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Motif ID: SPIB.p2

Z-value: 2.112

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_175207521	1.555	NM_003387	WIPF1	WAS/WASL interacting protein family, member 1
chr10_-_98470164	1.275	NM_152309	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1
chr17_-_40843530	1.124		ARHGAP27	Rho GTPase activating protein 27
chr11_-_60880799	1.099	NM_001161452	CYBASC3	cytochrome b, ascorbate dependent 3
chr1_-_59020875	1.041		JUN	jun proto-oncogene
chr5_+_140772691	1.001	NM_018913 NM_032090	PCDHGA10	protocadherin gamma subfamily A, 10
chr6_+_31661934	0.952	NM_205838 NM_205839	LST1	leukocyte specific transcript 1
chr22_-_39964001	0.909		CHADL	chondroadherin-like
chr9_+_130942029	0.898		PPP2R4	protein phosphatase 2A activator, regulatory subunit 4
chr17_-_18890963	0.890	NM_006613	GRAP	GRB2-related adaptor protein
chr6_-_56824672	0.871		DST	dystonin
chr11_+_63864263	0.868	NM_032251	CCDC88B	coiled-coil domain containing 88B
chr6_-_154719560	0.850	NM_001130700 NM_015553	IPCEF1	interaction protein for cytohesin exchange factors 1
chr2_-_47986160	0.846	NM_001190274	FBXO11	F-box protein 11
chr5_+_75734759	0.810	NM_006633	IQGAP2	IQ motif containing GTPase activating protein 2
chr6_-_25044156	0.810		FAM65B	family with sequence similarity 65, member B
chr13_-_32678142	0.810	NM_052851	STARD13	StAR-related lipid transfer (START) domain containing 13
chr14_+_99601498	0.783	NM_016337	EVL	Enah/Vasp-like
chr1_-_45988901	0.778	NM_001145349 NM_005897	IPP	intracisternal A particle-promoted polypeptide
chrX_-_47374187	0.768	NM_001145252	CFP	complement factor properdin
chr4_-_25473528	0.762	NM_015187	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)
chr19_+_3129735	0.762	NM_003775	S1PR4	sphingosine-1-phosphate receptor 4
chr2_-_213723298	0.740	NM_016260	IKZF2	IKAROS family zinc finger 2 (Helios)
chr11_+_59979857	0.718	NM_021950 NM_152866	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr15_+_38849450	0.705	NM_001130448	C15orf62	chromosome 15 open reading frame 62
chr3_+_195889845	0.702		FAM43A	family with sequence similarity 43, member A
chr17_+_64922420	0.680	NM_002758	MAP2K6	mitogen-activated protein kinase kinase 6
chr17_+_37693090	0.677	NM_003152	STAT5A	signal transducer and activator of transcription 5A
chr11_-_60475558	0.670	NM_016582	SLC15A3	solute carrier family 15, member 3
chr6_-_11490487	0.663	NM_001142393	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr14_+_99601517	0.654		EVL	Enah/Vasp-like
chr7_+_87401368	0.653	NM_004194 NM_016351 NM_021721 NM_021722 NM_021723	ADAM22	ADAM metallopeptidase domain 22
chr12_+_93066370	0.639	NM_005761	PLXNC1	plexin C1
chr12_-_8584658	0.617	NM_014358	CLEC4E	C-type lectin domain family 4, member E
chr11_-_77806500	0.609	NM_080491	GAB2	GRB2-associated binding protein 2
chr11_-_77806413	0.605		GAB2	GRB2-associated binding protein 2
chr7_+_37926943	0.603		EPDR1	ependymin related protein 1 (zebrafish)
chr3_-_120761092	0.601	NM_005191	CD80	CD80 molecule
chr13_+_107720475	0.588		TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b
chr10_-_27189898	0.587		ABI1	abl-interactor 1
chr8_+_11388918	0.587	NM_001715	BLK	B lymphoid tyrosine kinase
chr2_+_149118791	0.578		EPC2	enhancer of polycomb homolog 2 (Drosophila)
chr6_-_56824371	0.578		DST	dystonin
chr9_+_70509925	0.575	NM_003558	PIP5K1B	phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr2_+_65308332	0.565	NM_001005386 NM_005722	ACTR2	ARP2 actin-related protein 2 homolog (yeast)
