Motif ID: TGIF1.p2

Z-value: 1.888


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
TGIF1 7050 TGFB-induced factor homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TGIF1chr18_+_34437710.552.8e-02Click!


Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_33213111 3.460 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr5_-_20024050 2.844 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr1_-_143750988 2.414 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr2_-_172458970 2.234 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr10_+_123862430 1.889 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_78858675 1.822 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_-_87498225 1.770 NM_000899
NM_003994
KITLG

KIT ligand

chr2_-_188021117 1.739 NM_005795
CALCRL
calcitonin receptor-like
chr20_+_18742369 1.658 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr14_-_49543987 1.521 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr13_-_59223074 1.516


chr17_+_65677255 1.498 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr1_+_161305019 1.486 NM_001102445
RGS4
regulator of G-protein signaling 4
chr13_-_32757835 1.436 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr10_-_11614279 1.407 NM_001080491
USP6NL
USP6 N-terminal like
chr14_+_23575460 1.405 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr7_-_84654106 1.403 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr14_+_62740878 1.396 NM_020663
RHOJ
ras homolog gene family, member J
chr2_+_190916863 1.384 INPP1
inositol polyphosphate-1-phosphatase
chr12_-_21649019 1.378 NM_021957
GYS2
glycogen synthase 2 (liver)
chr2_+_114916368 1.361 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr22_-_36212160 1.350 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr14_+_23527866 1.324 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr8_-_49996353 1.309 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr1_+_161305188 1.302 NM_005613
RGS4
regulator of G-protein signaling 4
chr2_-_179623030 1.289 NM_173648
CCDC141
coiled-coil domain containing 141
chr6_+_31059463 1.277 NM_001010909
MUC21
mucin 21, cell surface associated
chr6_-_46155937 1.239 NM_001114086
CLIC5
chloride intracellular channel 5
chr7_-_107558021 1.234 NM_007356
LAMB4
laminin, beta 4
chr6_+_41128917 1.231 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr17_-_36915329 1.216 NM_002274
NM_153490
KRT13

keratin 13

chr6_+_73133152 1.214 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr4_+_8935987 1.205 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr18_+_64616296 1.172 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr2_-_225519974 1.150 DOCK10
dedicator of cytokinesis 10
chr11_+_128751044 1.143 NM_003658
BARX2
BARX homeobox 2
chr1_-_150328153 1.122 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_-_43756964 1.105 NM_001101330
LOC728819
hCG1645220
chr4_+_166519392 1.096 NM_001873
CPE
carboxypeptidase E
chr20_-_60435983 1.089 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr4_+_187227302 1.077 NM_003265
TLR3
toll-like receptor 3
chr2_+_118562499 1.075 NM_016133
INSIG2
insulin induced gene 2
chr10_+_115300579 1.068 NM_001177660
HABP2
hyaluronan binding protein 2
chrX_+_135397790 1.066 NM_001727
BRS3
bombesin-like receptor 3
chr1_-_197173159 1.063 LOC100131234
familial acute myelogenous leukemia related factor
chr3_-_192063158 1.060 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr22_-_34343249 1.055 NM_005368
NM_203378
MB

myoglobin

chr4_+_3341521 1.053 NM_198227
RGS12
regulator of G-protein signaling 12
chr12_+_100512877 1.033 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr5_+_179065282 1.024 CANX
calnexin
chr2_-_202271598 1.021 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr6_-_119137923 1.010 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr7_+_54577512 1.008 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr10_+_103995297 1.008 NM_004193
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr11_+_68124400 1.007 PPP6R3
protein phosphatase 6, regulatory subunit 3
chr22_+_40093245 0.993 NM_001145398
TEF
thyrotrophic embryonic factor
chr11_+_111353218 0.982 NM_033425
DIXDC1
DIX domain containing 1
chr1_+_101474892 0.982 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr18_+_59295123 0.973 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr2_+_223625105 0.973 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr8_-_11891168 0.972 NM_001033019
DEFB134
defensin, beta 134
chr4_-_186814852 0.972 SORBS2
sorbin and SH3 domain containing 2
chr12_+_36996823 0.972 NM_001013620
ALG10B
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
chr4_-_158111916 0.971 PDGFC
platelet derived growth factor C
chr4_-_158111995 0.970 NM_016205
PDGFC
platelet derived growth factor C
chr11_-_83706027 0.968 DLG2
discs, large homolog 2 (Drosophila)
chr2_-_40593074 0.954 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr9_-_21999270 0.954 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr1_-_184916044 0.945 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr7_+_39839337 0.945


