Motif ID: PITX1..3.p2

Z-value: 4.164


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PITX2chr4_-_111763356-0.621.0e-02Click!
PITX3chr10_-_1039912190.273.1e-01Click!
PITX1chr5_-_1343977400.194.8e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_31871530 4.893 NM_006295
VARS
valyl-tRNA synthetase
chr7_-_98643024 4.497 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr22_-_20314274 4.340 NM_001017964
YDJC
YdjC homolog (bacterial)
chr22_-_20314366 3.691 YDJC
YdjC homolog (bacterial)
chr22_+_20350272 3.186 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr12_+_38306238 3.132 NM_001031748
C12orf40
chromosome 12 open reading frame 40
chr19_+_10673105 3.082 NM_031209
QTRT1
queuine tRNA-ribosyltransferase 1
chr11_+_120036237 3.020 NM_014619
GRIK4
glutamate receptor, ionotropic, kainate 4
chr17_-_71995401 3.014 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr22_-_16060485 2.973 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr6_-_44341296 2.879 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr15_+_63690622 2.802 SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr17_+_38412267 2.755 NM_005533
IFI35
interferon-induced protein 35
chr9_+_134884627 2.706 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr22_-_16080265 2.695 CECR1
cat eye syndrome chromosome region, candidate 1
chr19_+_16860807 2.645 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr3_+_188222337 2.612 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_-_56585603 2.606 NM_001193623
LOC147646
hypothetical protein LOC147646
chrX_+_134803450 2.594 NM_018666
SAGE1
sarcoma antigen 1
chr19_-_44135166 2.581 NM_148169
FBXO17
F-box protein 17
chr19_-_60241424 2.556 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr6_-_32206029 2.502 NM_022110
FKBPL
FK506 binding protein like
chr22_+_20715340 2.493


chr3_+_10181562 2.378 NM_001570
IRAK2
interleukin-1 receptor-associated kinase 2
chr3_-_197422653 2.378 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr17_+_69875140 2.373 NM_181790
GPR142
G protein-coupled receptor 142
chr19_+_3536541 2.363 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr19_+_951295 2.352 NM_138690
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr17_-_24062998 2.304 NM_152465
PROCA1
protein interacting with cyclin A1
chr7_-_6557591 2.283 NM_001145118
GRID2IP
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein
chrX_+_153101278 2.265 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr6_-_52217185 2.221 NM_052872
IL17F
interleukin 17F
chr2_-_97016027 2.196 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr1_-_16006779 2.165 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chr7_-_100645032 2.162 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr12_-_116021473 2.159 NM_001168325
NM_017899
TESC

tescalcin

chr1_+_109450116 2.154


chr9_-_116200569 2.132 AKNA
AT-hook transcription factor
chr19_+_53656317 2.120 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr12_+_120132233 2.115 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr4_-_38710376 2.106 NM_024943
TMEM156
transmembrane protein 156
chr22_+_19248810 2.104 MED15
mediator complex subunit 15
chr19_-_50834483 2.098 EML2
echinoderm microtubule associated protein like 2
chr19_+_16115454 2.083 HSH2D
hematopoietic SH2 domain containing
chr19_-_8670054 2.054 NM_178525
ACTL9
actin-like 9
chr22_+_19248733 2.046 MED15
mediator complex subunit 15
chr19_-_50834502 2.035 NM_012155
EML2
echinoderm microtubule associated protein like 2
chr14_-_19252330 2.024 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr16_+_170334 2.019 NM_005331
HBQ1
hemoglobin, theta 1
chr16_+_65918220 1.977 NM_018296
LRRC36
leucine rich repeat containing 36
chr19_-_12028126 1.973 NM_001080404
ZNF878
zinc finger protein 878
chr19_-_17236522 1.952 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr6_-_26297282 1.936 NM_003539
HIST1H4D
histone cluster 1, H4d
chr22_-_22714230 1.920 NM_000853
GSTT1
glutathione S-transferase theta 1
chr6_-_31882704 1.918 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_-_1300680 1.889 NM_017900
AURKAIP1
aurora kinase A interacting protein 1
chr17_+_73654028 1.888 NM_001163075
C17orf99
chromosome 17 open reading frame 99
chr9_-_94226380 1.873 NM_005014
OMD
osteomodulin
chr16_+_88511787 1.866 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr7_+_99793561 1.850 NM_178238
PILRB
paired immunoglobin-like type 2 receptor beta
chr1_-_226357663 1.842 C1orf35
chromosome 1 open reading frame 35
chr1_+_24713396 1.828 RCAN3
RCAN family member 3
chr5_-_10361167 1.823 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr6_+_16237264 1.807 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr16_+_11966464 1.765 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_+_56168120 1.763 MARS
methionyl-tRNA synthetase
chr10_-_43383912 1.752 NM_005674
ZNF239
zinc finger protein 239
chr1_-_35879619 1.748 PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chr11_-_117718532 1.744 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr19_-_2036227 1.741 MOBKL2A
MOB1, Mps One Binder kinase activator-like 2A (yeast)
chr15_+_89274413 1.741 NM_001039675
UNC45A
unc-45 homolog A (C. elegans)
chr6_+_16237300 1.735 MYLIP
myosin regulatory light chain interacting protein
chr16_+_25135783 1.721 NM_001169
AQP8
aquaporin 8
chr2_+_151974630 1.718 NM_001177663
NM_018151
NM_001177664
RIF1


