Motif ID: TFAP2B.p2

Z-value: 4.075


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_508943970.381.5e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_43671355 6.326 NM_173354
SIK1
salt-inducible kinase 1
chr16_-_87535106 5.319 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr14_-_104705753 4.489 JAG2
jagged 2
chr12_-_122322117 4.395 NM_004642
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr17_+_17525571 4.123


chr19_+_3175700 4.056 NM_021938
NM_001172673
CELF5

CUGBP, Elav-like family member 5

chr19_+_3175734 4.033 CELF5
CUGBP, Elav-like family member 5
chr10_+_134060681 3.897 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr1_-_1274618 3.888 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr14_-_104706159 3.834 NM_002226
NM_145159
JAG2

jagged 2

chr22_+_36286350 3.804 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr4_+_7245218 3.760 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr9_+_137119339 3.645 OLFM1
olfactomedin 1
chrX_+_9943793 3.624 NM_015691
WWC3
WWC family member 3
chr10_+_99176028 3.600 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_-_63292688 3.582 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr2_+_96845704 3.531 NM_017623
NM_199078
CNNM3

cyclin M3

chr5_+_1061900 3.481 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr9_+_137119334 3.443 OLFM1
olfactomedin 1
chr10_-_99175685 3.430


chr10_+_99176007 3.429 NM_002629
PGAM1
phosphoglycerate mutase 1 (brain)
chr10_+_99176002 3.423 PGAM1
phosphoglycerate mutase 1 (brain)
chr20_+_56701224 3.416 NM_024663
NPEPL1
aminopeptidase-like 1
chr12_-_108802561 3.407 NM_016433
GLTP
glycolipid transfer protein
chr8_-_144583718 3.282 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr10_+_99176032 3.273 PGAM1
phosphoglycerate mutase 1 (brain)
chr17_+_15788955 3.233 NM_000676
ADORA2B
adenosine A2b receptor
chr10_+_99175967 3.217 PGAM1
phosphoglycerate mutase 1 (brain)
chr17_+_15789147 3.176 ADORA2B
adenosine A2b receptor
chr8_+_107351519 3.170 NM_001198533
NM_018002
LOC346887
OXR1

similar to solute carrier family 16 (monocarboxylic acid transporters), member 14
oxidation resistance 1

chr10_+_99175933 3.150 PGAM1
phosphoglycerate mutase 1 (brain)
chr1_-_1274160 3.126 NM_004421
DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr10_+_99175949 3.107 PGAM1
phosphoglycerate mutase 1 (brain)
chr10_+_99176030 3.089 PGAM1
phosphoglycerate mutase 1 (brain)
chr16_-_79395379 3.084 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr17_+_72376022 3.047 NM_144677
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr15_+_97009194 3.033 IGF1R
insulin-like growth factor 1 receptor
chr16_-_1404635 2.999 NM_001037125
NM_001193388
UNKL

unkempt homolog (Drosophila)-like

chr17_-_53387493 2.964 CUEDC1
CUE domain containing 1
chr10_+_99175994 2.876 PGAM1
phosphoglycerate mutase 1 (brain)
chr3_-_127677400 2.851 ZXDC
ZXD family zinc finger C
chr17_+_17525497 2.831 NM_030665
RAI1
retinoic acid induced 1
chr6_+_1556543 2.779 FOXC1
forkhead box C1
chr22_-_40652724 2.737 NM_052945
TNFRSF13C
tumor necrosis factor receptor superfamily, member 13C
chr1_+_39729885 2.724 NM_181809
BMP8A
bone morphogenetic protein 8a
chr8_+_28615062 2.701 NM_001440
EXTL3
exostoses (multiple)-like 3
chr10_-_69836912 2.699 NM_017987
NM_001042417
RUFY2

