Motif ID: SMAD1..7,9.p2

Z-value: 1.584


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD3chr15_+_65217412-0.783.7e-04Click!
SMAD9chr13_-_36392370-0.458.1e-02Click!
SMAD4chr18_+_468104810.411.2e-01Click!
SMAD7chr18_-_44729700-0.381.5e-01Click!
SMAD1chr4_+_146622154-0.361.7e-01Click!
SMAD5chr5_+_135496421-0.282.9e-01Click!
SMAD6chr15_+_647879830.273.1e-01Click!
SMAD2chr18_-_437111430.243.8e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_43370333 3.085 NM_003833
NM_030590
NM_030592
MATN4


matrilin 4


chr6_-_30151526 2.074 NM_170769
NM_025236
RNF39

ring finger protein 39

chr12_-_56496107 1.924 NM_006576
AVIL
advillin
chr11_-_65860450 1.525 NM_004292
RIN1
Ras and Rab interactor 1
chr1_-_43523825 1.410 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr2_-_108972100 1.383 NM_022336
EDAR
ectodysplasin A receptor
chr1_+_15145001 1.203 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr16_-_73830025 1.120 BCAR1
breast cancer anti-estrogen resistance 1
chr17_+_19377732 1.095 NM_018242
SLC47A1
solute carrier family 47, member 1
chr12_+_56406296 1.046 LOC100130776
hypothetical LOC100130776
chr9_+_123083540 1.034 GSN
gelsolin
chr16_+_22732982 1.005 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_-_39180036 0.988 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr12_+_106236281 0.988 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr2_-_108972048 0.915 EDAR
ectodysplasin A receptor
chr7_-_1562272 0.881 NM_001097620
TMEM184A
transmembrane protein 184A
chr8_-_10550026 0.877 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr6_+_32057779 0.851 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr14_-_49543987 0.794 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr17_+_69941430 0.794 NM_018653
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr16_-_29817841 0.793 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr19_+_3659358 0.783 TJP3
tight junction protein 3 (zona occludens 3)
chr16_+_29373365 0.763 NM_001014999
NM_001015000
NM_024044
NM_178044
SLX1A-SULT1A3
SLX1A

SLX1B

SLX1A-SULT1A3 read-through transcript
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr2_-_110231431 0.757 NM_005434
MALL
mal, T-cell differentiation protein-like
chr16_-_29818334 0.749 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr6_+_35373572 0.728 NM_022047
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr16_+_56219802 0.720 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr21_-_44803049 0.705 NM_198696
KRTAP10-3
keratin associated protein 10-3
chr9_-_138387926 0.695 NM_052813
NM_052814
CARD9

caspase recruitment domain family, member 9

chr11_+_303852 0.684 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr17_+_7199178 0.668 NM_198154
TMEM95
transmembrane protein 95
chr21_+_44881700 0.667 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr9_-_138387903 0.662 CARD9
caspase recruitment domain family, member 9
chr2_+_17923404 0.658 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr2_-_101370291 0.656 CREG2
cellular repressor of E1A-stimulated genes 2
chr17_+_35038276 0.654 NM_181505
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_9933763 0.650 NM_032732
NM_153460
NM_153461
IL17RC


