Motif ID: PRRX1,2.p2

Z-value: 4.122


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2



Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_17599438 14.957 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr8_-_122722674 12.234 NM_005328
HAS2
hyaluronan synthase 2
chr4_-_152366970 10.742 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr4_+_160408447 10.369 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr7_+_91762227 10.074


chr13_-_37070862 9.969 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr11_-_85103438 9.553 NM_032379
SYTL2
synaptotagmin-like 2
chr10_+_69539255 9.481 NM_032578
MYPN
myopalladin
chr12_-_15706340 9.238 EPS8
epidermal growth factor receptor pathway substrate 8
chr8_+_107807415 9.107 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr7_-_92615593 9.080 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_+_69895310 8.911 NM_001184967
MITF
microphthalmia-associated transcription factor
chr9_-_116920232 8.874 NM_002160
TNC
tenascin C
chr4_-_152368492 8.699 SH3D19
SH3 domain containing 19
chrX_+_114734074 8.634 NM_001136025
NM_001172335
PLS3

plastin 3

chr3_-_143230124 8.589 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr2_-_162808123 8.343 NM_004460
FAP
fibroblast activation protein, alpha
chr6_-_139654807 8.237 NM_153235
TXLNB
taxilin beta
chr7_+_18501876 8.092 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr4_+_86918870 8.056 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr3_-_55489973 7.978 WNT5A
wingless-type MMTV integration site family, member 5A
chr5_-_169340321 7.972 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr1_+_168898898 7.828 PRRX1
paired related homeobox 1
chr11_+_5667494 7.789 NM_006074
TRIM22
tripartite motif containing 22
chr4_+_86918882 7.778 ARHGAP24
Rho GTPase activating protein 24
chr5_+_36642424 7.632 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_3341521 7.625 NM_198227
RGS12
regulator of G-protein signaling 12
chr17_-_1211263 7.612 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr5_+_36642213 7.503 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr4_-_138673014 7.432 PCDH18
protocadherin 18
chr18_+_19826734 7.366 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr3_-_11598829 7.360 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_-_55090759 7.319 NM_007008
RTN4
reticulon 4
chr3_-_115960807 7.296 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr7_-_104696678 7.226 NM_182691
SRPK2
SRSF protein kinase 2
chr5_-_75954807 7.073 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr5_+_174084137 7.047 NM_002449
MSX2
msh homeobox 2
chr3_-_116272911 6.934 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_94442941 6.857 MCTP1
multiple C2 domains, transmembrane 1
chr1_+_194887630 6.826 NM_000186
NM_001014975
CFH

complement factor H

chr2_+_36777406 6.722 VIT
vitrin
chr11_+_5667392 6.709 TRIM22
tripartite motif containing 22
chr15_+_55298908 6.676 NM_207040
TCF12
transcription factor 12
chrX_+_135058402 6.661 NM_001159700
FHL1
four and a half LIM domains 1
chr17_-_46479127 6.646 SPAG9
sperm associated antigen 9
chr2_-_133145539 6.579 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr8_-_120720200 6.524 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr7_+_115650240 6.522 NM_152829
TES
testis derived transcript (3 LIM domains)
chr21_-_34820916 6.470 NM_203418
RCAN1
regulator of calcineurin 1
chr2_-_175170674 6.457 WIPF1
WAS/WASL interacting protein family, member 1
chr8_-_28403652 6.391 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr7_-_76667045 6.384 NM_006682
FGL2
fibrinogen-like 2
chr12_-_90029328 6.340 LUM
lumican
chr3_-_115585178 6.272 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_242283129 6.130 NM_006352
ZNF238
zinc finger protein 238
chr1_-_171441234 6.097 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr8_-_82557956 6.076 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr2_-_206790871 6.038 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr6_+_136214495 5.988 NM_018945
PDE7B
phosphodiesterase 7B
chr3_+_174598937 5.953 NM_014932
NLGN1
neuroligin 1
chr15_+_97990705 5.943 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr2_-_198248828 5.824 NM_144629
RFTN2
raftlin family member 2
chr18_+_30427279 5.767 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr1_+_213245507 5.751 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr11_+_128067598 5.747 NM_001167681
FLI1
Friend leukemia virus integration 1
chr9_+_18464138 5.744 ADAMTSL1
ADAMTS-like 1
chr8_-_108579270 5.696 NM_001146
ANGPT1
angiopoietin 1
chr8_+_42671718 5.648 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr11_-_104421240 5.638 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr18_+_30544193 5.595 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr4_+_146820805 5.594 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr13_-_98428244 5.575 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr2_+_210152399 5.568 MAP2
microtubule-associated protein 2
chr9_-_94338072 5.372 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr1_+_84540921 5.357 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr3_-_62334229 5.345 NM_018008
FEZF2
FEZ family zinc finger 2
chr7_-_13992351 5.343 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr7_-_7724762 5.325 NM_002947
RPA3
replication protein A3, 14kDa
chr13_+_100902942 5.319 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr4_-_41579325 5.292