RUN and FYVE domain containing 2

chr9_+_133259330 2.677 PRRC2B
proline-rich coiled-coil 2B
chr22_-_30072217 2.668 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr13_+_97593411 2.661 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr17_-_19711580 2.653 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr1_-_42274160 2.644


chr7_+_3307445 2.594 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr17_-_34015631 2.561 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr1_+_108904191 2.512 FAM102B
family with sequence similarity 102, member B
chr14_-_92651260 2.479 ITPK1
inositol 1,3,4-triphosphate 5/6 kinase
chr3_+_195688974 2.459 FLJ34208
hypothetical LOC401106
chr3_+_198214173 2.450 LOC100507057
MFI2
hypothetical LOC100507057
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr20_+_48241334 2.441 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr12_+_130878870 2.440 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr22_-_37569962 2.440 NM_014293
NPTXR
neuronal pentraxin receptor
chr8_-_143748391 2.424 NM_001077527
NM_003724
JRK

jerky homolog (mouse)

chr16_-_11798507 2.421 ZC3H7A
zinc finger CCCH-type containing 7A
chr1_-_226661089 2.397 NM_145214
TRIM11
tripartite motif containing 11
chr22_-_41913002 2.392 TTLL12
tubulin tyrosine ligase-like family, member 12
chr11_-_74914514 2.391 GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr13_-_100039008 2.388 NM_001195087
A2LD1
AIG2-like domain 1
chr13_+_97593469 2.387 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr1_+_33494745 2.351 NM_152493
ZNF362
zinc finger protein 362
chr22_-_30072329 2.335 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr13_+_20175481 2.333 NM_138284
IL17D
interleukin 17D
chr8_+_28614929 2.328 EXTL3
exostoses (multiple)-like 3
chr19_+_39664706 2.303 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr7_+_18093068 2.280 HDAC9
histone deacetylase 9
chr4_-_25473528 2.253 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr4_+_14614462 2.250 CPEB2
cytoplasmic polyadenylation element binding protein 2
chr13_-_27967215 2.227 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr1_-_94147574 2.225 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr11_-_74914066 2.209 NM_030792
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr12_+_50271283 2.205 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr13_+_32058630 2.204 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr17_-_59131194 2.188 LIMD2
LIM domain containing 2
chr9_+_138680064 2.184 EGFL7
EGF-like-domain, multiple 7
chr17_+_78070853 2.174 NM_004514
FOXK2
forkhead box K2
chr6_+_167970334 2.171 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr19_+_18391423 2.163


chr1_-_94147537 2.143 GCLM
glutamate-cysteine ligase, modifier subunit
chr16_+_88169612 2.126 NM_014427
NM_153636
CPNE7

copine VII

chr1_-_39814659 2.110 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr1_-_39815048 2.102 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr2_-_197883739 2.100 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr13_+_32058651 2.068 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr3_-_127677451 2.056 NM_001040653
NM_025112
ZXDC

ZXD family zinc finger C

chr19_-_7896974 2.051 NM_206833
CTXN1
cortexin 1
chr8_+_99508425 2.047 NM_020697
KCNS2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
chr2_-_96899326 2.045 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr15_+_29406335 2.028 NM_015995
KLF13
Kruppel-like factor 13
chr1_+_89871212 2.016 LRRC8C
leucine rich repeat containing 8 family, member C
chr10_-_92607650 2.015 NM_000872
NM_019859
NM_019860
HTR7


5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)


chr4_-_809879 2.014 NM_006651
CPLX1
complexin 1
chr1_-_6162669 2.001 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr22_-_41913075 1.991 TTLL12
tubulin tyrosine ligase-like family, member 12
chr21_+_32167175 1.989 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr16_-_3870121 1.975 NM_001079846
NM_004380
CREBBP

CREB binding protein

chr5_-_112285721 1.960 NM_005669
REEP5
receptor accessory protein 5
chr18_-_24011349 1.949 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr7_-_27136876 1.945 NM_002141
HOXA4
homeobox A4
chr13_+_32488477 1.934 NM_004795
KL
klotho
chr1_+_22909916 1.927 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr7_+_6596183 1.926 NM_024067
C7orf26
chromosome 7 open reading frame 26
chr11_+_66643311 1.926 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chr1_+_178466064 1.918 NM_033343
LHX4
LIM homeobox 4
chr13_+_32058537 1.894 NM_015032
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr1_+_226937732 1.890 RHOU
ras homolog gene family, member U
chr19_-_38485281 1.881 CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr9_-_131444098 1.880 NM_017873
NM_177999
ASB6