interleukin 17 receptor C


chr17_-_77638264 0.646 FASN
fatty acid synthase
chr3_-_52463070 0.645 NM_003280
TNNC1
troponin C type 1 (slow)
chr17_-_33753218 0.642 NM_001004334
GPR179
G protein-coupled receptor 179
chr12_-_121780835 0.638 NM_032554
GPR81
G protein-coupled receptor 81
chr11_-_116199145 0.636 NM_000482
APOA4
apolipoprotein A-IV
chr2_-_110230927 0.634 MALL
mal, T-cell differentiation protein-like
chr11_+_74548472 0.625 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr1_+_45046740 0.622 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr16_-_29373785 0.618 NM_001031827
NM_001039182
BOLA2
BOLA2B
bolA homolog 2 (E. coli)
bolA homolog 2B (E. coli)
chr1_+_15964045 0.614 NM_001024216
FBLIM1
filamin binding LIM protein 1
chr20_-_32363268 0.604 NM_001161766
AHCY
adenosylhomocysteinase
chr1_-_41722883 0.603 NM_001956
EDN2
endothelin 2
chr14_+_36196523 0.599 NM_006194
PAX9
paired box 9
chr17_-_40858775 0.594 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr1_-_159257567 0.593 F11R
F11 receptor
chr21_+_44818033 0.579 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr1_+_202033273 0.573 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr1_-_159257595 0.572 NM_016946
F11R
F11 receptor
chr8_-_143864933 0.566 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr15_+_92575767 0.552 MCTP2
multiple C2 domains, transmembrane 2
chr2_+_71148915 0.549 NM_017567
NAGK
N-acetylglucosamine kinase
chr13_-_96444604 0.548 NM_080818
OXGR1
oxoglutarate (alpha-ketoglutarate) receptor 1
chr1_+_27062215 0.547 NM_006142
SFN
stratifin
chr1_+_232416618 0.545 SLC35F3
solute carrier family 35, member F3
chr18_+_586997 0.545 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr21_-_44784499 0.544 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr19_+_49972965 0.541 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr2_-_101370355 0.540 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chrX_-_153256122 0.539 FLNA
filamin A, alpha
chr9_+_135276940 0.536 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr4_-_54152480 0.534 NM_001126328
LNX1
ligand of numb-protein X 1
chr19_-_48133089 0.528 NM_002783
PSG7
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
chr1_-_26553168 0.528 NM_001039775
AIM1L
absent in melanoma 1-like
chr6_+_34590624 0.524 PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr1_-_21868380 0.521 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr1_-_159257486 0.519 F11R
F11 receptor
chr20_+_2744947 0.518 NM_001167670
LOC100288797
hypothetical protein LOC100288797
chr17_-_33982580 0.515 SRCIN1
SRC kinase signaling inhibitor 1
chr15_+_89247569 0.514 MAN2A2
mannosidase, alpha, class 2A, member 2
chr16_+_82544327 0.513 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr9_+_123369219 0.507 NM_032552
DAB2IP
DAB2 interacting protein
chr19_-_41034734 0.502 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr1_+_32485404 0.497 NM_032648
FAM167B
family with sequence similarity 167, member B
chr14_-_94053933 0.492 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr6_+_31016755 0.490 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr2_-_236741352 0.490 NM_001485
GBX2
gastrulation brain homeobox 2
chr19_-_59368625 0.489 NM_001145303
NM_144686
TMC4

transmembrane channel-like 4

chr17_-_38081967 0.487 NM_024927
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_+_55237193 0.486 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr16_+_87232501 0.483 NM_013278
IL17C
interleukin 17C
chr2_+_101981888 0.482 NM_173343
IL1R2
interleukin 1 receptor, type II
chr11_-_310925 0.478 IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr11_-_2138984 0.475 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr15_-_27901628 0.475 TJP1
tight junction protein 1 (zona occludens 1)
chr9_+_130839033 0.464 NM_032809
FAM73B
family with sequence similarity 73, member B
chr11_+_116580892 0.460 TAGLN
transgelin
chr7_-_94863558 0.459 NM_000940
PON3
paraoxonase 3
chr17_-_19560470 0.459 NM_001099646
NM_152908
SLC47A2

solute carrier family 47, member 2

chr14_+_23527866 0.457 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr1_-_218168548 0.456 NM_018713
SLC30A10
solute carrier family 30, member 10
chr3_-_140246423 0.455 NM_001134657
PRR23C
proline rich 23C
chr21_+_44871467 0.455 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr4_-_187884721 0.454


chr17_+_58915909 0.453 NM_001178057
NM_152830
ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

chr1_-_24342158 0.447 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr11_-_17522430 0.446 NM_005709
NM_153676
USH1C