chr1_-_89261021 5.268 NM_018284
GBP3
guanylate binding protein 3
chr3_+_69895651 5.251 NM_006722
MITF
microphthalmia-associated transcription factor
chr6_-_127882192 5.209 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr3_+_133798770 5.186 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr21_+_29439768 5.166 C21orf7
chromosome 21 open reading frame 7
chr3_+_29297806 5.160 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr5_+_147775652 5.153 FBXO38
F-box protein 38
chr8_-_72431274 5.153 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr1_-_197173159 5.128 LOC100131234
familial acute myelogenous leukemia related factor
chrX_-_19727775 5.113 SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_68470585 5.107 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_+_124835608 5.106 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chrX_+_102471769 5.040 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr3_+_89239494 5.020 EPHA3
EPH receptor A3
chr1_+_81544432 4.996 LPHN2
latrophilin 2
chr7_-_41709191 4.959 NM_002192
INHBA
inhibin, beta A
chr8_-_102029997 4.954 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_115099007 4.913 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr11_-_104411065 4.907 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr4_-_87989291 4.887 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr7_-_81237162 4.856 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr16_+_85169615 4.805 NM_005250
FOXL1
forkhead box L1
chr12_-_52939584 4.784 NM_001127322
CBX5
chromobox homolog 5
chr17_-_44026321 4.776 HOXB5
homeobox B5
chr3_-_55490401 4.718 WNT5A
wingless-type MMTV integration site family, member 5A
chr4_-_138673078 4.681 NM_019035
PCDH18
protocadherin 18
chr4_+_77575276 4.671 NM_020859
SHROOM3
shroom family member 3
chr3_-_152585226 4.671 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr7_+_90177082 4.658 CDK14
cyclin-dependent kinase 14
chr9_-_15240113 4.634 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr3_-_71262426 4.626 FOXP1
forkhead box P1
chrX_+_77889861 4.620 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr3_+_190831909 4.607 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr3_-_55490442 4.604 WNT5A
wingless-type MMTV integration site family, member 5A
chr12_-_90029672 4.576 NM_002345
LUM
lumican
chr4_+_120029426 4.556 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr1_-_114215768 4.555 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr10_+_86174665 4.525 FAM190B
family with sequence similarity 190, member B
chr6_-_46401363 4.517 NM_005822
RCAN2
regulator of calcineurin 2
chr11_-_128399218 4.503 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr10_-_49483002 4.492 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr17_+_36515166 4.492 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr10_-_95231933 4.485 NM_013451
NM_133337
MYOF

myoferlin

chrX_-_19727828 4.457 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr3_-_71262405 4.454 FOXP1
forkhead box P1
chr11_-_3759886 4.451 NUP98
nucleoporin 98kDa
chr22_-_34566210 4.443 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr21_-_35174742 4.437 RUNX1
runt-related transcription factor 1
chr2_-_202271598 4.434 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr13_-_34948758 4.433 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr4_-_90197140 4.401 NM_014883
FAM13A
family with sequence similarity 13, member A
chr5_+_127012611 4.400 NM_001048252
CTXN3
cortexin 3
chr12_-_52939636 4.380 NM_001127321
CBX5
chromobox homolog 5
chr4_+_86968069 4.348 ARHGAP24
Rho GTPase activating protein 24
chr5_-_124108672 4.333 NM_020747
ZNF608
zinc finger protein 608
chr22_+_27998367 4.327 EWSR1
Ewing sarcoma breakpoint region 1
chr1_+_175406685 4.322 FAM5B
family with sequence similarity 5, member B
chr15_-_53996597 4.287 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr12_+_88268845 4.285 LOC100131490
hypothetical LOC100131490
chr7_+_102340579 4.276 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr20_+_11846536 4.267 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr7_+_17349425 4.257 AHR
aryl hydrocarbon receptor
chr15_-_68781662 4.250 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr1_+_84402962 4.248 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr15_-_70838703 4.245


