Motif ID: HSF1,2.p2

Z-value: 1.322


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2



Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_202379442 1.846 NM_139158
CDK15
cyclin-dependent kinase 15
chr8_+_40130143 1.692 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr12_+_118100977 1.549 NM_014365
HSPB8
heat shock 22kDa protein 8
chr13_+_23742846 1.438 SPATA13
spermatogenesis associated 13
chr7_-_75876830 1.373 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr5_-_110090264 1.330 NM_001039763
TMEM232
transmembrane protein 232
chr1_+_54786394 1.280 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr2_-_188127294 1.229 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_+_210152399 1.182 MAP2
microtubule-associated protein 2
chr2_-_188127430 1.173 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr13_-_45577144 1.142 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr10_-_116434364 1.138 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr10_+_104525877 1.108 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr17_-_78599695 1.102 B3GNTL1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr2_-_105421661 1.091 NM_201557
FHL2
four and a half LIM domains 2
chr3_-_195553297 1.080 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr20_+_41576459 1.068 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr1_+_221168388 1.032 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr12_-_14887648 1.025 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr17_+_9686572 0.962 GLP2R
glucagon-like peptide 2 receptor
chr2_+_210152609 0.956 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr9_-_90983501 0.946 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr2_-_162638174 0.945 DPP4
dipeptidyl-peptidase 4
chr7_+_113842407 0.943 FOXP2
forkhead box P2
chr7_+_113842284 0.936 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr11_+_7463175 0.924 NM_198474
OLFML1
olfactomedin-like 1
chr6_+_151688327 0.917 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr2_+_11600287 0.911 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr2_+_11600238 0.898 GREB1
growth regulation by estrogen in breast cancer 1
chr7_+_113842470 0.880 FOXP2
forkhead box P2
chr7_+_129807467 0.879 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr11_+_62893836 0.878 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr22_+_19458378 0.876 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr9_-_90983195 0.864 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr1_-_159459999 0.862 NM_001643
APOA2
apolipoprotein A-II
chr1_-_159459814 0.861 APOA2
apolipoprotein A-II
chr1_+_45046740 0.846 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr16_+_3055642 0.845 NM_001012632
NM_001012636
IL32

interleukin 32

chr6_-_131333173 0.831 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr20_+_31334601 0.828 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr16_+_3055639 0.825 NM_001012634
IL32
interleukin 32
chr8_-_93181091 0.825 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_+_94584449 0.823 NM_001013848
EXOC6
exocyst complex component 6
chr16_+_3055640 0.818 IL32
interleukin 32
chr11_-_34491878 0.813 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr9_-_126309510 0.804 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr8_-_142307854 0.801 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr1_+_26220852 0.799 NM_004455
EXTL1
exostoses (multiple)-like 1
chr6_+_167624792 0.790 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr18_+_27425727 0.769 NM_000371
TTR
transthyretin
chr8_-_82769761 0.752 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr12_-_21818881 0.743 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr8_-_13018123 0.741 NM_001164271
DLC1
deleted in liver cancer 1
chr1_-_148155986 0.741 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chrX_+_46825179 0.734 RGN
regucalcin (senescence marker protein-30)
chr3_+_45042754 0.730 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr22_+_22907417 0.728 SUSD2
sushi domain containing 2
chr22_+_22907443 0.724 NM_019601
SUSD2
sushi domain containing 2
chr17_+_38306339 0.719 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr10_-_116434102 0.719 ABLIM1
actin binding LIM protein 1
chr16_+_3055602 0.718 NM_001012635
IL32
interleukin 32
chr19_+_52504914 0.714 NM_001736
C5AR1
complement component 5a receptor 1
chr2_-_224611568 0.700 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_+_123369219 0.697 NM_032552
DAB2IP
DAB2 interacting protein
chr7_+_129771865 0.684 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr20_+_19818209 0.683 NM_018993
RIN2
Ras and Rab interactor 2
chr6_+_116939500 0.677 NM_153711
FAM26E
family with sequence similarity 26, member E
chr1_+_48460943 0.676 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr9_-_115877104 0.675 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_116455898 0.672 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr9_-_74757735 0.672 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr3_-_42892195 0.658 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr6_+_129245978 0.656 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr11_-_47467094 0.654 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr10_+_95838801 0.625 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr13_+_23042722 0.622 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr14_+_38653177 0.618 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr3_-_52844274 0.608 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr2_+_128119908 0.608 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr7_-_99411573 0.597 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr16_+_14187965 0.591 MKL2
MKL/myocardin-like 2
chr9_-_15240113 0.590 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr10_+_70650064 0.586 NM_025130
HKDC1
hexokinase domain containing 1
chr2_+_228386800 0.583 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr10_+_5396975 0.581 NM_053049
UCN3
urocortin 3 (stresscopin)
chr7_+_101704145 0.580 CUX1
cut-like homeobox 1
chr12_-_7172641 0.568 NM_031491
RBP5
retinol binding protein 5, cellular
chr7_-_27125738 0.568 NM_030661
HOXA3
homeobox A3
chr17_+_72883759 0.564 NM_001113494
SEPT9
septin 9
chr7_+_1094248 0.562 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr6_+_32021899 0.561 CFB
complement factor B
chr10_-_69267774 0.559 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr7_+_134483305 0.556 NM_018295
TMEM140
transmembrane protein 140
chr6_+_32021687 0.555 NM_001710
CFB
complement factor B
chr11_-_404975 0.554 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_-_166965034 0.552 NM_001937
DPT
dermatopontin
chr16_+_3055313 0.551 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr18_-_50776276 0.548 NM_001143829
CCDC68
coiled-coil domain containing 68
chr11_-_111287657 0.545 NM_001885
CRYAB
crystallin, alpha B
chr4_-_22126437 0.543 NM_145290
GPR125
G protein-coupled receptor 125
chr16_-_73012740 0.539 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr6_+_32021742 0.539 CFB
complement factor B
chr8_-_52884456 0.539 NM_144651
PXDNL
peroxidasin homolog (Drosophila)-like
chr11_-_905057 0.535 NM_001142675
CHID1
chitinase domain containing 1
chr22_+_34109095 0.534 HMOX1
heme oxygenase (decycling) 1
chr16_+_68765428 0.533 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr1_+_179164195 0.531


