Motif ID: ATF2.p2

Z-value: 1.636


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2



Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_23500706 2.900 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr8_+_70567634 2.352 SULF1
sulfatase 1
chr3_-_21767819 2.292 NM_024697
ZNF385D
zinc finger protein 385D
chr11_+_116575249 2.270 NM_001001522
NM_003186
TAGLN

transgelin

chr12_-_123568781 2.170


chr3_+_62279707 2.111 C3orf14
chromosome 3 open reading frame 14
chr8_+_70567581 2.058 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr12_+_70119785 2.038 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr16_-_78192111 1.984 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr6_-_127822227 1.973 NM_014702
KIAA0408
KIAA0408
chr6_+_39868116 1.947


chr14_+_95740916 1.899 BDKRB2
bradykinin receptor B2
chr7_-_41709191 1.896 NM_002192
INHBA
inhibin, beta A
chr2_+_10969513 1.865 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr3_-_64186151 1.865 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr3_+_189354167 1.850 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr6_+_39868126 1.820 DAAM2
dishevelled associated activator of morphogenesis 2
chr4_-_186693574 1.799 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr3_+_42107711 1.773 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr7_+_28415495 1.770 LOC401317
hypothetical LOC401317
chr9_+_17568952 1.727 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr5_+_14493905 1.719 TRIO
triple functional domain (PTPRF interacting)
chr1_-_16355013 1.706 NM_004431
EPHA2
EPH receptor A2
chr22_-_42589543 1.696 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr3_+_141136691 1.694 NM_022131
CLSTN2
calsyntenin 2
chr20_+_32610161 1.658 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chrX_-_83644054 1.656 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chrX_+_110226030 1.628 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_138238891 1.609 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr1_+_182040837 1.607 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr5_-_138238877 1.591 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr20_+_19863716 1.525 RIN2
Ras and Rab interactor 2
chr14_+_62740878 1.501 NM_020663
RHOJ
ras homolog gene family, member J
chr13_-_47885018 1.497 LPAR6
lysophosphatidic acid receptor 6
chr5_+_66160359 1.493 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr22_+_40286957 1.488 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr6_+_108593907 1.485 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr10_-_95350949 1.478 NM_006744
RBP4
retinol binding protein 4, plasma
chr14_-_79748273 1.470 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr10_-_90957028 1.454 NM_003956
CH25H
cholesterol 25-hydroxylase
chr4_+_3341521 1.448 NM_198227
RGS12
regulator of G-protein signaling 12
chr8_+_134272463 1.402 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr17_-_46479127 1.395 SPAG9
sperm associated antigen 9
chr8_+_40130143 1.387 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr20_-_14266200 1.366 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr2_-_134042500 1.342 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr4_+_145786622 1.338 NM_022475
HHIP
hedgehog interacting protein
chr5_+_32747194 1.330 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr8_-_72436832 1.326 EYA1
eyes absent homolog 1 (Drosophila)
chr12_+_12935619 1.312 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr2_-_73170290 1.307 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr15_-_61460967 1.304 CA12
carbonic anhydrase XII
chr4_-_142273881 1.298 NM_020724
RNF150
ring finger protein 150
chr15_-_61461127 1.296 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr4_-_111777651 1.286 PITX2
paired-like homeodomain 2
chr4_-_111777584 1.282 PITX2
paired-like homeodomain 2
chr16_-_4528739 1.265 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr2_-_213723298 1.262 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr3_-_102194938 1.249 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr8_-_72437020 1.241 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr1_+_165330710 1.235 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr19_-_56919032 1.233 NM_001523
HAS1
hyaluronan synthase 1
chr1_+_66570683 1.232 PDE4B
phosphodiesterase 4B, cAMP-specific
chrX_-_131918905 1.228 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr6_+_148705421 1.219 NM_015278
SASH1
SAM and SH3 domain containing 1
chr10_+_63803921 1.214 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr14_+_95740768 1.213 NM_000623
BDKRB2
bradykinin receptor B2
chr1_+_66570363 1.205 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr13_+_75232797 1.200 NM_015842
LMO7
LIM domain 7
chr14_+_95792299 1.188 NM_000710
BDKRB1
bradykinin receptor B1
chr21_-_42060334 1.188 RIPK4
receptor-interacting serine-threonine kinase 4
chr5_-_139992621 1.187 NM_000591
CD14
CD14 molecule
chr5_-_138238953 1.168 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr5_-_54317102 1.168 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr13_-_47885248 1.160 LPAR6
lysophosphatidic acid receptor 6
chr1_+_99502655 1.158 LPPR4
lipid phosphate phosphatase-related protein type 4
chr12_-_90029328 1.140 LUM
lumican
chr5_+_118719591 1.133 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr4_+_120167264 1.126 SYNPO2
synaptopodin 2
chr4_-_187884721 1.111


