Motif ID: SP1.p2

Z-value: 2.380


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor



Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_62151216 2.774 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr19_-_55524445 2.618 NM_004977
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr7_-_150305933 2.600 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr7_-_150306169 2.520 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr2_+_112529270 2.474 NM_032824
TMEM87B
transmembrane protein 87B
chr9_-_122679387 2.150 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr2_+_112529371 2.130 TMEM87B
transmembrane protein 87B
chr22_+_20101661 2.107 NM_015094
HIC2
hypermethylated in cancer 2
chr19_-_7840806 2.097 FLJ22184
hypothetical protein FLJ22184
chr1_+_3679168 2.096 NM_001163724
LOC388588
hypothetical protein LOC388588
chr17_+_71033339 2.024 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr19_-_6718417 1.943 NM_005490
SH2D3A
SH2 domain containing 3A
chr17_+_34114924 1.889 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr22_-_18807805 1.870 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chrX_+_9392980 1.850 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr8_-_145609737 1.840 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr19_+_34994701 1.826 NM_001238
CCNE1
cyclin E1
chr11_+_45900731 1.818 GYLTL1B
glycosyltransferase-like 1B
chrX_+_138060 1.814 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr22_-_21231421 1.796 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr12_-_123617962 1.775 NM_001077261
NM_006312
NCOR2

nuclear receptor corepressor 2

chr11_+_359723 1.768 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr19_+_659766 1.716 NM_001040134
NM_002579
PALM

paralemmin

chr1_+_945331 1.699 NM_198576
AGRN
agrin
chr19_+_8180179 1.694 NM_024552
LASS4
LAG1 homolog, ceramide synthase 4
chr16_-_2186465 1.683 NM_020764
CASKIN1
CASK interacting protein 1
chr20_-_60963390 1.658 NM_006602
TCFL5
transcription factor-like 5 (basic helix-loop-helix)
chr7_-_100078270 1.650 TFR2
transferrin receptor 2
chr11_-_65070625 1.631 LTBP3
latent transforming growth factor beta binding protein 3
chr16_+_87047159 1.628 ZFPM1
zinc finger protein, multitype 1
chr20_+_44083667 1.614 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_3558958 1.613 NM_005427
TP73
tumor protein p73
chr6_+_7052798 1.602 NM_001168344
RREB1
ras responsive element binding protein 1
chr14_-_20562962 1.593 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr19_-_772913 1.582 NM_024888
LPPR3
lipid phosphate phosphatase-related protein type 3
chr19_-_56585603 1.578 NM_001193623
LOC147646
hypothetical protein LOC147646
chr4_-_71924477 1.577 NM_002092
GRSF1
G-rich RNA sequence binding factor 1
chr4_-_71924409 1.576 GRSF1
G-rich RNA sequence binding factor 1
chr9_+_138726737 1.575 NM_152421
FAM69B
family with sequence similarity 69, member B
chr1_+_6767968 1.545 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr1_+_945399 1.530


chr20_+_61841662 1.524 SLC2A4RG
SLC2A4 regulator
chr8_-_146023228 1.485 LOC100130027
hypothetical LOC100130027
chr17_+_40681060 1.467 LOC100133991
similar to hCG1995169
chr18_+_75256702 1.457 NM_006162
NM_172388
NM_172390
NFATC1


nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1


chr19_-_60350118 1.452 TNNT1
troponin T type 1 (skeletal, slow)
chr2_-_174537354 1.451 SP3
Sp3 transcription factor
chr16_+_87047418 1.450 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr7_-_150283794 1.444 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr22_-_17545872 1.443 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_+_27931685 1.438 NM_133455
EMID1
EMI domain containing 1
chr12_+_56230110 1.437 NM_004984
KIF5A
kinesin family member 5A
chr7_-_151764004 1.437 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr19_-_864138 1.432 C19orf22
chromosome 19 open reading frame 22
chr19_-_772966 1.431 LPPR3
lipid phosphate phosphatase-related protein type 3
chr3_+_47004457 1.431 NBEAL2
neurobeachin-like 2
chr6_+_34312979 1.430 HMGA1
high mobility group AT-hook 1
chr1_-_44269615 1.427 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr19_-_60350122 1.425 TNNT1
troponin T type 1 (skeletal, slow)
chr1_+_30964199 1.418 LOC100129196
hypothetical LOC100129196
chr18_+_586997 1.418 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr16_+_665680 1.417 RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr22_+_21852743 1.412 BCR
breakpoint cluster region
chr4_+_995609 1.400 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr9_-_122679283 1.395 PHF19
PHD finger protein 19
chr8_+_144706699 1.388 NM_001166237
GSDMD
gasdermin D
chrX_+_153318452 1.376 NM_001493
GDI1
GDP dissociation inhibitor 1
chr9_+_138680064 1.360 EGFL7
EGF-like-domain, multiple 7
chr1_-_1840564 1.359 NM_178545
TMEM52
transmembrane protein 52
chr1_+_224317030 1.357 H3F3A
H3 histone, family 3A
chr12_+_6290127 1.353 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr19_-_18409788 1.346 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr21_-_39642935 1.345 HMGN1
high-mobility group nucleosome binding domain 1
chr22_+_21742364 1.340 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr6_+_43846735 1.328 VEGFA
vascular endothelial growth factor A
chr16_+_1323627 1.321 BAIAP3
BAI1-associated protein 3
chr21_+_46473494 1.315 MCM3AP-AS1
MCM3AP antisense RNA 1 (non-protein coding)
chr9_-_139068269 1.312 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr19_+_1200882 1.310 MIDN
midnolin
chrX_+_109132507 1.309 NM_017698
TMEM164
transmembrane protein 164
chr22_+_21742727 1.307 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr22_+_38183480 1.300 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr19_-_3431514 1.300 NM_001136503
C19orf77
chromosome 19 open reading frame 77
chr12_+_56230073 1.300 KIF5A
kinesin family member 5A
chr22_-_17546276 1.295 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chrX_-_129072333 1.294 NM_001127197
ELF4
E74-like factor 4 (ets domain transcription factor)
chr22_-_17546296 1.285 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_-_17489912 1.285 NM_001173533
NM_001173534
NM_001184781
NM_005137
DGCR2



DiGeorge syndrome critical region gene 2



chr1_+_224317056 1.280 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr22_-_17546234 1.279 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_+_59064795 1.279 MYADM
myeloid-associated differentiation marker
chr19_-_864224 1.278 NM_138774
C19orf22
chromosome 19 open reading frame 22
chr1_+_224317062 1.274 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr19_-_60483302 1.267 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr1_-_199259133 1.262 KIF21B
kinesin family member 21B
chr20_+_32045214 1.259 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr6_+_34313007 1.258 HMGA1
high mobility group AT-hook 1
chr14_+_99775032 1.254 YY1
YY1 transcription factor
chr17_-_73867748 1.252 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr19_-_4016467 1.250 ZBTB7A
zinc finger and BTB domain containing 7A
chr20_+_56899904 1.248 GNAS
GNAS complex locus
chr17_+_53515725 1.246 NM_080677
DYNLL2
dynein, light chain, LC8-type 2
chr17_+_35532315 1.244 NM_001012241
MSL1
male-specific lethal 1 homolog (Drosophila)
chr19_-_864203 1.239 C19orf22
chromosome 19 open reading frame 22
chr16_+_2503676 1.229 NM_001198569
NM_001694
ATP6V0C

