0.915 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr4_+_8935987 0.908 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr13_+_38159172 0.907 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr4_-_186537145 0.842 NM_018409
LRP2BP
LRP2 binding protein
chr1_-_144779601 0.764 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr20_+_56369012 0.757


chr13_-_32757835 0.731 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr10_+_63092724 0.699 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr14_+_93455010 0.657 NM_138344
FAM181A
family with sequence similarity 181, member A
chr4_+_86968069 0.636 ARHGAP24
Rho GTPase activating protein 24
chr19_-_11127451 0.634 NM_182513
SPC24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr3_+_173951163 0.617 ECT2
epithelial cell transforming sequence 2 oncogene
chr13_-_97916768 0.616 STK24
serine/threonine kinase 24
chr14_-_75196911 0.611 C14orf1
chromosome 14 open reading frame 1
chr7_+_106897737 0.597 NM_005295
GPR22
G protein-coupled receptor 22
chr12_+_77782719 0.595 SYT1
synaptotagmin I
chr7_-_27108826 0.566 NM_006735
HOXA2
homeobox A2
chr3_-_53139457 0.554 NM_052859
RFT1
RFT1 homolog (S. cerevisiae)
chr12_+_100512877 0.534 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr15_+_39032927 0.529 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr22_+_28164571 0.510 NM_021026
RFPL1
ret finger protein-like 1
chr3_-_113495763 0.509 NM_183061
SLC9A10
solute carrier family 9, member 10
chr22_-_28972683 0.500 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr1_+_109036431 0.497 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr4_-_70115037 0.489 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr13_-_109236897 0.488 NM_003749
IRS2
insulin receptor substrate 2
chr10_-_44794146 0.483 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr12_+_53534565 0.474 NM_058173
MUCL1
mucin-like 1
chr8_-_25371858 0.472 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr8_+_99145925 0.471 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr8_+_18123456 0.458 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr4_+_8940733 0.441 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr2_-_179380301 0.438 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr10_+_103976132 0.431 NM_152310
ELOVL3
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
chr12_+_63090008 0.430 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr1_+_246409910 0.427 NM_001004688
OR2M2
olfactory receptor, family 2, subfamily M, member 2
chr3_-_188870799 0.422 NM_001048
SST
somatostatin
chr6_-_166960496 0.419 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_+_113671744 0.418 NM_006169
NNMT
nicotinamide N-methyltransferase
chr9_+_112470871 0.417 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr18_+_45342398 0.417 NM_006033
LIPG
lipase, endothelial
chr5_+_3649167 0.412 NM_024337
IRX1
iroquois homeobox 1
chr15_+_39363442 0.408 LOC729082
hypothetical LOC729082
chr9_-_83494198 0.404 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr10_+_69539255 0.403 NM_032578
MYPN
myopalladin
chr6_+_26153590 0.401 NM_003531
HIST1H3C
histone cluster 1, H3c
chr10_+_115514567 0.399 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr3_+_44667504 0.393 ZNF35
zinc finger protein 35
chr5_+_86712376 0.392


chr4_+_87734489 0.390 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr8_+_69026895 0.389 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr6_-_166960649 0.386 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chrX_+_145698993 0.376 NM_001144064
CXorf51
chromosome X open reading frame 51
chr6_-_166960690 0.376 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr10_+_17310263 0.371 NM_003380
VIM
vimentin
chr1_-_58920315 0.367


chr18_+_31074985 0.362 NM_001135178
NM_032347
ZNF397

zinc finger protein 397

chr6_+_149763187 0.361 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr3_+_112934016 0.359 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_154043403 0.357 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr4_+_70180805 0.356 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr3_-_88190737 0.350 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr2_+_241944333 0.348 NM_014808
FARP2
FERM, RhoGEF and pleckstrin domain protein 2
chr21_-_35174742 0.347 RUNX1
runt-related transcription factor 1
chrX_+_110252960 0.345 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr1_+_24713396 0.344 RCAN3
RCAN family member 3
chr17_-_36436979 0.338 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr5_-_58607673 0.334 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_+_26333361 0.333 NM_003532
HIST1H3E
histone cluster 1, H3e
chr14_+_73621408 0.329 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr2_-_192767844 0.329 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr14_+_75197303 0.328 NM_015072
TTLL5
tubulin tyrosine ligase-like family, member 5
chrX_-_10548458 0.324 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr5_+_15553288 0.322 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr2_-_189752575 0.317 NM_000393
COL5A2
collagen, type V, alpha 2
chr13_-_47510033 0.315 SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr17_-_42012324 0.315 NM_001113738
NM_016632
NM_001039083
ARL17A