chr1_-_143643064 0.909 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_+_66094324 0.904 NM_173471
SLC25A26
solute carrier family 25, member 26
chr1_-_58815753 0.898 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr2_-_215711313 0.897 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr3_+_114733907 0.893 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr5_+_32824701 0.892 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_+_38858830 0.886 NM_024775
GEMIN6
gem (nuclear organelle) associated protein 6
chr2_+_102456193 0.876 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr2_-_179380301 0.874 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr20_+_35240936 0.867 RPN2
ribophorin II
chr3_-_69381995 0.858 FRMD4B
FERM domain containing 4B
chr18_+_52469559 0.852 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr16_+_52037186 0.847 RBL2
retinoblastoma-like 2 (p130)
chr4_-_122357104 0.843 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr6_-_134680888 0.843 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr14_+_92049396 0.841 NM_024832
RIN3
Ras and Rab interactor 3
chr20_+_8997791 0.837 PLCB4
phospholipase C, beta 4
chr22_+_42726423 0.831 NM_001003828
PARVB
parvin, beta
chr7_-_19123765 0.828 TWIST1
twist homolog 1 (Drosophila)
chr22_-_28564253 0.823 NM_032204
ASCC2
activating signal cointegrator 1 complex subunit 2
chr11_+_12088639 0.821 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr17_-_36409632 0.820 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr3_-_145049853 0.816 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr7_+_154351087 0.814 LOC100132707
hypothetical LOC100132707
chr3_+_73193499 0.813 NM_018029
EBLN2
endogenous Borna-like N element-2
chr7_-_16811131 0.808 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr3_-_191650291 0.807 NM_207316
TMEM207
transmembrane protein 207
chr6_+_53043729 0.805 NM_012347
FBXO9
F-box protein 9
chr1_+_202033273 0.804 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr10_-_88843806 0.804 GLUD1
glutamate dehydrogenase 1
chr5_-_172976212 0.799 BOD1
biorientation of chromosomes in cell division 1
chr17_-_43963270 0.796 NM_002144
HOXB1
homeobox B1
chr12_+_34066679 0.794 ALG10
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe)
chr2_+_232979795 0.792 NM_031313
ALPPL2
alkaline phosphatase, placental-like 2
chr14_+_37746937 0.790 NM_001049
SSTR1
somatostatin receptor 1
chrX_-_79951838 0.789 NM_153252
BRWD3
bromodomain and WD repeat domain containing 3
chr3_-_113495763 0.788 NM_183061
SLC9A10
solute carrier family 9, member 10
chr4_-_158111504 0.786 PDGFC
platelet derived growth factor C
chr6_-_41238899 0.785 NM_018965
TREM2
triggering receptor expressed on myeloid cells 2
chr12_-_47604930 0.781 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr14_-_98807574 0.781 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr4_+_167013859 0.769 NM_012464
TLL1
tolloid-like 1
chr3_-_130807865 0.769 NM_015103
PLXND1
plexin D1
chr6_+_80771108 0.765 TTK
TTK protein kinase
chr17_-_36587965 0.759 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr3_-_129024665 0.757 NM_001003794
MGLL
monoglyceride lipase
chr22_-_28564141 0.756 ASCC2
activating signal cointegrator 1 complex subunit 2
chr17_-_7434113 0.756 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr7_+_33911636 0.754 NM_133468
BMPER
BMP binding endothelial regulator
chr5_+_134012133 0.753 NM_021982
SEC24A
SEC24 family, member A (S. cerevisiae)
chr4_-_184478920 0.751 NM_001111319
CLDN22
claudin 22
chr21_-_30720100 0.749 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr8_+_134272463 0.747 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr21_-_30614477 0.747 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr14_+_20048451 0.746 NM_001012975
RNASE10
ribonuclease, RNase A family, 10 (non-active)
chr14_-_99912390 0.745 WARS
tryptophanyl-tRNA synthetase
chr14_+_23852152 0.737 NM_181657
LTB4R
leukotriene B4 receptor
chr9_+_122923864 0.735 CEP110
centrosomal protein 110kDa
chr14_-_99912340 0.734 WARS
tryptophanyl-tRNA synthetase
chr5_-_88235624 0.734 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr10_-_62002672 0.731 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr12_+_73217817 0.730 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr1_-_42157077 0.728 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr12_+_53534565 0.720 NM_058173
MUCL1
mucin-like 1
chr6_-_41971064 0.720 NM_018561
USP49
ubiquitin specific peptidase 49
chr12_+_19484387 0.719 AEBP2
AE binding protein 2
chr4_-_114902285 0.717 NM_001221
NM_172114
NM_172115
NM_172127
NM_172128
NM_172129
CAMK2D





calcium/calmodulin-dependent protein kinase II delta





chr17_+_39213328 0.717 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chrX_+_145698993 0.714 NM_001144064
CXorf51
chromosome X open reading frame 51
chr1_-_145163779 0.713 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr7_-_19123787 0.712 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr17_+_3324096 0.710 NM_001128085
ASPA
aspartoacylase
chr14_-_99912429 0.708 NM_173701
NM_213645
WARS