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

chr7_+_26207569 1.226 NM_007276
CBX3
chromobox homolog 3
chr19_-_864201 1.226 C19orf22
chromosome 19 open reading frame 22
chr9_+_130491644 1.221 SET
SET nuclear oncogene
chr21_-_39642880 1.217 NM_004965
HMGN1
high-mobility group nucleosome binding domain 1
chr8_-_145187553 1.205 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr16_-_87570716 1.205 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr19_-_864194 1.204 C19orf22
chromosome 19 open reading frame 22
chr3_-_187025438 1.204 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr9_+_132961723 1.202 AIF1L
allograft inflammatory factor 1-like
chr16_-_88295595 1.202 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr6_+_7052985 1.195 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr1_+_15608974 1.195 NM_024329
EFHD2
EF-hand domain family, member D2
chr19_-_44503328 1.195


chr7_-_97868101 1.192 BAIAP2L1
BAI1-associated protein 2-like 1
chr6_+_34312906 1.178 HMGA1
high mobility group AT-hook 1
chrX_-_153016368 1.178 NM_001110792
NM_004992
MECP2

methyl CpG binding protein 2 (Rett syndrome)

chr11_+_46359878 1.177 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr2_+_10360471 1.175 NM_002149
HPCAL1
hippocalcin-like 1
chr2_-_96899396 1.171 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr9_+_139619918 1.168 ARRDC1
arrestin domain containing 1
chr4_+_995395 1.168 FGFRL1
fibroblast growth factor receptor-like 1
chr18_+_75256931 1.168 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr19_-_51829778 1.152 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr22_+_48951286 1.148 NM_001160300
NM_052839
PANX2

pannexin 2

chr12_-_56526484 1.147 CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr1_+_945472 1.147 AGRN
agrin
chr20_-_34635091 1.146


chr16_+_29725311 1.145 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr3_-_187025501 1.145 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr19_+_59385930 1.145 NM_024075
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr6_+_163755773 1.141 QKI
quaking homolog, KH domain RNA binding (mouse)
chr17_+_78303202 1.138 NM_005993
TBCD
tubulin folding cofactor D
chr19_-_52666886 1.136 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr1_+_15609009 1.131 EFHD2
EF-hand domain family, member D2
chr14_+_104267270 1.127 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr13_-_113066366 1.125 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr2_+_10101822 1.123 NM_001177718
KLF11
Kruppel-like factor 11
chr17_-_40839082 1.123 NM_001159330
ARHGAP27
Rho GTPase activating protein 27
chr9_-_138701721 1.122 NM_001012727
NM_006412
AGPAT2

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)

chr19_+_10261646 1.122 NM_003259
ICAM5
intercellular adhesion molecule 5, telencephalin
chr7_-_97868362 1.117 NM_018842
BAIAP2L1
BAI1-associated protein 2-like 1
chr1_-_199259447 1.117 NM_017596
KIF21B
kinesin family member 21B
chr17_-_70401299 1.116 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr18_+_75256915 1.115 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr2_+_79593567 1.110 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr12_+_6290359 1.105 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr9_+_139619969 1.102 ARRDC1
arrestin domain containing 1
chr19_-_1441403 1.099 NM_017573
PCSK4
proprotein convertase subtilisin/kexin type 4
chr7_-_149101227 1.080 NM_207336
ZNF467
zinc finger protein 467
chr1_+_224317036 1.080 NM_002107
H3F3A
H3 histone, family 3A
chr1_+_66570363 1.079 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr14_+_104337923 1.077 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr22_+_18081968 1.075 NM_002688
SEPT5
septin 5
chr16_-_79687367 1.071 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr19_-_7845325 1.064 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr12_-_107649418 1.064 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr8_+_70541631 1.061 SULF1
sulfatase 1
chr12_+_19484044 1.060 AEBP2
AE binding protein 2
chr7_-_158073121 1.060 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr20_+_32045319 1.057 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr17_-_53515563 1.053


