Motif ID: NR3C1.p2

Z-value: 1.730


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)



Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_143171918 3.231 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr16_-_66075216 3.078 NM_001138
AGRP
agouti related protein homolog (mouse)
chr1_-_202726068 2.444 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr6_+_64289585 2.117 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr9_-_70780574 2.057


chr2_+_143603368 1.936 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr6_+_36752244 1.936 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr17_-_31441390 1.893 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr2_-_31293882 1.846 NM_001145122
CAPN14
calpain 14
chr1_-_205161821 1.706 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr20_-_44612619 1.661 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr1_-_158759606 1.587 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr1_-_181889070 1.538 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr12_+_6925997 1.483 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr14_-_105804211 1.479 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr21_+_29322100 1.478 USP16
ubiquitin specific peptidase 16
chr17_-_9870292 1.460 NM_001130831
GAS7
growth arrest-specific 7
chr15_-_72288362 1.441 NM_001142617
NM_001142619
NM_001142620
STRA6


stimulated by retinoic acid gene 6 homolog (mouse)


chr12_-_9804682 1.392 NM_001781
CD69
CD69 molecule
chr2_-_233586145 1.330 NGEF
neuronal guanine nucleotide exchange factor
chr6_-_6265874 1.320 F13A1
coagulation factor XIII, A1 polypeptide
chrX_-_70243362 1.309 NM_001025265
CXorf65
chromosome X open reading frame 65
chr5_+_169749068 1.290


chr1_+_67404756 1.289 NM_144701
IL23R
interleukin 23 receptor
chr19_-_47724365 1.286 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr20_-_10360569 1.265 NM_018848
MKKS
McKusick-Kaufman syndrome
chr14_+_87541220 1.263 NM_003608
GPR65
G protein-coupled receptor 65
chr14_-_91403609 1.246 NM_001128596
TC2N
tandem C2 domains, nuclear
chr6_-_36412562 1.241 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr8_-_110724594 1.235 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr4_+_2783743 1.231 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr12_+_6926014 1.204 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_+_15644885 1.188 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr2_-_233586164 1.158 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr20_+_61838389 1.153 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr16_-_67039874 1.126 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr17_-_40843530 1.097 ARHGAP27
Rho GTPase activating protein 27
chr4_+_72423633 1.080 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr22_+_36008465 1.064 CYTH4
cytohesin 4
chr1_+_111544469 1.055


chr11_+_73036241 1.051 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_+_32417909 1.033 NM_175852
TXLNA
taxilin alpha
chr6_-_6265896 1.006 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr1_-_111544784 1.004 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr13_+_45174446 1.001 NM_152719
SPERT
spermatid associated
chr22_-_40666168 0.993 NM_001110215
CENPM
centromere protein M
chr5_-_169749215 0.992 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr3_+_99733432 0.980 NM_005290
GPR15
G protein-coupled receptor 15
chr1_-_94359266 0.966 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr22_+_36008511 0.959 CYTH4
cytohesin 4
chr16_+_8722068 0.957 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chrX_+_128741578 0.945 SASH3
SAM and SH3 domain containing 3
chr19_-_15869870 0.945 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr17_-_43470134 0.940 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr3_+_52254782 0.938 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr4_-_146315341 0.935 NM_017493
OTUD4
OTU domain containing 4
chr1_-_111544603 0.932


chr8_-_101384633 0.909 NM_015435
RNF19A
ring finger protein 19A
chr4_+_91035025 0.908 NM_007351
MMRN1
multimerin 1
chr17_-_59363352 0.904 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr19_-_56841819 0.899 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr1_+_117345894 0.889 NM_004258
CD101
CD101 molecule
chr3_-_184316553 0.884 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chrX_+_128741562 0.875 NM_018990
SASH3
SAM and SH3 domain containing 3
chrX_+_118598325 0.863 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr3_+_16949585 0.849 NM_015184
PLCL2
phospholipase C-like 2
chr19_-_1989937 0.844 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr17_-_60439764 0.841 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr11_+_66927976 0.811 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr4_-_10295412 0.809 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr17_+_35078032 0.788 NM_002686
PNMT
phenylethanolamine N-methyltransferase
chr20_+_61838479 0.785 LIME1
Lck interacting transmembrane adaptor 1
chr11_+_10439253 0.770 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr1_-_111544820 0.754 DENND2D
DENN/MADD domain containing 2D
chr6_+_37511383 0.742


