Motif ID: PRDM1.p3

Z-value: 1.298


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_106653429-0.234.0e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_187227302 2.895 NM_003265
TLR3
toll-like receptor 3
chr4_+_14985272 2.200 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr4_-_186815116 2.132 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr1_+_2975590 2.104 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr4_-_186814852 2.053 SORBS2
sorbin and SH3 domain containing 2
chr9_+_108665168 1.933 NM_021224
ZNF462
zinc finger protein 462
chr16_+_55580910 1.836 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr1_+_160868932 1.759 DDR2
discoidin domain receptor tyrosine kinase 2
chr4_+_142777172 1.600 NM_000585
NM_172174
IL15

interleukin 15

chr2_+_230900121 1.487 NM_138402
SP140L
SP140 nuclear body protein-like
chr9_-_16717887 1.435 BNC2
basonuclin 2
chr11_+_28088406 1.408 METTL15
methyltransferase like 15
chr8_-_23596346 1.353 NM_006167
NKX3-1
NK3 homeobox 1
chr11_-_40272239 1.312 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr4_+_37569093 1.300 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr1_-_111548440 1.266 DENND2D
DENN/MADD domain containing 2D
chr2_-_189752575 1.257 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_-_142795269 1.247 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr8_+_134272463 1.237 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr6_-_105691235 1.218 NM_007073
BVES
blood vessel epicardial substance
chr3_-_115825742 1.190 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr9_-_34700062 1.167 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr2_+_165858586 1.146 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr8_-_145132551 1.144 PARP10
poly (ADP-ribose) polymerase family, member 10
chr6_-_112682459 1.132 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr8_+_144711619 1.116 NM_024736
GSDMD
gasdermin D
chr6_-_112682573 1.098 LAMA4
laminin, alpha 4
chr8_-_145132582 1.055 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr11_-_104344473 1.040 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_-_112682401 1.028 LAMA4
laminin, alpha 4
chr6_-_105691675 0.973 BVES
blood vessel epicardial substance
chr21_+_25856311 0.967 MIR155HG
MIR155 host gene (non-protein coding)
chr10_-_44200458 0.940 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr9_-_8723893 0.920 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr19_+_40931285 0.912 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr9_-_116608113 0.845 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr12_+_6431437 0.841 NM_018009
TAPBPL
TAP binding protein-like
chr19_-_52427698 0.833 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr6_-_112682038 0.817 LAMA4
laminin, alpha 4
chr17_-_45626364 0.805


chr6_+_127481740 0.796 NM_032784
RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr9_+_136673464 0.777 NM_000093
COL5A1
collagen, type V, alpha 1
chr7_-_92301147 0.767 NM_001259
CDK6
cyclin-dependent kinase 6
chr17_+_17339059 0.757


chr11_+_32069183 0.739 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr20_+_13924014 0.738 NM_080676
MACROD2
MACRO domain containing 2
chr3_+_8518539 0.733 LMCD1
LIM and cysteine-rich domains 1
chr20_+_13924263 0.733 MACROD2
MACRO domain containing 2
chr2_-_230792844 0.727 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr15_+_68971835 0.726 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr3_+_8518508 0.714 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr14_-_80934523 0.711 NM_033104
STON2
stonin 2
chr17_+_3326045 0.707 NM_000049
ASPA
aspartoacylase
chr11_+_63060848 0.702 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr14_-_23685629 0.698 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr8_+_39890484 0.689 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr17_+_6599879 0.686 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr22_-_34886727 0.677 NM_145640
APOL3
apolipoprotein L, 3
chr3_-_49826360 0.669 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr2_+_205118961 0.637 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr6_+_127481496 0.635 RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr3_+_51952326 0.612 PARP3
poly (ADP-ribose) polymerase family, member 3
chr3_-_49826221 0.608 UBA7
ubiquitin-like modifier activating enzyme 7
chr1_+_220884257 0.608 MIA3
melanoma inhibitory activity family, member 3
chr3_-_189354510 0.593 LOC339929
hypothetical LOC339929
chr16_-_71650034 0.558 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_+_160868822 0.547 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr9_+_33785558 0.545 NM_002771
PRSS3
protease, serine, 3
chr17_+_53602013 0.543 NM_001004707
OR4D2
olfactory receptor, family 4, subfamily D, member 2
chr11_+_60366004 0.540 NM_024098
CCDC86
coiled-coil domain containing 86
chr3_+_51951314 0.540 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr3_-_8518327 0.519 LOC100288428
hypothetical LOC100288428
chr10_+_91051685 0.514 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr17_+_75851984 0.512