chr2_-_47986160 1.045 NM_001190274
FBXO11
F-box protein 11
chr3_-_50315983 1.039 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr16_+_620932 1.036 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr19_-_52667056 1.035 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr19_-_18493886 1.034 NM_006532
ELL
elongation factor RNA polymerase II
chr19_-_53841064 1.032 NM_001217
CA11
carbonic anhydrase XI
chr6_+_167970334 1.031 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr6_+_163755788 1.031 QKI
quaking homolog, KH domain RNA binding (mouse)
chr20_+_56899867 1.031 GNAS
GNAS complex locus
chr7_-_151763857 1.031 MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr19_-_56196611 1.030 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr5_-_179166378 1.028 NM_014275
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr12_+_56230047 1.028 KIF5A
kinesin family member 5A
chr10_+_45189617 1.027 NM_000698
ALOX5
arachidonate 5-lipoxygenase
chr20_+_56899643 1.027 NM_001077489
NM_000516
NM_080426
GNAS


GNAS complex locus


chr22_-_18384251 1.021 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr20_+_34635362 1.019 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr16_-_88613287 1.018 NM_001042610
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chrX_-_152643016 1.016 NM_005745
BCAP31
B-cell receptor-associated protein 31
chrX_-_152643042 1.016 BCAP31
B-cell receptor-associated protein 31
chr22_+_21852699 1.014 BCR
breakpoint cluster region
chr9_-_138701681 1.014 AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr6_-_6632197 1.011


chr21_+_45649429 1.005 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr19_+_12810258 1.005 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr5_-_59100194 1.003 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_-_2672337 1.002 NM_145173
DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr17_-_34157962 1.001 NM_007144
PCGF2
polycomb group ring finger 2
chr19_+_7834124 0.999 EVI5L
ecotropic viral integration site 5-like
chr16_-_960982 0.998 NM_022773
LMF1
lipase maturation factor 1
chr16_+_1979959 0.998 NM_004209
SYNGR3
synaptogyrin 3
chr17_-_77422561 0.997 NM_001185078
NM_004309
ARHGDIA

