Motif ID: EN1,2.p2

Z-value: 5.031


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2



Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_40211324 13.823 RBM47
RNA binding motif protein 47
chr7_+_50318801 11.987 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr6_-_30188845 8.367 NM_007028
TRIM31
tripartite motif containing 31
chr12_-_7172641 8.199 NM_031491
RBP5
retinol binding protein 5, cellular
chr1_+_173111306 8.011 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr2_+_102401580 7.118 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr3_+_188197029 6.678


chr22_+_38627031 6.177 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr1_-_180822686 5.538 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr11_+_22652957 4.890 GAS2
growth arrest-specific 2
chr2_+_96355661 4.860 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr4_-_80466177 4.769 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr16_-_28425632 4.723 NM_145659
IL27
interleukin 27
chr11_+_22652894 4.711 NM_005256
GAS2
growth arrest-specific 2
chr20_-_45410033 4.654 ZMYND8
zinc finger, MYND-type containing 8
chr22_+_38627129 4.480 GRAP2
GRB2-related adaptor protein 2
chr10_-_98021144 4.422 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_-_158008763 4.376 NM_004288
CYTIP
cytohesin 1 interacting protein
chr4_+_39874921 4.257 NM_004310
RHOH
ras homolog gene family, member H
chr6_-_25834733 4.205 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr12_+_91620749 4.168 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr17_-_31441390 4.068 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr11_-_47356650 3.954 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr2_+_68855436 3.947 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr11_+_59979857 3.914 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr16_-_79811475 3.873 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr11_-_47356562 3.846 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356642 3.734 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr3_-_184756101 3.727 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chrX_+_65152004 3.658


chr3_+_99733432 3.629 NM_005290
GPR15
G protein-coupled receptor 15
chrX_-_48212683 3.616 SLC38A5
solute carrier family 38, member 5
chr11_+_123600553 3.613 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr6_+_28601767 3.597 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr11_-_47356672 3.579 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr4_-_54152480 3.482 NM_001126328
LNX1
ligand of numb-protein X 1
chr12_+_6424293 3.475 NM_001242
CD27
CD27 molecule
chr17_-_74361620 3.456 TIMP2
TIMP metallopeptidase inhibitor 2
chr9_+_95886558 3.287 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr14_+_87541220 3.245 NM_003608
GPR65
G protein-coupled receptor 65
chr12_-_103846186 3.212 NM_032148
SLC41A2
solute carrier family 41, member 2
chr3_-_185578621 3.193 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr1_+_159032551 3.140 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr22_-_48865797 3.085 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr9_+_124072947 3.069 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr17_-_40843530 3.034 ARHGAP27
Rho GTPase activating protein 27
chr20_+_54420574 3.030 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr22_-_48865907 3.016 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chrX_+_41433169 3.010 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr6_-_32121784 2.985 NM_032470
TNXB
tenascin XB
chr14_-_20340377 2.978 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr1_+_111217244 2.962 NM_000560
CD53
CD53 molecule
chr12_+_55018925 2.940 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr6_-_123999640 2.911 NM_006073
TRDN
triadin
chr1_+_157526127 2.823 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr20_+_61838479 2.822 LIME1
Lck interacting transmembrane adaptor 1
chrX_+_36163971 2.819 NM_001098843
CXorf30
chromosome X open reading frame 30
chr19_-_53515143 2.811 NM_144577
CCDC114
coiled-coil domain containing 114
chr19_+_47073029 2.799 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr10_-_48036698 2.793 NM_016204
GDF2
growth differentiation factor 2
chr14_-_22658078 2.793 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr11_-_47356479 2.774 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr1_+_154390939 2.768 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr22_-_48865864 2.703 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr11_+_123639909 2.657 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr2_+_171316462 2.649 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr8_-_107023 2.625 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr12_-_51585004 2.611 NM_002273
KRT8
keratin 8
chr12_-_94469357 2.596 NM_032147
USP44
ubiquitin specific peptidase 44
chr16_-_88358946 2.588 FANCA
Fanconi anemia, complementation group A
chr19_+_45973139 2.505 NM_006533
MIA
melanoma inhibitory activity
chr9_-_34681135 2.494 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr22_+_49333327 2.491 NM_138433
KLHDC7B
kelch domain containing 7B
chr7_-_25234582 2.487 NM_022150
NPVF
neuropeptide VF precursor
chr16_+_56567839 2.471 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr1_+_246635918 2.428 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr16_-_20271530 2.419 NM_001008389
NM_003361
UMOD

