Motif ID: bHLH_family.p2

Z-value: 2.347


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3



Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_120289735 3.605 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr12_-_47604930 3.407 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr16_-_66827449 3.345 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr7_-_27162688 3.290 NM_006896
HOXA7
homeobox A7
chr1_+_148521852 3.044 NM_144697
C1orf51
chromosome 1 open reading frame 51
chrX_-_107866262 2.943 NM_003604
IRS4
insulin receptor substrate 4
chr16_+_67236699 2.617 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr16_+_639278 2.549 NM_145294
WDR90
WD repeat domain 90
chr9_+_696744 2.527 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chrX_-_114703273 2.505


chr16_-_52876390 2.439 IRX3
iroquois homeobox 3
chr4_+_54660954 2.436 NM_133267
GSX2
GS homeobox 2
chr12_+_52806103 2.431 LOC400043
hypothetical LOC400043
chr10_+_101079099 2.345 CNNM1
cyclin M1
chr4_-_17392232 2.321 NM_015688
FAM184B
family with sequence similarity 184, member B
chr19_-_19599973 2.314 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr2_-_217267742 2.277 IGFBP5
insulin-like growth factor binding protein 5
chr4_-_15694407 2.230 PROM1
prominin 1
chr12_+_52653176 2.184 NM_014212
HOXC11
homeobox C11
chr14_-_19999324 2.154 TMEM55B
transmembrane protein 55B
chr11_+_126378507 2.152 NCRNA00288
non-protein coding RNA 288
chr6_-_80713589 2.146 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr7_-_27149750 2.139 NM_019102
HOXA5
homeobox A5
chr7_-_1562272 2.113 NM_001097620
TMEM184A
transmembrane protein 184A
chr8_+_95722448 2.060 ESRP1
epithelial splicing regulatory protein 1
chr14_-_19999475 2.038 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr16_-_4528380 2.003 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr3_-_126414252 1.955 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr8_-_17702991 1.955


chr3_-_49370682 1.949 GPX1
glutathione peroxidase 1
chr1_+_201364050 1.929 ADORA1
adenosine A1 receptor
chr22_+_34107087 1.897 HMOX1
heme oxygenase (decycling) 1
chr10_+_101078784 1.871 NM_020348
CNNM1
cyclin M1
chr3_-_49370755 1.846 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr9_+_17124974 1.825 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr8_-_75396016 1.728 NM_020647
JPH1
junctophilin 1
chr12_+_52713098 1.727 NM_018953
HOXC5
homeobox C5
chr12_+_6703686 1.711 NM_001164093
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr1_+_208178160 1.702 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr1_+_148137778 1.699 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr15_-_98699628 1.685 NM_139057
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr2_+_223625105 1.637 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr6_-_18230829 1.626 NM_198586
NHLRC1
NHL repeat containing 1
chr13_-_19665036 1.619 GJB2
gap junction protein, beta 2, 26kDa
chr19_-_5291700 1.601 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr2_-_219633481 1.590 NM_002181
IHH
Indian hedgehog
chr16_+_67236730 1.577 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr10_-_91285290 1.569 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr7_-_22363036 1.550 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr9_+_70926205 1.517 TJP2
tight junction protein 2 (zona occludens 2)
chr8_+_95722516 1.516 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr10_+_112826774 1.512 NM_000681
ADRA2A
adrenergic, alpha-2A-, receptor
chr8_+_95722575 1.509 ESRP1
epithelial splicing regulatory protein 1
chr13_+_112999462 1.504 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr17_-_74487527 1.475 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr8_-_99375739 1.464 NM_024759
NIPAL2
NIPA-like domain containing 2
chr18_+_17076166 1.455 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr3_+_106568334 1.450 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr12_+_94861201 1.443 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr19_+_54149941 1.441 BAX
BCL2-associated X protein
chr17_+_9489578 1.438 NM_153210
USP43
ubiquitin specific peptidase 43
chr8_+_123863075 1.425 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr13_+_112999538 1.423 LAMP1
lysosomal-associated membrane protein 1
chr2_-_133144094 1.420 LYPD1
LY6/PLAUR domain containing 1
chr17_-_36469869 1.408 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr20_+_13924263 1.392 MACROD2
MACRO domain containing 2
chr1_-_20931288 1.381 SH2D5
SH2 domain containing 5
chr11_-_116691574 1.378 BACE1
beta-site APP-cleaving enzyme 1
chrX_+_73557809 1.376 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr12_-_57600564 1.376 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr11_+_120399966 1.371 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr12_+_6703549 1.371 COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr3_+_139636104 1.367 NM_031913
ESYT3
extended synaptotagmin-like protein 3
chr19_+_54149963 1.367 BAX
BCL2-associated X protein
chr13_+_27392136 1.354 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr8_+_22492198 1.352 NM_021630
PDLIM2
PDZ and LIM domain 2 (mystique)
chr2_-_139254273 1.327 NM_007226
NXPH2
neurexophilin 2
chr8_+_123863169 1.325 ZHX2
zinc fingers and homeoboxes 2
chr17_-_68769613 1.321 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr3_+_139636111 1.311 ESYT3
extended synaptotagmin-like protein 3
chr1_+_95058488 1.305 NM_001114106
SLC44A3
solute carrier family 44, member 3
chr16_-_65742323 1.303 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr20_-_2769245 1.291 NM_022760
FAM113A
family with sequence similarity 113, member A
chr11_+_66915997 1.288 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr13_+_112999590 1.288 LAMP1
lysosomal-associated membrane protein 1
chr12_+_52618815 1.281 NM_017410
HOXC13
homeobox C13
chr3_+_50629872 1.278 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr12_+_6703410 1.270 NM_001164094
NM_016319
NM_001164095
COPS7A


COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)


chr2_-_154043403 1.265 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr12_-_94860504 1.264 NM_182496
CCDC38
coiled-coil domain containing 38
chr9_+_70926009 1.261 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr4_-_158111504 1.260 PDGFC
platelet derived growth factor C
chr1_+_237616457 1.260 CHRM3
cholinergic receptor, muscarinic 3
chr12_-_50871953 1.258 NM_001081492
NM_182507
KRT80

keratin 80

chr2_+_176761552 1.257 NM_024501
HOXD1
homeobox D1
chr1_+_95058687 1.249 NM_152369
SLC44A3
solute carrier family 44, member 3
chr7_+_55054416 1.247 EGFR
epidermal growth factor receptor
chr12_-_57600336 1.223 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_+_42701460 1.217 CCDC30
coiled-coil domain containing 30
chr12_+_6703525 1.217 COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr7_-_82630063 1.214 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr20_+_43953428 1.209 CTSA
cathepsin A
chr16_-_4528739 1.205 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr19_+_54149843 1.205 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr1_-_199635057 1.201 LAD1
ladinin 1
chrX_+_102749489 1.195 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr6_-_30151526 1.194 NM_170769
NM_025236
RNF39

ring finger protein 39

chr2_-_216944911 1.192 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr10_+_52421120 1.190 PRKG1
protein kinase, cGMP-dependent, type I
chr14_+_64240902 1.189 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr13_-_27572646 1.186 NM_004119
FLT3
fms-related tyrosine kinase 3
chr17_-_17050355 1.179 NM_178836
PLD6
phospholipase D family, member 6
chr1_+_95058781 1.177 SLC44A3
solute carrier family 44, member 3
chr7_+_27190688 1.176


chr17_-_17050326 1.173 PLD6
phospholipase D family, member 6
chr17_-_40866062 1.173 NM_174919
SH3D20
SH3 domain containing 20
chr14_+_75114692 1.166 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr2_+_173308765 1.157 NM_007023
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr7_-_11838260 1.153 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr5_+_80292213 1.149 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr2_+_176680251 1.145 NM_021192
HOXD11
homeobox D11
chr12_+_64504408 1.143 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr6_-_42218692 1.133 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr4_-_158111995 1.130 NM_016205
PDGFC
platelet derived growth factor C
chr18_-_72973750 1.127 NM_001025100
NM_001025101
MBP

myelin basic protein

chr12_+_52634950 1.115 NM_173860
HOXC12
homeobox C12
chr1_-_143786993 1.115 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_+_132176921 1.114 NM_175873
ANKRD43
ankyrin repeat domain 43
chr8_+_32525269 1.111 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr2_-_101134146 1.109 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr19_+_12996368 1.109 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_+_77529070 1.102 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr2_-_166358951 1.101 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_-_199635240 1.094 NM_005558
LAD1
ladinin 1
chr7_+_74862838 1.090 NM_198924
TRIM73
TRIM74
tripartite motif containing 73
tripartite motif containing 74
chr1_-_152459667 1.083 C1orf43
chromosome 1 open reading frame 43
chr21_+_36993302 1.082