Usher syndrome 1C (autosomal recessive, severe)

chrX_-_48213508 0.444 SLC38A5
solute carrier family 38, member 5
chr2_+_128009782 0.441 NM_001080527
MYO7B
myosin VIIB
chr1_+_183970093 0.430 NM_031935
HMCN1
hemicentin 1
chr13_+_112704051 0.427 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_-_35911340 0.427 NM_032865
TNS4
tensin 4
chr1_-_6341553 0.426 NM_181866
ACOT7
acyl-CoA thioesterase 7
chr19_-_3920736 0.425 NM_001348
DAPK3
death-associated protein kinase 3
chr22_+_27609889 0.424 NM_032173
ZNRF3
zinc and ring finger 3
chr16_+_30112707 0.423 NM_001014999
NM_001015000
NM_024044
NM_178044
SLX1A-SULT1A3
SLX1A

SLX1B

SLX1A-SULT1A3 read-through transcript
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr14_+_34521854 0.422 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr12_+_48784057 0.421 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr17_-_36346240 0.419 KRT23
keratin 23 (histone deacetylase inducible)
chr6_+_132170847 0.418 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr5_+_40945315 0.415 NM_000587
C7
complement component 7
chr11_-_117200618 0.412 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr14_+_34521945 0.412 SRP54
signal recognition particle 54kDa
chr17_+_71582486 0.410 NM_003857
GALR2
galanin receptor 2
chrX_-_48213545 0.409 NM_033518
SLC38A5
solute carrier family 38, member 5
chr20_-_62052922 0.409 NM_001193379
UCKL1
uridine-cytidine kinase 1-like 1
chr17_-_67628523 0.408 FLJ37644
hypothetical LOC400618
chr20_-_33580861 0.407 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr12_-_51629874 0.403 KRT8
keratin 8
chr11_+_45900731 0.403 GYLTL1B
glycosyltransferase-like 1B
chr6_-_32121784 0.402 NM_032470
TNXB
tenascin XB
chr14_+_20608179 0.402 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr19_-_1989937 0.402 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr11_-_34491878 0.400 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr15_-_81744469 0.398 NM_001717
BNC1
basonuclin 1
chr10_+_46503539 0.396 NM_005972
PPYR1
pancreatic polypeptide receptor 1
chr17_-_37221443 0.394


chr20_+_21634515 0.394 PAX1
paired box 1
chr21_-_41140908 0.389 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr1_+_15935395 0.388 NM_207348
SLC25A34
solute carrier family 25, member 34
chr1_+_109810622 0.387 NM_001040709
SYPL2
synaptophysin-like 2
chrX_+_24621984 0.386 NM_016937
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr3_-_13896618 0.382 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr9_-_103289154 0.381 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr13_-_37341859 0.381 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr20_+_34163671 0.380 NM_177996
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr22_+_40093245 0.377 NM_001145398
TEF
thyrotrophic embryonic factor
chr6_+_132170888 0.377 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr7_+_72883128 0.377 NM_001305
CLDN4
claudin 4
chr6_-_138470160 0.377 NM_022121
PERP
PERP, TP53 apoptosis effector
chr16_-_30113127 0.375 NM_001031827
NM_001039182
BOLA2
BOLA2B
bolA homolog 2 (E. coli)
bolA homolog 2B (E. coli)
chr15_-_40236061 0.374 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr20_+_19141364 0.372 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr1_+_17571277 0.370 NM_207421
PADI6
peptidyl arginine deiminase, type VI
chr9_-_34652629 0.370 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr16_+_8714687 0.369 ABAT
4-aminobutyrate aminotransferase
chr19_-_56221681 0.367 NM_001136032
KLK11
kallikrein-related peptidase 11
chr5_+_40945374 0.367 C7
complement component 7
chr3_+_11009419 0.367 NM_003042
SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr15_+_83092854 0.364 ZNF592
zinc finger protein 592
chr3_+_112934016 0.364 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr9_-_126309510 0.364 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr11_-_116692128 0.363 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr3_-_140222440 0.360 NM_001013650
PRR23B
proline rich 23B
chr6_-_2787068 0.358 NM_030666
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr4_-_187713512 0.357 NM_005958
MTNR1A
melatonin receptor 1A
chr12_+_6292077 0.357 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr8_+_22493928 0.356 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr2_+_71148936 0.356 NAGK
N-acetylglucosamine kinase
chr15_-_64644758 0.356 NM_207338
LCTL
lactase-like
chr6_+_44463265 0.355 NM_001253
CDC5L
CDC5 cell division cycle 5-like (S. pombe)
chr19_-_40995606 0.354 PRODH2
proline dehydrogenase (oxidase) 2
chr17_-_77647505 0.353 FASN
fatty acid synthase
chr3_+_9919511 0.353 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr14_-_93859394 0.351 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr8_-_6722848 0.350 NM_005218
DEFB1
defensin, beta 1
chr12_+_2032964 0.348 CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr20_+_21634293 0.344 NM_006192
PAX1
paired box 1
chr22_+_21407066 0.342