chr2_+_43919606 0.742 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr22_+_21042091 0.723 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_-_144426918 0.722 NM_007053
CD160
CD160 molecule
chr16_-_67943157 0.715 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr10_-_69125932 0.714 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr20_-_24987615 0.714 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr6_-_130585650 0.713 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr10_+_24795465 0.712 KIAA1217
KIAA1217
chr1_+_173111306 0.705 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr22_+_21053972 0.699


chr10_+_24795446 0.698 KIAA1217
KIAA1217
chr11_+_59804634 0.692 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr3_+_188197029 0.672


chr6_-_108252200 0.671 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr14_+_22136968 0.667 NM_022060
ABHD4
abhydrolase domain containing 4
chr2_+_37282516 0.661 LOC100505876
hypothetical LOC100505876
chr6_-_32299757 0.661 NM_004557
NOTCH4
notch 4
chr1_+_32417846 0.659 TXLNA
taxilin alpha
chr4_+_2783764 0.653 SH3BP2
SH3-domain binding protein 2
chr1_-_54861656 0.648 NM_176782
FAM151A
family with sequence similarity 151, member A
chr22_-_37480898 0.643 SUN2
Sad1 and UNC84 domain containing 2
chr17_-_53849929 0.633 NM_017763
RNF43
ring finger protein 43
chr7_-_20223467 0.633 NM_182762
MACC1
metastasis associated in colon cancer 1
chr1_-_219977424 0.632 NM_144728
DUSP10
dual specificity phosphatase 10
chr22_+_33792125 0.626 NM_001008494
ISX
intestine-specific homeobox
chr4_+_74498042 0.606 ALB
albumin
chr14_-_106270497 0.599 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr20_-_4743768 0.588 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr17_-_74231266 0.585 CYTH1
cytohesin 1
chr17_+_42641426 0.581 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr4_+_74496660 0.577 ALB
albumin
chr10_+_106003941 0.577 NM_001191003
GSTO1
glutathione S-transferase omega 1
chr2_-_104834344 0.574 LOC100506421
hypothetical LOC100506421
chr17_-_68100537 0.571 LOC100499467
hypothetical LOC100499467
chr1_-_159099090 0.555 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr15_+_40481879 0.554 NM_173088
CAPN3
calpain 3, (p94)
chr11_+_72658586 0.550 NM_176798
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr13_+_77213295 0.550 NM_144595
SLAIN1
SLAIN motif family, member 1
chr19_+_40511909 0.542 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr14_-_64416307 0.540 SPTB
spectrin, beta, erythrocytic
chr6_+_150731720 0.539 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr16_+_70654625 0.538 NM_020995
HPR
haptoglobin-related protein
chr6_-_53321545 0.528 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr1_-_54256390 0.527 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr17_-_53849888 0.525 RNF43
ring finger protein 43
chr19_-_2233174 0.522 NM_198532
C19orf35
chromosome 19 open reading frame 35
chr11_-_64906683 0.519 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr19_+_59865935 0.518 NM_001081438
NM_006847
LILRB4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4

chr5_+_140690387 0.513 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr10_-_116241572 0.512


chr3_-_120761092 0.500 NM_005191
CD80
CD80 molecule
chr7_+_128795280 0.498 AHCYL2
adenosylhomocysteinase-like 2
chr5_+_67622242 0.497 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_+_7900926 0.481


chr2_-_85749374 0.471 NM_000542
NM_198843
SFTPB

surfactant protein B

chr11_-_117589283 0.462 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr4_+_74497998 0.459 ALB
albumin
chr2_-_121964373 0.453 CLASP1
cytoplasmic linker associated protein 1
chr12_-_55730125 0.449 NM_005379
MYO1A
myosin IA
chrX_+_78087484 0.445 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr19_-_46504831 0.437