chr10_+_18469611 0.497 NM_201593
NM_201596
NM_201597
NM_001167945
NM_201571
NM_201572
CACNB2





calcium channel, voltage-dependent, beta 2 subunit





chr11_+_71387572 0.486 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr19_+_56958452 0.477 NM_001462
FPR2
formyl peptide receptor 2
chr10_+_92970487 0.463 PCGF5
polycomb group ring finger 5
chr2_+_230989177 0.457 SP100
SP100 nuclear antigen
chr17_+_6600080 0.454 XAF1
XIAP associated factor 1
chr2_-_19421852 0.452 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr2_+_205118801 0.449 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr10_+_91082218 0.436 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_-_131652007 0.425 NM_001005463
EBF3
early B-cell factor 3
chr14_-_68329407 0.409 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr3_+_120495906 0.401 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr8_-_79880095 0.399 NM_000880
IL7
interleukin 7
chr17_+_7406040 0.395 NM_015670
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr19_-_11500912 0.395 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr8_+_97575071 0.394 SDC2
syndecan 2
chr15_-_53996597 0.380 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr3_+_189354167 0.378 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr13_-_109600709 0.378 COL4A1
collagen, type IV, alpha 1
chr1_-_166171702 0.375 BRP44
brain protein 44
chr8_+_97575196 0.372 SDC2
syndecan 2
chr11_-_85107569 0.371 NM_206929
SYTL2
synaptotagmin-like 2
chr2_-_190893015 0.348 NM_014362
NM_198047
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr7_+_134483305 0.347 NM_018295
TMEM140
transmembrane protein 140
chr1_-_166171838 0.347 NM_015415
BRP44
brain protein 44
chr22_+_37766554 0.341 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr7_+_89681069 0.336 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr3_+_176059763 0.336 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr10_-_35143900 0.330 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr12_-_69289889 0.325 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_-_56137553 0.319 NM_001004740
OR5M1
olfactory receptor, family 5, subfamily M, member 1
chr17_+_7405944 0.315 SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr8_+_97575244 0.314 SDC2
syndecan 2
chr8_+_97575052 0.308 NM_002998
SDC2
syndecan 2
chr1_+_20353284 0.306


chr12_-_55791388 0.299 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr14_+_57781352 0.298 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr3_-_11598829 0.296 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr6_-_10520592 0.292 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr11_-_104411065 0.290 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr9_+_111582317 0.280 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr21_-_42219849 0.279 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr13_+_30207690 0.271 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr22_-_34965498 0.267 APOL2
apolipoprotein L, 2
chr14_+_57781308 0.265 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr14_+_101297887 0.264 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr3_-_113495763 0.264 NM_183061
SLC9A10
solute carrier family 9, member 10
chr2_+_230989150 0.263 SP100
SP100 nuclear antigen
chr12_+_120055013 0.262 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr10_+_102113410 0.259


chr11_-_92570693 0.258 NM_152313
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr2_+_230989114 0.254 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr7_+_154943466 0.253 NM_001427
EN2
engrailed homeobox 2
chr12_+_11694172 0.251 ETV6
ets variant 6
chr11_-_28086263 0.248 KIF18A
kinesin family member 18A
chr21_-_34820916 0.247 NM_203418
RCAN1
regulator of calcineurin 1
chr22_-_34965945 0.242 NM_145637
APOL2
apolipoprotein L, 2
chr11_-_28086222 0.239 KIF18A
kinesin family member 18A
chr12_+_27511009 0.239 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr12_-_47605478 0.235 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr11_+_77209807 0.231 NM_024684
C11orf67
chromosome 11 open reading frame 67
chr2_+_205118710 0.231 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr15_-_40537002 0.230 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr6_-_101018271 0.227 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr8_-_42184350 0.227 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr12_-_55791202 0.227 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_-_28086277 0.225 NM_031217
KIF18A
kinesin family member 18A
chr5_+_96237923 0.223 ERAP2
endoplasmic reticulum aminopeptidase 2
chr8_+_96215144 0.221 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr10_+_92970302 0.214 NM_032373
PCGF5
polycomb group ring finger 5
chr1_-_219982016 0.212 DUSP10
dual specificity phosphatase 10
chr13_+_52114565 0.212 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chrX_-_106248706 0.211 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr12_-_66839589 0.208 NM_000619
IFNG
interferon, gamma
chrX_-_106248674 0.206 RBM41
RNA binding motif protein 41
chr18_+_46659424 0.206 NM_001168335
NM_002396
ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial

chr1_+_158063278 0.206 SLAMF8
SLAM family member 8
chr13_+_30207668 0.203 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_-_219982049 0.200 DUSP10
dual specificity phosphatase 10
chr1_+_32438788 0.199 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr14_+_57781210 0.199 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr3_+_69998064 0.199 NM_198177
MITF
microphthalmia-associated transcription factor
chr2_-_224611568 0.195 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr1_+_210848592 0.194 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr1_+_147819626 0.191 NM_178230
NM_001135789
PPIAL4A
PPIAL4G
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr1_+_159435728 0.186 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr8_+_96215118 0.182 NM_024613
PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr12_-_55791443 0.178 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr16_-_70763849 0.177 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr11_-_77209398 0.176 NM_016578
RSF1
remodeling and spacing factor 1
chr11_-_85015961 0.175 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr9_+_119506428 0.169 TLR4
toll-like receptor 4
chr3_-_102888090 0.169 NM_000986
RPL24
ribosomal protein L24
chr11_+_28086373 0.167 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr2_-_144991556 0.167 ZEB2
zinc finger E-box binding homeobox 2
chr9_+_101717278 0.166 STX17
syntaxin 17
chr6_+_30018287 0.165 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr15_-_39195621 0.163 NM_017553
INO80
INO80 homolog (S. cerevisiae)
chr6_+_167445284 0.162 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr10_+_114125955 0.161 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_134114701 0.160 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr9_+_18464138 0.159 ADAMTSL1
ADAMTS-like 1
chr14_+_88130482 0.158 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr4_-_153523113 0.158 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr8_-_9046460 0.154 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr10_+_114125927 0.145 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_+_146623405 0.145 NM_001003688
SMAD1
SMAD family member 1
chr3_+_159844980 0.144 NM_024996
GFM1
G elongation factor, mitochondrial 1
chr2_-_202216451 0.143 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr9_+_122890394 0.142 NM_007018
CEP110
centrosomal protein 110kDa
chr5_+_139869819 0.142


chrX_+_10084984 0.139 NM_001830
CLCN4
chloride channel 4
chr10_+_91077581 0.139 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr16_-_46738061 0.138 NM_033226
ABCC12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr8_-_42184194 0.137 PLAT
plasminogen activator, tissue
chr10_-_93992982 0.137 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr5_+_152850276 0.135 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr5_+_49998528 0.133 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr11_-_85108030 0.133 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_+_5220342 0.132 NM_001033520
WIPI2
WD repeat domain, phosphoinositide interacting 2
chr14_+_67238355 0.132 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr22_+_37747063 0.131 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr2_+_17585462 0.127 VSNL1
visinin-like 1
chr2_+_17585287 0.126 NM_003385
VSNL1
visinin-like 1
chr14_+_72595020 0.124 RBM25
RNA binding motif protein 25
chr17_-_78000890 0.123 NM_001193655
C17orf62
chromosome 17 open reading frame 62

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.28 1.54e-03 GO:0002376 immune system process
2.42 1.04e-02 GO:0051704 multi-organism process
2.46 1.65e-02 GO:0006508 proteolysis
2.46 1.65e-02 GO:0006952 defense response
2.57 2.57e-02 GO:0002682 regulation of immune system process
40.54 3.50e-02 GO:0002483 antigen processing and presentation of endogenous peptide antigen
40.54 3.50e-02 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
7.63 3.86e-02 GO:0060337 type I interferon-mediated signaling pathway
7.63 3.86e-02 GO:0071357 cellular response to type I interferon
7.51 4.29e-02 GO:0034340 response to type I interferon

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.02 2.18e-02 GO:0005126 cytokine receptor binding