ankyrin repeat and SOCS box containing 6

chr8_-_143748324 1.875 JRK
jerky homolog (mouse)
chr6_-_136913235 1.866 MAP7
microtubule-associated protein 7
chr4_-_83570318 1.866 NM_031372
HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr7_-_120823556 1.857 FAM3C
family with sequence similarity 3, member C
chr10_+_104394185 1.856 NM_030912
TRIM8
tripartite motif containing 8
chr18_-_27518392 1.852 NM_004775
B4GALT6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr6_+_138524717 1.838 NM_020340
KIAA1244
KIAA1244
chrX_-_154341451 1.824 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr13_+_32058610 1.824 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr5_-_179568730 1.822 NM_175062
RASGEF1C
RasGEF domain family, member 1C
chr22_-_37569679 1.808


chr5_-_158459006 1.802 EBF1
early B-cell factor 1
chr10_+_134201262 1.795 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr1_+_108904493 1.793 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr22_-_30071761 1.779 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr10_-_92607397 1.769 HTR7
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
chr3_-_195835298 1.766 NM_001011655
NM_001166305
NM_001166306
NM_138399
TMEM44



transmembrane protein 44



chr18_+_8599670 1.765


chr1_-_29321599 1.762 NM_001171868
TMEM200B
transmembrane protein 200B
chr10_-_134449467 1.758 NM_177400
NKX6-2
NK6 homeobox 2
chr10_+_72826656 1.757 NM_001171930
NM_001171931
NM_001171932
NM_022124
NM_052836
CDH23




cadherin-related 23




chr10_+_116571485 1.751 NM_001135051
NM_020940
FAM160B1

family with sequence similarity 160, member B1

chr19_+_18391211 1.744 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr9_-_21999270 1.741 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr13_+_50694364 1.738 NM_145019
FAM124A
family with sequence similarity 124A
chr20_-_4177519 1.736 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chrX_+_153767803 1.736 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr7_-_148825760 1.730 ZNF746
zinc finger protein 746
chr3_-_195835593 1.722 TMEM44
transmembrane protein 44
chr1_+_89871281 1.722 LRRC8C
leucine rich repeat containing 8 family, member C
chr13_+_97593711 1.719 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr17_+_8865547 1.718 NM_004822
NTN1
netrin 1
chr2_-_197883703 1.718 ANKRD44
ankyrin repeat domain 44
chr14_+_102128844 1.715 NM_015156
RCOR1
REST corepressor 1
chr8_+_30361485 1.712 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr22_+_47350781 1.708 NM_015381
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr10_+_171410 1.706 ZMYND11
zinc finger, MYND-type containing 11
chr17_+_77582774 1.703 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr12_+_109956210 1.695 NM_015267
CUX2
cut-like homeobox 2
chr4_+_186368277 1.683 NM_031953
SNX25
sorting nexin 25
chr8_+_61753912 1.679 CHD7
chromodomain helicase DNA binding protein 7
chr15_+_89300973 1.677 RCCD1
RCC1 domain containing 1
chr4_+_7096043 1.673 NM_152293
TADA2B
transcriptional adaptor 2B
chr1_-_94147616 1.672 GCLM
glutamate-cysteine ligase, modifier subunit
chr11_-_119104463 1.667 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr16_+_66153810 1.653 NM_001191022
NM_006565
CTCF

CCCTC-binding factor (zinc finger protein)

chr15_+_90198031 1.646 SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr14_-_104718565 1.644 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr1_+_89871231 1.636 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr11_+_33235743 1.629 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr14_-_92651896 1.622 NM_001142593
NM_001142594
NM_014216
ITPK1


