Motif ID: SPZ1.p2

Z-value: 1.869


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPZ1chr5_+_79651545-0.457.7e-02Click!


Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_29373365 1.746 NM_001014999
NM_001015000
NM_024044
NM_178044
SLX1A-SULT1A3
SLX1A

SLX1B

SLX1A-SULT1A3 read-through transcript
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr17_+_35075124 1.576 NM_003673
TCAP
titin-cap (telethonin)
chr3_+_152287365 1.545 NM_053002
MED12L
mediator complex subunit 12-like
chr10_+_123862430 1.161 TACC2
transforming, acidic coiled-coil containing protein 2
chr16_-_66535457 1.115 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr19_+_59077241 0.896 NM_002739
PRKCG
protein kinase C, gamma
chr17_-_40344203 0.889 GFAP
glial fibrillary acidic protein
chr4_+_184257337 0.888 NM_024949
WWC2
WW and C2 domain containing 2
chr16_-_66535923 0.861 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr17_-_36469869 0.836 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr5_-_45731976 0.830 NM_021072
HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr4_-_22126437 0.808 NM_145290
GPR125
G protein-coupled receptor 125
chr4_-_158111995 0.792 NM_016205
PDGFC
platelet derived growth factor C
chr8_-_22145795 0.792 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr4_-_187884721 0.788


chr5_-_176914143 0.777 NM_001190946
FAM193B
family with sequence similarity 193, member B
chr19_+_45799060 0.761 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr5_+_139473873 0.760 NM_005859
PURA
purine-rich element binding protein A
chr5_-_45731588 0.757 HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr22_-_22970850 0.752 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr7_+_100025131 0.740 NM_001163499
NM_012172
FBXO24

F-box protein 24

chr14_+_34521945 0.736 SRP54
signal recognition particle 54kDa
chr2_+_201385019 0.729 BZW1
basic leucine zipper and W2 domains 1
chr17_+_71582486 0.714 NM_003857
GALR2
galanin receptor 2
chr3_+_9933763 0.699 NM_032732
NM_153460
NM_153461
IL17RC


interleukin 17 receptor C


chr1_+_221168388 0.693 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chrX_+_105856531 0.681 NM_194463
RNF128
ring finger protein 128
chr16_+_29726962 0.677 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr11_+_65594361 0.673 NM_018026
PACS1
phosphofurin acidic cluster sorting protein 1
chr7_-_20791907 0.672


chr3_-_150858274 0.672 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr19_+_50041400 0.669 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr17_-_40401138 0.667 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr4_-_118226119 0.666 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr17_-_35017650 0.657 NEUROD2
neurogenic differentiation 2
chr19_-_44032449 0.654 NM_001533
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr2_-_136005238 0.647 NM_032143
ZRANB3
zinc finger, RAN-binding domain containing 3
chr4_+_144477432 0.643 NM_002039
NM_207123
GAB1

GRB2-associated binding protein 1

chr19_+_50041387 0.642 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr14_-_22891263 0.634 NM_020372
SLC22A17
solute carrier family 22, member 17
chr4_-_158111916 0.632 PDGFC
platelet derived growth factor C
chr18_-_50777634 0.626 NM_025214
CCDC68
coiled-coil domain containing 68
chr9_-_85342868 0.625 NM_174938
FRMD3
FERM domain containing 3
chr16_-_65984836 0.623 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr20_-_391048 0.622 TBC1D20
TBC1 domain family, member 20
chr11_+_59279481 0.622 STX3
syntaxin 3
chr2_-_158440587 0.620 NM_001111067
ACVR1
activin A receptor, type I
chr6_+_122762449 0.620 HSF2
heat shock transcription factor 2
chr19_+_45973139 0.618 NM_006533
MIA
melanoma inhibitory activity
chr17_-_40344322 0.618


chr17_-_35017691 0.618 NM_006160
NEUROD2
neurogenic differentiation 2
chr1_+_27925054 0.617 NM_001143912
NM_001143913
NM_001143914
NM_001143915
NM_152660
FAM76A