chr2_-_21084911 0.529 APOB
apolipoprotein B (including Ag(x) antigen)
chr19_-_38052481 0.529 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr6_+_32021831 0.524 CFB
complement factor B
chr9_-_94338072 0.524 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr8_-_37576515 0.520 LOC157860
hypothetical protein LOC157860
chr2_-_215998181 0.516 FN1
fibronectin 1
chr18_-_490583 0.515 NM_130386
COLEC12
collectin sub-family member 12
chr20_-_17487480 0.515 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr14_-_22610572 0.514 ACIN1
apoptotic chromatin condensation inducer 1
chr20_+_41621119 0.512 SGK2
serum/glucocorticoid regulated kinase 2
chr17_+_18796202 0.511 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr6_-_76259976 0.510 NM_015687
FILIP1
filamin A interacting protein 1
chr14_+_62740878 0.505 NM_020663
RHOJ
ras homolog gene family, member J
chr2_-_152538694 0.496 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr14_-_21074875 0.490 NM_005407
SALL2
sal-like 2 (Drosophila)
chr3_-_9895471 0.489 CIDEC
cell death-inducing DFFA-like effector c
chr18_+_30427279 0.486 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr10_-_28611020 0.485 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr6_+_32021793 0.484 CFB
complement factor B
chr3_-_113841200 0.483 CCDC80
coiled-coil domain containing 80
chr8_+_75066117 0.481 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr19_+_3659358 0.478 TJP3
tight junction protein 3 (zona occludens 3)
chr4_+_74500748 0.473 ALB
albumin
chr5_-_83052606 0.470 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr14_-_74400288 0.469 NM_001080408
PROX2
prospero homeobox 2
chr20_+_41621079 0.467 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr12_+_79362256 0.466 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr13_+_112746908 0.462 MCF2L
MCF.2 cell line derived transforming sequence-like
chr19_+_15079141 0.462 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr1_+_57093030 0.458 NM_000562
C8A
complement component 8, alpha polypeptide
chr13_+_75232797 0.458 NM_015842
LMO7
LIM domain 7
chr3_-_124893875 0.458 MYLK
myosin light chain kinase
chr15_-_97366313 0.455 NM_001102612
PGPEP1L
pyroglutamyl-peptidase I-like
chr6_-_127822227 0.451 NM_014702
KIAA0408
KIAA0408
chr18_-_51219880 0.449 TCF4
transcription factor 4
chr6_-_110843432 0.441 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr2_-_198073242 0.440 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr17_+_38259620 0.440 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr15_+_87540238 0.440 ABHD2
abhydrolase domain containing 2
chr14_-_22610610 0.435 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr12_-_68369322 0.434 NM_152439
BEST3
bestrophin 3
chr17_-_40348378 0.431 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr12_+_6768960 0.430 CD4
CD4 molecule
chr12_+_6768966 0.422 CD4
CD4 molecule
chr19_-_53914768 0.421 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr4_+_187385618 0.420 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chrX_-_2892288 0.418 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr3_-_140677990 0.416 NM_004164
RBP2
retinol binding protein 2, cellular
chr1_-_220788048 0.414 NM_024746
HHIPL2
HHIP-like 2
chr17_-_76897590 0.410 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr15_-_87565813 0.409 NM_000326
RLBP1
retinaldehyde binding protein 1
chr10_-_74384569 0.406 PLA2G12B
phospholipase A2, group XIIB
chr6_+_44234525 0.404 NM_007058
CAPN11
calpain 11