inositol 1,3,4-triphosphate 5/6 kinase


chr7_+_882704 1.621 NM_015949
GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr8_+_145662510 1.609 NM_145754
KIFC2
kinesin family member C2
chr18_-_59138192 1.599 BCL2
B-cell CLL/lymphoma 2
chr16_-_3870714 1.594 CREBBP
CREB binding protein
chr15_-_50608296 1.593 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr17_-_77512346 1.591 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr1_-_95165037 1.586 CNN3
calponin 3, acidic
chr7_+_151792052 1.585 LOC100128822
hypothetical LOC100128822
chr8_-_74822206 1.580 STAU2
staufen, RNA binding protein, homolog 2 (Drosophila)
chr16_+_2959467 1.575 PAQR4
progestin and adipoQ receptor family member IV
chr19_+_1200882 1.573 MIDN
midnolin
chr12_+_50104936 1.571 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr14_+_99329198 1.567 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr1_-_39815106 1.564 NM_001135653
NM_001135654
NM_003819
PABPC4


poly(A) binding protein, cytoplasmic 4 (inducible form)


chr7_-_148825679 1.560 ZNF746
zinc finger protein 746
chr4_-_170428768 1.556 NM_020870
SH3RF1
SH3 domain containing ring finger 1
chr8_+_81560971 1.555 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr10_+_123912930 1.555 TACC2
transforming, acidic coiled-coil containing protein 2
chr19_-_38485161 1.550


chr1_+_107485071 1.545 NTNG1
netrin G1
chr7_+_98084531 1.542 NM_002523
NPTX2
neuronal pentraxin II
chr22_-_41913076 1.535 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr3_+_151609395 1.531 NM_014779
TSC22D2
TSC22 domain family, member 2
chr22_-_41446740 1.528 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr1_-_3437834 1.526 MEGF6
multiple EGF-like-domains 6
chr6_+_4721825 1.512 CDYL
chromodomain protein, Y-like
chr3_-_195835197 1.509 TMEM44
transmembrane protein 44
chr15_+_73281288 1.506 C15orf39
chromosome 15 open reading frame 39
chr11_-_558419 1.506


