Motif ID: TLX2.p2

Z-value: 1.296


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_74595073-0.674.6e-03Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_26294332 1.083 APP
amyloid beta (A4) precursor protein
chr1_-_151333624 0.946 NM_001024209
SPRR2E
small proline-rich protein 2E
chr6_-_32839244 0.934 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr2_-_79168626 0.848 NM_006507
REG1B
regenerating islet-derived 1 beta
chr7_+_31693155 0.843 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr12_-_90096275 0.834 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr7_-_32077504 0.790 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr2_-_174537021 0.729 NM_001017371
SP3
Sp3 transcription factor
chr21_-_36870736 0.708 NM_001146077
CLDN14
claudin 14
chr11_-_71501385 0.703 NM_014042
C11orf51
chromosome 11 open reading frame 51
chr11_-_8571988 0.701 NM_030906
STK33
serine/threonine kinase 33
chr7_+_54577512 0.688 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr10_-_5436781 0.687 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr4_+_120276386 0.684 NM_016599
MYOZ2
myozenin 2
chr6_+_26548678 0.669 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr6_+_131190237 0.659 NM_001195597
LOC285733
hypothetical LOC285733
chr10_-_46593923 0.658 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr6_+_55300225 0.644 NM_207410
GFRAL
GDNF family receptor alpha like
chr14_-_35859545 0.641 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr2_-_174536761 0.637 SP3
Sp3 transcription factor
chr10_-_82039158 0.629 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr3_-_12858006 0.629 NM_000994
NM_001007073
RPL32

ribosomal protein L32

chr6_+_73133152 0.622 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr6_-_41114905 0.608 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr1_-_74971276 0.608 CRYZ
crystallin, zeta (quinone reductase)
chrX_+_153279764 0.579 NM_006013
RPL10
ribosomal protein L10
chr12_-_49708279 0.579 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr3_-_78749633 0.557 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_-_15814678 0.550 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr2_-_139254273 0.548 NM_007226
NXPH2
neurexophilin 2
chr6_-_52736231 0.542 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr16_-_28130662 0.537 NM_015171
XPO6
exportin 6
chr12_+_54400417 0.531 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr7_+_130445394 0.528 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr12_-_41269679 0.519 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr11_+_65096395 0.518 NM_001098784
NM_001098785
NM_152832
FAM89B


family with sequence similarity 89, member B


chr11_+_66952462 0.516 NM_003952
RPS6KB2
ribosomal protein S6 kinase, 70kDa, polypeptide 2
chr15_-_48198697 0.515 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr12_-_32940931 0.510 NM_001005242
NM_004572
PKP2

plakophilin 2

chr4_+_166468266 0.507 NM_001017369
NM_006745
SC4MOL

sterol-C4-methyl oxidase-like

chr1_-_167969802 0.504 NM_000450
SELE
selectin E
chr4_-_75938710 0.500 NM_001729
BTC
betacellulin
chr19_-_4468715 0.493 NM_001080400
PLIN4
perilipin 4
chr3_+_185580554 0.493 NM_003741
CHRD
chordin
chr12_+_56202874 0.491 NM_052897
MBD6
methyl-CpG binding domain protein 6
chr7_-_150408824 0.486 NM_006712
NM_033015
FASTK

Fas-activated serine/threonine kinase

chr6_+_160068135 0.482 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chr4_+_38722593 0.480 NM_001007075
NM_001171654
KLHL5

kelch-like 5 (Drosophila)

