ISMARA results for ENCODE cell lines, H3K4me2, averaged replicates (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Averaging sample configuration

Sample Condition
Rep1_GM12878 GM12878
Rep1_HepG2 HepG2
Rep1_HMEC HMEC
Rep1_HSMM HSMM
Rep1_Huvec Huvec
Rep1_K562 K562
Rep1_NHEK NHEK
Rep1_NHLF NHLF
Rep2_GM12878 GM12878
Rep2_HepG2 HepG2
Rep2_HMEC HMEC
Rep2_HSMM HSMM
Rep2_Huvec Huvec
Rep2_K562 K562
Rep2_NHEK NHEK
Rep2_NHLF NHLF

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
HNF1A.p2 13.305 HNF1A (HNF1, LFB1)
PITX1..3.p2 8.866 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
HNF4A_NR2F1,2.p2 7.194 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
SNAI1..3.p2 7.063 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
RUNX1..3.p2 6.929 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
HOX{A6,A7,B6,B7}.p2 5.728 HOXB6
HOXA7
HOXB7
HOXA6
HIC1.p2 5.254 HIC1 (ZBTB29)
TEAD1.p2 5.145 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
MZF1.p2 5.077 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
FOS_FOS{B,L1}_JUN{B,D}.p2 5.037 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
EN1,2.p2 5.031 EN1
EN2
TCF4_dimer.p2 4.505 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
SPIB.p2 4.481 SPIB (SPI-B)
FOXA2.p3 4.446 FOXA2
MTF1.p2 4.411 MTF1
GATA6.p2 4.378 GATA6
EHF.p2 4.337 EHF
HBP1_HMGB_SSRP1_UBTF.p2 4.141 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
PRRX1,2.p2 4.122 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
FEV.p2 4.056 FEV (PET-1, HSRNAFEV)
KLF4.p3 4.033 KLF4 (EZF, GKLF)
POU2F1..3.p2 3.966 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
NFY{A,B,C}.p2 3.898 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
NR1H4.p2 3.855 NR1H4 (FXR, RIP14, HRR1, HRR-1)
SPI1.p2 3.837 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
POU5F1.p2 3.809 POU5F1 (OCT3, Oct4, MGC22487)
NFKB1_REL_RELA.p2 3.802 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
PRDM1.p3 3.714 PRDM1 (PRDI-BF1)
IRF1,2,7.p3 3.616 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
HAND1,2.p2 3.606 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
DBP.p2 3.596 DBP (DABP)
GFI1B.p2 3.546 GFI1B
GTF2I.p2 3.527 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
CTCF.p2 3.508 CTCF
ETS1,2.p2 3.493 ETS2
ETS1 (FLJ10768, ETS-1)
NFE2L2.p2 3.489 NFE2L2 (NRF2)
MAFB.p2 3.450 MAFB
ONECUT1,2.p2 3.390 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
TFAP2{A,C}.p2 3.315 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
NRF1.p2 3.220 NRF1 (EWG, ALPHA-PAL)
MYOD1.p2 3.175 MYOD1 (PUM, MYOD, bHLHc1)
YY1.p2 3.169 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
NHLH1,2.p2 3.158 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
ZEB1.p2 3.128 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
ZNF143.p2 3.119 ZNF143 (SBF, pHZ-1, STAF)
ESRRA.p2 3.111 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
LEF1_TCF7_TCF7L1,2.p2 3.079 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
RFX1..5_RFXANK_RFXAP.p2 3.003 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
DMAP1_NCOR{1,2}_SMARC.p2 2.981 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
NR5A1,2.p2 2.972 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
ZIC1..3.p2 2.954 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
PATZ1.p2 2.853 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