chr10_+_29006530 1.506 BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr11_-_2863536 1.506 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr12_-_41163680 1.502 NM_001144881
PRICKLE1
prickle homolog 1 (Drosophila)
chr6_-_132764257 1.500 NM_015529
MOXD1
monooxygenase, DBH-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 9.92e-24 GO:0009987 cellular process
1.17 3.99e-23 GO:0044237 cellular metabolic process
1.19 8.99e-18 GO:0044260 cellular macromolecule metabolic process
1.14 7.64e-16 GO:0044238 primary metabolic process
1.12 5.70e-15 GO:0008152 metabolic process
1.12 1.45e-14 GO:0050794 regulation of cellular process
1.11 5.99e-12 GO:0050789 regulation of biological process
1.10 8.26e-12 GO:0065007 biological regulation
1.15 9.21e-12 GO:0043170 macromolecule metabolic process
1.17 8.70e-11 GO:0031323 regulation of cellular metabolic process
1.18 5.14e-10 GO:0034641 cellular nitrogen compound metabolic process
1.17 5.62e-10 GO:0080090 regulation of primary metabolic process
1.19 1.41e-09 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 2.27e-09 GO:0032502 developmental process
1.17 3.71e-09 GO:0060255 regulation of macromolecule metabolic process
1.20 4.58e-09 GO:0044249 cellular biosynthetic process
1.17 6.15e-09 GO:0006807 nitrogen compound metabolic process
1.15 1.76e-08 GO:0019222 regulation of metabolic process
1.16 3.05e-08 GO:0016043 cellular component organization
1.19 5.88e-08 GO:0009058 biosynthetic process
1.16 7.42e-08 GO:0007275 multicellular organismal development
1.15 9.79e-08 GO:0071840 cellular component organization or biogenesis
1.34 1.65e-07 GO:0051128 regulation of cellular component organization
1.20 1.77e-07 GO:0090304 nucleic acid metabolic process
1.24 3.80e-07 GO:0007399 nervous system development
1.18 3.86e-07 GO:0071842 cellular component organization at cellular level
1.17 4.16e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 4.25e-07 GO:0010468 regulation of gene expression
1.19 4.34e-07 GO:0051252 regulation of RNA metabolic process
1.16 4.41e-07 GO:0048856 anatomical structure development
1.20 5.15e-07 GO:0048523 negative regulation of cellular process
1.18 5.48e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.17 6.71e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.24 7.17e-07 GO:0009653 anatomical structure morphogenesis
1.17 8.70e-07 GO:0071841 cellular component organization or biogenesis at cellular level
1.22 9.00e-07 GO:0034645 cellular macromolecule biosynthetic process
1.21 1.37e-06 GO:0006464 protein modification process
1.31 1.56e-06 GO:0048699 generation of neurons
1.22 1.66e-06 GO:0009059 macromolecule biosynthetic process
1.18 1.91e-06 GO:0048519 negative regulation of biological process
1.31 2.79e-06 GO:0006351 transcription, DNA-dependent
1.16 5.63e-06 GO:0048731 system development
1.29 7.03e-06 GO:0022008 neurogenesis
1.39 8.78e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.17 9.93e-06 GO:0044267 cellular protein metabolic process
1.59 1.03e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.28 1.16e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.19 1.34e-05 GO:0043412 macromolecule modification
1.16 1.69e-05 GO:0031326 regulation of cellular biosynthetic process
1.21 1.98e-05 GO:0023051 regulation of signaling
1.34 2.42e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.16 2.61e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.22 4.00e-05 GO:0009966 regulation of signal transduction
1.17 4.25e-05 GO:0006355 regulation of transcription, DNA-dependent
1.16 5.11e-05 GO:0048522 positive regulation of cellular process
1.17 7.17e-05 GO:0048869 cellular developmental process
1.37 1.03e-04 GO:0000904 cell morphogenesis involved in differentiation
1.17 1.26e-04 GO:0030154 cell differentiation
1.19 1.36e-04 GO:0016070 RNA metabolic process
1.22 1.54e-04 GO:0035556 intracellular signal transduction
1.15 1.70e-04 GO:0009889 regulation of biosynthetic process
1.30 2.30e-04 GO:0009790 embryo development
1.39 2.61e-04 GO:0007409 axonogenesis
1.40 3.85e-04 GO:0007264 small GTPase mediated signal transduction
1.25 4.60e-04 GO:0032774 RNA biosynthetic process
1.14 5.14e-04 GO:0048518 positive regulation of biological process
1.37 5.86e-04 GO:0048812 neuron projection morphogenesis
1.37 6.52e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.40 8.39e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.18 9.85e-04 GO:0006996 organelle organization
1.42 1.04e-03 GO:0007411 axon guidance
1.26 1.17e-03 GO:0033554 cellular response to stress
1.31 1.24e-03 GO:0010629 negative regulation of gene expression
1.24 1.77e-03 GO:0048468 cell development