family with sequence similarity 76, member A




chr16_+_29819647 0.613 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr12_-_24606616 0.610 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr22_-_30476119 0.605 NM_173566
PRR14L
proline rich 14-like
chr2_-_216944911 0.604 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr21_+_44844924 0.602 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr18_+_3439972 0.599 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr11_+_45900731 0.597 GYLTL1B
glycosyltransferase-like 1B
chr1_+_176748834 0.594 NM_001170722
NM_001170723
NM_001170724
NM_032126
C1orf49



chromosome 1 open reading frame 49



chr14_+_36196523 0.593 NM_006194
PAX9
paired box 9
chr10_-_105411339 0.592 SH3PXD2A
SH3 and PX domains 2A
chr20_+_35241109 0.580 RPN2
ribophorin II
chr12_+_56406296 0.575 LOC100130776
hypothetical LOC100130776
chr17_-_39556483 0.573 HDAC5
histone deacetylase 5
chr8_+_69405510 0.570 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr17_-_40858775 0.565 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr20_+_19141282 0.564 NM_020689
SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr19_+_50041424 0.554 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_-_150070849 0.550 NM_005060
RORC
RAR-related orphan receptor C
chr1_-_32574185 0.548 NM_023009
MARCKSL1
MARCKS-like 1
chr2_+_201384889 0.536 NM_014670
BZW1
basic leucine zipper and W2 domains 1
chr2_+_201384880 0.536 BZW1
basic leucine zipper and W2 domains 1
chr5_-_139402909 0.535 NRG2
neuregulin 2
chr1_-_148175345 0.533 MTMR11
myotubularin related protein 11
chr2_+_201384904 0.531 BZW1
basic leucine zipper and W2 domains 1
chr10_-_101180191 0.530 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr2_-_127580975 0.526 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr2_-_177838104 0.525 NM_006164
NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr17_+_45405128 0.524 NM_001934
DLX4
distal-less homeobox 4
chr12_+_439803 0.520 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr14_-_22516271 0.519 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr2_+_171280944 0.517 SP5
Sp5 transcription factor
chr2_+_201384842 0.516 BZW1
basic leucine zipper and W2 domains 1
chr16_+_67236730 0.516 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr17_-_45626967 0.515


chr16_+_67236699 0.514 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr18_+_32131628 0.510 NM_025135
FHOD3
formin homology 2 domain containing 3
chr19_+_50041232 0.509 NM_001042724
NM_002856
PVRL2

poliovirus receptor-related 2 (herpesvirus entry mediator B)

chr8_-_22145462 0.508 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr7_-_93357881 0.503 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr12_+_106236281 0.502 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr12_+_65949631 0.501 CAND1
cullin-associated and neddylation-dissociated 1
chr6_+_6670117 0.501


chr17_-_1499849 0.500 NM_031430
RILP
Rab interacting lysosomal protein
chr6_-_116488458 0.497 NM_002031
FRK
fyn-related kinase
chr1_+_27541086 0.496 SYTL1
synaptotagmin-like 1
chr12_+_6363482 0.494 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr6_+_39868116 0.492


chr20_+_34667566 0.490 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr20_+_34667597 0.490 C20orf24
chromosome 20 open reading frame 24
chr13_+_92677012 0.490 NM_005708
GPC6
glypican 6
chr20_-_22513050 0.489 NM_021784
FOXA2
forkhead box A2
chr2_-_192767844 0.487 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr13_-_39075355 0.485 NM_005780
LHFP
lipoma HMGIC fusion partner
chr12_+_7233536 0.485 NM_001131023
NM_001131024
NM_001131025
PEX5


peroxisomal biogenesis factor 5


chr20_+_21054718 0.480 PLK1S1
polo-like kinase 1 substrate 1
chr20_+_43952189 0.480 CTSA
cathepsin A
chr14_-_23107106 0.477 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr11_-_3775547 0.477 NM_005387
NM_016320
NM_139131
NM_139132
NUP98



