Motif ID: GFI1.p2

Z-value: 2.662


Transcription factors associated with GFI1.p2:

Gene SymbolEntrez IDGene Name
GFI1 2672 growth factor independent 1 transcription repressor



Activity profile for motif GFI1.p2.

activity profile for motif GFI1.p2


Sorted Z-values histogram for motif GFI1.p2

Sorted Z-values for motif GFI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_23816062 5.685 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_27162688 3.963 NM_006896
HOXA7
homeobox A7
chr5_+_174084137 3.583 NM_002449
MSX2
msh homeobox 2
chr4_+_183302105 3.571 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr8_-_41286088 3.062 NM_003012
SFRP1
secreted frizzled-related protein 1
chr5_+_66160359 2.912 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_-_127901633 2.865 NM_001999
FBN2
fibrillin 2
chr2_-_189752575 2.853 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_+_26333361 2.833 NM_003532
HIST1H3E
histone cluster 1, H3e
chr6_+_26153590 2.829 NM_003531
HIST1H3C
histone cluster 1, H3c
chr4_+_167013859 2.763 NM_012464
TLL1
tolloid-like 1
chr10_-_101680645 2.730 DNMBP
dynamin binding protein
chr2_-_45090025 2.721 NM_016932
SIX2
SIX homeobox 2
chr4_-_122063118 2.538 NM_018699
PRDM5
PR domain containing 5
chr4_-_138673014 2.430 PCDH18
protocadherin 18
chr1_-_68470585 2.403 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr4_-_76774594 2.385 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr4_-_138673078 2.372 NM_019035
PCDH18
protocadherin 18
chr7_-_27153892 2.127 NM_024014
HOXA6
homeobox A6
chr7_+_87095640 2.121 NM_001134405
NM_001134406
NM_138290
RUNDC3B


RUN domain containing 3B


chr13_-_77391525 2.017


chr19_-_11352850 1.978 EPOR
erythropoietin receptor
chr4_+_95898098 1.944 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr16_+_81218074 1.900 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr1_+_161305558 1.883 NM_001113381
RGS4
regulator of G-protein signaling 4
chr9_-_78710698 1.878 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr3_+_173951163 1.869 ECT2
epithelial cell transforming sequence 2 oncogene
chr11_-_40272239 1.809 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr14_-_57834558 1.790 FLJ31306
hypothetical LOC379025
chr4_-_115120251 1.787 NM_024590
ARSJ
arylsulfatase family, member J
chr11_-_8849485 1.771 ST5
suppression of tumorigenicity 5
chr17_-_45427565 1.764 NM_005220
DLX3
distal-less homeobox 3
chr19_-_9982041 1.749 NM_015719
COL5A3
collagen, type V, alpha 3
chr2_-_216944911 1.743 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr8_+_17398940 1.724 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr12_+_83954229 1.690 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr3_+_112876212 1.671 NM_001185106
NM_153268
PLCXD2

phosphatidylinositol-specific phospholipase C, X domain containing 2

chr18_+_42780784 1.660 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr1_+_82038669 1.637 NM_012302
LPHN2
latrophilin 2
chr10_+_102782156 1.625 SFXN3
sideroflexin 3
chr4_+_185063421 1.625 NM_020225
STOX2
storkhead box 2
chr3_-_87122958 1.604 VGLL3
vestigial like 3 (Drosophila)
chr6_-_26125939 1.599 NM_005325
HIST1H1A
histone cluster 1, H1a
chrX_+_56275510 1.582 NM_007250
NM_001159296
KLF8

Kruppel-like factor 8

chr2_+_149895274 1.579 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr6_-_26379567 1.578 NM_003534
HIST1H3G
histone cluster 1, H3g
chr14_-_90596665 1.572 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr3_-_87122936 1.567 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr4_+_120167264 1.558 SYNPO2
synaptopodin 2
chr5_-_20024050 1.541 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr11_-_72111027 1.534 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr3_-_192063158 1.522 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr3_-_69517913 1.516 FRMD4B
FERM domain containing 4B
chr22_-_26527469 1.510 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr10_-_93382779 1.508 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr4_-_159313613 1.493 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr8_-_78074851 1.487 NM_000318
NM_001079867
PEX2

peroxisomal biogenesis factor 2

chr7_+_29570024 1.471 PRR15
proline rich 15
chr10_-_93382735 1.470 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr10_-_123346148 1.470 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr6_+_26128656 1.466 NM_003529
HIST1H3A
histone cluster 1, H3a
chr1_+_66570683 1.462 PDE4B
phosphodiesterase 4B, cAMP-specific
chr8_-_42184350 1.456 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr10_-_93382837 1.454 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr3_-_147361912 1.449 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr14_-_51605695 1.444 NM_007361
NID2
nidogen 2 (osteonidogen)
chr1_-_36688556 1.434 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr4_-_118226119 1.403 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr9_+_91115924 1.398 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr7_+_29569978 1.389 PRR15
proline rich 15
chr10_-_71576458 1.386 NM_001040273
NM_173555
TYSND1