chr11_+_72607040 1.079 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr1_+_222870573 1.077 CNIH3
cornichon homolog 3 (Drosophila)
chr3_-_123995216 1.073 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr4_-_158111916 1.073 PDGFC
platelet derived growth factor C
chr1_-_239587007 1.073 RGS7
regulator of G-protein signaling 7
chr5_+_80292313 1.070 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chrX_+_95826507 1.069 DIAPH2
diaphanous homolog 2 (Drosophila)
chr17_+_75689955 1.067 GAA
glucosidase, alpha; acid
chr11_-_70641267 1.063 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_199635339 1.060 LAD1
ladinin 1
chr4_+_95898098 1.051 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr20_+_43953372 1.046 CTSA
cathepsin A
chr1_-_191422346 1.044 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr22_-_49317408 1.041 ODF3B
outer dense fiber of sperm tails 3B
chr3_+_98016114 1.041 NM_001080448
EPHA6
EPH receptor A6
chr17_+_45527507 1.040 NM_002611
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chr5_-_159672060 1.032 NM_024565
CCNJL
cyclin J-like
chr5_+_94981735 1.026 NM_199243
GPR150
G protein-coupled receptor 150
chr11_+_125279481 1.020 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr4_-_40326603 1.015 NM_001098634
RBM47
RNA binding motif protein 47
chr20_-_2769120 1.014 FAM113A
family with sequence similarity 113, member A
chr11_+_72607254 1.012 P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr1_-_239587090 1.010 NM_002924
RGS7
regulator of G-protein signaling 7
chr22_-_42619139 1.005 NM_001177675
NM_138814
PNPLA5

patatin-like phospholipase domain containing 5

chr17_+_1574782 1.001 NM_001163809
WDR81
WD repeat domain 81
chr4_+_8251818 1.000 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr22_+_38720881 0.997 NM_138435
FAM83F
family with sequence similarity 83, member F
chr2_+_173308880 0.995 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr7_-_27190882 0.992 HOXA11
homeobox A11
chr11_+_7491789 0.991 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_-_210744158 0.991 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr11_+_111294810 0.972 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr17_-_29930431 0.970 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr17_-_7078446 0.968 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr8_+_22492586 0.967 PDLIM2
PDZ and LIM domain 2 (mystique)
chr14_-_91483325 0.965 FBLN5
fibulin 5
chr20_+_43953606 0.964 CTSA
cathepsin A
chr10_+_131155490 0.964 MGMT
O-6-methylguanine-DNA methyltransferase
chr2_-_166358792 0.962 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr4_-_40327396 0.961 RBM47
RNA binding motif protein 47
chr2_-_238164042 0.960 RAB17
RAB17, member RAS oncogene family
chr8_-_121893468 0.957 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr14_-_23981493 0.956 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr12_-_47605478 0.950 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr1_-_31942142 0.946 COL16A1
collagen, type XVI, alpha 1
chr7_-_84654106 0.945 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr7_-_82629735 0.942 PCLO
piccolo (presynaptic cytomatrix protein)
chr16_+_65790514 0.940 NM_024712
ELMO3
engulfment and cell motility 3
chr5_+_96024434 0.940 CAST
calpastatin
chr7_-_45927263 0.935 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr4_-_15694691 0.935 NM_001145847
NM_001145848
PROM1

prominin 1

chr17_+_2627099 0.930 RAP1GAP2
RAP1 GTPase activating protein 2
chr10_-_93382779 0.930 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr15_-_73719546 0.926 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr20_-_56523251 0.924 NM_153360
APCDD1L
adenomatosis polyposis coli down-regulated 1-like
chr9_+_132310068 0.921 ASS1
argininosuccinate synthase 1
chr11_-_1725924 0.918 NM_001170820
LOC402778
CD225 family protein FLJ76511
chr14_-_23106372 0.913 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr14_+_64240996 0.910 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr17_-_40865987 0.909 SH3D20
SH3 domain containing 20
chr2_+_74594093 0.907 TLX2
T-cell leukemia homeobox 2
chr10_-_93382837 0.904 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chrX_-_131919896 0.902 HS6ST2
heparan sulfate 6-O-sulfotransferase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.25 9.63e-07 GO:0048856 anatomical structure development
1.23 2.95e-06 GO:0007275 multicellular organismal development
1.25 5.06e-06 GO:0048731 system development
1.21 9.72e-06 GO:0032502 developmental process
1.08 6.50e-05 GO:0009987 cellular process
1.33 1.20e-04 GO:0007399 nervous system development
1.26 7.46e-04 GO:0030154 cell differentiation
1.25 1.37e-03 GO:0048869 cellular developmental process
1.09 1.85e-02 GO:0065007 biological regulation
1.10 3.33e-02 GO:0050794 regulation of cellular process
1.50 3.56e-02 GO:0051094 positive regulation of developmental process
1.38 4.06e-02 GO:2000026 regulation of multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 2.02e-03 GO:0044459 plasma membrane part
2.25 1.02e-02 GO:0005604 basement membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.76 4.80e-03 GO:0015291 secondary active transmembrane transporter activity
1.09 9.55e-03 GO:0005515 protein binding
1.47 1.10e-02 GO:0030695 GTPase regulator activity
1.46 1.42e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.37 2.43e-02 GO:0043565 sequence-specific DNA binding
1.05 2.99e-02 GO:0005488 binding
1.30 3.16e-02 GO:0001071 nucleic acid binding transcription factor activity
1.30 3.16e-02 GO:0003700 sequence-specific DNA binding transcription factor activity