ARL17B
ADP-ribosylation factor-like 17A

ADP-ribosylation factor-like 17B
chr5_+_90711887 0.308 LOC100129716
hypothetical LOC100129716
chr14_+_75197345 0.305 TTLL5
tubulin tyrosine ligase-like family, member 5
chr14_-_91642703 0.304 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr11_+_69176391 0.304 CCND1
cyclin D1
chr2_-_232037308 0.301 NM_005381
NCL
nucleolin
chr8_-_25371708 0.297 KCTD9
potassium channel tetramerisation domain containing 9
chrX_-_103288263 0.294 NM_001012755
MCART6
mitochondrial carrier triple repeat 6
chr4_+_81325447 0.294 NM_020226
PRDM8
PR domain containing 8
chr3_-_52906608 0.293 TMEM110-MUSTN1
TMEM110-MUSTN1 readthrough
chr3_+_185762233 0.292 NM_004443
EPHB3
EPH receptor B3
chr1_-_148050534 0.290 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr12_+_27568311 0.290 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr3_-_150286812 0.289 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr1_+_15862887 0.288


chr2_-_192767494 0.287 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr17_+_8132539 0.280 NM_001177801
NM_001177802
NM_016492
RANGRF


RAN guanine nucleotide release factor


chr13_+_56613052 0.279 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr10_+_90474280 0.278 NM_001080518
LIPK
lipase, family member K
chr7_-_138014329 0.276 NM_001139456
SVOPL
SVOP-like
chr6_+_54281161 0.274 NM_014464
TINAG
tubulointerstitial nephritis antigen
chrX_+_55666557 0.274 NM_198451
FOXR2
forkhead box R2
chr12_+_47009029 0.272 NM_181788
H1FNT
H1 histone family, member N, testis-specific
chr4_-_111777956 0.267 NM_153426
NM_153427
PITX2

paired-like homeodomain 2

chr2_-_232037454 0.263 NCL
nucleolin
chr16_+_81218074 0.262 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr4_+_37638450 0.260 NM_006607
PTTG2
pituitary tumor-transforming 2
chr14_+_75197409 0.258 TTLL5
tubulin tyrosine ligase-like family, member 5
chr14_-_74600469 0.257 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr14_-_91642641 0.257 ATXN3
ATXN8
ataxin 3
ataxin 8
chr10_-_102880892 0.256 NM_001085398
TLX1NB
TLX1 neighbor
chr3_-_71196696 0.255 FOXP1
forkhead box P1
chr14_+_60045621 0.255 NM_007374
SIX6
SIX homeobox 6
chr10_+_99390459 0.255 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr19_+_14501413 0.253 TECR
trans-2,3-enoyl-CoA reductase
chr8_+_98857190 0.251 LAPTM4B
lysosomal protein transmembrane 4 beta
chr8_-_25371663 0.250 KCTD9
potassium channel tetramerisation domain containing 9
chr4_+_71418886 0.248 NM_212557
AMTN
amelotin
chr8_+_42129620 0.248 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr3_-_152144712 0.241 NM_052995
CLRN1
clarin 1
chr1_-_171442937 0.241 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_-_32892705 0.241 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr4_-_177950658 0.238 NM_005429
VEGFC
vascular endothelial growth factor C
chr13_+_56639331 0.238 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr8_-_49996353 0.237 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr4_+_77575276 0.236 NM_020859
SHROOM3
shroom family member 3
chr4_-_118226119 0.235 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr2_-_27457088 0.230 NM_144631
ZNF513
zinc finger protein 513
chrX_-_145703940 0.229 NM_001144064
CXorf51
chromosome X open reading frame 51
chr17_+_56109940 0.229 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr1_+_35623688 0.229 ZMYM4
zinc finger, MYM-type 4
chr1_+_144374513 0.228 RNF115
ring finger protein 115
chr8_-_28403652 0.226 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr4_+_84175262 0.225 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr14_+_61532293 0.225 NM_031914
SYT16
synaptotagmin XVI
chr11_+_122258600 0.216 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chrX_-_142432884 0.216 NM_001009609
SPANXN3
SPANX family, member N3
chr15_-_32875040 0.215 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr15_-_70399523 0.215 CELF6
CUGBP, Elav-like family member 6
chr11_+_66140628 0.214 NM_001198845
NM_001198846
NM_001198836
NM_001198837
NM_006328
RBM14-RBM4