chr7_+_37689903 0.479


chr14_-_22825072 0.478 HOMEZ
homeobox and leucine zipper encoding
chr11_-_77411933 0.476 NM_023930
KCTD14
potassium channel tetramerisation domain containing 14
chr19_+_627346 0.476 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr1_+_36462625 0.474 THRAP3
thyroid hormone receptor associated protein 3
chr1_-_6368324 0.471 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr2_-_111152075 0.469 NM_004336
BUB1
budding uninhibited by benzimidazoles 1 homolog (yeast)
chr14_-_22825148 0.465 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr1_-_151296611 0.463 NM_005988
SPRR2A
small proline-rich protein 2A
chr4_-_24641404 0.461 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr1_-_151045730 0.461 NM_178351
LCE1C
late cornified envelope 1C
chr14_+_38804226 0.455 NM_203354
CTAGE5
CTAGE family, member 5
chr17_-_57497380 0.454 NM_005121
MED13
mediator complex subunit 13
chr9_-_124715392 0.453 NM_006626
ZBTB6
zinc finger and BTB domain containing 6
chr18_-_26935883 0.449 NM_004949
NM_024422
DSC2

desmocollin 2

chr6_+_44418374 0.446 NM_145026
SPATS1
spermatogenesis associated, serine-rich 1
chr6_-_155818728 0.444 NM_015718
NOX3
NADPH oxidase 3
chr8_+_55210333 0.443 NM_014175
MRPL15
mitochondrial ribosomal protein L15
chr12_-_90029328 0.440 LUM
lumican
chr16_+_82544327 0.436 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr2_+_27848085 0.436 NM_004891
NM_145330
MRPL33

mitochondrial ribosomal protein L33

chr1_+_116181927 0.436 NHLH2
nescient helix loop helix 2
chr8_-_68821131 0.435 NM_020361
CPA6
carboxypeptidase A6
chr1_-_233391129 0.431 NM_001161533
NM_015014
RBM34

RNA binding motif protein 34

chr4_-_145281237 0.429 NM_002099
GYPA
glycophorin A (MNS blood group)
chr2_-_40593074 0.428 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_+_36462583 0.425 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr10_+_47216925 0.424 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr15_+_24799174 0.424 NM_033223
GABRG3
gamma-aminobutyric acid (GABA) A receptor, gamma 3
chr16_+_30293598 0.423 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr3_+_123279439 0.421 NM_006889
CD86
CD86 molecule
chr19_+_56990222 0.420 NM_002030
FPR3
formyl peptide receptor 3
chr12_+_14429499 0.419 ATF7IP
activating transcription factor 7 interacting protein
chr3_+_140545528 0.419 NM_020191
MRPS22
mitochondrial ribosomal protein S22
chr16_+_83411086 0.418 NM_031476
CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr11_-_66245288 0.417 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr6_+_26473376 0.415 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr1_+_151209751 0.412 NM_173080
SPRR4
small proline-rich protein 4
chr5_-_13997588 0.402 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr2_-_233060774 0.401 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr8_-_18710575 0.399 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_114925734 0.398 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr5_+_146594718 0.395 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr16_+_88224175 0.393 DPEP1
dipeptidase 1 (renal)
chr17_-_78391178 0.390 NM_024702
ZNF750
zinc finger protein 750
chr1_-_94475504 0.390 ARHGAP29
Rho GTPase activating protein 29
chr15_-_24569201 0.389 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_+_144149794 0.389 NM_006472
TXNIP
thioredoxin interacting protein
chr3_-_192063158 0.386 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr17_+_40494201 0.386 NM_021079
NMT1
N-myristoyltransferase 1
chr6_-_33822659 0.386 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr15_-_32289561 0.384 NM_024713
C15orf29
chromosome 15 open reading frame 29
chr3_+_101462375 0.381 NM_018309
TBC1D23
TBC1 domain family, member 23
chr8_-_91726915 0.381 TMEM64
transmembrane protein 64
chr20_-_61356247 0.380 NM_152864
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr13_+_113023938 0.378 LAMP1
lysosomal-associated membrane protein 1
chr15_+_46285789 0.378 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr22_-_35914200 0.377 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr1_+_148020869 0.376 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr20_+_2224612 0.376 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr1_-_202449659 0.375 NM_198447
GOLT1A
golgi transport 1A
chr21_-_38954433 0.375 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr8_+_133948384 0.375 NM_003235
TG
thyroglobulin
chr11_-_127962662 0.371 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr5_-_40871082 0.370 NM_000997
RPL37
ribosomal protein L37
chr2_-_217433018 0.370 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr6_-_24597717 0.370 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chrX_+_154097894 0.369 NM_003372
VBP1
von Hippel-Lindau binding protein 1
chr7_-_26198673 0.368 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_+_32578513 0.366 FGD4
FYVE, RhoGEF and PH domain containing 4
chr10_+_76541351 0.366 NM_001174156
NM_144660
SAMD8