Rho GDP dissociation inhibitor (GDI) alpha

chr19_+_10404110 0.996 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr16_+_2461500 0.996 NM_006181
NTN3
netrin 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.70e-28 GO:0009987 cellular process
1.14 2.49e-26 GO:0044237 cellular metabolic process
1.17 3.40e-26 GO:0044260 cellular macromolecule metabolic process
1.11 1.23e-20 GO:0008152 metabolic process
1.12 4.89e-20 GO:0044238 primary metabolic process
1.17 1.43e-17 GO:0060255 regulation of macromolecule metabolic process
1.13 2.42e-17 GO:0043170 macromolecule metabolic process
1.16 3.39e-17 GO:0031323 regulation of cellular metabolic process
1.16 3.94e-17 GO:0080090 regulation of primary metabolic process
1.09 6.42e-16 GO:0065007 biological regulation
1.10 8.36e-16 GO:0050794 regulation of cellular process
1.15 2.58e-15 GO:0019222 regulation of metabolic process
1.09 8.62e-15 GO:0050789 regulation of biological process
1.19 1.46e-14 GO:0010468 regulation of gene expression
1.19 3.50e-14 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.20 4.03e-14 GO:0048523 negative regulation of cellular process
1.24 4.09e-14 GO:0006996 organelle organization
1.21 3.18e-13 GO:0043412 macromolecule modification
1.18 4.99e-13 GO:0044267 cellular protein metabolic process
1.18 1.01e-12 GO:0048519 negative regulation of biological process
1.18 1.09e-12 GO:0010556 regulation of macromolecule biosynthetic process
1.21 1.19e-12 GO:0006464 protein modification process
1.17 1.24e-12 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 1.90e-12 GO:0051252 regulation of RNA metabolic process
1.17 7.81e-12 GO:0071842 cellular component organization at cellular level
1.18 2.91e-11 GO:0006355 regulation of transcription, DNA-dependent
1.16 6.74e-11 GO:0051171 regulation of nitrogen compound metabolic process
1.16 1.20e-10 GO:0071841 cellular component organization or biogenesis at cellular level
1.16 1.36e-10 GO:0031326 regulation of cellular biosynthetic process
1.14 3.15e-10 GO:0016043 cellular component organization
1.20 3.41e-10 GO:0016070 RNA metabolic process
1.16 3.72e-10 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 3.84e-10 GO:0010605 negative regulation of macromolecule metabolic process
1.14 4.13e-10 GO:0034641 cellular nitrogen compound metabolic process
1.17 4.55e-10 GO:0090304 nucleic acid metabolic process
1.15 5.66e-10 GO:0009889 regulation of biosynthetic process
1.13 2.68e-09 GO:0006807 nitrogen compound metabolic process
1.16 3.00e-09 GO:0044249 cellular biosynthetic process
1.26 4.49e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.13 5.20e-09 GO:0071840 cellular component organization or biogenesis
1.15 7.36e-09 GO:0009058 biosynthetic process
1.41 9.53e-09 GO:0016568 chromatin modification
1.25 1.27e-08 GO:0009892 negative regulation of metabolic process
1.19 1.97e-08 GO:0023051 regulation of signaling
1.56 2.06e-08 GO:0016569 covalent chromatin modification
1.56 2.64e-08 GO:0016570 histone modification
1.32 2.92e-08 GO:0010629 negative regulation of gene expression
1.26 3.13e-08 GO:0006351 transcription, DNA-dependent
1.14 3.40e-08 GO:0048518 positive regulation of biological process
1.24 3.48e-08 GO:0007049 cell cycle
1.26 3.77e-08 GO:0031324 negative regulation of cellular metabolic process
1.31 4.11e-08 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.24 4.16e-08 GO:0032268 regulation of cellular protein metabolic process
1.23 9.13e-08 GO:0051246 regulation of protein metabolic process
1.13 1.04e-07 GO:0019538 protein metabolic process
1.14 2.47e-07 GO:0048522 positive regulation of cellular process
1.29 3.52e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.18 4.53e-07 GO:0034645 cellular macromolecule biosynthetic process
1.32 4.63e-07 GO:0045892 negative regulation of transcription, DNA-dependent