uromodulin

chr12_-_101396459 2.382 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr14_-_20340830 2.364 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr4_-_17415918 2.352 DCAF16
DDB1 and CUL4 associated factor 16
chr11_-_123918759 2.351 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr5_+_140605100 2.340 PCDHB15
protocadherin beta 15
chr17_-_36928604 2.332 NM_002275
KRT15
keratin 15
chr12_-_69434330 2.324 PTPRR
protein tyrosine phosphatase, receptor type, R
chrX_-_47374647 2.315 NM_002621
CFP
complement factor properdin
chr6_-_76022565 2.313 TMEM30A
transmembrane protein 30A
chr20_+_61838389 2.304 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr1_+_25471470 2.291 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr10_-_104169458 2.277 PSD
pleckstrin and Sec7 domain containing
chr11_-_31789360 2.264 PAX6
paired box 6
chr5_-_22889487 2.255 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr18_+_27210737 2.254 NM_001134453
NM_177986
DSG4

desmoglein 4

chr1_-_202726068 2.209 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr3_+_171022403 2.209 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr7_+_106897737 2.207 NM_005295
GPR22
G protein-coupled receptor 22
chr1_+_86707113 2.187 NM_001285
CLCA1
chloride channel accessory 1
chr4_-_54152385 2.146 LNX1
ligand of numb-protein X 1
chr6_+_25834983 2.117 NM_170610
HIST1H2BA
histone cluster 1, H2ba
chr11_-_31789431 2.102 NM_000280
NM_001604
PAX6

paired box 6

chr11_+_123625632 2.091 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr19_-_44518465 2.086 GMFG
glia maturation factor, gamma
chr17_-_37181626 2.083


chr2_+_68445936 2.078 PLEK
pleckstrin
chr17_-_53764867 2.066


chr6_+_6533932 2.062 NM_004271
LY86
lymphocyte antigen 86
chr1_+_149877955 2.020 SNX27
sorting nexin family member 27
chr12_-_121767272 2.020 NM_006018
GPR109B
G protein-coupled receptor 109B
chr7_+_74017015 2.014 NM_001145063
GATSL1
GATSL2
GATS protein-like 1
GATS protein-like 2
chr12_+_51783554 1.998 SOAT2
sterol O-acyltransferase 2
chr1_-_159306037 1.978 ARHGAP30
Rho GTPase activating protein 30
chr12_+_49922592 1.953 DAZAP2
DAZ associated protein 2
chr21_+_42583259 1.947 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr12_+_6926014 1.944 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr16_+_28850760 1.933 NM_001178098
NM_001770
CD19

CD19 molecule

chr10_-_104168890 1.920 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr1_+_57093030 1.918 NM_000562
C8A
complement component 8, alpha polypeptide
chr17_-_74361975 1.908 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_+_43165608 1.900 NM_013351
TBX21
T-box 21
chr12_-_101036407 1.892 NM_024057
NUP37
nucleoporin 37kDa
chr4_+_74488947 1.886 ALB
albumin
chr6_+_30212488 1.877 NM_138700
TRIM40
tripartite motif containing 40
chr6_-_43703024 1.876 GTPBP2
GTP binding protein 2
chr4_+_74500748 1.869 ALB
albumin
chrX_+_128741578 1.862 SASH3
SAM and SH3 domain containing 3
chr12_+_6925997 1.860 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr11_-_64403712 1.857 EHD1
EH-domain containing 1
chr11_-_56761250 1.852 NM_005161
APLNR
apelin receptor
chr3_+_52788976 1.851 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr17_+_35471971 1.850 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr12_+_63510481 1.832


chr11_+_62231741 1.832 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr6_-_33085290 1.829 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr4_+_186587537 1.819 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr19_-_44518516 1.814 NM_004877
GMFG
glia maturation factor, gamma
chr15_+_42815851 1.812 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr7_-_38355949 1.807


chr6_+_41411505 1.802 NM_004828
NCR2
natural cytotoxicity triggering receptor 2
chr4_+_71235259 1.801 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr6_+_32515596 1.789 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr7_+_117651947 1.787 NM_019644
ANKRD7
ankyrin repeat domain 7
chr1_+_43063817 1.785 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chrX_-_7855400 1.775 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr14_+_59782222 1.773 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr5_+_180514548 1.755 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr19_+_13999959 1.751 NM_080864
RLN3
relaxin 3
chr11_-_31789334 1.750 PAX6
paired box 6
chr11_-_62231636 1.748 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_+_35373632 1.746 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr19_-_40925151 1.713 NM_024660
TMEM149
transmembrane protein 149
chr17_-_69869552 1.705 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chrX_+_128741562 1.705 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_+_111544469 1.703