chrX_-_100527799	0.561	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chr5_-_176869463	0.560	NM_024872	DOK3	docking protein 3
chr6_-_32268267	0.557		GPSM3	G-protein signaling modulator 3
chr5_-_176869148	0.557
chr5_+_139485703	0.553	NM_001007189	C5orf53	chromosome 5 open reading frame 53
chr18_+_30875297	0.550	NM_014268	MAPRE2	microtubule-associated protein, RP/EB family, member 2
chr9_-_115077644	0.550	NM_139286	CDC26	cell division cycle 26 homolog (S. cerevisiae)
chrX_+_51562894	0.543	NM_001005332	MAGED1	melanoma antigen family D, 1
chr2_-_242449662	0.539	NM_005018	PDCD1	programmed cell death 1
chr11_-_58099884	0.537	NM_004811	LPXN	leupaxin
chr10_-_53129315	0.534	NM_015235	CSTF2T	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
chr19_-_53558961	0.533	NM_018273	TMEM143	transmembrane protein 143
chr5_-_176869440	0.532		DOK3	docking protein 3
chr12_+_48765300	0.532		SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr7_-_23476497	0.528	NM_006547	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr8_-_120914233	0.527	NM_003184	TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
chr16_+_74868676	0.525	NM_033401	CNTNAP4	contactin associated protein-like 4
chrX_+_77267477	0.520		PGK1	phosphoglycerate kinase 1
chr1_-_156078115	0.518	NM_005894	CD5L	CD5 molecule-like
chr14_+_88130482	0.518	NM_207662	ZC3H14	zinc finger CCCH-type containing 14
chr18_-_65766068	0.515		CD226	CD226 molecule
chr12_-_47604930	0.514	NM_001143781	FKBP11	FK506 binding protein 11, 19 kDa
chr7_+_139175420	0.514	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr1_-_181826086	0.511		NCF2	neutrophil cytosolic factor 2
chr17_-_41625921	0.509	NM_001193466	KIAA1267	KIAA1267
chr18_-_16945763	0.508	NM_005406	ROCK1	Rho-associated, coiled-coil containing protein kinase 1
chr11_+_65026382	0.508
chr11_-_66961709	0.506	NM_005608	PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein
chr18_-_16945613	0.498		ROCK1	Rho-associated, coiled-coil containing protein kinase 1
chr12_-_24628348	0.494		C12orf67	chromosome 12 open reading frame 67
chr11_-_9182356	0.489		DENND5A	DENN/MADD domain containing 5A
chr19_-_46550788	0.481		TGFB1	transforming growth factor, beta 1
chr7_+_23187970	0.481	NM_007342	NUPL2	nucleoporin like 2
chr10_-_103567773	0.480		MGEA5	meningioma expressed antigen 5 (hyaluronidase)
chr12_-_56422120	0.476	NM_014770	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr14_+_61653827	0.475		FLJ43390	hypothetical LOC646113
chr7_-_135312387	0.469		MTPN	myotrophin
chr18_-_51219880	0.465		TCF4	transcription factor 4
chr3_-_122862391	0.464		HCLS1	hematopoietic cell-specific Lyn substrate 1
chr2_-_197165495	0.464	NM_020760	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr12_+_48443232	0.461		TMBIM6	transmembrane BAX inhibitor motif containing 6
chr14_-_21074875	0.459	NM_005407	SALL2	sal-like 2 (Drosophila)
chr12_-_56157898	0.456	NM_001080156	ARHGAP9	Rho GTPase activating protein 9
chr7_+_99793561	0.456	NM_178238	PILRB	paired immunoglobin-like type 2 receptor beta
chrX_-_111809929	0.456	NM_178175	LHFPL1	lipoma HMGIC fusion partner-like 1
chr7_+_149779011	0.455		GIMAP8	GTPase, IMAP family member 8
chr2_+_233633348	0.455		INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chrX_-_130792297	0.455		LOC286467	hypothetical LOC286467
chr5_+_176955595	0.454
chr6_-_132875858	0.453	NM_003569	STX7	syntaxin 7
chr6_-_32268615	0.451		GPSM3	G-protein signaling modulator 3
chr1_-_28287658	0.450	NM_001990	EYA3	eyes absent homolog 3 (Drosophila)
chr7_-_135312574	0.449		MTPN	myotrophin