trypsin domain containing 1

chr10_-_62002672 1.374 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_77829634 1.371 SHROOM3
shroom family member 3
chr3_-_115960807 1.368 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr9_-_83494198 1.358 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr5_+_102229612 1.355 PAM
peptidylglycine alpha-amidating monooxygenase
chr14_-_51605487 1.345 NID2
nidogen 2 (osteonidogen)
chr1_+_66570363 1.341 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_-_64186151 1.340 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr9_+_136673534 1.331 COL5A1
collagen, type V, alpha 1
chr4_+_46728051 1.323 NM_000812
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr5_+_15553539 1.317 FBXL7
F-box and leucine-rich repeat protein 7
chr14_+_20580224 1.313 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr14_-_51605461 1.312 NID2
nidogen 2 (osteonidogen)
chr3_+_182912405 1.310 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr17_-_5330204 1.303 NM_016041
DERL2
Der1-like domain family, member 2
chr14_-_51605515 1.299 NID2
nidogen 2 (osteonidogen)
chr5_+_57914658 1.296 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr8_-_49996353 1.294 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr7_+_29569913 1.289 NM_175887
PRR15
proline rich 15
chr1_+_32703225 1.270 NM_001145720
ZBTB8B
zinc finger and BTB domain containing 8B
chr12_+_77782719 1.263 SYT1
synaptotagmin I
chr1_+_161305188 1.252 NM_005613
RGS4
regulator of G-protein signaling 4
chr19_-_63643400 1.244 NM_003433
ZNF132
zinc finger protein 132
chr15_-_81744469 1.241 NM_001717
BNC1
basonuclin 1
chr4_+_77829743 1.238 SHROOM3
shroom family member 3
chr2_-_179380301 1.225 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr5_+_15553288 1.222 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr10_+_102782151 1.214 SFXN3
sideroflexin 3
chr12_-_83954185 1.211 NM_001100917
TSPAN19
tetraspanin 19
chr8_-_93144039 1.206


chr9_-_34319151 1.205 NM_194313
KIF24
kinesin family member 24
chr2_+_149894744 1.203 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr2_+_219180821 1.202 PLCD4
phospholipase C, delta 4
chr9_+_136673464 1.199 NM_000093
COL5A1
collagen, type V, alpha 1
chr7_-_121571472 1.198 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr17_+_19222319 1.187 NM_002749
NM_139034
MAPK7

mitogen-activated protein kinase 7

chr4_-_75083160 1.186 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr6_-_30289092 1.176 NM_003449
TRIM26
tripartite motif containing 26
chrX_+_17665483 1.176 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr11_-_118799058 1.174 THY1
Thy-1 cell surface antigen
chr11_-_117640407 1.164 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chrX_-_99551926 1.160 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr7_-_27120015 1.158 HOXA3
homeobox A3
chr17_+_19221606 1.152 NM_139032
NM_139033
MAPK7

mitogen-activated protein kinase 7

chr5_-_124108672 1.148 NM_020747
ZNF608
zinc finger protein 608
chr9_-_20612476 1.148 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_+_114414064 1.147 NM_033254
BOC
Boc homolog (mouse)
chr2_+_219180875 1.145 NM_032726
PLCD4
phospholipase C, delta 4
chr13_-_25693927 1.144 NM_183043
RNF6
ring finger protein (C3H2C3 type) 6
chr1_-_103346639 1.142 NM_001190709
NM_001854
NM_080629
NM_080630
COL11A1



collagen, type XI, alpha 1



chr14_-_91483757 1.140 NM_006329
FBLN5
fibulin 5
chrX_-_33139349 1.138 NM_004006
DMD
dystrophin
chr11_+_128751044 1.129 NM_003658
BARX2
BARX homeobox 2
chr21_+_29439768 1.128 C21orf7
chromosome 21 open reading frame 7
chr19_-_59355246 1.123 NM_024316
LENG1
leukocyte receptor cluster (LRC) member 1
chr5_+_31229609 1.122 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr11_-_85074848 1.109 NM_152723
CCDC89
coiled-coil domain containing 89
chr9_-_90983501 1.098 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr15_-_40537002 1.097 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr5_-_92942680 1.092 FLJ42709
hypothetical LOC441094
chr17_+_4922478 1.090 ZFP3
zinc finger protein 3 homolog (mouse)
chr1_-_103346482 1.090 COL11A1
collagen, type XI, alpha 1
chr11_+_43658718 1.087 NM_016142
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr13_-_25693821 1.084 NM_183044
RNF6
ring finger protein (C3H2C3 type) 6
chr5_+_102229425 1.078 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr12_+_77782579 1.078 NM_005639
SYT1
synaptotagmin I
chr5_-_59819642 1.077 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_-_28403652 1.076 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr3_+_50248749 1.072 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr4_+_15080586 1.070 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr10_-_126128539 1.065 NM_001146340
NKX1-2
NK1 homeobox 2
chr17_+_4922445 1.064 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr5_+_140835788 1.053 PCDHGC3
protocadherin gamma subfamily C, 3
chr22_+_31080871 1.052 NM_006604
RFPL3
ret finger protein-like 3
chr20_+_43875078 1.052 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr15_+_96304911 1.051 NM_183376
ARRDC4
arrestin domain containing 4
chrX_-_131451675 1.050 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr12_+_6473552 1.048 NM_014865
NCAPD2
non-SMC condensin I complex, subunit D2
chr17_+_35109802 1.048 ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr6_-_166960496 1.043 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_-_168935287 1.037 NM_007217
NM_145860
NM_145859
PDCD10


