Motif ID: TFAP4.p2

Z-value: 1.683


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_42626960.767.1e-04Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_20068039 3.060 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr22_-_20235372 2.204 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr1_-_21868380 1.790 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr22_+_21393107 1.525 IGLJ3
immunoglobulin lambda joining 3
chr9_+_139292094 1.424 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr1_+_200429740 1.416 NM_001017403
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr16_-_87405817 1.412 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr5_+_176726918 1.386 RGS14
regulator of G-protein signaling 14
chr10_+_72826656 1.318 NM_001171930
NM_001171931
NM_001171932
NM_022124
NM_052836
CDH23




cadherin-related 23




chr9_-_132804243 1.293 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr22_+_20326541 1.254 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr12_-_46499834 1.247 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr10_+_64563009 1.194 NM_030759
NRBF2
nuclear receptor binding factor 2
chr22_+_20326572 1.141 SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326615 1.139 SDF2L1
stromal cell-derived factor 2-like 1
chr2_+_3620296 1.115 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr22_+_20326591 1.107 SDF2L1
stromal cell-derived factor 2-like 1
chr1_-_32176562 1.070 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr19_-_54618410 1.037 NM_178449
PTH2
parathyroid hormone 2
chr22_+_21359175 0.975 IGLV3-25
immunoglobulin lambda variable 3-25
chr10_+_64563069 0.963 NRBF2
nuclear receptor binding factor 2
chr1_+_153302825 0.962 NM_005227
NM_182689
NM_182690
EFNA4


ephrin-A4


chr1_+_43769065 0.956 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr2_-_158440587 0.933 NM_001111067
ACVR1
activin A receptor, type I
chr22_+_19248733 0.923 MED15
mediator complex subunit 15
chr1_+_205561439 0.922 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr1_+_205561632 0.911 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr12_-_91063441 0.899 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr1_+_205561709 0.878 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr7_-_148418666 0.878 ZNF786
zinc finger protein 786
chr7_-_86526880 0.866 NM_001142749
KIAA1324L
KIAA1324-like
chr22_+_21094094 0.856


chr1_-_32176475 0.846 PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr1_+_205561693 0.844 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr15_-_72922577 0.840 NM_001099436
ULK3
unc-51-like kinase 3 (C. elegans)
chr8_-_38127489 0.828 NM_000349
STAR
steroidogenic acute regulatory protein
chr17_-_36451189 0.828 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr1_-_218168137 0.825 SLC30A10
solute carrier family 30, member 10
chr22_-_49311439 0.799 NM_001169110
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr19_-_8670054 0.786 NM_178525
ACTL9
actin-like 9
chr1_-_51583281 0.783 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr1_-_226661089 0.769 NM_145214
TRIM11
tripartite motif containing 11
chr19_-_17420375 0.765 NM_001190844
TMEM221
transmembrane protein 221
chr13_+_112704028 0.763 MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_+_19651446 0.754 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr12_+_108636569 0.752 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr8_+_56954953 0.749 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr10_+_80498782 0.748 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr4_-_1827475 0.745 NM_012318
LETM1
leucine zipper-EF-hand containing transmembrane protein 1
chr1_+_246087230 0.740 TRIM58
tripartite motif containing 58
chr1_-_39877928 0.727 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr12_-_107257205 0.727 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr9_+_133154896 0.727 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr15_-_72922482 0.726 ULK3
unc-51-like kinase 3 (C. elegans)
chr2_+_220007943 0.725 NM_005876
SPEG
SPEG complex locus
chr13_+_112704051 0.723 MCF2L
MCF.2 cell line derived transforming sequence-like
chr15_-_72922533 0.722 ULK3
unc-51-like kinase 3 (C. elegans)
chr22_+_17539198 0.721


chr8_-_145640579 0.719 TONSL
tonsoku-like, DNA repair protein
chr3_-_120236355 0.715 NM_001015887
IGSF11
immunoglobulin superfamily, member 11
chr15_-_72922532 0.710 ULK3
unc-51-like kinase 3 (C. elegans)
chr22_+_19248810 0.709 MED15
mediator complex subunit 15
chrX_+_152562013 0.705 DUSP9
dual specificity phosphatase 9
chr13_+_112704077 0.705 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_39877883 0.701 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr22_+_21116283 0.700


chr3_-_120236118 0.699 IGSF11
immunoglobulin superfamily, member 11
chr12_+_56135353 0.691 NM_031479
INHBE
inhibin, beta E
chr8_+_104452877 0.690 CTHRC1
collagen triple helix repeat containing 1
chr14_-_20340830 0.687 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr8_-_145097031 0.685 NM_201380
PLEC
plectin
chr4_+_55218663 0.675 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr16_-_21197138 0.673 CRYM
crystallin, mu
chr22_-_49311722 0.669 NM_001169109
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr21_+_42946719 0.666 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr7_-_148418745 0.665 ZNF786
zinc finger protein 786
chr9_-_122679283 0.665 PHF19
PHD finger protein 19
chr1_-_925332 0.663 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr7_-_148418799 0.656 NM_152411
ZNF786
zinc finger protein 786
chr3_+_150191884 0.654 NM_001184720
NM_001184721
NM_004130
GYG1