RBM14


RBM14-RBM4 readthrough

RNA binding motif protein 14


chr2_-_95846109 0.214 LOC150759
hypothetical LOC150759
chr2_-_218843109 0.213 NM_001087
AAMP
angio-associated, migratory cell protein
chr8_+_69027277 0.213 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr20_-_45848043 0.212 NM_018837
SULF2
sulfatase 2
chr11_-_85115105 0.212 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr3_-_52906381 0.211 TMEM110
transmembrane protein 110
chr12_-_28016182 0.210 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr18_+_30427279 0.206 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr16_-_66571863 0.206 NM_001129758
NM_022357
DPEP3

dipeptidase 3

chr18_-_55177430 0.205 NM_005570
LMAN1
lectin, mannose-binding, 1
chrX_+_46581290 0.205 NM_006915
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr22_-_30919386 0.203 NM_006605
RFPL2
ret finger protein-like 2
chrX_-_15263586 0.200 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr3_-_21767819 0.200 NM_024697
ZNF385D
zinc finger protein 385D
chr16_-_70306198 0.200 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr14_-_57834558 0.200 FLJ31306
hypothetical LOC379025
chr19_+_54872220 0.199 PRMT1
protein arginine methyltransferase 1
chr15_-_70399301 0.199 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr8_+_69027143 0.197 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr4_-_69218909 0.196 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr14_+_51025604 0.196 NM_001042481
FRMD6
FERM domain containing 6
chr12_-_119123292 0.195 RPLP0
ribosomal protein, large, P0
chr13_-_106018445 0.195 NM_018011
ARGLU1
arginine and glutamate rich 1
chr3_-_79899748 0.195 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr4_+_74505710 0.195


chr9_-_72926333 0.194 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr12_-_119123276 0.194 RPLP0P6
RPLP0
ribosomal protein, large, P0 pseudogene 6
ribosomal protein, large, P0
chr16_+_81218142 0.193 CDH13
cadherin 13, H-cadherin (heart)
chr19_+_56990222 0.192 NM_002030
FPR3
formyl peptide receptor 3
chrX_-_15263596 0.191 NM_002641
NM_020473
PIGA

phosphatidylinositol glycan anchor biosynthesis, class A

chr12_+_77782648 0.190 SYT1
synaptotagmin I
chr14_+_99017485 0.189 NM_001099402
CCNK
cyclin K
chr5_+_140227951 0.187 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chrX_+_56606686 0.187 NM_013444
UBQLN2
ubiquilin 2
chr6_+_26381122 0.186 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr11_-_102174032 0.184 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr3_+_186563529 0.184 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr10_-_14919973 0.184 NM_001029954
CDNF
cerebral dopamine neurotrophic factor
chr2_-_218843039 0.182 AAMP
angio-associated, migratory cell protein
chr12_+_64982542 0.181 NM_033647
HELB
helicase (DNA) B
chr12_+_102859354 0.180 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr19_+_13924318 0.177 NM_138353
DCAF15
DDB1 and CUL4 associated factor 15
chr4_+_141514251 0.171 SCOC
short coiled-coil protein
chr1_+_170656450 0.170 NM_139240
C1orf105
chromosome 1 open reading frame 105
chrX_+_46581368 0.170 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr6_+_83834080 0.169 NM_015018
DOPEY1
dopey family member 1
chr1_+_203064397 0.168 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr8_-_12033677 0.167 NM_201402
USP17L2
ubiquitin specific peptidase 17-like 2
chr9_-_128910132 0.167 ANGPTL2
angiopoietin-like 2
chr9_-_37455250 0.166 ZBTB5
zinc finger and BTB domain containing 5
chr14_+_54104383 0.166 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr11_+_5925152 0.165 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr8_+_54926920 0.164 NM_170587
RGS20
regulator of G-protein signaling 20
chr15_-_70399181 0.164 CELF6
CUGBP, Elav-like family member 6
chr9_+_70840298 0.163 NM_000144
NM_001161706
NM_181425
FXN


frataxin


chr13_+_96726197 0.162 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_146076704 0.162 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr17_-_5330204 0.162 NM_016041
DERL2
Der1-like domain family, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.61 6.47e-06 GO:0071842 cellular component organization at cellular level
1.58 2.01e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.74 1.37e-04 GO:0006996 organelle organization
1.44 9.86e-04 GO:0016043 cellular component organization
1.42 1.76e-03 GO:0071840 cellular component organization or biogenesis
2.14 3.20e-03 GO:0051276 chromosome organization
2.49 5.55e-03 GO:0034622 cellular macromolecular complex assembly
3.84 1.41e-02 GO:0065004 protein-DNA complex assembly
3.40 1.91e-02 GO:0006333 chromatin assembly or disassembly
3.64 2.77e-02 GO:0071824 protein-DNA complex subunit organization
2.49 4.97e-02 GO:0000280 nuclear division
2.49 4.97e-02 GO:0007067 mitosis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 9.96e-03 GO:0043229 intracellular organelle
1.14 1.22e-02 GO:0043226 organelle

Nothing significant found in function category.