chr13_+_34948977 4.239 NBEA
neurobeachin
chr17_-_44026042 4.235 NM_002147
HOXB5
homeobox B5
chr6_-_56824672 4.205 DST
dystonin
chr9_+_674193 4.175


chr2_-_188021117 4.173 NM_005795
CALCRL
calcitonin receptor-like
chr6_-_33862690 4.136 NM_001143944
LEMD2
LEM domain containing 2
chr13_+_51933228 4.114 CKAP2
cytoskeleton associated protein 2
chr5_-_94443300 4.109 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr2_+_151922350 4.092 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr22_-_34564611 4.092 RPL41P5
ribosomal protein L41 pseudogene 5
chr4_-_74307637 4.091 ANKRD17
ankyrin repeat domain 17
chr6_+_121798443 4.047 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr17_+_3326045 4.011 NM_000049
ASPA
aspartoacylase
chr8_-_93181091 4.005 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_114703273 3.999


chr9_-_4656665 3.993 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr4_-_153493133 3.986 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr6_+_118976134 3.969 NM_002667
PLN
phospholamban
chr8_-_110689396 3.966 SYBU
syntabulin (syntaxin-interacting)
chr22_-_34566276 3.960 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_-_90100710 3.921 DCN
decorin
chr8_-_93144039 3.866


chr4_+_169789327 3.843 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr12_-_52281050 3.832 NM_001130059
ATF7
activating transcription factor 7
chr12_-_90100733 3.816 NM_001920
DCN
decorin
chr14_+_51025604 3.815 NM_001042481
FRMD6
FERM domain containing 6
chr13_-_59223074 3.804


chr2_-_231697999 3.798 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr5_+_36644187 3.798 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr21_-_35153664 3.781 RUNX1
runt-related transcription factor 1
chr7_-_87180499 3.773 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_+_36493927 3.757 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr21_-_42219849 3.754 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr7_-_83116414 3.698 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_-_55053398 3.696


chr4_-_83566246 3.667 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr2_-_227952249 3.655 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr11_+_131285747 3.646 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr17_-_44006808 3.637 NM_002146
HOXB3
homeobox B3
chr3_+_161040439 3.618 SCHIP1
schwannomin interacting protein 1
chr11_-_76058542 3.613 NM_005512
LRRC32
leucine rich repeat containing 32
chr7_-_26202626 3.603 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr15_+_47502666 3.590 NM_002009
FGF7
fibroblast growth factor 7
chr17_-_36436979 3.585 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr15_+_45797977 3.584 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr1_+_169421011 3.584 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr10_-_32707549 3.584 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr3_-_11585264 3.580 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr2_-_183095308 3.563 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr6_-_76259976 3.560 NM_015687
FILIP1
filamin A interacting protein 1
chr3_+_161040343 3.557 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr3_-_152517204 3.556 NM_023915
GPR87
G protein-coupled receptor 87
chr9_+_18464090 3.537 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr11_-_58099884 3.530 NM_004811
LPXN
leupaxin
chr7_+_129720209 3.530 NM_001163446
NM_016352
CPA4

carboxypeptidase A4


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 1.90e-04 GO:0048731 system development
1.17 8.10e-04 GO:0007275 multicellular organismal development
1.16 9.21e-04 GO:0023052 signaling
1.17 1.04e-03 GO:0007165 signal transduction
1.18 1.79e-03 GO:0048856 anatomical structure development
1.16 1.95e-03 GO:0032502 developmental process
1.12 2.81e-03 GO:0032501 multicellular organismal process
1.14 3.58e-03 GO:0051716 cellular response to stimulus
1.23 4.11e-03 GO:0048513 organ development
1.33 6.03e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.39 7.20e-03 GO:0045595 regulation of cell differentiation
1.36 1.50e-02 GO:2000026 regulation of multicellular organismal development
1.49 2.43e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.55 2.52e-02 GO:0060284 regulation of cell development
1.31 2.69e-02 GO:0050793 regulation of developmental process
1.70 3.40e-02 GO:0007517 muscle organ development
1.20 3.47e-02 GO:0048869 cellular developmental process
1.20 4.54e-02 GO:0030154 cell differentiation

Nothing significant found in compartment category.

Nothing significant found in function category.