chr5_-_158567411	0.447	NM_144726	RNF145	ring finger protein 145
chr2_+_233633279	0.447	NM_001017915 NM_005541	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
chr15_+_79376295	0.446	NM_004513	IL16	interleukin 16 (lymphocyte chemoattractant factor)
chr2_-_96174865	0.444	NM_004418	DUSP2	dual specificity phosphatase 2
chr1_-_27353987	0.441	NM_003047	SLC9A1	solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr17_+_39778191	0.441		GRN	granulin
chr12_+_6930734	0.440		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr11_+_86426518	0.437	NM_001168724 NM_022918	TMEM135	transmembrane protein 135
chrX_-_85189194	0.436	NM_000390 NM_001145414	CHM	choroideremia (Rab escort protein 1)
chr1_+_110031940	0.435	NM_000561 NM_146421	GSTM1	glutathione S-transferase mu 1
chr14_+_49157150	0.435	NM_002408	MGAT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr3_-_122862447	0.434	NM_005335	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr5_-_71838875	0.430	NM_152625	ZNF366	zinc finger protein 366
chr13_-_32822759	0.430		STARD13	StAR-related lipid transfer (START) domain containing 13
chrX_-_134257624	0.429	NM_001185063 NM_007131	ZNF75D	zinc finger protein 75D
chr15_+_64466285	0.428		MAP2K1	mitogen-activated protein kinase kinase 1
chr1_+_12325632	0.426		VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr16_-_3567354	0.424	NM_178844	NLRC3	NLR family, CARD domain containing 3
chr1_+_151442542	0.423	NM_001010857	LELP1	late cornified envelope-like proline-rich 1
chr12_+_6930778	0.420		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr7_+_149778869	0.415	NM_175571	GIMAP8	GTPase, IMAP family member 8
chr12_+_97433545	0.415		TMPO	thymopoietin
chr7_-_130443379	0.415		FLJ43663	hypothetical LOC378805
chr3_-_15814678	0.414	NM_001195098	ANKRD28	ankyrin repeat domain 28
chr7_+_128651976	0.413	NM_001130720 NM_015328	AHCYL2	adenosylhomocysteinase-like 2
chr10_+_70553936	0.412		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr12_-_104153920	0.411	NM_018171	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr10_+_70553949	0.411		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr15_+_64466161	0.410	NM_002755	MAP2K1	mitogen-activated protein kinase kinase 1
chr3_-_107070400	0.408	NM_170662	CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr10_+_70553945	0.407		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr13_+_107720561	0.406		TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b
chr4_-_166118267	0.406	NM_001012414	TRIM61	tripartite motif containing 61
chr17_+_55269974	0.405
chr11_-_95715976	0.403	NM_032427	MAML2	mastermind-like 2 (Drosophila)
chr11_+_298106	0.402	NM_006435	IFITM2	interferon induced transmembrane protein 2 (1-8D)
chr1_-_167969802	0.401	NM_000450	SELE	selectin E
chr12_+_79625538	0.401	NM_002469	MYF6	myogenic factor 6 (herculin)
chr17_-_7061641	0.400	NM_001128827	DLG4	discs, large homolog 4 (Drosophila)
chr4_-_101658094	0.399	NM_001159694 NM_016242	EMCN	endomucin
chr12_+_6930694	0.398	NM_002831 NM_080549	PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr4_-_103968104	0.398	NM_003340 NM_181886 NM_181888 NM_181889	UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
chr9_-_115077504	0.397		FKBP15	FK506 binding protein 15, 133kDa
chr17_+_34871775	0.396		CDK12	cyclin-dependent kinase 12
chr10_+_70553862	0.396	NM_001035260 NM_004896	VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chrX_+_70419766	0.395	NM_001145408 NM_001145409 NM_001145410 NM_007363	NONO	non-POU domain containing, octamer-binding