FOX{I1,J2}.p2 2.821 FOXI1 (FREAC6)
FOXJ2 (FHX)
ZNF384.p2 2.798 ZNF384 (CAGH1A, CIZ, NMP4, NP)
TLX1..3_NFIC{dimer}.p2 2.796 TLX1
TLX3 (RNX)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 2.780 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
CEBPA,B_DDIT3.p2 2.767 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
HLF.p2 2.749 HLF (MGC33822)
RREB1.p2 2.737 RREB1 (HNT)
MYFfamily.p2 2.706 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
GFI1.p2 2.662 GFI1
MSX1,2.p2 2.613 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
POU3F1..4.p2 2.606 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
GTF2A1,2.p2 2.533 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
GATA1..3.p2 2.487 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
POU5F1_SOX2{dimer}.p2 2.478 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
NKX2-1,4.p2 2.443 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
HOX{A5,B5}.p2 2.415 HOXB5
HOXA5
NFATC1..3.p2 2.395 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
SP1.p2 2.380 SP1
bHLH_family.p2 2.347 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
E2F1..5.p2 2.332 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
MEF2{A,B,C,D}.p2 2.328 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
TFCP2.p2 2.307 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
BPTF.p2 2.253 BPTF (FAC1, NURF301)
MAZ.p2 2.237 MAZ (ZF87, Pur-1, Zif87, ZNF801)
TGIF1.p2 2.216 TGIF1
EBF1.p2 2.193 EBF1 (OLF1)
IKZF2.p2 2.189 IKZF2 (Helios)
ZFP161.p2 2.171 ZFP161 (ZNF478, ZBTB14)
NKX3-1.p2 2.162 NKX3-1 (NKX3.1, BAPX2)
JUN.p2 2.157 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
POU6F1.p2 2.124 POU6F1 (BRN5, MPOU, TCFB1)
SRF.p3 2.102 SRF (MCM1)
ZNF238.p2 2.099 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
EVI1.p2 2.089 EVI1 (MDS1-EVI1, PRDM3)
EP300.p2 2.079 EP300 (p300, KAT3B)
ZNF423.p2 1.998 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
PPARG.p2 1.983 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
POU1F1.p2 1.979 POU1F1 (GHF-1)
ELK1,4_GABP{A,B1}.p3 1.978 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
NANOG{mouse}.p2 1.959 NANOG (FLJ12581, FLJ40451)
TAL1_TCF{3,4,12}.p2 1.947 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
MYBL2.p2 1.913 MYBL2 (BMYB, B-MYB)
NFE2L1.p2 1.897 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
FOXO1,3,4.p2 1.890 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
FOX{D1,D2}.p2 1.888 FOXD2 (FREAC9)
FOXD1 (FREAC4)
SOX{8,9,10}.p2 1.883 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
FOXQ1.p2 1.880 FOXQ1 (HFH1)
EGR1..3.p2 1.861 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
FOX{F1,F2,J1}.p2 1.821 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
NFIX.p2 1.819 NFIX (NF1A)
FOXL1.p2 1.805 FOXL1 (FREAC7, FKH6)
ATF5_CREB3.p2 1.791 ATF5
CREB3 (LZIP, Luman)
ZBTB16.p2 1.764 ZBTB16 (PLZF)
XBP1.p3 1.739 XBP1
NKX3-2.p2 1.737 NKX3-2 (NKX3B, NKX3.2)
REST.p3 1.734 REST (NRSF, XBR)
ELF1,2,4.p2 1.732 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
NR3C1.p2 1.730 NR3C1 (GR)
T.p2 1.720 T
ZNF148.p2 1.709 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
FOXN1.p2 1.705 FOXN1 (FKHL20)
RBPJ.p2 1.705 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
HOX{A4,D4}.p2 1.685 HOXA4
HOXD4
FOX{C1,C2}.p2 1.654 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