chr17_+_35425139 0.404 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr20_+_61337679 0.403 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr12_-_121577410 0.402 NM_023012
RSRC2
arginine/serine-rich coiled-coil 2
chr12_+_6768934 0.402 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr7_+_102340579 0.400 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr20_+_4614796 0.394 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr15_+_70477707 0.392 NM_001080462
TMEM202
transmembrane protein 202
chr5_-_44424423 0.390 NM_004465
FGF10
fibroblast growth factor 10
chr3_-_42892636 0.390 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_+_222871109 0.388 NM_153038
CCDC140
coiled-coil domain containing 140
chr11_+_101488380 0.387 NM_001195045
YAP1
Yes-associated protein 1
chr12_+_6768866 0.387 NM_000616
CD4
CD4 molecule
chr10_-_74384485 0.387 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr2_-_219742950 0.387 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr12_-_55134692 0.382 NM_012064
MIP
major intrinsic protein of lens fiber
chr9_+_124835608 0.377 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr19_-_47638890 0.376 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr1_-_171442937 0.375 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_-_78217278 0.374 FUBP1
far upstream element (FUSE) binding protein 1
chr1_-_177106702 0.372 NM_004673
ANGPTL1
angiopoietin-like 1
chr17_+_1593040 0.371 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr9_+_130719034 0.370 LRRC8A
leucine rich repeat containing 8 family, member A
chr3_-_113841448 0.365 CCDC80
coiled-coil domain containing 80
chr9_+_4829763 0.360 RCL1
RNA terminal phosphate cyclase-like 1
chr3_+_52504410 0.360 STAB1
stabilin 1
chr2_+_198073257 0.359 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr5_-_111119846 0.358 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr12_+_74160779 0.357 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr14_+_38714111 0.357 NM_002687
PNN
pinin, desmosome associated protein
chr20_-_3097070 0.352 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr20_+_29598848 0.350 HM13
histocompatibility (minor) 13
chr11_-_65081967 0.349 LTBP3
latent transforming growth factor beta binding protein 3
chr2_+_159533329 0.345 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr7_+_143263191 0.345 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr2_+_198073358 0.344 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr11_+_64079665 0.343 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr8_+_42671718 0.339 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr10_+_44726635 0.338 NM_001123376
TMEM72
transmembrane protein 72
chr4_-_152366970 0.336 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr19_-_47723183 0.336 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 7.59e-04 GO:0009987 cellular process
1.14 5.52e-03 GO:0044238 primary metabolic process
1.98 2.12e-02 GO:0006457 protein folding
1.16 2.33e-02 GO:0043170 macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.02 4.91e-03 GO:0031983 vesicle lumen
2.97 1.13e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.97 1.92e-02 GO:0031093 platelet alpha granule lumen
1.36 2.14e-02 GO:0044421 extracellular region part
2.91 2.57e-02 GO:0034774 secretory granule lumen
2.71 2.63e-02 GO:0031091 platelet alpha granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 1.42e-06 GO:0005515 protein binding
2.28 8.85e-03 GO:0051082 unfolded protein binding