chr12_+_45896511	0.394		FAM113B	family with sequence similarity 113, member B
chr5_+_143171918	0.393	NM_021182	HMHB1	histocompatibility (minor) HB-1
chr10_+_70553962	0.391		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr1_+_149638633	0.390	NM_002796	PSMB4	proteasome (prosome, macropain) subunit, beta type, 4
chr12_+_6930799	0.389		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr8_+_64243741	0.389		YTHDF3	YTH domain family, member 3
chr12_+_6930792	0.389		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr8_+_64243662	0.388	NM_152758	YTHDF3	YTH domain family, member 3
chr17_-_7064092	0.388	NM_001365	DLG4	discs, large homolog 4 (Drosophila)
chrX_-_70248022	0.387	NM_000206	IL2RG	interleukin 2 receptor, gamma
chr7_+_149778815	0.387		GIMAP8	GTPase, IMAP family member 8
chr19_-_7976468	0.387	NM_001419	ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
chr10_+_91051685	0.387	NM_001547	IFIT2	interferon-induced protein with tetratricopeptide repeats 2
chr5_-_124108672	0.387	NM_020747	ZNF608	zinc finger protein 608
chr6_+_31647854	0.386	NM_001159740	LTA	lymphotoxin alpha (TNF superfamily, member 1)
chr2_+_154436670	0.383	NM_052917	GALNT13	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr10_+_70553993	0.383		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr2_+_113648036	0.383		PSD4	pleckstrin and Sec7 domain containing 4
chr12_+_53177758	0.383	NM_005337	NCKAP1L	NCK-associated protein 1-like
chr10_+_35524060	0.382	NM_182717 NM_182718 NM_182719 NM_182720	CREM	cAMP responsive element modulator
chr12_+_6930804	0.381		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr11_+_5602782	0.381	NM_021616	TRIM34	tripartite motif containing 34
chr22_-_37425937	0.380	NM_014876	JOSD1	Josephin domain containing 1
chr12_-_131816604	0.380		ANKLE2	ankyrin repeat and LEM domain containing 2
chr10_-_27189995	0.379	NM_001012750 NM_001012751 NM_001012752 NM_001178116 NM_001178119 NM_001178120 NM_001178121 NM_001178122 NM_001178123 NM_001178124 NM_001178125 NM_005470	ABI1	abl-interactor 1
chr14_-_66896167	0.379	NM_015994	ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr14_+_38720085	0.379		PNN	pinin, desmosome associated protein
chr3_-_130323033	0.378		RAB43	RAB43, member RAS oncogene family
chr11_+_4571844	0.378	NM_001005169	OR52I1	olfactory receptor, family 52, subfamily I, member 1
chr10_+_70553983	0.376		VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr1_+_202000906	0.376	NM_001136190 NM_017773	LAX1	lymphocyte transmembrane adaptor 1
chr12_+_53177789	0.376		NCKAP1L	NCK-associated protein 1-like
chr8_-_108579270	0.373	NM_001146	ANGPT1	angiopoietin 1
chr17_+_18971506	0.372	NM_001129778	GRAPL	GRB2-related adaptor protein-like
chr18_-_59137488	0.372	NM_000633 NM_000657	BCL2	B-cell CLL/lymphoma 2
chr12_+_53177806	0.371		NCKAP1L	NCK-associated protein 1-like
chr17_-_41018291	0.371
chr1_+_149877955	0.371		SNX27	sorting nexin family member 27
chr11_+_119712113	0.370		ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12
chr12_-_53071285	0.370	NM_001130967 NM_001130968	ZNF385A	zinc finger protein 385A
chr10_+_35524835	0.369	NM_182721 NM_182722 NM_182723 NM_182724 NM_182725	CREM	cAMP responsive element modulator
chr1_-_200395741	0.368	NM_080588	PTPN7	protein tyrosine phosphatase, non-receptor type 7
chr9_+_126094067	0.367	NM_001166170 NM_001166171	NEK6	NIMA (never in mitosis gene a)-related kinase 6
chr15_+_40427592	0.366	NM_212465	CAPN3	calpain 3, (p94)
chr12_+_4253143	0.366	NM_001759	CCND2	cyclin D2