nucleoporin 98kDa



chr20_+_21054623 0.474 NM_001163022
NM_001163023
NM_018474
PLK1S1


polo-like kinase 1 substrate 1


chr6_-_138231006 0.470


chr19_-_60646041 0.468 NM_001145176
SHISA7
shisa homolog 7 (Xenopus laevis)
chr4_-_158111504 0.468 PDGFC
platelet derived growth factor C
chr15_+_36332258 0.466 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr20_+_34667590 0.462 C20orf24
chromosome 20 open reading frame 24
chr5_+_42459568 0.462 NM_000163
GHR
growth hormone receptor
chr11_+_119616112 0.461 NM_014352
POU2F3
POU class 2 homeobox 3
chr16_+_65765256 0.458 NM_003946
NM_001185057
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr14_+_34521854 0.458 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr19_+_49972965 0.458 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr20_+_34667605 0.456 C20orf24
chromosome 20 open reading frame 24
chr2_+_33025872 0.453 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr10_+_123912930 0.452 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_115433570 0.450 NM_005725
TSPAN2
tetraspanin 2
chr6_-_18230829 0.449 NM_198586
NHLRC1
NHL repeat containing 1
chr7_+_94374862 0.448 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr13_-_39075200 0.446 LHFP
lipoma HMGIC fusion partner
chr6_+_122762384 0.443 NM_001135564
NM_004506
HSF2

heat shock transcription factor 2

chr16_+_66244314 0.440 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_-_74231266 0.440 CYTH1
cytohesin 1
chr16_+_29726931 0.439 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_-_170428564 0.436 SH3RF1
SH3 domain containing ring finger 1
chr13_-_39075304 0.432 LHFP
lipoma HMGIC fusion partner
chr1_+_32485404 0.431 NM_032648
FAM167B
family with sequence similarity 167, member B
chr12_+_64504835 0.430 HMGA2
high mobility group AT-hook 2
chr11_-_68537243 0.430 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr10_-_105410840 0.429


chr6_+_17390273 0.427 NM_001143941
RBM24
RNA binding motif protein 24
chr19_+_17483420 0.427 NM_012088
PGLS
6-phosphogluconolactonase
chr16_-_4778317 0.424 NM_001154458
NM_144605
SEPT12

septin 12

chr14_+_21015211 0.423 TOX4
TOX high mobility group box family member 4
chr1_-_36562341 0.421 NM_018166
FAM176B
family with sequence similarity 176, member B
chr17_+_38576707 0.421 NM_005899
NBR1
neighbor of BRCA1 gene 1
chr14_+_89597860 0.420 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr11_-_118167036 0.419 DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr7_+_100156358 0.419 NM_000799
EPO
erythropoietin
chr6_+_32090516 0.419 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr19_+_17483445 0.419 PGLS
6-phosphogluconolactonase
chr14_+_21015168 0.417 NM_014828
TOX4
TOX high mobility group box family member 4
chr20_+_35240844 0.417 NM_001135771
NM_002951
RPN2

ribophorin II

chr2_-_96174502 0.415 DUSP2
dual specificity phosphatase 2
chr2_-_27147995 0.412 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr11_+_59279377 0.412 STX3
syntaxin 3
chr14_+_96038451 0.412 NM_032632
PAPOLA
poly(A) polymerase alpha
chr1_-_148175383 0.412 NM_001145862
MTMR11
myotubularin related protein 11
chr17_+_4434024 0.412 NM_198501
SMTNL2
smoothelin-like 2
chr6_+_32057779 0.411 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr6_+_39868126 0.411 DAAM2
dishevelled associated activator of morphogenesis 2
chr6_+_132170888 0.411 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr14_-_36059084 0.409 NM_001079668
NKX2-1
NK2 homeobox 1
chr20_+_35241161 0.408 RPN2
ribophorin II
chr20_-_50241581 0.408 ZFP64
zinc finger protein 64 homolog (mouse)
chr12_+_70435176 0.407 RAB21
RAB21, member RAS oncogene family
chr9_-_4289574 0.406 GLIS3
GLIS family zinc finger 3
chr3_+_31549123 0.406 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr17_-_37586716 0.405 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr1_-_32479785 0.404 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr1_+_3378030 0.404 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr14_+_102128741 0.402 RCOR1
REST corepressor 1
chr13_-_26643775 0.402 USP12
ubiquitin specific peptidase 12
chr9_+_35595275 0.402 NM_006285
TESK1
testis-specific kinase 1
chr10_+_123913094 0.401 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr1_+_199130571 0.398 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr14_+_21015198 0.397 TOX4
TOX high mobility group box family member 4
chr11_-_9292737 0.396 NM_001165030
NM_015012
TMEM41B