programmed cell death 10


chr6_+_32970477 1.037 LOC100294145
hypothetical LOC100294145
chr2_-_192767844 1.032 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr8_+_42129620 1.032 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr7_+_48041632 1.027 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr4_-_90978469 1.023 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_5761194 1.018 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr22_-_17891777 1.017 CLDN5
claudin 5
chr2_-_192767494 1.015 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr8_-_98359248 1.011 TSPYL5
TSPY-like 5
chr8_+_25372429 1.003 NM_152562
CDCA2
cell division cycle associated 2
chr9_+_1040600 1.000 NM_181872
DMRT2
doublesex and mab-3 related transcription factor 2
chr6_-_169395847 0.999 THBS2
thrombospondin 2
chr19_+_45976001 0.999 NM_016154
RAB4B-EGLN2
RAB4B
RAB4B-EGLN2 read-through transcript
RAB4B, member RAS oncogene family
chr2_+_162908869 0.998 GCA
grancalcin, EF-hand calcium binding protein
chr11_-_133332089 0.997 NM_014987
IGSF9B
immunoglobulin superfamily, member 9B
chr14_-_54727958 0.997 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr17_-_17816425 0.996 NM_001033551
NM_001082968
TOM1L2

target of myb1-like 2 (chicken)

chr17_-_30783631 0.996 NM_018042
SLFN12
schlafen family member 12
chr15_+_96304942 0.994 ARRDC4
arrestin domain containing 4
chr3_-_147361626 0.994 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr1_-_60312013 0.985 NM_152377
C1orf87
chromosome 1 open reading frame 87
chr1_+_162795328 0.983 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr9_-_20612433 0.981 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_+_219180862 0.978 PLCD4
phospholipase C, delta 4
chr5_-_64894687 0.976 NM_022145
CENPK
centromere protein K
chr14_-_92284626 0.969 NM_001008530
NM_005606
LGMN

legumain

chr14_-_52088786 0.969 NM_001160047
NM_020784
TXNDC16

thioredoxin domain containing 16

chr17_+_5330439 0.965 MIS12
MIS12, MIND kinetochore complex component, homolog (S. pombe)
chr10_-_105411339 0.959 SH3PXD2A
SH3 and PX domains 2A
chr3_-_116348780 0.956 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_65677255 0.953 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr10_-_71576415 0.952 TYSND1
trypsin domain containing 1
chr5_-_92982927 0.952


chr6_-_41148061 0.952 NM_145063
C6orf130
chromosome 6 open reading frame 130
chr4_-_23500706 0.950 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_-_219404755 0.950 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr21_-_35174742 0.948 RUNX1
runt-related transcription factor 1
chr13_+_35904408 0.947 NM_001111045
NM_003914
CCNA1

cyclin A1

chr3_+_129355006 0.943 EEFSEC
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr17_+_35109779 0.940 NM_004448
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr7_-_93357881 0.935 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr5_+_140835727 0.934 NM_002588
NM_032402
NM_032403
PCDHGC3


protocadherin gamma subfamily C, 3


chr1_+_42701460 0.931 CCDC30
coiled-coil domain containing 30
chr20_+_19903778 0.929 RIN2
Ras and Rab interactor 2
chr17_-_36436979 0.929 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr11_+_58631190 0.928 NM_001142703
NM_001142704
NM_198947
FAM111B


family with sequence similarity 111, member B


chr12_+_6473519 0.928 NCAPD2
non-SMC condensin I complex, subunit D2
chr1_-_95165089 0.927 NM_001839
CNN3
calponin 3, acidic

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 3.37e-03 GO:0007049 cell cycle
1.56 1.81e-02 GO:0000278 mitotic cell cycle
1.79 2.26e-02 GO:0000087 M phase of mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 1.75e-08 GO:0005634 nucleus
1.12 4.06e-07 GO:0043229 intracellular organelle
1.12 5.18e-07 GO:0043226 organelle
1.13 5.75e-07 GO:0043231 intracellular membrane-bounded organelle
1.09 6.70e-07 GO:0005622 intracellular
1.13 7.79e-07 GO:0043227 membrane-bounded organelle
1.09 6.31e-06 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.06 7.45e-03 GO:0005488 binding
1.22 3.43e-02 GO:0003677 DNA binding
1.24 4.36e-02 GO:0008270 zinc ion binding