1.19 7.94e-07 GO:0009966 regulation of signal transduction
1.29 1.41e-06 GO:0000278 mitotic cell cycle
1.17 1.79e-06 GO:0009059 macromolecule biosynthetic process
1.30 1.83e-06 GO:0051253 negative regulation of RNA metabolic process
1.32 3.61e-06 GO:0006325 chromatin organization
1.28 4.35e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.24 5.46e-06 GO:0022402 cell cycle process
1.22 5.82e-06 GO:0032774 RNA biosynthetic process
1.28 6.21e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.15 7.41e-06 GO:0010467 gene expression
1.26 7.68e-06 GO:0009890 negative regulation of biosynthetic process
1.26 8.71e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.20 2.07e-05 GO:0010646 regulation of cell communication
1.26 2.42e-05 GO:0051276 chromosome organization
1.18 4.35e-05 GO:0051641 cellular localization
1.39 6.34e-05 GO:0016567 protein ubiquitination
1.24 6.76e-05 GO:0022403 cell cycle phase
1.22 7.52e-05 GO:0031399 regulation of protein modification process
1.37 1.21e-04 GO:0032446 protein modification by small protein conjugation
1.34 1.29e-04 GO:0070647 protein modification by small protein conjugation or removal
1.28 1.34e-04 GO:0051338 regulation of transferase activity
1.16 2.73e-04 GO:0035556 intracellular signal transduction
1.24 3.71e-04 GO:0051726 regulation of cell cycle
1.18 4.35e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.30 5.20e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.27 5.40e-04 GO:0043549 regulation of kinase activity
1.70 6.02e-04 GO:0006475 internal protein amino acid acetylation
1.27 7.39e-04 GO:0045859 regulation of protein kinase activity
1.17 1.04e-03 GO:0051649 establishment of localization in cell
1.63 1.07e-03 GO:0030336 negative regulation of cell migration
1.63 1.07e-03 GO:2000146 negative regulation of cell motility
1.33 1.22e-03 GO:0048285 organelle fission
1.33 1.64e-03 GO:0000087 M phase of mitotic cell cycle
1.20 1.69e-03 GO:0046907 intracellular transport
1.69 1.75e-03 GO:0018393 internal peptidyl-lysine acetylation
1.33 2.24e-03 GO:0051270 regulation of cellular component movement
1.15 2.32e-03 GO:0007399 nervous system development
1.59 2.33e-03 GO:0051271 negative regulation of cellular component movement
1.68 2.97e-03 GO:0016573 histone acetylation
1.34 3.05e-03 GO:0030334 regulation of cell migration
1.26 3.49e-03 GO:0010648 negative regulation of cell communication
1.14 3.70e-03 GO:0065009 regulation of molecular function
1.31 3.71e-03 GO:0006511 ubiquitin-dependent protein catabolic process
1.15 3.93e-03 GO:0009893 positive regulation of metabolic process
1.35 4.09e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.66 4.12e-03 GO:0018394 peptidyl-lysine acetylation
1.31 4.15e-03 GO:0019941 modification-dependent protein catabolic process
1.26 4.45e-03 GO:0023057 negative regulation of signaling
1.34 4.58e-03 GO:2000145 regulation of cell motility
1.32 4.77e-03 GO:0000280 nuclear division
1.32 4.77e-03 GO:0007067 mitosis
1.33 5.04e-03 GO:0001568 blood vessel development
1.16 5.06e-03 GO:0031325 positive regulation of cellular metabolic process
1.34 5.33e-03 GO:0051248 negative regulation of protein metabolic process
1.32 5.62e-03 GO:0040012 regulation of locomotion
1.30 7.68e-03 GO:0043632 modification-dependent macromolecule catabolic process
1.20 8.10e-03 GO:0009790 embryo development
1.54 8.54e-03 GO:0040013 negative regulation of locomotion
1.26 8.98e-03 GO:0032583 regulation of gene-specific transcription
1.18 9.89e-03 GO:0033554 cellular response to stress
1.08 9.95e-03 GO:0051179 localization
1.23 1.04e-02 GO:0044265 cellular macromolecule catabolic process
1.26 1.17e-02 GO:0009968 negative regulation of signal transduction
1.08 1.22e-02 GO:0007275 multicellular organismal development