transmembrane protein 41B

chr22_-_44751671 0.396 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr6_-_31347867 0.393 HLA-C
major histocompatibility complex, class I, C
chr17_+_260408 0.392 NM_001013672
C17orf97
chromosome 17 open reading frame 97
chr3_-_95175282 0.389 PROS1
protein S (alpha)
chr18_-_26935883 0.385 NM_004949
NM_024422
DSC2

desmocollin 2

chr8_+_98725670 0.385 MTDH
metadherin
chr15_-_76700174 0.384 CHRNA3
cholinergic receptor, nicotinic, alpha 3
chr1_-_21868380 0.382 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr6_+_45498262 0.381 RUNX2
runt-related transcription factor 2
chrX_-_63342209 0.380 NM_152424
FAM123B
family with sequence similarity 123B
chr12_+_66328760 0.378 NM_003583
NM_006482
DYRK2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

chr6_-_26324850 0.376 NM_003518
HIST1H2BG
NCALD
histone cluster 1, H2bg
neurocalcin delta
chr1_-_151848039 0.375 S100A16
S100 calcium binding protein A16
chr5_-_139402989 0.374 NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
NRG2




neuregulin 2




chr4_-_170428681 0.372 SH3RF1
SH3 domain containing ring finger 1
chr11_-_118167065 0.372 DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr3_-_24511456 0.370 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr8_+_98950453 0.369 NM_002380
NM_030583
MATN2