PBX1.p2 1.652 PBX1
CDC5L.p2 1.642 CDC5L (PCDC5RP, hCDC5, CEF1)
ATF2.p2 1.636 ATF2 (TREB7, CRE-BP1, HB16)
IKZF1.p2 1.630 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
BACH2.p2 1.618 BACH2
TBP.p2 1.607 TBP (TFIID)
AHR_ARNT_ARNT2.p2 1.605 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
HOXA9_MEIS1.p2 1.595 MEIS1
HOXA9
AIRE.p2 1.580 AIRE (PGA1, APS1)
NKX2-2,8.p2 1.559 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
RXRA_VDR{dimer}.p2 1.551 VDR (NR1I1)
ALX1.p2 1.548 ALX1
FOXP3.p2 1.543 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
STAT2,4,6.p2 1.504 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
EWSR1-FLI1.p2 1.496 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
PAX4.p2 1.494 PAX4
SPZ1.p2 1.479 SPZ1 (NYD-TSP1, FLJ25709)
NKX6-1,2.p2 1.467 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
LMO2.p2 1.466 LMO2 (TTG2, RHOM2, RBTN2)
HMX1.p2 1.458 HMX1 (H6, NKX5-3)
ARID5B.p2 1.457 ARID5B (FLJ21150, MRF2)
FOSL2.p2 1.446 FOSL2 (FRA2, FLJ23306)
TLX2.p2 1.426 TLX2 (Enx, Tlx2, NCX)
PAX5.p2 1.420 PAX5 (BSAP)
SOX5.p2 1.418 SOX5 (L-SOX5, MGC35153)
NANOG.p2 1.407 NANOG (FLJ12581, FLJ40451)
TFAP4.p2 1.407 TFAP4 (AP-4)
ATF4.p2 1.399 ATF4 (TAXREB67, CREB-2)
CRX.p2 1.359 CRX (CRD, LCA7, OTX3)
CUX2.p2 1.357 CUX2 (KIAA0293, CDP2)
SRY.p2 1.346 SRY (TDF)
MYB.p2 1.340 MYB (c-myb)
TP53.p2 1.336 TP53 (p53, LFS1)
CREB1.p2 1.325 CREB1
HSF1,2.p2 1.322 HSF1 (HSTF1)
HSF2
GLI1..3.p2 1.317 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
HIF1A.p2 1.313 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
STAT5{A,B}.p2 1.305 STAT5B
STAT5A (MGF)
NFE2.p2 1.298 NFE2 (NF-E2)
TFEB.p2 1.287 TFEB
AR.p2 1.269 AR (AIS, NR3C4, SMAX1, HUMARA)
KLF12.p2 1.257 KLF12 (AP-2rep, HSPC122, AP2REP)
NR6A1.p2 1.253 NR6A1 (GCNF1, RTR)
ADNP_IRX_SIX_ZHX.p2 1.250 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
EOMES.p2 1.236 EOMES (TBR2)
SOX2.p2 1.203 SOX2
FOXD3.p2 1.199 FOXD3 (Genesis, HFH2)
NKX2-3_NKX2-5.p2 1.178 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
SREBF1,2.p2 1.172 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
SMAD1..7,9.p2 1.168 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
TBX4,5.p2 1.156 TBX5
TBX4
VSX1,2.p2 1.154 VSX2 (RET1)
VSX1 (PPD)
TFAP2B.p2 1.141 TFAP2B (AP2-B)
CDX1,2,4.p2 1.130 CDX1
CDX2
CDX4
TFDP1.p2 1.126 TFDP1 (Dp-1, DRTF1, DP1)
HES1.p2 1.123 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
HMGA1,2.p2 1.121 HMGA1
HMGA2 (BABL, LIPO)
LHX3,4.p2 1.099 LHX3
LHX4 (Gsh4)
ZBTB6.p2 0.995 ZBTB6 (ZID)
NFIL3.p2 0.988 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
RXRG_dimer.p3 0.967 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
PAX2.p2 0.941 PAX2
PAX6.p2 0.932 PAX6 (D11S812E, AN, WAGR)
STAT1,3.p3 0.903 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
ESR1.p2 0.894 ESR1 (NR3A1, Era)
RXR{A,B,G}.p2 0.855 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
ATF6.p2 0.832 ATF6 (ATF6A)
PDX1.p2 0.631 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
GZF1.p2 0.607 GZF1 (dJ322G13.2, ZBTB23)
SOX17.p2 0.605 SOX17
RORA.p2 0.591 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
PAX8.p2 0.385 PAX8
PAX3,7.p2 0.279 PAX7 (Hup1)
PAX3 (HUP2)

All samples sorted alphabetically


Your email address:
Project name:

Sample name Condition Replicate/Batch
GM12878
HepG2
HMEC
HSMM
Huvec
K562
NHEK
NHLF