1.60 1.23e-02 GO:0006473 protein acetylation
1.08 1.27e-02 GO:0032502 developmental process
1.20 1.40e-02 GO:0010628 positive regulation of gene expression
1.23 1.40e-02 GO:0048585 negative regulation of response to stimulus
1.17 1.43e-02 GO:0022008 neurogenesis
1.30 1.46e-02 GO:0051325 interphase
1.29 1.48e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.23 1.49e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.28 1.49e-02 GO:0051301 cell division
1.42 1.58e-02 GO:0032147 activation of protein kinase activity
1.29 1.61e-02 GO:0060284 regulation of cell development
1.26 1.61e-02 GO:0007264 small GTPase mediated signal transduction
1.30 1.80e-02 GO:0051329 interphase of mitotic cell cycle
1.20 2.05e-02 GO:0051254 positive regulation of RNA metabolic process
1.20 2.08e-02 GO:0042325 regulation of phosphorylation
1.20 2.15e-02 GO:0019220 regulation of phosphate metabolic process
1.20 2.15e-02 GO:0051174 regulation of phosphorus metabolic process
1.54 2.22e-02 GO:0018205 peptidyl-lysine modification
1.54 2.22e-02 GO:0043543 protein acylation
1.42 2.27e-02 GO:0031396 regulation of protein ubiquitination
1.20 2.39e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.21 2.71e-02 GO:0009057 macromolecule catabolic process
1.28 2.75e-02 GO:0044257 cellular protein catabolic process
1.88 2.88e-02 GO:0034968 histone lysine methylation
1.16 2.90e-02 GO:0043067 regulation of programmed cell death
1.23 2.96e-02 GO:0072358 cardiovascular system development
1.23 2.96e-02 GO:0072359 circulatory system development
1.16 3.03e-02 GO:0006793 phosphorus metabolic process
1.16 3.03e-02 GO:0006796 phosphate metabolic process
1.34 3.26e-02 GO:0045786 negative regulation of cell cycle
1.15 3.31e-02 GO:0010941 regulation of cell death
1.30 3.32e-02 GO:0001944 vasculature development
1.17 3.36e-02 GO:0016265 death
1.17 3.37e-02 GO:0008219 cell death
1.18 3.39e-02 GO:0051128 regulation of cellular component organization
1.26 3.54e-02 GO:0030163 protein catabolic process
1.26 3.61e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.15 4.00e-02 GO:0042981 regulation of apoptosis
1.32 4.31e-02 GO:0051129 negative regulation of cellular component organization
1.15 4.39e-02 GO:0008104 protein localization
1.14 4.41e-02 GO:0044248 cellular catabolic process
1.20 4.94e-02 GO:0045893 positive regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 1.76e-74 GO:0005622 intracellular
1.12 1.95e-74 GO:0044424 intracellular part
1.15 5.05e-61 GO:0043227 membrane-bounded organelle
1.15 7.80e-61 GO:0043231 intracellular membrane-bounded organelle
1.13 3.77e-58 GO:0043229 intracellular organelle
1.13 4.39e-58 GO:0043226 organelle
1.12 1.87e-39 GO:0005737 cytoplasm
1.17 5.64e-38 GO:0005634 nucleus
1.16 9.69e-34 GO:0044422 organelle part
1.16 2.09e-33 GO:0044446 intracellular organelle part
1.13 4.72e-26 GO:0044444 cytoplasmic part
1.25 1.52e-25 GO:0044428 nuclear part
1.26 1.44e-21 GO:0031981 nuclear lumen
1.22 7.90e-21 GO:0031974 membrane-enclosed lumen
1.22 5.25e-20 GO:0070013 intracellular organelle lumen
1.22 2.29e-19 GO:0043233 organelle lumen
1.22 8.57e-19 GO:0005829 cytosol
1.26 3.41e-15 GO:0005654 nucleoplasm
1.03 2.55e-13 GO:0044464 cell part
1.03 3.00e-13 GO:0005623 cell
1.21 8.79e-12 GO:0012505 endomembrane system
1.15 2.94e-11 GO:0043234 protein complex
1.30 1.02e-10 GO:0044451 nucleoplasm part
1.12 2.04e-09 GO:0032991 macromolecular complex
1.16 5.85e-09 GO:0031090 organelle membrane
1.13 1.95e-08 GO:0043228 non-membrane-bounded organelle
1.13 1.95e-08 GO:0043232 intracellular non-membrane-bounded organelle
1.28 2.21e-08 GO:0015630 microtubule cytoskeleton
1.37 6.40e-06 GO:0005874 microtubule
1.19 3.63e-05 GO:0005794 Golgi apparatus
1.18 5.46e-05 GO:0005783 endoplasmic reticulum
1.24 1.69e-04 GO:0005694 chromosome