glycogenin 1


chr1_-_202595666 0.652 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_-_16217025 0.651 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr14_+_102659464 0.645 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr19_-_11355882 0.644 NM_000121
EPOR
erythropoietin receptor
chr6_+_7052798 0.641 NM_001168344
RREB1
ras responsive element binding protein 1
chr7_-_104441679 0.640 LOC100216545
hypothetical LOC100216545
chr9_+_129588135 0.640 CDK9
cyclin-dependent kinase 9
chr16_+_711139 0.634 NM_023933
FAM173A
family with sequence similarity 173, member A
chr16_+_3253743 0.631 FLJ39639
hypothetical protein FLJ39639
chr6_-_154873396 0.627 NM_173515
CNKSR3
CNKSR family member 3
chr14_+_104337923 0.624 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr14_-_20340377 0.619 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr4_+_78089931 0.618 SEPT11
septin 11
chr6_-_154873480 0.615 CNKSR3
CNKSR family member 3
chr1_+_3378030 0.614 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr1_+_246087104 0.612 NM_015431
TRIM58
tripartite motif containing 58
chr22_-_18687511 0.609 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr7_+_100515439 0.608 NM_030961
TRIM56
tripartite motif containing 56
chr11_+_63730720 0.606 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr11_+_1848674 0.604 NM_001013254
NM_001013255
LSP1

lymphocyte-specific protein 1

chr2_+_190753833 0.594 NM_001042519
NM_032321
C2orf88

chromosome 2 open reading frame 88

chr1_-_247119516 0.593 NM_001136036
ZNF692
zinc finger protein 692
chr6_+_32230172 0.590 PPT2
palmitoyl-protein thioesterase 2
chr10_-_61139328 0.590 NM_194298
LOC100129721
SLC16A9
hypothetical protein LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr14_+_102636233 0.589 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr19_+_44681374 0.589 NM_016941
NM_203486
DLL3

delta-like 3 (Drosophila)

chr17_-_4640335 0.588 LOC284014
hypothetical protein LOC284014
chr17_-_60345364 0.587 NM_199340
LRRC37A3
leucine rich repeat containing 37, member A3
chr16_+_170334 0.583 NM_005331
HBQ1
hemoglobin, theta 1
chr11_-_75595098 0.582 NM_004626
WNT11
wingless-type MMTV integration site family, member 11
chr16_-_31013626 0.577 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr12_+_732349 0.572 NM_001184985
NM_014823
NM_018979
NM_213655
WNK1



WNK lysine deficient protein kinase 1



chr7_-_91601711 0.569 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr1_-_1840564 0.568 NM_178545
TMEM52
transmembrane protein 52
chr11_+_32870935 0.564 NM_001076786
QSER1
glutamine and serine rich 1
chr7_-_4889772 0.563 NM_018059
RADIL
Ras association and DIL domains
chr6_+_160310118 0.563 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr4_+_89519004 0.561 HERC6
hect domain and RLD 6
chr1_-_32176275 0.561 PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr10_-_74526662 0.560 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I



chr8_+_22280942 0.559 NM_001135153
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr1_-_218168404 0.556


chr6_+_138767151 0.556 HEBP2
heme binding protein 2
chr6_-_154873344 0.556 CNKSR3
CNKSR family member 3
chr4_+_89519134 0.555 HERC6
hect domain and RLD 6
chr6_+_138767007 0.554 NM_014320
HEBP2
heme binding protein 2
chr5_-_139402909 0.553 NRG2
neuregulin 2
chr16_-_21197072 0.551 CRYM
crystallin, mu
chr12_+_54361685 0.550 METTL7B
methyltransferase like 7B
chr2_-_27147995 0.548 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr1_+_225124864 0.546 NM_000447
NM_012486
PSEN2

presenilin 2 (Alzheimer disease 4)

chr1_+_205694237 0.545 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr3_-_38040999 0.545 PLCD1
phospholipase C, delta 1
chr20_+_23419765 0.540 NM_005492
CST8
cystatin 8 (cystatin-related epididymal specific)
chr15_+_89444433 0.539 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr11_-_44288188 0.535 NM_021926
ALX4
ALX homeobox 4
chr5_-_139402989 0.535 NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
NRG2