chrX_+_134482387	0.366		DDX26B	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr17_+_7180571	0.365	NM_014716	ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr3_+_9451506	0.363
chr11_+_125163215	0.363	NM_001129883	PATE3	prostate and testis expressed 3
chr2_+_113648020	0.363	NM_012455	PSD4	pleckstrin and Sec7 domain containing 4
chr3_-_181879955	0.362	NM_181426	CCDC39	coiled-coil domain containing 39
chr16_-_30301357	0.362		SEPT1	septin 1
chr13_+_107719977	0.358	NM_001145645 NM_006573	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b
chr7_+_23603495	0.358	NM_138771	CCDC126	coiled-coil domain containing 126
chr17_-_38087366	0.358	NM_016602	CCR10	chemokine (C-C motif) receptor 10
chr3_-_184756101	0.355	NM_130446	KLHL6	kelch-like 6 (Drosophila)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.37	1.06e-09	GO:0002376	immune system process
1.25	3.31e-06	GO:0010467	gene expression
1.14	1.57e-05	GO:0044260	cellular macromolecule metabolic process
1.83	2.11e-05	GO:0051251	positive regulation of lymphocyte activation
1.25	2.48e-05	GO:0016070	RNA metabolic process
1.76	6.47e-05	GO:0050867	positive regulation of cell activation
1.16	8.66e-05	GO:0007165	signal transduction
1.37	8.92e-05	GO:0006955	immune response
1.32	1.33e-04	GO:0032774	RNA biosynthetic process
1.75	1.52e-04	GO:0002696	positive regulation of leukocyte activation
1.85	2.17e-04	GO:0050870	positive regulation of T cell activation
1.68	2.27e-04	GO:0051249	regulation of lymphocyte activation
1.23	2.49e-04	GO:0034645	cellular macromolecule biosynthetic process
1.23	2.52e-04	GO:0009059	macromolecule biosynthetic process
1.76	2.52e-04	GO:0050863	regulation of T cell activation
1.36	4.43e-04	GO:0002682	regulation of immune system process
2.23	8.41e-04	GO:0031294	lymphocyte costimulation
2.23	8.41e-04	GO:0031295	T cell costimulation
1.14	8.89e-04	GO:0023052	signaling
1.19	9.38e-04	GO:0090304	nucleic acid metabolic process
1.60	9.43e-04	GO:0050865	regulation of cell activation
1.61	9.94e-04	GO:0002694	regulation of leukocyte activation
1.09	2.96e-03	GO:0050794	regulation of cellular process
1.19	8.28e-03	GO:0048583	regulation of response to stimulus
1.40	1.22e-02	GO:0002684	positive regulation of immune system process
1.12	1.24e-02	GO:0051716	cellular response to stimulus
1.44	1.41e-02	GO:0051056	regulation of small GTPase mediated signal transduction
1.38	1.48e-02	GO:0001775	cell activation
1.28	1.71e-02	GO:0006351	transcription, DNA-dependent
1.87	1.75e-02	GO:0050851	antigen receptor-mediated signaling pathway
1.67	2.10e-02	GO:0050900	leukocyte migration
1.16	2.34e-02	GO:0048522	positive regulation of cellular process
1.37	2.51e-02	GO:0007599	hemostasis
1.37	2.64e-02	GO:0007596	blood coagulation
1.37	2.64e-02	GO:0050817	coagulation
1.07	2.67e-02	GO:0065007	biological regulation
1.60	3.18e-02	GO:0002764	immune response-regulating signaling pathway
1.07	3.98e-02	GO:0050789	regulation of biological process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.18	1.33e-03	GO:0005829	cytosol
1.03	1.43e-03	GO:0005623	cell
1.03	1.73e-03	GO:0044464	cell part
1.04	6.66e-03	GO:0005622	intracellular
1.04	2.12e-02	GO:0044424	intracellular part
1.06	3.33e-02	GO:0005737	cytoplasm
1.16	4.43e-02	GO:0031981	nuclear lumen

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.10	4.25e-07	GO:0005515	protein binding
1.31	3.82e-04	GO:0003723	RNA binding
1.36	1.24e-02	GO:0030695	GTPase regulator activity
1.35	1.60e-02	GO:0060589	nucleoside-triphosphatase regulator activity
1.44	2.27e-02	GO:0005083	small GTPase regulator activity