1.40 3.66e-04 GO:0005819 spindle
1.20 3.82e-04 GO:0044432 endoplasmic reticulum part
1.25 3.82e-04 GO:0005730 nucleolus
1.19 6.87e-04 GO:0031410 cytoplasmic vesicle
1.20 7.70e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.19 9.57e-04 GO:0031988 membrane-bounded vesicle
1.22 1.45e-03 GO:0044431 Golgi apparatus part
1.31 1.54e-03 GO:0012506 vesicle membrane
1.31 1.75e-03 GO:0030659 cytoplasmic vesicle membrane
1.69 1.85e-03 GO:0034708 methyltransferase complex
1.69 1.85e-03 GO:0035097 histone methyltransferase complex
1.63 2.26e-03 GO:0000123 histone acetyltransferase complex
1.19 2.72e-03 GO:0005789 endoplasmic reticulum membrane
1.19 3.36e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.18 4.27e-03 GO:0031982 vesicle
2.06 8.47e-03 GO:0031519 PcG protein complex
1.27 8.89e-03 GO:0044433 cytoplasmic vesicle part
1.19 1.09e-02 GO:0030054 cell junction
1.39 1.48e-02 GO:0000151 ubiquitin ligase complex
1.21 1.73e-02 GO:0044427 chromosomal part
1.24 2.44e-02 GO:0048471 perinuclear region of cytoplasm
1.34 3.32e-02 GO:0070161 anchoring junction
1.48 3.80e-02 GO:0000790 nuclear chromatin
1.20 4.06e-02 GO:0000139 Golgi membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 2.86e-41 GO:0005515 protein binding
1.07 4.66e-28 GO:0005488 binding
1.30 6.87e-15 GO:0030528 transcription regulator activity
1.11 1.94e-12 GO:0003824 catalytic activity
1.29 3.10e-10 GO:0019899 enzyme binding
1.15 1.90e-08 GO:0003677 DNA binding
1.42 2.61e-08 GO:0016564 transcription repressor activity
1.17 2.97e-08 GO:0016740 transferase activity
1.14 1.29e-07 GO:0000166 nucleotide binding
1.34 1.30e-07 GO:0019904 protein domain specific binding
1.12 1.79e-07 GO:0003676 nucleic acid binding
1.35 4.26e-07 GO:0000988 protein binding transcription factor activity
1.35 4.26e-07 GO:0000989 transcription factor binding transcription factor activity
1.35 5.82e-07 GO:0003712 transcription cofactor activity
1.21 1.74e-06 GO:0001071 nucleic acid binding transcription factor activity
1.21 1.74e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.37 5.55e-06 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.21 1.64e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.14 2.08e-05 GO:0017076 purine nucleotide binding
1.14 2.14e-05 GO:0032553 ribonucleotide binding
1.14 2.14e-05 GO:0032555 purine ribonucleotide binding
1.29 2.31e-05 GO:0016874 ligase activity
1.14 3.57e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.34 5.23e-05 GO:0016563 transcription activator activity
1.37 5.33e-05 GO:0016881 acid-amino acid ligase activity
1.43 8.72e-05 GO:0003682 chromatin binding
1.15 1.02e-04 GO:0030554 adenyl nucleotide binding
1.15 1.04e-04 GO:0032559 adenyl ribonucleotide binding
1.15 1.98e-04 GO:0005524 ATP binding
1.25 2.48e-04 GO:0008092 cytoskeletal protein binding
1.62 4.23e-04 GO:0031625 ubiquitin protein ligase binding
1.37 6.23e-04 GO:0004842 ubiquitin-protein ligase activity
1.21 6.27e-04 GO:0043565 sequence-specific DNA binding
1.36 6.56e-04 GO:0019787 small conjugating protein ligase activity
1.12 8.40e-04 GO:0008270 zinc ion binding
1.19 1.63e-03 GO:0042802 identical protein binding
1.33 1.94e-03 GO:0003702 RNA polymerase II transcription factor activity
1.19 2.04e-03 GO:0016301 kinase activity
1.30 3.36e-03 GO:0008134 transcription factor binding
1.41 5.70e-03 GO:0003714 transcription corepressor activity
1.10 6.76e-03 GO:0046914 transition metal ion binding
1.07 7.23e-03 GO:0043169 cation binding
1.07 8.99e-03 GO:0043167 ion binding
1.07 1.57e-02 GO:0046872 metal ion binding
1.18 1.70e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.26 1.87e-02 GO:0003779 actin binding
1.48 1.99e-02 GO:0016566 specific transcriptional repressor activity
1.30 4.35e-02 GO:0003713 transcription coactivator activity