chr14_+_100362204 1.095 MEG3
maternally expressed 3 (non-protein coding)
chr21_-_34820916 1.088 NM_203418
RCAN1
regulator of calcineurin 1
chr11_-_62213577 1.070 LRRN4CL
LRRN4 C-terminal like
chr15_-_81412354 1.070 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr2_-_31491057 1.065 XDH
xanthine dehydrogenase
chr19_+_18584666 1.053 NM_012109
TMEM59L
transmembrane protein 59-like
chr4_+_120276386 1.044 NM_016599
MYOZ2
myozenin 2
chr17_-_13445942 1.043 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr11_+_108798084 1.039 C11orf87
chromosome 11 open reading frame 87
chr16_-_71639670 1.036 NM_006885
ZFHX3
zinc finger homeobox 3
chr2_-_152664056 1.034 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr13_+_31503436 1.031 NM_023037
FRY
furry homolog (Drosophila)
chr8_-_42184194 1.028 PLAT
plasminogen activator, tissue
chr6_+_42896771 1.025 NM_015349
KIAA0240
KIAA0240
chr8_-_42184350 1.023 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr9_-_128924819 1.022 NM_012098
ANGPTL2
angiopoietin-like 2
chr14_+_100362236 1.020 MEG3
maternally expressed 3 (non-protein coding)
chr22_-_27787793 1.018 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr11_+_108798047 1.015 NM_207645
C11orf87
chromosome 11 open reading frame 87
chr15_-_81037554 1.011 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr7_-_45095017 1.011 NM_001146334
NACAD
NAC alpha domain containing
chr4_-_156517423 1.006 MAP9
microtubule-associated protein 9
chr2_+_5750229 1.006 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr2_-_31491102 1.003 NM_000379
XDH
xanthine dehydrogenase
chr11_-_8849485 1.000 ST5
suppression of tumorigenicity 5
chr6_-_46566969 0.999 RCAN2
regulator of calcineurin 2
chr5_+_159276317 0.999 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr4_-_156517394 0.998 MAP9
microtubule-associated protein 9
chr5_+_118719448 0.990 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr3_-_8518327 0.989 LOC100288428
hypothetical LOC100288428
chr4_-_96689373 0.988 NM_003728
UNC5C
unc-5 homolog C (C. elegans)
chr1_-_177106702 0.976 NM_004673
ANGPTL1
angiopoietin-like 1
chr21_-_42060266 0.972 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chrX_+_102471769 0.970 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr5_-_94442941 0.963 MCTP1
multiple C2 domains, transmembrane 1
chr8_+_99145925 0.962 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr4_-_54119159 0.947 NM_032622
LNX1
ligand of numb-protein X 1
chr5_-_111119846 0.944 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_+_85300580 0.938 NM_145172
WDR63
WD repeat domain 63
chr12_+_55201854 0.937 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr6_+_136214495 0.935 NM_018945
PDE7B
phosphodiesterase 7B
chr4_-_54119123 0.922 LNX1
ligand of numb-protein X 1
chr10_+_123913094 0.920 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr5_-_94443300 0.919 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr4_-_54119102 0.911 LNX1
ligand of numb-protein X 1
chr20_+_10147455 0.908 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr2_-_224175339 0.906 SCG2
secretogranin II
chr8_-_67253234 0.902 NM_000756
CRH
corticotropin releasing hormone
chr4_+_113958652 0.897 NM_001127493
ANK2
ankyrin 2, neuronal
chr5_-_147266257 0.890 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr12_+_12935759 0.887 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr9_-_128924782 0.886 ANGPTL2
angiopoietin-like 2
chr20_-_33489383 0.879 NM_000557
GDF5
growth differentiation factor 5
chr12_+_79625538 0.879 NM_002469
MYF6
myogenic factor 6 (herculin)
chr3_+_89239494 0.877 EPHA3
EPH receptor A3
chr4_-_44145580 0.874 NM_198353
KCTD8
potassium channel tetramerisation domain containing 8
chr4_-_156517544 0.873 NM_001039580
MAP9
microtubule-associated protein 9
chr12_-_90029672 0.871 NM_002345
LUM
lumican
chr4_-_24641404 0.864 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr3_+_89239363 0.863 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr17_-_19592178 0.863 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr11_-_8788765 0.858 NM_213618
ST5
suppression of tumorigenicity 5
chr2_-_152663748 0.851 NM_000726
NM_001145798
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr22_+_39583001 0.847 NM_022098
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr6_+_148705646 0.838 SASH1
SAM and SH3 domain containing 1
chr10_-_99780336 0.832 CRTAC1
cartilage acidic protein 1
chr1_+_29435534 0.828 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr5_-_139993469 0.825 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr11_+_12652427 0.817 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr2_-_224611568 0.816 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr2_-_188021117 0.810 NM_005795
CALCRL
calcitonin receptor-like
chr2_+_206847658 0.809 NM_020923
ZDBF2
zinc finger, DBF-type containing 2
chr2_-_224175293 0.803 SCG2
secretogranin II
chr1_+_99502435 0.795 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr5_-_127901376 0.791 FBN2
fibrillin 2
chr12_-_7935010 0.787 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr3_+_151608673 0.783 TSC22D2
TSC22 domain family, member 2
chr17_+_36515166 0.776 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr11_+_61204392 0.774 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr11_-_62213946 0.773 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr8_-_95343716 0.771 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr4_-_153493133 0.762 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr6_-_46401174 0.761 RCAN2
regulator of calcineurin 2
chr2_-_142605010 0.754 LRP1B
low density lipoprotein receptor-related protein 1B
chr11_+_24475091 0.751 NM_001009909
LUZP2
leucine zipper protein 2
chr3_-_56784634 0.751 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr9_-_128924706 0.747 ANGPTL2
angiopoietin-like 2
chr4_-_153820535 0.744 NM_152680
TMEM154
transmembrane protein 154
chr18_-_35634247 0.741 LOC647946
hypothetical LOC647946
chr8_-_95343696 0.737 GEM
GTP binding protein overexpressed in skeletal muscle
chr5_+_36642213 0.735 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr3_+_141136896 0.730 CLSTN2
calsyntenin 2
chr15_+_66658626 0.725 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr12_+_70120028 0.725 NM_003667
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr5_+_54491702 0.722 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chrX_-_13866565 0.714 NM_001001994
GPM6B
glycoprotein M6B
chr10_-_102663070 0.707