RAP1 interacting factor homolog (yeast)


chr1_+_141560298 1.714


chr19_+_10083196 1.695 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr12_+_56168082 1.695 NM_004990
MARS
methionyl-tRNA synthetase
chr6_-_132064233 1.680 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr16_-_15057328 1.676 NM_173474
NTAN1
N-terminal asparagine amidase
chr12_-_100657321 1.674 NM_001177948
NM_001177949
NM_153694
SYCP3


synaptonemal complex protein 3


chr16_+_32660135 1.670 LOC100289574
hect domain and RLD 2 pseudogene
chr7_-_138109321 1.609 NM_130841
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chr7_+_99562255 1.605 NM_203397
MBLAC1
metallo-beta-lactamase domain containing 1
chr14_-_106119742 1.594 IGLJ3
IGHG1
immunoglobulin lambda joining 3
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_126325132 1.579 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr9_+_130504591 1.569 NM_013355
PKN3
protein kinase N3
chr1_+_45542138 1.562 LOC400752
hypothetical LOC400752
chrX_-_119927878 1.554 NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr3_-_197726587 1.548 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr21_+_34658192 1.547 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr9_+_140164359 1.547 TUBBP5
tubulin, beta pseudogene 5
chr17_-_64823368 1.539 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr6_-_27966548 1.539 NM_003535
HIST1H3J
histone cluster 1, H3j
chr16_+_43009 1.534 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr6_-_44341222 1.527 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr12_+_120132319 1.525 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr20_+_35445350 1.523 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr16_+_29378694 1.522 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr5_-_43029180 1.514 FLJ32255
hypothetical LOC643977
chr19_-_59383944 1.513 MBOAT7
membrane bound O-acyltransferase domain containing 7
chrX_+_153138396 1.502 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr1_+_6607511 1.501 NM_001195753
THAP3
THAP domain containing, apoptosis associated protein 3
chr6_-_31668476 1.495 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chrX_-_2892288 1.493 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr20_-_43853945 1.492 NM_080614
WFDC3
WAP four-disulfide core domain 3
chr10_+_35504526 1.490 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr6_-_31871452 1.489 VARS
valyl-tRNA synthetase
chr6_-_137536412 1.463 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr19_-_6384772 1.463 NM_173637
SLC25A41
solute carrier family 25, member 41
chr15_-_53587723 1.452 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr7_-_143587653 1.451 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr7_+_156435163 1.444 NM_138400
NOM1
nucleolar protein with MIF4G domain 1
chr6_-_3390197 1.443 NM_021945
SLC22A23
solute carrier family 22, member 23
chr11_+_76423082 1.438 NM_138706
B3GNT6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr19_+_3831617 1.434 NM_033064
ATCAY
ataxia, cerebellar, Cayman type
chr12_-_120219941 1.431 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr16_+_86561124 1.413 NM_001173543
BANP
BTG3 associated nuclear protein
chr10_-_69957589 1.412 NM_152707
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chrX_+_73440749 1.411 NM_203303
ZCCHC13
zinc finger, CCHC domain containing 13
chr9_-_205892 1.409 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr12_-_55042793 1.406 NM_001638
APOF
apolipoprotein F
chr10_-_7701619 1.400 NM_032817
ITIH5
inter-alpha (globulin) inhibitor H5
chr19_-_44497815 1.396 NM_020862
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr6_-_26355183 1.388 NM_003547
HIST1H4G
histone cluster 1, H4g
chr19_-_44386731 1.388 NM_001080468
SYCN
syncollin
chr1_+_45738442 1.379 NM_015506
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr1_-_24112345 1.377 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr18_+_2896178 1.371 EMILIN2
elastin microfibril interfacer 2
chr2_+_100545827 1.368 NM_024065
PDCL3
phosducin-like 3
chr7_+_141136485 1.364 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr22_-_48835181 1.360 NM_001080447
TTLL8
tubulin tyrosine ligase-like family, member 8
chr1_-_11082394 1.360 NM_001001998
NM_002685
EXOSC10

exosome component 10

chr19_+_16860871 1.360 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr19_+_3679373 1.357 NM_014428
TJP3
tight junction protein 3 (zona occludens 3)
chr22_-_21193037 1.357 ZNF280B
zinc finger protein 280B
chrX_-_138875342 1.354 NM_001013403
CXorf66
chromosome X open reading frame 66
chr3_-_47530083 1.347 NM_001031703
C3orf75
chromosome 3 open reading frame 75
chr16_+_30293598 1.345 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr12_-_55929189 1.345