1.29 2.05e-03 GO:0032989 cellular component morphogenesis
1.33 2.37e-03 GO:0031175 neuron projection development
1.21 2.52e-03 GO:0031325 positive regulation of cellular metabolic process
1.41 2.91e-03 GO:0060284 regulation of cell development
1.30 3.76e-03 GO:0000902 cell morphogenesis
1.46 4.05e-03 GO:0046578 regulation of Ras protein signal transduction
1.27 5.67e-03 GO:0030182 neuron differentiation
1.31 6.56e-03 GO:0032990 cell part morphogenesis
1.16 7.63e-03 GO:0010467 gene expression
1.20 7.73e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.28 7.84e-03 GO:0030030 cell projection organization
1.31 8.05e-03 GO:0048858 cell projection morphogenesis
1.28 8.34e-03 GO:0051726 regulation of cell cycle
1.29 8.57e-03 GO:0048666 neuron development
1.12 1.11e-02 GO:0019538 protein metabolic process
1.23 1.15e-02 GO:0016265 death
1.36 1.22e-02 GO:0016568 chromatin modification
1.23 1.38e-02 GO:0008219 cell death
1.19 1.39e-02 GO:0009893 positive regulation of metabolic process
1.21 1.41e-02 GO:0007049 cell cycle
1.26 1.76e-02 GO:0051254 positive regulation of RNA metabolic process
1.29 2.11e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.09 2.62e-02 GO:0051716 cellular response to stimulus
1.27 2.91e-02 GO:0009887 organ morphogenesis
1.28 3.08e-02 GO:0051253 negative regulation of RNA metabolic process
1.20 3.31e-02 GO:0032268 regulation of cellular protein metabolic process
1.23 3.33e-02 GO:0031399 regulation of protein modification process
1.44 3.40e-02 GO:0045786 negative regulation of cell cycle
1.23 3.44e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.24 3.51e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.24 4.67e-02 GO:0012501 programmed cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 2.69e-52 GO:0005622 intracellular
1.12 1.71e-49 GO:0044424 intracellular part
1.15 9.45e-34 GO:0005737 cytoplasm
1.12 7.54e-33 GO:0043226 organelle
1.12 2.21e-32 GO:0043229 intracellular organelle
1.13 7.31e-31 GO:0043227 membrane-bounded organelle
1.13 1.05e-30 GO:0043231 intracellular membrane-bounded organelle
1.17 4.29e-22 GO:0005634 nucleus
1.04 5.97e-19 GO:0044464 cell part
1.04 6.90e-19 GO:0005623 cell
1.14 4.66e-16 GO:0044444 cytoplasmic part
1.13 2.77e-13 GO:0044422 organelle part
1.25 4.82e-13 GO:0005829 cytosol
1.13 5.63e-13 GO:0044446 intracellular organelle part
1.21 5.58e-10 GO:0044428 nuclear part
1.28 7.61e-10 GO:0005654 nucleoplasm
1.20 4.62e-09 GO:0070013 intracellular organelle lumen
1.22 6.40e-09 GO:0031981 nuclear lumen
1.19 7.35e-09 GO:0031974 membrane-enclosed lumen
1.19 1.05e-08 GO:0043233 organelle lumen
1.24 8.46e-05 GO:0005794 Golgi apparatus
1.27 3.65e-04 GO:0044451 nucleoplasm part
1.14 1.60e-03 GO:0031090 organelle membrane
1.27 2.46e-03 GO:0044431 Golgi apparatus part
1.30 2.85e-03 GO:0000139 Golgi membrane
1.16 3.44e-03 GO:0012505 endomembrane system
1.51 5.21e-03 GO:0031300 intrinsic to organelle membrane
1.94 5.97e-03 GO:0031228 intrinsic to Golgi membrane
1.94 1.19e-02 GO:0030173 integral to Golgi membrane
1.51 1.81e-02 GO:0031301 integral to organelle membrane
1.48 2.28e-02 GO:0005912 adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 1.04e-28 GO:0005515 protein binding
1.08 9.92e-21 GO:0005488 binding
1.29 8.91e-08 GO:0030528 transcription regulator activity
1.28 8.22e-07 GO:0001071 nucleic acid binding transcription factor activity
1.28 8.22e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.20 1.53e-06 GO:0016740 transferase activity
1.17 7.71e-06 GO:0003677 DNA binding
1.13 8.31e-06 GO:0003676 nucleic acid binding
1.09 3.08e-05 GO:0003824 catalytic activity
1.26 3.31e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.15 2.04e-04 GO:0000166 nucleotide binding
1.43 2.33e-04 GO:0008134 transcription factor binding
1.28 2.63e-04 GO:0043565 sequence-specific DNA binding
1.26 3.55e-04 GO:0016301 kinase activity
1.39 1.11e-03 GO:0016563 transcription activator activity
1.16 1.11e-03 GO:0017076 purine nucleotide binding
1.15 1.57e-03 GO:0032553 ribonucleotide binding
1.15 1.57e-03 GO:0032555 purine ribonucleotide binding
1.25 1.83e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.53 2.86e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.15 4.83e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.52 6.11e-03 GO:0004721 phosphoprotein phosphatase activity
1.16 8.08e-03 GO:0030554 adenyl nucleotide binding
1.16 1.38e-02 GO:0032559 adenyl ribonucleotide binding
1.23 1.40e-02 GO:0042802 identical protein binding
1.35 1.74e-02 GO:0016564 transcription repressor activity
1.39 2.11e-02 GO:0016791 phosphatase activity
1.24 3.08e-02 GO:0004672 protein kinase activity