matrilin 2

chr12_+_51932136 0.369 NM_032889
MFSD5
major facilitator superfamily domain containing 5
chr15_+_41597097 0.367 NM_002373
MAP1A
microtubule-associated protein 1A
chr22_+_21065207 0.366 IGLJ3
immunoglobulin lambda joining 3
chr18_-_18002926 0.365 LOC100128893
hypothetical LOC100128893
chr22_+_21065134 0.364 LOC100290481
immunoglobulin lambda light chain-like
chr7_-_75461814 0.364 TMEM120A
transmembrane protein 120A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 2.02e-12 GO:0009987 cellular process
1.13 1.30e-10 GO:0065007 biological regulation
1.14 1.52e-10 GO:0050794 regulation of cellular process
1.38 3.21e-10 GO:0009653 anatomical structure morphogenesis
1.13 5.07e-10 GO:0050789 regulation of biological process
1.21 3.91e-09 GO:0032502 developmental process
1.36 1.46e-08 GO:0007399 nervous system development
1.28 2.11e-08 GO:0048523 negative regulation of cellular process
1.24 4.68e-08 GO:0048518 positive regulation of biological process
1.22 1.31e-07 GO:0048856 anatomical structure development
1.26 1.48e-07 GO:0048519 negative regulation of biological process
1.20 2.32e-07 GO:0007275 multicellular organismal development
1.23 2.38e-07 GO:0048731 system development
1.31 5.39e-07 GO:0023051 regulation of signaling
1.19 6.28e-07 GO:0023052 signaling
1.24 6.60e-07 GO:0048522 positive regulation of cellular process
1.25 4.56e-06 GO:0048869 cellular developmental process
1.19 5.10e-06 GO:0007165 signal transduction
1.31 6.80e-06 GO:0009966 regulation of signal transduction
1.25 7.09e-06 GO:0030154 cell differentiation
1.50 9.04e-06 GO:0009887 organ morphogenesis
1.40 9.27e-06 GO:0022008 neurogenesis
1.40 2.16e-05 GO:0048699 generation of neurons
1.37 2.19e-05 GO:0032879 regulation of localization
1.47 2.20e-05 GO:0032989 cellular component morphogenesis
1.46 2.39e-05 GO:0030030 cell projection organization
1.43 4.87e-05 GO:0030182 neuron differentiation
1.70 5.88e-05 GO:0035295 tube development
1.52 6.77e-05 GO:0031175 neuron projection development
1.37 7.14e-05 GO:0048468 cell development
1.51 8.44e-05 GO:0000904 cell morphogenesis involved in differentiation
1.50 9.39e-05 GO:0032990 cell part morphogenesis
1.46 1.12e-04 GO:0000902 cell morphogenesis
1.47 1.38e-04 GO:0048666 neuron development
1.17 1.53e-04 GO:0016043 cellular component organization
1.50 1.60e-04 GO:0048858 cell projection morphogenesis
1.53 1.67e-04 GO:0048812 neuron projection morphogenesis
1.42 1.74e-04 GO:0009890 negative regulation of biosynthetic process
1.47 2.42e-04 GO:0051253 negative regulation of RNA metabolic process
1.47 2.88e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.31 3.23e-04 GO:0031325 positive regulation of cellular metabolic process
1.63 3.71e-04 GO:0048729 tissue morphogenesis
1.42 4.74e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.16 4.81e-04 GO:0071840 cellular component organization or biogenesis
1.32 4.83e-04 GO:0010646 regulation of cell communication
1.32 4.94e-04 GO:0051246 regulation of protein metabolic process
1.63 5.05e-04 GO:0051270 regulation of cellular component movement
1.43 5.75e-04 GO:0010629 negative regulation of gene expression
1.51 5.88e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.40 6.28e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.29 6.37e-04 GO:0009893 positive regulation of metabolic process
1.14 7.13e-04 GO:0051716 cellular response to stimulus
1.33 7.82e-04 GO:0042127 regulation of cell proliferation
1.15 9.56e-04 GO:0019222 regulation of metabolic process
1.51 1.19e-03 GO:0007409 axonogenesis
1.32 1.27e-03 GO:0032268 regulation of cellular protein metabolic process
1.94 1.50e-03 GO:0033673 negative regulation of kinase activity
1.28 1.58e-03 GO:0051239 regulation of multicellular organismal process
1.40 2.28e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.63 2.34e-03 GO:2000145 regulation of cell motility
1.29 2.37e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.96 2.38e-03 GO:0060541 respiratory system development
1.67 2.50e-03 GO:0002009 morphogenesis of an epithelium
1.84 2.50e-03 GO:0001655 urogenital system development
1.63 2.59e-03 GO:0030334 regulation of cell migration
1.45 2.70e-03 GO:0043549 regulation of kinase activity
1.31 2.72e-03 GO:0009892 negative regulation of metabolic process
1.22 2.77e-03 GO:0048583 regulation of response to stimulus
2.57 2.78e-03 GO:0032368 regulation of lipid transport
2.03 2.87e-03 GO:0030323 respiratory tube development
2.04 2.94e-03 GO:0030324 lung development
1.59 3.33e-03 GO:0040012 regulation of locomotion
2.34 3.38e-03 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
1.40 3.63e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.89 3.76e-03 GO:0001763 morphogenesis of a branching structure