tryptophanyl-tRNA synthetase

chr17_+_56832255 0.706 TBX2
T-box 2
chr6_-_41238842 0.705 TREM2
triggering receptor expressed on myeloid cells 2
chr5_+_157103280 0.691 NM_173491
LSM11
LSM11, U7 small nuclear RNA associated
chr7_-_80386258 0.683 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_-_172976196 0.682 BOD1
biorientation of chromosomes in cell division 1
chr1_+_66230977 0.681 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chrX_-_62564934 0.679 LOC92249
hypothetical LOC92249
chr9_+_17124974 0.679 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr11_-_57927457 0.676 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr18_-_52456655 0.675 TXNL1
thioredoxin-like 1
chr5_-_36337756 0.673 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr11_-_123261549 0.670 NM_001013743
TMEM225
transmembrane protein 225
chr16_+_27320983 0.667 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr1_-_42156957 0.666 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr3_+_67131416 0.666 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr17_-_36436979 0.659 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr11_-_119504726 0.658 TRIM29
tripartite motif containing 29
chr9_-_106407728 0.655 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr17_-_60439764 0.655 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr4_-_68766392 0.654 NM_001129907
TMPRSS11BNL
TMPRSS11B N terminal-like
chr2_+_234333653 0.654 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr4_-_15837169 0.654 TAPT1
transmembrane anterior posterior transformation 1
chr10_+_68355797 0.653 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr17_-_36779399 0.650 NM_002279
KRT33B
keratin 33B
chr20_-_9767406 0.648 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr6_+_149763187 0.648 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr6_+_55300225 0.646 NM_207410
GFRAL
GDNF family receptor alpha like
chr4_+_183482130 0.637 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr11_+_32808045 0.635 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr8_-_134184491 0.633 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr12_+_73217889 0.631 ATXN7L3B
ataxin 7-like 3B
chr13_+_28900776 0.627 NM_015233
MTUS2
microtubule associated tumor suppressor candidate 2
chr3_-_56784634 0.624 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_+_102505180 0.623 NM_017564
STAB2
stabilin 2
chr20_+_2224612 0.622 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr9_-_14769530 0.618 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr6_+_80771040 0.615 NM_001166691
NM_003318
TTK

TTK protein kinase

chr12_+_98565663 0.615 NM_153364
FAM71C
family with sequence similarity 71, member C
chr20_+_8997660 0.606 NM_001172646
PLCB4
phospholipase C, beta 4
chr11_-_83071084 0.605 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr16_-_54547443 0.605 NM_001190158
CES5A
carboxylesterase 5A
chr10_+_85994788 0.602 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr5_-_172976259 0.601 NM_001159651
NM_138369
BOD1

biorientation of chromosomes in cell division 1

chr2_-_210888010 0.599 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr3_-_189354510 0.597 LOC339929
hypothetical LOC339929
chr1_-_145163520 0.597 FMO5
flavin containing monooxygenase 5
chr4_-_83702123 0.593 NM_001080506
TMEM150C
transmembrane protein 150C
chr5_+_115326035 0.593 NM_173800
AQPEP
laeverin
chr4_-_143987053 0.592 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr8_+_67201684 0.592 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr14_+_64523192 0.591 NM_002028
FNTB
farnesyltransferase, CAAX box, beta
chr2_+_165860528 0.590 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr7_+_94123556 0.586 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr1_+_168381811 0.585 NM_001136107
METTL11B
methyltransferase like 11B
chr3_-_191322919 0.581 NM_001134418
LEPREL1
leprecan-like 1
chr11_-_57964221 0.578 NM_001004733
OR5B12
olfactory receptor, family 5, subfamily B, member 12
chr14_-_106352471 0.576



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.40e-03 GO:0032501 multicellular organismal process
1.29 6.07e-03 GO:0048731 system development
1.26 7.83e-03 GO:0007275 multicellular organismal development
2.49 1.11e-02 GO:0019216 regulation of lipid metabolic process
1.33 1.70e-02 GO:0048523 negative regulation of cellular process
2.00 2.29e-02 GO:0061061 muscle structure development
1.31 2.50e-02 GO:0048519 negative regulation of biological process
1.23 3.04e-02 GO:0032502 developmental process
1.25 3.62e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.50 3.77e-06 GO:0005856 cytoskeleton
1.23 3.64e-04 GO:0005886 plasma membrane
1.23 3.80e-04 GO:0071944 cell periphery
2.26 1.02e-03 GO:0045111 intermediate filament cytoskeleton
2.33 1.78e-03 GO:0005882 intermediate filament
1.93 4.19e-03 GO:0015629 actin cytoskeleton
2.54 5.34e-03 GO:0030016 myofibril
1.80 5.60e-03 GO:0009986 cell surface
2.80 1.39e-02 GO:0045095 keratin filament
2.39 1.53e-02 GO:0043292 contractile fiber
1.25 2.05e-02 GO:0043228 non-membrane-bounded organelle
1.25 2.05e-02 GO:0043232 intracellular non-membrane-bounded organelle
3.30 2.17e-02 GO:0030658 transport vesicle membrane
2.21 2.39e-02 GO:0005912 adherens junction
2.14 2.50e-02 GO:0070161 anchoring junction
2.52 2.81e-02 GO:0030017 sarcomere
4.95 3.76e-02 GO:0030134 ER to Golgi transport vesicle

Nothing significant found in function category.