sterile alpha motif domain containing 8

chr2_+_207215386 0.363 NM_001102659
LOC200726
hCG1657980
chr7_+_142692165 0.361 NM_153345
TMEM139
transmembrane protein 139
chr17_+_38412267 0.360 NM_005533
IFI35
interferon-induced protein 35
chr7_+_100156358 0.359 NM_000799
EPO
erythropoietin
chr4_-_38534802 0.359 NM_006068
TLR6
toll-like receptor 6
chr7_+_133982070 0.359 NM_001724
NM_199186
BPGM

2,3-bisphosphoglycerate mutase

chr1_+_184532027 0.358 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr2_-_200038055 0.357 NM_001172517
SATB2
SATB homeobox 2
chr1_+_23890880 0.357 NM_000975
RPL11
ribosomal protein L11
chr2_-_55413253 0.356 CCDC88A
coiled-coil domain containing 88A
chr5_+_173405343 0.355 HMP19
HMP19 protein
chr6_-_66473790 0.354 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr18_+_27332024 0.351 NM_001943
DSG2
desmoglein 2
chr9_-_115877104 0.350 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_-_46140015 0.350 NM_052855
ANKRD40
ankyrin repeat domain 40
chr21_+_17841297 0.349 CXADR
coxsackie virus and adenovirus receptor
chr12_-_6450015 0.348 NM_014231
NM_016830
NM_199245
VAMP1


vesicle-associated membrane protein 1 (synaptobrevin 1)


chr2_-_220144254 0.348 OBSL1
obscurin-like 1
chr18_+_27281729 0.346 NM_001944
DSG3
desmoglein 3
chr4_-_73653331 0.345 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr4_+_86968069 0.345 ARHGAP24
Rho GTPase activating protein 24
chr12_-_48508411 0.344 NM_001037806
NCKAP5L
NCK-associated protein 5-like
chrX_+_109132507 0.344 NM_017698
TMEM164
transmembrane protein 164
chr18_+_54013575 0.343 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_-_97316933 0.342 NM_006294
UQCRB
ubiquinol-cytochrome c reductase binding protein
chr2_+_27848090 0.341 MRPL33
mitochondrial ribosomal protein L33
chr10_-_116408046 0.340 NM_002313
ABLIM1
actin binding LIM protein 1
chr15_-_32289480 0.340 C15orf29
chromosome 15 open reading frame 29
chr6_+_31059463 0.339 NM_001010909
MUC21
mucin 21, cell surface associated
chr17_+_38403935 0.339 NM_000988
RPL27
ribosomal protein L27
chr1_-_94475840 0.338 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr10_+_86174665 0.338 FAM190B
family with sequence similarity 190, member B
chr1_-_24342158 0.337 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr6_-_35804337 0.337 NM_001145775
FKBP5
FK506 binding protein 5
chr10_-_74863303 0.337 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr16_+_70437394 0.336 NM_001137675
ATXN1L
ataxin 1-like
chrX_-_30817329 0.334 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr10_+_123744131 0.334 TACC2
transforming, acidic coiled-coil containing protein 2
chrX_-_31194867 0.333 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr6_-_32265489 0.332 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr1_+_48460943 0.332 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr1_-_239869826 0.331 NM_014322
OPN3
opsin 3
chr9_-_32563057 0.330 NM_002493
NM_182739
NDUFB6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa

chr15_-_24569253 0.327 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr7_-_150408785 0.327 FASTK
Fas-activated serine/threonine kinase
chr8_+_38877909 0.326 NM_021623
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr8_+_32905027 0.325


chr1_+_195213289 0.323 NM_030787
CFHR5
complement factor H-related 5
chr11_+_63766163 0.323 NM_057092
FKBP2
FK506 binding protein 2, 13kDa
chr7_+_93373755 0.322 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr21_+_40161216 0.322 NM_006198
PCP4
Purkinje cell protein 4
chr19_+_45564549 0.321 PLD3
phospholipase D family, member 3
chr6_+_112515366 0.320 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr1_+_23890857 0.318 RPL11
ribosomal protein L11
chr1_+_1360765 0.318 NM_022834
NM_199121
VWA1

von Willebrand factor A domain containing 1

chr1_+_112811562 0.318 NM_004185
WNT2B
wingless-type MMTV integration site family, member 2B
chr15_-_24569309 0.317 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr3_-_122951200 0.317 NM_004487
GOLGB1
golgin B1
chr3_-_180272229 0.316 ZMAT3
zinc finger, matrin-type 3
chr5_+_173405298 0.316 NM_015980
HMP19
HMP19 protein
chr17_+_58440629 0.315 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr3_-_168935287 0.314 NM_007217
NM_145860
NM_145859
PDCD10


programmed cell death 10


chr1_+_116744992 0.313 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr3_+_153469421 0.312 MBNL1
muscleblind-like (Drosophila)
chr21_-_18697829 0.311 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr14_+_23008723 0.310 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr3_+_2115449 0.310 CNTN4
contactin 4
chr1_-_203985963 0.309 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr16_-_28130201 0.308 XPO6
exportin 6
chr2_+_201099093 0.308 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr1_-_155788775 0.308 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr4_+_71418886 0.307 NM_212557
AMTN
amelotin
chr19_+_40474867 0.307 NM_002361
NM_080600
MAG

myelin associated glycoprotein

chr10_-_71753684 0.307 LRRC20
leucine rich repeat containing 20
chr6_-_99979850 0.306 NM_015491
NM_032870
SFRS18

splicing factor, arginine/serine-rich 18

chr20_+_42537927 0.306 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr20_+_56318415 0.306 RAB22A
RAB22A, member RAS oncogene family
chrX_-_131375217 0.306 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr2_+_113119985 0.302 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr10_-_71713455 0.301 NM_022146
NPFFR1
neuropeptide FF receptor 1
chr6_+_31741814 0.299 CSNK2B
casein kinase 2, beta polypeptide

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.85 1.63e-03 GO:0019080 viral genome expression
2.85 1.63e-03 GO:0019083 viral transcription
3.59 4.07e-03 GO:0051258 protein polymerization
2.64 1.23e-02 GO:0006415 translational termination
2.27 1.55e-02 GO:0019058 viral infectious cycle
1.22 2.49e-02 GO:0048856 anatomical structure development
2.49 2.69e-02 GO:0043241 protein complex disassembly
2.49 2.69e-02 GO:0043624 cellular protein complex disassembly
2.38 3.14e-02 GO:0032984 macromolecular complex disassembly
2.38 3.14e-02 GO:0034623 cellular macromolecular complex disassembly
4.04 3.60e-02 GO:0010043 response to zinc ion
2.17 4.26e-02 GO:0031016 pancreas development
1.24 4.60e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 2.77e-04 GO:0005829 cytosol
2.70 4.64e-03 GO:0022626 cytosolic ribosome
2.09 8.50e-03 GO:0044445 cytosolic part
1.22 1.47e-02 GO:0043228 non-membrane-bounded organelle
1.22 1.47e-02 GO:0043232 intracellular non-membrane-bounded organelle
3.19 4.61e-02 GO:0022625 cytosolic large ribosomal subunit

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.03 4.71e-02 GO:0003735 structural constituent of ribosome