chr10_-_73953699 0.433 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr16_-_20246309 0.419 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr17_-_34014390 0.419 SRCIN1
SRC kinase signaling inhibitor 1
chr8_-_95289945 0.418 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr11_+_67532592 0.416 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr10_-_75352540 0.414 NM_001001791
C10orf55
chromosome 10 open reading frame 55
chr11_-_58099884 0.409 NM_004811
LPXN
leupaxin
chr8_+_62363078 0.405 NM_173519
CLVS1
clavesin 1
chr14_+_34831294 0.404 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr6_+_32713160 0.402 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr21_-_36836767 0.402 NM_001146078
CLDN14
claudin 14
chr4_-_155731288 0.399 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr12_+_5023345 0.394 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr15_-_43280664 0.394 NM_138356
SHF
Src homology 2 domain containing F
chr2_-_238164042 0.394 RAB17
RAB17, member RAS oncogene family
chr3_-_52712639 0.392 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr22_+_42726423 0.386 NM_001003828
PARVB
parvin, beta
chr1_-_239865724 0.382 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr17_-_71352182 0.381 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr1_+_158975662 0.381 NM_021181
SLAMF7
SLAM family member 7
chr8_+_54956069 0.380 RGS20
regulator of G-protein signaling 20
chr12_+_52126131 0.377 PRR13
proline rich 13
chr17_-_35327318 0.376 NM_018530
GSDMB
gasdermin B
chr20_+_55569542 0.373 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr12_+_102859354 0.371 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr16_-_70591377 0.370 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr15_+_88593765 0.368 NM_001029964
TTLL13
tubulin tyrosine ligase-like family, member 13
chrX_-_47374187 0.365 NM_001145252
CFP
complement factor properdin
chr10_-_90601655 0.365 NM_144590
ANKRD22
ankyrin repeat domain 22
chr11_-_33678861 0.364 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr14_-_106184988 0.363 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_100764757 0.362 NM_016607
NM_177947
ARMCX3

armadillo repeat containing, X-linked 3

chr17_+_19917420 0.360 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr16_+_56134037 0.359 GPR114
G protein-coupled receptor 114
chr2_-_43919392 0.357 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr21_+_44597911 0.352 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr6_+_35544155 0.350 NM_007104
RPL10A
ribosomal protein L10a
chrX_-_135577102 0.348 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_+_159032551 0.345 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr8_-_110726921 0.345 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr11_+_117680504 0.342 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr19_-_59568222 0.337 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr17_-_39500512 0.336 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr17_-_10265991 0.336 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr6_-_53321658 0.330 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr6_+_35544174 0.329 RPL10A
ribosomal protein L10a
chr6_+_31651319 0.329 NM_000594
TNF
tumor necrosis factor
chr19_-_4131778 0.328 SIRT6
sirtuin 6
chr2_-_158008763 0.324 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_+_179759181 0.322 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_+_111571803 0.322 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr9_-_103237851 0.321 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr9_+_125158268 0.318 NM_173689
CRB2
crumbs homolog 2 (Drosophila)
chr6_-_33016561 0.317 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr12_+_56114724 0.317 NM_005538
INHBC
inhibin, beta C
chr10_+_685887 0.316 C10orf108
chromosome 10 open reading frame 108
chr19_-_56825400 0.316 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr7_-_98643024 0.309 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr21_+_37713076 0.309 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr3_-_150858274 0.307 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr11_+_22652957 0.302 GAS2
growth arrest-specific 2
chr17_-_36418869 0.302 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr4_+_35962038 0.299 NM_001170700
DTHD1
death domain containing 1
chr1_+_32512298 0.298 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.35 6.34e-03 GO:0009897 external side of plasma membrane
1.29 2.95e-02 GO:0005886 plasma membrane
1.28 3.07e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
11.10 1.81e-02 GO:0004522 pancreatic ribonuclease activity