chr9_-_109291130 0.341 KLF4
Kruppel-like factor 4 (gut)
chr3_+_185450108 0.341 NM_014693
NM_032331
ECE2

endothelin converting enzyme 2

chr17_+_72958330 0.340 SEPT9
septin 9
chr20_-_62081434 0.340 NM_080621
SAMD10
sterile alpha motif domain containing 10
chr11_-_310775 0.339 NM_021034
IFITM3
interferon induced transmembrane protein 3 (1-8U)
chr21_+_46355797 0.339 COL6A2
collagen, type VI, alpha 2
chr12_+_51730101 0.339 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_-_16217871 0.339 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr6_+_17708483 0.337 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr6_+_35373632 0.337 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chrX_-_153698930 0.336 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr10_-_76538859 0.336 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr2_-_218516950 0.335 NM_022648
TNS1
tensin 1
chr1_+_20751518 0.334 NM_207334
FAM43B
family with sequence similarity 43, member B
chr1_+_144439069 0.333 NM_002614
PDZK1
PDZ domain containing 1
chr10_+_135333667 0.332 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_-_117640407 0.331 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr19_-_16145285 0.331 NM_054113
CIB3
calcium and integrin binding family member 3
chr6_+_31976754 0.330 NM_001178063
C2
complement component 2
chr17_-_7173179 0.328 NM_001005408
NM_032442
NEURL4

neuralized homolog 4 (Drosophila)

chr15_+_78775008 0.327 FAM108C1
family with sequence similarity 108, member C1
chr3_+_185762233 0.326 NM_004443
EPHB3
EPH receptor B3
chr1_-_54392030 0.326 NM_201546
CDCP2
CUB domain containing protein 2
chr12_-_51457371 0.324 NM_015848
KRT76
keratin 76
chrX_+_101853912 0.323 NM_001004051
NM_001184874
NM_001184875
NM_001184876
NM_138437
GPRASP2




G protein-coupled receptor associated sorting protein 2





Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 2.12e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 2.59e-03 GO:0030054 cell junction
1.93 3.66e-03 GO:0070161 anchoring junction
1.23 3.89e-03 GO:0044459 plasma membrane part
1.95 7.28e-03 GO:0005912 adherens junction
1.70 2.18e-02 GO:0016323 basolateral plasma membrane
2.03 3.28e-02 GO:0030055 cell-substrate junction
1.87 3.34e-02 GO:0045211 postsynaptic membrane
2.04 3.86e-02 GO:0005924 cell-substrate adherens junction
1.30 4.21e-02 GO:0000267 cell fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.47 2.16e-02 GO:0008092 cytoskeletal protein binding
1.59 3.51e-02 GO:0003779 actin binding
3.29 3.74e-02 GO:0008066 glutamate receptor activity