chr17_-_4589911 1.703 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr19_-_4491024 1.677 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr3_-_113334657 1.663 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr17_+_70244553 1.658 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr6_-_41811916 1.657 NM_001167827
TFEB
transcription factor EB
chr7_-_131843377 1.651 PLXNA4
plexin A4
chr15_+_41672543 1.646 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr2_+_218954995 1.642 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr20_-_1257782 1.632 SDCBP2
syndecan binding protein (syntenin) 2
chr19_-_14030970 1.631 NM_001145028
PALM3
paralemmin 3
chr17_-_36594652 1.627 NM_033060
KRTAP4-1
keratin associated protein 4-1
chrX_+_9391314 1.623 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr14_+_22581215 1.623 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr22_+_19660361 1.619 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr16_-_49272617 1.617 SNX20
sorting nexin 20
chr18_+_70352779 1.616 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr16_-_49272741 1.614 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr7_+_94130752 1.612 PEG10
paternally expressed 10
chr6_+_47732181 1.608 NM_153839
GPR111
G protein-coupled receptor 111
chr14_+_99601498 1.597 NM_016337
EVL
Enah/Vasp-like
chr17_-_36209672 1.593 NM_181535
KRT28
keratin 28
chr19_+_39402167 1.591 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr3_+_48239865 1.587 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr7_+_106293112 1.585 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr6_-_43703057 1.584 GTPBP2
GTP binding protein 2
chr8_-_82769761 1.572 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr22_+_33792125 1.570 NM_001008494
ISX
intestine-specific homeobox
chr1_-_164402575 1.569 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr10_+_114123828 1.560 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chrX_-_48655978 1.560 PIM2
pim-2 oncogene
chr11_-_116605761 1.559 PCSK7
proprotein convertase subtilisin/kexin type 7
chr14_-_64479198 1.551 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_-_59349867 1.551 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr17_-_37181636 1.536 JUP
junction plakoglobin
chr5_+_57823017 1.535 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr10_+_5976354 1.535 NM_032807
FBXO18
F-box protein, helicase, 18
chrX_+_134803450 1.534 NM_018666
SAGE1
sarcoma antigen 1
chr6_-_33085329 1.534 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr10_-_72032447 1.532 PRF1
perforin 1 (pore forming protein)
chr16_+_49288550 1.531 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr2_-_65013070 1.529 LOC400958
hypothetical LOC400958
chr12_-_89922875 1.523 EPYC
epiphycan
chr5_+_132021763 1.523 NM_002188
IL13
interleukin 13
chr11_+_94398069 1.522 NM_001161630
KDM4DL
lysine (K)-specific demethylase 4D-like
chr11_+_118269310 1.517 NM_032966
CXCR5
chemokine (C-X-C motif) receptor 5
chr11_+_62231689 1.506 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr2_-_162717159 1.503 NM_002054
GCG
glucagon
chr21_-_33805490 1.503 GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.94 3.82e-36 GO:0007608 sensory perception of smell
3.74 5.68e-36 GO:0007606 sensory perception of chemical stimulus
2.65 3.78e-26 GO:0007600 sensory perception
2.01 5.73e-18 GO:0050877 neurological system process
1.88 8.55e-18 GO:0003008 system process
1.33 1.06e-13 GO:0050896 response to stimulus
1.32 4.41e-10 GO:0032501 multicellular organismal process
1.91 7.35e-07 GO:0006955 immune response
1.56 3.44e-04 GO:0002376 immune system process
1.68 1.10e-03 GO:0006952 defense response
1.94 1.15e-02 GO:0045087 innate immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.47 7.48e-18 GO:0071944 cell periphery
1.47 1.57e-17 GO:0005886 plasma membrane
1.29 1.69e-09 GO:0031224 intrinsic to membrane
1.28 9.86e-09 GO:0016021 integral to membrane
1.22 2.95e-07 GO:0044425 membrane part
1.43 1.10e-05 GO:0005576 extracellular region
1.16 5.15e-05 GO:0016020 membrane
1.57 2.81e-04 GO:0044421 extracellular region part
1.66 2.87e-04 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.06 1.86e-37 GO:0004984 olfactory receptor activity
2.66 4.12e-28 GO:0004930 G-protein coupled receptor activity
2.20 8.66e-25 GO:0004888 transmembrane receptor activity
1.93 5.25e-21 GO:0004872 receptor activity
1.80 2.60e-20 GO:0004871 signal transducer activity
1.80 2.60e-20 GO:0060089 molecular transducer activity