chr11_-_35397675 0.707 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_12510030 0.702 MYOCD
myocardin
chr2_-_206790871 0.698 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr2_-_238861830 0.688 NM_022817
PER2
period homolog 2 (Drosophila)
chr11_-_85107569 0.684 NM_206929
SYTL2
synaptotagmin-like 2
chr5_-_64813459 0.682 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr11_-_85108030 0.680 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr8_+_94999167 0.676 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr5_+_36642424 0.671 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_159872960 0.656 NM_020169
LXN
latexin
chr3_-_12561962 0.656 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr2_+_219779737 0.656 NM_138802
ZFAND2B
zinc finger, AN1-type domain 2B
chr3_-_126257425 0.654 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr16_-_4528380 0.653 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr2_+_37425240 0.653 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr6_-_46401363 0.641 NM_005822
RCAN2
regulator of calcineurin 2
chr9_-_32542573 0.639 NM_001195622
NM_005802
TOPORS

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

chr6_+_148705817 0.634 SASH1
SAM and SH3 domain containing 1
chr9_-_36390212 0.628 NM_022781
NM_194329
RNF38

ring finger protein 38

chr4_+_54790190 0.624 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr4_+_158361185 0.623 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr5_+_73145098 0.623 RGNEF
190 kDa guanine nucleotide exchange factor
chr1_-_42157077 0.620 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 7.16e-04 GO:0032502 developmental process
1.37 8.77e-04 GO:0048856 anatomical structure development
1.40 1.06e-03 GO:0048731 system development
1.33 5.39e-03 GO:0007275 multicellular organismal development
1.23 1.64e-02 GO:0032501 multicellular organismal process
1.16 3.16e-02 GO:0065007 biological regulation
2.18 3.42e-02 GO:0001501 skeletal system development
1.54 3.42e-02 GO:0051239 regulation of multicellular organismal process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 8.61e-03 GO:0005515 protein binding
3.86 4.79e-02 GO:0004879 ligand-dependent nuclear receptor activity