1.15 3.85e-03 GO:0060255 regulation of macromolecule metabolic process
1.37 4.65e-03 GO:0042325 regulation of phosphorylation
1.87 4.73e-03 GO:0051348 negative regulation of transferase activity
1.10 5.03e-03 GO:0050896 response to stimulus
1.43 5.25e-03 GO:0051338 regulation of transferase activity
1.80 5.68e-03 GO:0060562 epithelial tube morphogenesis
1.39 6.35e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 6.79e-03 GO:0051128 regulation of cellular component organization
1.14 7.79e-03 GO:0031323 regulation of cellular metabolic process
1.44 7.83e-03 GO:0072358 cardiovascular system development
1.44 7.83e-03 GO:0072359 circulatory system development
1.89 8.24e-03 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.44 8.71e-03 GO:0045859 regulation of protein kinase activity
1.10 9.45e-03 GO:0044237 cellular metabolic process
1.36 9.73e-03 GO:0019220 regulation of phosphate metabolic process
1.36 9.73e-03 GO:0051174 regulation of phosphorus metabolic process
1.24 9.79e-03 GO:0065009 regulation of molecular function
1.56 1.15e-02 GO:0071900 regulation of protein serine/threonine kinase activity
1.88 1.18e-02 GO:0006469 negative regulation of protein kinase activity
1.37 1.25e-02 GO:0001932 regulation of protein phosphorylation
1.33 1.45e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.69 1.53e-02 GO:0035239 tube morphogenesis
1.30 1.64e-02 GO:0031324 negative regulation of cellular metabolic process
1.17 1.64e-02 GO:0071842 cellular component organization at cellular level
1.41 1.69e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.36 1.84e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.50 1.94e-02 GO:0007411 axon guidance
1.08 2.06e-02 GO:0008152 metabolic process
1.31 2.10e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.14 2.21e-02 GO:0080090 regulation of primary metabolic process
1.09 2.29e-02 GO:0044238 primary metabolic process
1.32 2.46e-02 GO:0031399 regulation of protein modification process
1.33 2.71e-02 GO:0051049 regulation of transport
1.18 2.73e-02 GO:0042221 response to chemical stimulus
1.16 2.98e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.28 3.16e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.30 3.44e-02 GO:0009891 positive regulation of biosynthetic process
1.29 3.49e-02 GO:0050793 regulation of developmental process
1.19 3.51e-02 GO:0048513 organ development
1.33 4.21e-02 GO:0045595 regulation of cell differentiation
1.91 4.49e-02 GO:0048754 branching morphogenesis of a tube
1.29 4.57e-02 GO:0009888 tissue development
1.10 4.81e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.03e-06 GO:0005737 cytoplasm
1.46 8.13e-06 GO:0030054 cell junction
1.27 1.57e-05 GO:0005856 cytoskeleton
1.22 3.00e-05 GO:0005829 cytosol
1.84 4.27e-05 GO:0070161 anchoring junction
1.06 4.44e-05 GO:0044424 intracellular part
1.05 1.13e-04 GO:0005622 intracellular
1.50 2.59e-04 GO:0043005 neuron projection
1.64 4.52e-04 GO:0016323 basolateral plasma membrane
1.79 6.88e-04 GO:0005912 adherens junction
1.06 9.28e-04 GO:0043226 organelle
1.06 1.22e-03 GO:0043229 intracellular organelle
1.15 1.93e-03 GO:0043234 protein complex
1.18 2.98e-03 GO:0044459 plasma membrane part
1.09 8.38e-03 GO:0044444 cytoplasmic part
1.25 8.83e-03 GO:0044430 cytoskeletal part
1.09 1.44e-02 GO:0044422 organelle part
1.80 1.61e-02 GO:0030055 cell-substrate junction
1.09 2.02e-02 GO:0044446 intracellular organelle part
1.26 2.69e-02 GO:0042995 cell projection
1.39 2.78e-02 GO:0045202 synapse
1.14 2.85e-02 GO:0043228 non-membrane-bounded organelle
1.14 2.85e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.24 3.05e-02 GO:0005794 Golgi apparatus
1.78 3.22e-02 GO:0005924 cell-substrate adherens junction
1.12 4.01e-02 GO:0032991 macromolecular complex
1.59 4.41e-02 GO:0043025 neuronal cell body

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 6.20e-18 GO:0005515 protein binding
1.06 3.74e-06 GO:0005488 binding
1.46 4.79e-05 GO:0008092 cytoskeletal protein binding
1.37 1.68e-04 GO:0019899 enzyme binding
1.32 4.74e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.33 1.64e-03 GO:0016301 kinase activity
1.29 2.35e-03 GO:0001071 nucleic acid binding transcription factor activity
1.29 2.35e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.17 7.23e-03 GO:0000166 nucleotide binding
1.34 8.35e-03 GO:0046983 protein dimerization activity
1.31 1.16e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.51 2.23e-02 GO:0032403 protein complex binding
1.39 2.45e-02 GO:0019904 protein domain specific binding
1.31 3.26e-02 GO:0043565 sequence-specific DNA binding
3.20 3.26e-02 GO:0005024 transforming growth factor beta receptor activity
1.32 4.91e-02 GO:0004672 protein kinase activity