neuregulin 2




chr3_-_13436802 0.534 NM_024923
NUP210
nucleoporin 210kDa
chr22_+_21559959 0.533 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr3_-_110319598 0.532 NM_014429
MORC1
MORC family CW-type zinc finger 1
chr11_+_737428 0.532 NM_006755
TALDO1
transaldolase 1
chr1_+_157441824 0.530 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr1_+_178867780 0.529 XPR1
xenotropic and polytropic retrovirus receptor 1
chr8_-_41774296 0.529 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr6_+_16237264 0.527 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr19_-_14030970 0.525 NM_001145028
PALM3
paralemmin 3
chr12_+_54361596 0.524 NM_152637
METTL7B
methyltransferase like 7B
chr1_-_180626804 0.520 GLUL
glutamate-ammonia ligase
chr7_+_100037817 0.514 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr7_-_72574474 0.513 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr6_+_147566559 0.513 STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_+_31910623 0.512 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr1_-_114855281 0.511 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr16_-_65918126 0.510 NM_001100915
KCTD19
potassium channel tetramerisation domain containing 19
chr17_-_24248834 0.509 NM_004475
FLOT2
flotillin 2
chr2_+_46623325 0.509 NM_012249
RHOQ
ras homolog gene family, member Q
chr1_+_159959072 0.508 NM_001002901
FCRLB
Fc receptor-like B
chr4_-_175986952 0.507 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr2_+_188864975 0.506 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr2_+_10360471 0.505 NM_002149
HPCAL1
hippocalcin-like 1
chr11_+_737449 0.504 TALDO1
transaldolase 1
chr19_-_18867868 0.504 NM_021267
NM_198207
NM_001492
LASS1

GDF1
LAG1 homolog, ceramide synthase 1

growth differentiation factor 1
chr11_+_737424 0.504 TALDO1
transaldolase 1
chr21_-_43671355 0.503 NM_173354
SIK1
salt-inducible kinase 1
chr21_+_42697058 0.503 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr6_-_32184975 0.502 NM_019105
TNXB
tenascin XB
chr11_+_59279377 0.502 STX3
syntaxin 3
chr7_+_154720416 0.502 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr3_-_57209319 0.501 NM_003865
HESX1
HESX homeobox 1
chr12_+_52105131 0.501 AMHR2
anti-Mullerian hormone receptor, type II
chr8_-_143748391 0.499 NM_001077527
NM_003724
JRK

jerky homolog (mouse)

chr22_-_20637188 0.499 PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr15_-_19974402 0.498


chr8_+_22078622 0.495 BMP1
bone morphogenetic protein 1
chr10_+_70418482 0.494 NM_015634
KIAA1279
KIAA1279
chr8_-_143748324 0.493 JRK
jerky homolog (mouse)
chr19_-_54350457 0.489 NM_002152
HRC
histidine rich calcium binding protein
chr9_-_138958889 0.488 FBXW5
F-box and WD repeat domain containing 5
chr16_+_68765428 0.487 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr1_+_20385164 0.486 NM_152376
UBXN10
UBX domain protein 10
chr10_-_126839546 0.485 NM_001083914
CTBP2
C-terminal binding protein 2
chr9_+_129588125 0.484 NM_001261
CDK9
cyclin-dependent kinase 9
chr2_+_188864848 0.480 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr19_-_14447163 0.479 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr8_+_56954946 0.476 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr15_-_35180656 0.475 NM_002399
MEIS2
Meis homeobox 2
chr22_+_37407906 0.474 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr8_+_21968273 0.470 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr19_-_60350122 0.469 TNNT1
troponin T type 1 (skeletal, slow)
chr15_-_81527002 0.469 BTBD1
BTB (POZ) domain containing 1
chr15_+_89444556 0.468 SV2B
synaptic vesicle glycoprotein 2B
chrX_+_119268518 0.468 NM_006777
NM_001184742
ZBTB33

zinc finger and BTB domain containing 33

chr7_+_44045202 0.466 FLJ35390
hypothetical LOC255031
chr17_-_24248695 0.465 FLOT2
flotillin 2
chr14_-_22354457 0.465 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr8_+_22280703 0.464 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr22_-_20419975 0.464 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr19_-_59438411 0.462 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr9_+_19398924 0.461 NM_001010887
ACER2
alkaline ceramidase 2
chr7_+_100047877 0.460 NM_001040098
NM_001040099
NM_023948
MOSPD3


motile sperm domain containing 3



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 9.57e-03 GO:0065007 biological regulation
1.18 9.97e-03 GO:0007165 signal transduction
1.17 1.75e-02 GO:0023052 signaling
1.10 1.87e-02 GO:0050789 regulation of biological process
1.15 2.57e-02 GO:0051716 cellular response to stimulus
1.43 4.44e-02 GO:0007167 enzyme linked receptor protein signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.44 4.86e-02 GO:0031362 anchored to external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.15e-03 GO:0005515 protein binding