chr7_+_5886952 1.335 NM_001097622
OCM
oncomodulin
chr16_-_23371952 1.329 NM_153603
COG7
component of oligomeric golgi complex 7
chr1_+_10457579 1.323 NM_004565
PEX14
peroxisomal biogenesis factor 14
chr19_+_17198012 1.322 NM_024578
OCEL1
occludin/ELL domain containing 1
chr19_+_6312558 1.322 CLPP
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
chr15_-_87239745 1.302 NM_178232
HAPLN3
hyaluronan and proteoglycan link protein 3
chr2_-_170389669 1.290 METTL5
methyltransferase like 5
chr12_-_68291208 1.288 NM_201550
LRRC10
leucine rich repeat containing 10
chr15_-_38953628 1.286 NM_133639
RHOV
ras homolog gene family, member V
chr11_+_5558682 1.280 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr19_+_55123770 1.278 NM_012068
ATF5
activating transcription factor 5
chr1_-_1701313 1.271 NM_001198994
NADK
NAD kinase
chr15_-_63690459 1.271 NM_030800
NM_001136043
C15orf44

chromosome 15 open reading frame 44

chr6_+_10995049 1.256 NM_001040274
SYCP2L
synaptonemal complex protein 2-like
chr19_-_1352474 1.254 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr7_+_6380614 1.253 NM_006908
NM_018890
RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

chr6_-_26140266 1.253 NM_003537
HIST1H3B
histone cluster 1, H3b
chr1_-_142309117 1.246


chr6_-_31938572 1.243 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr19_-_43926953 1.234 NM_144691
CAPN12
calpain 12
chr19_+_4104593 1.233 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr21_-_38415273 1.232 NM_005867
DSCR4
Down syndrome critical region gene 4
chr17_+_73721924 1.220 BIRC5
baculoviral IAP repeat containing 5
chr6_-_2848460 1.216 NM_004155
SERPINB9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
chr16_-_15741438 1.212 MYH11
myosin, heavy chain 11, smooth muscle
chr16_+_56286212 1.210 NM_032269
CCDC135
coiled-coil domain containing 135
chr7_-_72360722 1.208 NM_001168347
NM_001168348
NM_018044
NM_148956
NSUN5



NOP2/Sun domain family, member 5



chr6_-_28999715 1.208 NM_006510
TRIM27
tripartite motif containing 27
chr6_+_31706345 1.198 PRRC2A
proline-rich coiled-coil 2A
chr1_+_32485404 1.194 NM_032648
FAM167B
family with sequence similarity 167, member B
chr19_+_56671649 1.193 NM_001080405
CEACAM18
carcinoembryonic antigen-related cell adhesion molecule 18
chr14_+_19365447 1.192 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr17_-_30838870 1.188 NM_001195790
SLFN12L
schlafen family member 12-like
chr13_+_109936080 1.187 COL4A2
collagen, type IV, alpha 2
chr8_+_49083522 1.185 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr19_+_14460757 1.184 NM_001146693
LOC100130932
small nuclear ribonucleoprotein G-like protein
chr11_-_64520964 1.183 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr10_+_43187095 1.175 NM_001184963
NM_173160
FXYD4

FXYD domain containing ion transport regulator 4

chr19_+_19837625 1.170 NM_021047
ZNF253
zinc finger protein 253
chr14_-_46190690 1.169 NM_080746
RPL10L
ribosomal protein L10-like
chr15_-_39310152 1.161 NM_152596
EXD1
exonuclease 3'-5' domain containing 1
chr16_+_29597829 1.161 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr19_+_18069596 1.160 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr19_+_51059357 1.155 NM_004497
FOXA3
forkhead box A3
chr3_-_110319598 1.154 NM_014429
MORC1
MORC family CW-type zinc finger 1
chr19_-_47623340 1.154 NM_005357
LIPE
lipase, hormone-sensitive
chr12_-_48285526 1.148 NM_032130
FAM186B
family with sequence similarity 186, member B
chr16_-_68349445 1.142


chr15_+_26876480 1.138


chr3_-_9895633 1.137 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr19_-_54857003 1.135 IRF3
interferon regulatory factor 3
chr6_-_31756119 1.132 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr19_-_50600128 1.127 NM_006663
PPP1R13L
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr19_+_58239802 1.117 NM_001191055
HERV-V2
envelope glycoprotein ENVV2
chr1_-_27573882 1.113 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr11_+_113155727 1.111 NM_001101389
CLDN25
claudin 25
chr5_-_145503190 1.109 LARS
leucyl-tRNA synthetase
chr3_+_171238427 1.101 NM_014373
GPR160
G protein-coupled receptor 160
chr22_-_22426551 1.100 NM_013378
VPREB3
pre-B lymphocyte 3
chr6_-_31618203 1.100 NM_004640
NM_080598
DDX39B

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr10_-_42507180 1.098



Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.18 6.25e-03 GO:0004982 N-formyl peptide receptor activity